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1. Maternal haemoglobin levels in pregnancy and child DNA methylation:a study in the pregnancy and childhood epigenetics consortium

Author: Ronkainen, J. (Justiina), Heiskala, A. (Anni), Vehmeijer, F. O. (Florianne O. L.), Lowry, E. (Estelle), Caramaschi, D. (Doretta), Estrada Gutierrez, G. (Guadalupe), Heiss, J. A. (Jonathan A.), Hummel, N. (Nadine), Keikkala, E. (Elina), Kvist, T. (Tuomas), Kupsco, A. (Allison), Melton, P. E. (Phillip E.), Pesce, G. (Giancarlo), Soomro, M. H. (Munawar H.), Vives-Usano, M. (Marta), Baiz, N. (Nour), Binder, E. (Elisabeth), Czamara, D. (Darina), Guxens, M. (Mònica), Mustaniemi, S. (Sanna), London, S. J. (Stephanie J.), Rauschert, S. (Sebastian), Vääräsmäki, M. (Marja), Vrijheid, M. (Martine), Ziegler, A.-G. (Anette-G.), Annesi-Maesano, I. (Isabella), Bustamante, M. (Mariona), Huang, R.-C. (Rae-Chi), Hummel, S. (Sandra), Just, A. C. (Allan C.), Kajantie, E. (Eero), Lahti, J. (Jari), Lawlor, D. (Deborah), Räikkönen, K. (Katri), Järvelin, M.-R. (Marjo-Riitta), Felix, J. F. (Janine F.), Sebert, S. (Sylvain), Ronkainen, J. (Justiina), Heiskala, A. (Anni), Vehmeijer, F. O. (Florianne O. L.), Lowry, E. (Estelle), Caramaschi, D. (Doretta), Estrada Gutierrez, G. (Guadalupe), Heiss, J. A. (Jonathan A.), Hummel, N. (Nadine), Keikkala, E. (Elina), Kvist, T. (Tuomas), Kupsco, A. (Allison), Melton, P. E. (Phillip E.), Pesce, G. (Giancarlo), Soomro, M. H. (Munawar H.), Vives-Usano, M. (Marta), Baiz, N. (Nour), Binder, E. (Elisabeth), Czamara, D. (Darina), Guxens, M. (Mònica), Mustaniemi, S. (Sanna), London, S. J. (Stephanie J.), Rauschert, S. (Sebastian), Vääräsmäki, M. (Marja), Vrijheid, M. (Martine), Ziegler, A.-G. (Anette-G.), Annesi-Maesano, I. (Isabella), Bustamante, M. (Mariona), Huang, R.-C. (Rae-Chi), Hummel, S. (Sandra), Just, A. C. (Allan C.), Kajantie, E. (Eero), Lahti, J. (Jari), Lawlor, D. (Deborah), Räikkönen, K. (Katri), Järvelin, M.-R. (Marjo-Riitta), Felix, J. F. (Janine F.), and Sebert, S. (Sylvain)
Abstract: Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. DNA methylation was measured using Illumina Infinium Methylation 450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for the association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
Published: 2022

2. Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the pregnancy and childhood epigenetics consortium

Author: Ronkainen, J. (Justiina), Heiskala, A. (Anni), Vehmeijer, F.O.L. (Florianne O.L.), Lowry, E. (Estelle), Caramaschi, D. (Doretta), Estrada Gutierrez, G. (Guadalupe), Heiss, J.A. (Jonathan A.), Hummel, N. (Nadine), Keikkala, E. (Elina), Kvist, T. (Tuomas), Kupsco, A. (Allison), Melton, P.E. (Phillip E.), Pesce, G. (Giancarlo), Soomro, M.H. (Munawar H.), Vives-Usano, M. (Marta), Baïz, N. (Nour), Binder, E.B. (Elisabeth), Czamara, D. (Darina), Guxens Junyent, M. (Mònica), Mustaniemi, S. (Sanna), London, S.J. (Stephanie J.), Rauschert, S. (Sebastian), Vääräsmäki, M. (Marja), Vrijheid, M. (Martine), Ziegler, A.-G. (Anette-G.), Annesi-Maesano, I. (Isabella), Bustamante, M. (Mariona), Huang, R.-C. (Rae-Chi), Hummel, S. (Sandra), Just, A.C. (Allan C.), Kajantie, E. (Eero), Lahti, J. (Jari), Lawlor, D. (Deborah), Räikkönen, K. (Katri), Järvelin, M.-R. (Marjo-Riitta), Felix, J.F. (Janine), Sebert, S. (Sylvain), Ronkainen, J. (Justiina), Heiskala, A. (Anni), Vehmeijer, F.O.L. (Florianne O.L.), Lowry, E. (Estelle), Caramaschi, D. (Doretta), Estrada Gutierrez, G. (Guadalupe), Heiss, J.A. (Jonathan A.), Hummel, N. (Nadine), Keikkala, E. (Elina), Kvist, T. (Tuomas), Kupsco, A. (Allison), Melton, P.E. (Phillip E.), Pesce, G. (Giancarlo), Soomro, M.H. (Munawar H.), Vives-Usano, M. (Marta), Baïz, N. (Nour), Binder, E.B. (Elisabeth), Czamara, D. (Darina), Guxens Junyent, M. (Mònica), Mustaniemi, S. (Sanna), London, S.J. (Stephanie J.), Rauschert, S. (Sebastian), Vääräsmäki, M. (Marja), Vrijheid, M. (Martine), Ziegler, A.