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5 results on '"Anne-Sophie Lot"'

1. Electrocardiogram abnormalities and prognosis in COVID-19

Author

Gabriel Chevrot, Marie Hauguel-Moreau, Marion Pépin, Antoine Vieillard-Baron, Anne-Sophie Lot, Mounir Ouadahi, Hélène Hergault, Vincent Aïdan, Ségolène Greffe, Adrien Costantini, Olivier Dubourg, Sébastien Beaune, and Nicolas Mansencal

Subjects
ECG, COVID-19, prognosis, SARS-CoV-2, repolarization, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundCOVID-19 is a major pandemic with potential cardiovascular complications. Few studies have focused on electrocardiogram (ECG) modifications in COVID-19 patients.Method and resultsWe reviewed from our database all patients referred to our hospital for COVID-19 between January 1st, 2020, and December 31st, 2020: 669 patients were included and 98 patients died from COVID-19 (14.6%). We systematically analyzed ECG at admission and during hospitalization if available. ECG was abnormal at admission in 478 patients (71.4%) and was more frequently abnormal in patients who did not survive (88.8 vs. 68.5%, p < 0.001). The most common ECG abnormalities associated with death were left anterior fascicular block (39.8 vs. 20.0% among alive patients, p < 0.001), left and right bundle branch blocks (p = 0.002 and p = 0.02, respectively), S1Q3 pattern (14.3 vs. 6.0%, p = 0.006). In multivariate analysis, at admission, the presence of left bundle branch block remained statistically related to death [OR = 3.82, 95% confidence interval (CI): 1.52–9.28, p < 0.01], as well as S1Q3 pattern (OR = 3.17, 95% CI: 1.38–7.03, p < 0.01) and repolarization abnormalities (OR = 2.41, 95% CI: 1.40–4.14, p < 0.01).On ECG performed during hospitalization, the occurrence of new repolarization abnormality was significantly related to death (OR = 2.72, 95% CI: 1.14–6.54, p = 0.02), as well as a new S1Q3 pattern (OR = 13.23, 95% CI: 1.49–286.56, p = 0.03) and new supraventricular arrhythmia (OR = 3.8, 95% CI: 1.11–13.35, p = 0.03).ConclusionThe presence of abnormal ECG during COVID-19 is frequent. Physicians should be aware of the usefulness of ECG for risk stratification during COVID-19.

Published
2022
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2. A Restructured Hospital Into a One-Building Organization for COVID-19 Patients: A Resilient and Effective Response to the Pandemic

Author

Simon Bessis, Aurélien Dinh, Sylvain Gautier, Benjamin Davido, Jonathan Levy, Christine Lawrence, Anne-Sophie Lot, Djamel Bensmail, Célia Rech, Muriel Farcy-Afif, Frédérique Bouchand, Pierre de Truchis, Jean-Louis Herrmann, Frédéric Barbot, David Orlikowski, Pierre Moine, Christian Perronne, Loïc Josseran, Hélène Prigent, and Djillali Annane

Subjects
COVID-19 outbreak, preparedness, infection control, emerging infection, resilience, Public aspects of medicine, RA1-1270
Abstract

The COVID-19 pandemic is a unique crisis challenging healthcare institutions as it rapidly overwhelmed hospitals due to a large influx of patients. This major event forced all the components of the healthcare systems to adapt and invent new workflows. Thus, our tertiary care hospital was reorganized entirely. During the cruising phase, additional staff was allocated to a one-building organization comprising an intensive care unit (ICU), an acute care unit, a physical medicine and rehabilitation unit, and a COVID-19 screening area. The transfer of patients from a ward to another was more efficient due to these organizations and pavilion structure. The observed mortality was low in the acute care ward, except in the palliative unit. No nosocomial infection with SARS-CoV-2 was reported in any other building of the hospital since this organization was set up. This type of one-building organization, integrating all the components for comprehensive patient care, seems to be the most appropriate response to pandemics.

Published
2022
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3. Occurrence of pulmonary embolism related to COVID-19

Author

Marie Hauguel-Moreau, Céline Bégué, Quentin De Baynast, Nicolas Mansencal, Hazrije Mustafic, Guillaume Geri, Robert Carlier, Mostafa El Hajjam, Anne-Sophie Lot, Olivier Dubourg, Antoine Vieillard-Baron, Sébastien Beaune, Thierry Chinet, Service de cardiologie et maladies vasculaires [CHU Ambroise Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Ambroise Paré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (BECCOH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and HAL UVSQ, Équipe

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Coronavirus disease 2019 (COVID-19), 030204 cardiovascular system & hematology, Risk Assessment, Gastroenterology, Article, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Risk Factors, Internal medicine, White blood cell, Heart rate, medicine, Humans, Hospital Mortality, 030212 general & internal medicine, Aged, Aged, 80 and over, business.industry, Incidence, Incidence (epidemiology), Pulmonary embolism, COVID-19, Thrombosis, Hematology, Wbc count, Middle Aged, Prognosis, medicine.disease, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Increased risk, medicine.anatomical_structure, Female, France, Cardiology and Cardiovascular Medicine, business, Cohort study
Abstract