-G. (Anette-G.), Annesi-Maesano, I. (Isabella), Bustamante, M. (Mariona), Huang, R.-C. (Rae-Chi), Hummel, S. (Sandra), Just, A.C. (Allan C.), Kajantie, E. (Eero), Lahti, J. (Jari), Lawlor, D. (Deborah), Räikkönen, K. (Katri), Järvelin, M.-R. (Marjo-Riitta), Felix, J.F. (Janine), and Sebert, S. (Sylvain)
Abstract: Altered maternal haemoglobin levels during pregnancy are associated with pre-clinical and clinical conditions affecting the fetus. Evidence from animal models suggests that these associations may be partially explained by differential DNA methylation in the newborn with possible long-term consequences. To test this in humans, we meta-analyzed the epigenome-wide associations of maternal haemoglobin levels during pregnancy with offspring DNA methylation in 3,967 newborn cord blood and 1,534 children and 1,962 adolescent whole-blood samples derived from 10 cohorts. DNA methylation was measured using Illumina Infinium Methylation 450K or MethylationEPIC arrays covering 450,000 and 850,000 methylation sites, respectively. There was no statistical support for the association of maternal haemoglobin levels with offspring DNA methylation either at individual methylation sites or clustered in regions. For most participants, maternal haemoglobin levels were within the normal range in the current study, whereas adverse perinatal outcomes often arise at the extremes. Thus, this study does not rule out the possibility that associations with offspring DNA methylation might be seen in studies with more extreme maternal haemoglobin levels.
Published: 2021
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3. Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Author: Sammallahti, S. (Sara), Cortes Hidalgo, A. P. (Andrea P.), Tuominen, S. (Samuli), Malmberg, A. (Anni), Mulder, R. H. (Rosa H.), Brunst, K. J. (Kelly J.), Alemany, S. (Silvia), McBride, N. S. (Nancy S.), Yousefi, P. (Paul), Heiss, J. A. (Jonathan A.), McRae, N. (Nia), Page, C. M. (Christian M.), Jin, J. (Jianping), Pesce, G. (Giancarlo), Caramaschi, D. (Doretta), Rifas-Shiman, S. L. (Sheryl L.), Koen, N. (Nastassja), Adams, C. D. (Charleen D.), Magnus, M. C. (Maria C.), Baiz, N. (Nour), Ratanatharathorn, A. (Andrew), Czamara, D. (Darina), Haberg, S. E. (Siri E.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Cardenas, A. (Andres), DeMeo, D. L. (Dawn L.), Lawlor, D. A. (Deborah A.), Relton, C. L. (Caroline L.), Felix, J. F. (Janine F.), van IJzendoorn, M. H. (Marinus H.), Bakermans-Kranenburg, M. J. (Marian J.), Kajantie, E. (Eero), Raikkonen, K. (Katri), Sunyer, J. (Jordi), Sharp, G. C. (Gemma C.), Houtepen, L. C. (Lotte C.), Nohr, E. A. (Ellen A.), Sorensen, T. I. (Thorkild I. A.), Tellez-Rojo, M. M. (Martha M.), Wright, R. O. (Robert O.), Annesi-Maesano, I. (Isabella), Wright, J. (John), Hivert, M.-F. (Marie-France), Wright, R. J. (Rosalind J.), Zar, H. J. (Heather J.), Stein, D. J. (Dan J.), London, S. J. (Stephanie J.), Cecil, C. A. (Charlotte A. M.), Tiemeier, H. (Henning), Lahti, J. (Jari), Sammallahti, S. (Sara), Cortes Hidalgo, A. P. (Andrea P.), Tuominen, S. (Samuli), Malmberg, A. (Anni), Mulder, R. H. (Rosa H.), Brunst, K. J. (Kelly J.), Alemany, S. (Silvia), McBride, N. S. (Nancy S.), Yousefi, P. (Paul), Heiss, J. A. (Jonathan A.), McRae, N. (Nia), Page, C. M. (Christian M.), Jin, J. (Jianping), Pesce, G. (Giancarlo), Caramaschi, D. (Doretta), Rifas-Shiman, S. L. (Sheryl L.), Koen, N. (Nastassja), Adams, C. D. (Charleen D.), Magnus, M. C. (Maria C.), Baiz, N. (Nour), Ratanatharathorn, A. (Andrew), Czamara, D. (Darina), Haberg, S. E. (Siri E.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Cardenas, A. (Andres), DeMeo, D. L. (Dawn L.), Lawlor, D. A. (Deborah A.), Relton, C. L. (Caroline L.), Felix, J. F. (Janine F.), van IJzendoorn, M. H. (Marinus H.), Bakermans-Kranenburg, M. J. (Marian J.), Kajantie, E. (Eero), Raikkonen, K. (Katri), Sunyer, J. (Jordi), Sharp, G. C. (Gemma C.), Houtepen, L. C. (Lotte C.), Nohr, E. A. (Ellen A.), Sorensen, T. I. (Thorkild I. A.), Tellez-Rojo, M. M. (Martha M.), Wright, R. O. (Robert O.), Annesi-Maesano, I. (Isabella), Wright, J. (John), Hivert, M.-F. (Marie-France), Wright, R. J. (Rosalind J.), Zar, H. J. (Heather J.), Stein, D. J. (Dan J.), London, S. J. (Stephanie J.), Cecil, C. A. (Charlotte A. M.), Tiemeier, H. (Henning), and Lahti, J. (Jari)
Abstract: Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation (DNAm) has been proposed as a potential underlying mechanism. In the current study, we performed a meta-analysis to examine the associations between maternal anxiety, measured prospectively during pregnancy, and genome-wide DNAm from umbilical cord blood. Sixteen non-overlapping cohorts from 12 independent longitudinal studies of the Pregnancy And Childhood Epigenetics Consortium participated, resulting in a combined dataset of 7243 mother-child dyads. We examined prenatal anxiety in relation to genome-wide DNAm and differentially methylated regions. We observed no association between the general symptoms of anxiety during pregnancy or pregnancy-related anxiety, and DNAm at any of the CpG sites, after multiple-testing correction. Furthermore, we identify no differentially methylated regions associated with maternal anxiety. At the cohort-level, of the 21 associations observed in individual cohorts, none replicated consistently in the other cohorts. In conclusion, contrary to some previous studies proposing cord blood DNAm as a promising potential mechanism explaining the link between maternal anxiety during pregnancy and adverse outcomes in offspring, we found no consistent evidence for any robust associations between maternal anxiety and DNAm in cord blood. Larger studies and analysis of DNAm in other tissues may be needed to establish subtle or subgroup-specific associations between maternal anxiety and the foetal epigenome.
Published: 2021

4. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Author: Merid, S.K. (Simon Kebede), Novoloaca, A. (Alexei), Sharp, G.C. (Gemma C.), Küpers, A.M. (Marlijn), Kho, A.T. (Alvin T.), Roy, R. (Ritu), Gao, L. (Lu), Annesi-Maesano, I. (Isabella), Jain, P. (Pooja), Plusquin, M. (Michelle), Kogevinas, M. (Manolis), Allard, C. (Catherine), Vehmeijer, F.O.L. (Florianne O.L.), Kazmi, N. (Nabila), Salas, L.A. (Lucas A.), Rezwan, F.I. (Faisal I.), Zhang, H. (Hongmei), Sebert, S. (Sylvain), Czamara, D. (Darina), Rifas-Shiman, S.L. (Sheryl), Melton, P.E. (Phillip E.), Lawlor, D.A. (Debbie A.), Pershagen, G. (Göran), Breton, C. (Carrie), Huen, K. (Karen), Baïz, N. (Nour), Gagliardi, L. (Luigi), Nawrot, T.S. (Tim S.), Corpeleijn, E. (Eva), Perron, P. (Patrice), Duijts, L. (Liesbeth), Nohr, C. (Christian), Bustamante, M. (Mariona), Ewart, S. (Susan), Karmaus, W. (Wilfried), Zhao, S. (Shanshan), Page, C.M. (Christian M.), Herceg, Z. (Zdenko), Jarvelin, M.