Recent reports have suggested an increased risk of pulmonary embolism (PE) related to COVID-19. The aim of this cohort study is to compare the incidence of PE during a 3-year period and to assess the characteristics of PE in COVID-19. We studied consecutive patients presenting with PE (January 2017–April 2020). Clinical presentation, computed tomography (CT) and biological markers were systematically assessed. We recorded the global number of hospitalizations during the COVID-19 pandemic and during the same period in 2018-2019. We included 347 patients: 326 without COVID-19 and 21 with COVID-19. Patients with COVID-19 experienced more likely dyspnea (p=0.04), had lower arterial oxygen saturation (p

Published
2020
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4. A Model of Primary Culture of Colorectal Cancer and Liver Metastasis to Predict Chemosensitivity

Author

Bernard Nordlinger, Alain Beauchet, Antoine Brouquet, Gregoire Prevost, Christophe Penna, Philippe Taleb, Anne-Sophie Lot, and Catherine Julié

Subjects
Oncology, medicine.medical_specialty, Proliferative index, Colorectal cancer, medicine.medical_treatment, Cell Culture Techniques, Adenocarcinoma, Irinotecan, Metastasis, Tissue culture, In vivo, Internal medicine, medicine, Humans, Polyhydroxyethyl Methacrylate, Chemotherapy, business.industry, Liver Neoplasms, medicine.disease, Antineoplastic Agents, Phytogenic, In vitro, Radiography, Ki-67 Antigen, Drug Resistance, Neoplasm, Camptothecin, Surgery, Drug Monitoring, Topoisomerase I Inhibitors, Colorectal Neoplasms, business, HT29 Cells, Cell Division, Immunostaining
Abstract

Prediction of chemosensitivity is a major goal of modern oncology. The aim of this study was to establish a simple and effective model of primary culture of colorectal cancer fragments and to test whether it allows prediction of chemosensitivity.Colorectal cancer fragments (primary tumors or liver metastases) of 94 consecutive and previously untreated patients were obtained, prepared, and cultured in polyHEMA. For each fragment cultured, a proliferative index (PI) was calculated after immunostaining at d 0 and after 7 d in culture with media alone or supplemented for 24h with the topoisomerase I inhibitor metabolite SN-38. The correlation between in vitro response (decrease in PI after exposure to the drug) and in vivo response (RECIST criteria) was studied in a subset of patients who had measurable metastases and were treated with a topoisomerase I inhibitor.PolyHEMA allowed three-dimensional culture of tumor fragments up to 7 d without fibroblastic invasion and with a slight but significant decrease of PI (59% at d 0 versus 51% after 7 d in culture, P0.001). In vitro drug efficacy was tested in 67 fragments, the mean PI after culture with SN-38 dropped to 22% (P0.001). In a subset of 12 patients, there was no statistically significant correlation between in vitro and in vivo response (P = 0.13).Primary culture in polyHEMA was easy to perform successfully in 71% of cases. On this model, the antiproliferative effect of SN-38 could be measured and results correlated to clinical data.

Published
2011
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5. Factors associated with the length of stay of patients discharged from emergency department in France

Author

Guillaume Debaty, Marie Ferrua, Henri Leleu, Frédéric Capuano, Bruno Riou, Anne-Sophie Lot, Etienne Minvielle, Marc Giroud, Dominique Brun-Ney, Christine Sagnes-Raffy, Dominique Pateron, Dept Food Microbiol, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Institut Gustave Roussy (IGR), Université Pierre et Marie Curie - Paris 6 (UPMC), SAMU, CHU Grenoble, Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée (TIMC-IMAG-PRETA), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), EA Management des Organisations de Santé (EA MOS), École des Hautes Études en Santé Publique [EHESP] (EHESP)-PRES Sorbonne Paris Cité, Service d'urgence de médecine et de chirurgie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Risk Assessment, Young Adult, Sex Factors, Medicine, Humans, Child, Emergency Treatment, Aged, business.industry, Age Factors, Emergency department, Length of Stay, Middle Aged, medicine.disease, emergency department management, Patient Discharge, Patient Outcome Assessment, quality, Child, Preschool, Emergency medicine, Emergency Medicine, [SHS.GESTION]Humanities and Social Sciences/Business administration, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Medical emergency, France, business, Emergency Service, Hospital, performance
Abstract

International audience; Objectives: The length of stay in the emergency department (ED) has been proposed as an indicator of performance in many countries. We conducted a survey of length of stay in two large areas in France and tested the hypothesis that patient and ED-related variables may influence it.Patients and methods: During 2007, we examined lengths of stay in ambulatory patients, that is, excluding admitted patients. The following variables were considered: (a) at the patient level, age, sex, the day and month of the visit, and the French clinical classification of emergency patients (CCEP) class; (b) at the ED level, annual ED total number of visits, mean age, the proportions of patients less than 15 and more than 75 years, and the proportions of admitted and clinically stable patients with CCEP class 1 and 2. A multilevel hierarchical analysis was carried out.Results: We analyzed 988 591 visits in 53 EDs. The ED-specific median length of stay was 98 (IQR: 62–137) min and the ED-specific median proportion of patients with length of stay of more than 4 h was 15 (5–24) %. There was a strong correlation between the ED-specific median length of stay and the ED-specific proportion of patients with a length of stay of more than 4 h (R=0.96, P

Published
2014
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