-R. (Marjo-Riitta), Lahti, J. (Jari), Baccarelli, A.A. (Andrea), Anderson, D. (Denise), Kachroo, P. (Priyadarshini), Relton, C.L. (Caroline), Bergström, A. (Anna), Eskenazi, B. (B.), Soomro, M.H. (Munawar Hussain), Vineis, P. (Paolo), Snieder, H. (Harold), Bouchard, L. (Luigi), Jaddoe, V.W.V. (Vincent), Sørensen, T.I.A. (Thorkild), Vrijheid, M. (Martine), Arshad, S.H. (Syed), Holloway, J.W. (John W.), Håberg, S.E. (Siri E), Magnus, P. (Per), Dwyer, T. (Terence), Binder, E.B. (Elisabeth), Demeo, D.L. (Dawn), Vonk, J.M. (Judith), Newnham, J.P. (John), Tantisira, K.G. (Kelan G.), Kull, C.A. (Christian), Wiemels, J. (Joseph), Heude, B. (Barbara), Sunyer, J. (Jordi), Nystad, W. (Wenche), Munthe-Kaas, M.C. (Monica Cheng), Räikkönen, K. (Katri), Oken, E. (Emily), Huang, R.-C. (Rae-Chi), Weiss, S.T. (Scott T.), Antó, J.M. (Josep Maria), Bousquet, J. (Jean), Kumar, A. (Ashish), Söderhäll, C. (Cilla), Almqvist, C. (Catarina), Cardenas, A. (Andres), Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Reese, S.E. (Sarah E.), Kere, J. (Juha), Brodin, P. (Petter), Solomon, O. (Olivia), Wielscher, M. (Matthias), Holland, N. (Nina), Ghantous, A. (Akram), Hivert, M.-F. (Marie-France), Felix, J.F. (Janine), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Melén, E. (Erik), Merid, S.K. (Simon Kebede), Novoloaca, A. (Alexei), Sharp, G.C. (Gemma C.), Küpers, A.M. (Marlijn), Kho, A.T. (Alvin T.), Roy, R. (Ritu), Gao, L. (Lu), Annesi-Maesano, I. (Isabella), Jain, P. (Pooja), Plusquin, M. (Michelle), Kogevinas, M. (Manolis), Allard, C. (Catherine), Vehmeijer, F.O.L. (Florianne O.L.), Kazmi, N. (Nabila), Salas, L.A. (Lucas A.), Rezwan, F.I. (Faisal I.), Zhang, H. (Hongmei), Sebert, S. (Sylvain), Czamara, D. (Darina), Rifas-Shiman, S.L. (Sheryl), Melton, P.E. (Phillip E.), Lawlor, D.A. (Debbie A.), Pershagen, G. (Göran), Breton, C. (Carrie), Huen, K. (Karen), Baïz, N. (Nour), Gagliardi, L. (Luigi), Nawrot, T.S. (Tim S.), Corpeleijn, E. (Eva), Perron, P. (Patrice), Duijts, L. (Liesbeth), Nohr, C. (Christian), Bustamante, M. (Mariona), Ewart, S. (Susan), Karmaus, W. (Wilfried), Zhao, S. (Shanshan), Page, C.M. (Christian M.), Herceg, Z. (Zdenko), Jarvelin, M.-R. (Marjo-Riitta), Lahti, J. (Jari), Baccarelli, A.A. (Andrea), Anderson, D. (Denise), Kachroo, P. (Priyadarshini), Relton, C.L. (Caroline), Bergström, A. (Anna), Eskenazi, B. (B.), Soomro, M.H. (Munawar Hussain), Vineis, P. (Paolo), Snieder, H. (Harold), Bouchard, L. (Luigi), Jaddoe, V.W.V. (Vincent), Sørensen, T.I.A. (Thorkild), Vrijheid, M. (Martine), Arshad, S.H. (Syed), Holloway, J.W. (John W.), Håberg, S.E. (Siri E), Magnus, P. (Per), Dwyer, T. (Terence), Binder, E.B. (Elisabeth), Demeo, D.L. (Dawn), Vonk, J.M. (Judith), Newnham, J.P. (John), Tantisira, K.G. (Kelan G.), Kull, C.A. (Christian), Wiemels, J. (Joseph), Heude, B. (Barbara), Sunyer, J. (Jordi), Nystad, W. (Wenche), Munthe-Kaas, M.C. (Monica Cheng), Räikkönen, K. (Katri), Oken, E. (Emily), Huang, R.-C. (Rae-Chi), Weiss, S.T. (Scott T.), Antó, J.M. (Josep Maria), Bousquet, J. (Jean), Kumar, A. (Ashish), Söderhäll, C. (Cilla), Almqvist, C. (Catarina), Cardenas, A. (Andres), Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Reese, S.E. (Sarah E.), Kere, J. (Juha), Brodin, P. (Petter), Solomon, O. (Olivia), Wielscher, M. (Matthias), Holland, N. (Nina), Ghantous, A. (Akram), Hivert, M.-F. (Marie-France), Felix, J.F. (Janine), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), and Melén, E. (Erik)
Abstract: BACKGROUND: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. METHODS: We performed meta-analysis of Illumina's HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4-18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. RESULTS: We identified 8899 CpGs in cord blood that were associated with gestational age (range 27-42 weeks), at Bonferroni significance, P < 1.06 × 10- 7, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. CONCLUSIONS: We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.
Published: 2020
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5. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Author: Merid, S. K. (Simon Kebede), Novoloaca, A. (Alexei), Sharp, G. C. (Gemma C.), Kupers, L. K. (Leanne K.), Kho, A. T. (Alvin T.), Roy, R. (Ritu), Gao, L. (Lu), Annesi-Maesano, I. (Isabella), Jain, P. (Pooja), Plusquin, M. (Michelle), Kogevinas, M. (Manolis), Allard, C. (Catherine), Vehmeijer, F. O. (Florianne O.), Kazmi, N. (Nabila), Salas, L. A. (Lucas A.), Rezwan, F. I. (Faisal I.), Zhang, H. (Hongmei), Sebert, S. (Sylvain), Czamara, D. (Darina), Rifas-Shiman, S. L. (Sheryl L.), Melton, P. E. (Phillip E.), Lawlor, D. A. (Debbie A.), Pershagen, G. (Goran), Breton, C. V. (Carrie V.), Huen, K. (Karen), Baiz, N. (Nour), Gagliardi, L. (Luigi), Nawrot, T. S. (Tim S.), Corpeleijn, E. (Eva), Perron, P. (Patrice), Duijts, L. (Liesbeth), Nohr, E. A. (Ellen Aagaard), Bustamante, M. (Mariona), Ewart, S. L. (Susan L.), Karmaus, W. (Wilfried), Zhao, S. (Shanshan), Page, C. M. (Christian M.), Herceg, Z. (Zdenko), Jarvelin, M.-R. (Marjo-Riitta), Lahti, J. (Jari), Baccarelli, A. A. (Andrea A.), Anderson, D. (Denise), Kachroo, P. (Priyadarshini), Relton, C. L. (Caroline L.), Bergstrom, A. (Anna), Eskenazi, B. (Brenda), Soomro, M. H. (Munawar Hussain), Vineis, P. (Paolo), Snieder, H. (Harold), Bouchard, L. (Luigi), Jaddoe, V. W. (Vincent W.), Sorensen, T. I. (Thorkild I. A.), Vrijheid, M. (Martine), Arshad, S. H. (S. Hasan), Holloway, J. W. (John W.), Haberg, S. E. (Siri E.), Magnus, P. (Per), Dwyer, T. (Terence), Binder, E. B. (Elisabeth B.), DeMeo, D. L. (Dawn L.), Vonk, J. M. (Judith M.), Newnham, J. (John), Tantisira, K. G. (Kelan G.), Kull, I. (Inger), Wiemels, J. L. (Joseph L.), Heude, B. (Barbara), Sunyer, J. (Jordi), Nystad, W. (Wenche), Munthe-Kaas, M. C. (Monica C.), Raikkonen, K. (Katri), Oken, E. (Emily), Huang, R.-C. (Rae-Chi), Weiss, S. T. (Scott T.), Anto, J. M. (Josep Maria), Bousquet, J. (Jean), Kumar, A. (Ashish), Soderhall, C. (Cilla), Almqvist, C. (Catarina), Cardenas, A. (Andres), Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Reese, S. E. (Sarah E.), Kere, J. (Juha), Brodin, P. (Petter), Solomon, O. (Olivia), Wielscher, M. (Matthias), Holland, N. (Nina), Ghantous, A. (Akram), Hivert, M.-F. (Marie-France), Felix, J. F. (Janine F.), Koppelman, G. H. (Gerard H.), London, S. J. (Stephanie J.), Melen, E. (Erik), Merid, S. K. (Simon Kebede), Novoloaca, A. (Alexei), Sharp, G. C. (Gemma C.), Kupers, L. K. (Leanne K.), Kho, A. T. (Alvin T.), Roy, R. (Ritu), Gao, L. (Lu), Annesi-Maesano, I. (Isabella), Jain, P. (Pooja), Plusquin, M. (Michelle), Kogevinas, M. (Manolis), Allard, C. (Catherine), Vehmeijer, F. O. (Florianne O.), Kazmi, N. (Nabila), Salas, L. A. (Lucas A.), Rezwan, F. I. (Faisal I.), Zhang, H. (Hongmei), Sebert, S. (Sylvain), Czamara, D. (Darina), Rifas-Shiman, S. L. (Sheryl L.), Melton, P. E. (Phillip E.), Lawlor, D. A. (Debbie A.), Pershagen, G. (Goran), Breton, C. V. (Carrie V.), Huen, K. (Karen), Baiz, N. (Nour), Gagliardi, L. (Luigi), Nawrot, T. S. (Tim S.), Corpeleijn, E. (Eva), Perron, P. (Patrice), Duijts, L. (Liesbeth), Nohr, E. A. (Ellen Aagaard), Bustamante, M. (Mariona), Ewart, S. L. (Susan L.), Karmaus, W. (Wilfried), Zhao, S. (Shanshan), Page, C. M. (Christian M.), Herceg, Z. (Zdenko), Jarvelin, M.-R. (Marjo-Riitta), Lahti, J. (Jari), Baccarelli, A. A. (Andrea A.), Anderson, D. (Denise), Kachroo, P. (Priyadarshini), Relton, C. L. (Caroline L.), Bergstrom, A. (Anna), Eskenazi, B. (Brenda), Soomro, M. H. (Munawar Hussain), Vineis, P. (Paolo), Snieder, H. (Harold), Bouchard, L. (Luigi), Jaddoe, V. W. (Vincent W.), Sorensen, T. I. (Thorkild I. A.), Vrijheid, M. (Martine), Arshad, S. H. (S. Hasan), Holloway, J. W. (John W.), Haberg, S. E. (Siri E.), Magnus, P. (Per), Dwyer, T. (Terence), Binder, E. B. (Elisabeth B.), DeMeo, D. L. (Dawn L.), Vonk, J. M. (Judith M.), Newnham, J. (John), Tantisira, K. G. (Kelan G.), Kull, I. (Inger), Wiemels, J. L. (Joseph L.), Heude, B. (Barbara), Sunyer, J. (Jordi), Nystad, W. (Wenche), Munthe-Kaas, M. C. (Monica C.), Raikkonen, K. (Katri), Oken, E. (Emily), Huang, R.-C. (Rae-Chi), Weiss, S. T. (Scott T.), Anto, J. M. (Josep Maria), Bousquet, J. (Jean), Kumar, A. (Ashish), Soderhall, C. (Cilla), Almqvist, C. (Catarina), Cardenas, A. (Andres), Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Reese, S. E. (Sarah E.), Kere, J. (Juha), Brodin, P. (Petter), Solomon, O. (Olivia), Wielscher, M. (Matthias), Holland, N. (Nina), Ghantous, A. (Akram), Hivert, M.-F. (Marie-France), Felix, J. F. (Janine F.), Koppelman, G. H. (Gerard H.), London, S. J. (Stephanie J.), and Melen, E. (Erik)
Abstract: Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods: We performed meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4–18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results: We identified 8899 CpGs in cord blood that were associated with gestational age (range 27–42 weeks), at Bonferroni significance, P < 1.06 × 10⁻⁷, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions: We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.
Published: 2020

6. Epigenome-wide meta-analysis of DNA methylation and childhood asthma

Author: Reese, S. E. (Sarah E.), Xu, C.-J. (Cheng-Jian), den Dekker, H. T. (Herman T.), Lee, M. K. (Mi Kyeong), Sikdar, S. (Sinjini), Ruiz-Arenas, C. (Carlos), Merid, S. K. (Simon K.), Rezwan, F. I. (Faisal I.), Page, C. M. (Christian M.), Ullemar, V. (Vilhelmina), Melton, P. E. (Phillip E.), Oh, S. S. (Sam S.), Yang, I. V. (Ivana V.), Burrows, K. (Kimberley), Söderhäll, C. (Cilla), Jima, D. D. (Dereje D.), Gao, L. (Lu), Arathimos, R. (Ryan), Küpers, L. K. (Leanne K.), Wielscher, M. (Matthias), Rzehak, P. (Peter), Lahti, J. (Jari), Laprise, C. (Catherine), Madore, A.-M. (Anne-Marie), Ward, J. (James), Bennett, B. D. (Brian D.), Wang, T. (Tianyuan), Bell, D. A. (Douglas A.), T. B. (The BIOS consortium), Vonk, J. M. (Judith M.), Håberg, S. E. (Siri E.), Zhao, S. (Shanshan), Karlsson, R. (Robert), Hollams, E. (Elysia), Hu, D. (Donglei), Richards, A. J. (Adam J.), Bergström, A. (Anna), Sharp, G. C. (Gemma C.), Felix, J. F. (Janine F.), Bustamante, M. (Mariona), Gruzieva, O. (Olena), Maguire, R. L. (Rachel L.), Gilliland, F. (Frank), Baïz, N. (Nour), Nohr, E. A. (Ellen A.), Corpeleijn, E. (Eva), Sebert, S. (Sylvain), Karmaus, W. (Wilfried), Grote, V. (Veit), Kajantie, E. (Eero), Magnus, M. C. (Maria C.), Örtqvist, A. K. (Anne K.), Eng, C. (Celeste), Liu, A. H. (Andrew H.), Kull, I. (Inger), Jaddoe, V. W. (Vincent W.V.), Sunyer, J. (Jordi), Kere, J. (Juha), Hoyo, C. (Cathrine), Annesi-Maesano, I. (Isabella), Arshad, S. H. (Syed Hasan), Koletzko, B. (Berthold), Brunekreef, B. (Bert), Binder, E. B. (Elisabeth B.), Räikkönen, K. (Katri), Reischl, E. (Eva), Holloway, J. W. (John W.), Järvelin, M.-R. (Marjo-Riitta), Snieder, H. (Harold), Kazmi, N. (Nabila), Breton, C. V. (Carrie V.), Murphy, S. K. (Susan K.), Pershagen, G. (Göran), Anto, J. M. (Josep Maria), Relton, C. L. (Caroline L.), Schwartz, D. A. (David A.), Burchard, E. G. (Esteban G.), Huang, R.-C. (Rae-Chi), Nystad, W. (Wenche), Almqvist, C. (Catarina), Henderson, A. J. (A. John), Melén, E. (Erik), Duijts, L. (Liesbeth), Koppelman, G. H. (Gerard H.), and London, S. J. (Stephanie J.)
Subjects: epigenetics, newborn, methylation, asthma, drug development, childhood
Abstract: Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods: Within the Pregnancy And Childhood Epigenetics consortium, we performed epigenome-wide meta-analyses of school-age asthma in relation to CpG methylation (Illumina450K) in blood measured either in newborns, in prospective analyses, or cross-sectionally in school-aged children. We also identified differentially methylated regions. Results: In newborns (8 cohorts, 668 cases), 9 CpGs (and 35 regions) were differentially methylated (epigenome-wide significance, false discovery rate < 0.05) in relation to asthma development. In a cross-sectional meta-analysis of asthma and methylation in children (9 cohorts, 631 cases), we identified 179 CpGs (false discovery rate < 0.05) and 36 differentially methylated regions. In replication studies of methylation in other tissues, most of the 179 CpGs discovered in blood replicated, despite smaller sample sizes, in studies of nasal respiratory epithelium or eosinophils. Pathway analyses highlighted enrichment for asthma-relevant immune processes and overlap in pathways enriched both in newborns and children. Gene expression correlated with methylation at most loci. Functional annotation supports a regulatory effect on gene expression at many asthma-associated CpGs. Several implicated genes are targets for approved or experimental drugs, including IL5RA and KCNH2. Conclusion: Novel loci differentially methylated in newborns represent potential biomarkers of risk of asthma by school age. Cross-sectional associations in children can reflect both risk for and effects of disease. Asthma-related differential methylation in blood in children was substantially replicated in eosinophils and respiratory epithelium.
Published: 2019

7. Next-generation care pathways for allergic rhinitis and asthma multimorbidity: A model for multimorbid non-communicable diseases—Meeting Report (Part 1)

Author: Bousquet, J. (Jean), Pham-Thi, N. (Nhân), Bedbrook, A. (Anna), Agache, I. (Ioana), Annesi-Maesano, I. (Isabella), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Benveniste, S. (Samuel), Bewick, M. (Mike), Billo, N. (Nils), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Brusselle, G.G. (Guy), Calderon, M. (Moises), Canonica, G. (Gwalter), Caraballo, L.R. (L.), Cardona, D. (Doris), Carriazo, A.M. (Ana Maria), Cash, E. (Eugene), Cecchi, L. (Lorenzo), Chu, D.K. (Derek K.), Colgan, E. (Elaine), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Durham, S.R. (Stephen), Ebisawa, M. (Motohiro), Erhola, M. (Marina), Fauquert, J.-L. (Jean-Luc), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Guldemond, N. (Nick), Iinuma, T. (Tomohisa), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Larenas-Linneman, D. (Désirée), Laune, D. (Daniel), Le, L.T.T. (Lan T.T.), Lourenço, O. (Olga), Malva, J.O. (Joao O.), Marien, G. (Gert), Menditto, E. (Enrica), Mullol, J. (Joaquim), Münter, L. (Lars), Okamoto, Y. (Yoshitaka), Onorato, G.L. (Gabrielle L.), Papadopoulos, N., Perala, M. (Maritta), Pfaar, O. (Oliver), Phillips, A. (Abigail), Phillips, J. (Jim), Pinnock, H. (Hilary), Portejoie, F. (Fabienne), Quinones-Delgado, P. (Pablo), Rolland, C. (Christine), Rodts, U. (Ulysse), Samolinski, B. (Boleslaw), Sanchez-Borges, M. (Mario), Schünemann, H.J. (Holger), Shamji, M. (Mohamed), Somekh, D. (David), Togias, A., Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Usmani, O. (Omar), Walker, S. (Samantha), Wallace, D. (D.), Valiulis, A. (Arunas), Van Der Kleij, R.M. (Rianne Mjj), Ventura, M.T. (Maria Teresa), Williams, S. (Sian), Yorgancioglu, A. (Arzu), Zuberbier, T. (Torsten), Bousquet, J. (Jean), Pham-Thi, N. (Nhân), Bedbrook, A. (Anna), Agache, I. (Ioana), Annesi-Maesano, I. (Isabella), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Benveniste, S. (Samuel), Bewick, M. (Mike), Billo, N. (Nils), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Brusselle, G.G. (Guy), Calderon, M. (Moises), Canonica, G. (Gwalter), Caraballo, L.R. (L.), Cardona, D. (Doris), Carriazo, A.M. (Ana Maria), Cash, E. (Eugene), Cecchi, L. (Lorenzo), Chu, D.K. (Derek K.), Colgan, E. (Elaine), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Durham, S.R. (Stephen), Ebisawa, M. (Motohiro), Erhola, M. (Marina), Fauquert, J.-L. (Jean-Luc), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Guldemond, N. (Nick), Iinuma, T. (Tomohisa), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Larenas-Linneman, D. (Désirée), Laune, D. (Daniel), Le, L.T.T. (Lan T.T.), Lourenço, O. (Olga), Malva, J.O. (Joao O.), Marien, G. (Gert), Menditto, E. (Enrica), Mullol, J. (Joaquim), Münter, L. (Lars), Okamoto, Y. (Yoshitaka), Onorato, G.L. (Gabrielle L.), Papadopoulos, N., Perala, M. (Maritta), Pfaar, O. (Oliver), Phillips, A. (Abigail), Phillips, J. (Jim), Pinnock, H. (Hilary), Portejoie, F. (Fabienne), Quinones-Delgado, P. (Pablo), Rolland, C. (Christine), Rodts, U. (Ulysse), Samolinski, B. (Boleslaw), Sanchez-Borges, M. (Mario), Schünemann, H.J. (Holger), Shamji, M. (Mohamed), Somekh, D. (David), Togias, A., Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Usmani, O. (Omar), Walker, S. (Samantha), Wallace, D. (D.), Valiulis, A. (Arunas), Van Der Kleij, R.M. (Rianne Mjj), Ventura, M.T. (Maria Teresa), Williams, S. (Sian), Yorgancioglu, A. (Arzu), and Zuberbier, T. (Torsten)
Published: 2019
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8. Next-generation care pathways for allergic rhinitis and asthma multimorbidity: A model for multimorbid non-communicable diseases—Meeting Report (Part 2)

Author: Bousquet, J. (Jean), Pham-Thi, N. (Nhân), Bedbrook, A. (Anna), Agache, I. (Ioana), Annesi-Maesano, I. (Isabella), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Benveniste, S. (Samuel), Bewick, M. (Mike), Billo, N. (Nils), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Brusselle, G.G. (Guy), Calderon, M. (Moises), Canonica, G. (Gwalter), Caraballo, L.R. (L.), Cardona, D. (Doris), Carriazo, A.M. (Ana Maria), Cash, E. (Eugene), Cecchi, L. (Lorenzo), Chu, D.K. (Derek K.), Colgan, E. (Elaine), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Durham, S.R. (Stephen), Ebisawa, M. (Motohiro), Erhola, M. (Marina), Fauquert, J.-L. (Jean-Luc), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Guldemond, N. (Nick), Iinuma, T. (Tomohisa), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Larenas-Linneman, D. (Désirée), Laune, D. (Daniel), Le, L.T.T. (Lan T.T.), Lourenço, O. (Olga), Malva, J.O. (Joao O.), Marien, G. (Gert), Menditto, E. (Enrica), Mullol, J. (Joaquim), Münter, L. (Lars), Okamoto, Y. (Yoshitaka), Onorato, G.L. (Gabrielle L.), Papadopoulos, N., Perala, M. (Maritta), Pfaar, O. (Oliver), Phillips, A. (Abigail), Phillips, J. (Jim), Pinnock, H. (Hilary), Portejoie, F. (Fabienne), Quinones-Delgado, P. (Pablo), Rolland, C. (Christine), Rodts, U. (Ulysse), Samolinski, B. (Boleslaw), Sanchez-Borges, M. (Mario), Schünemann, H.J. (Holger), Shamji, M. (Mohamed), Somekh, D. (David), Togias, A., Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Usmani, O. (Omar), Walker, S. (Samantha), Wallace, D. (D.), Valiulis, A. (Arunas), Van Der Kleij, R.M. (Rianne Mjj), Ventura, M.T. (Maria Teresa), Williams, S. (Sian), Yorgancioglu, A. (Arzu), Zuberbier, T. (Torsten), Bousquet, J. (Jean), Pham-Thi, N. (Nhân), Bedbrook, A. (Anna), Agache, I. (Ioana), Annesi-Maesano, I. (Isabella), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Benveniste, S. (Samuel), Bewick, M. (Mike), Billo, N. (Nils), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Brusselle, G.G. (Guy), Calderon, M. (Moises), Canonica, G. (Gwalter), Caraballo, L.R. (L.), Cardona, D. (Doris), Carriazo, A.M. (Ana Maria), Cash, E. (Eugene), Cecchi, L. (Lorenzo), Chu, D.K. (Derek K.), Colgan, E. (Elaine), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Durham, S.R. (Stephen), Ebisawa, M. (Motohiro), Erhola, M. (Marina), Fauquert, J.-L. (Jean-Luc), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Guldemond, N. (Nick), Iinuma, T. (Tomohisa), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Larenas-Linneman, D. (Désirée), Laune, D. (Daniel), Le, L.T.T. (Lan T.T.), Lourenço, O. (Olga), Malva, J.O. (Joao O.), Marien, G. (Gert), Menditto, E. (Enrica), Mullol, J. (Joaquim), Münter, L. (Lars), Okamoto, Y. (Yoshitaka), Onorato, G.L. (Gabrielle L.), Papadopoulos, N., Perala, M. (Maritta), Pfaar, O. (Oliver), Phillips, A. (Abigail), Phillips, J. (Jim), Pinnock, H. (Hilary), Portejoie, F. (Fabienne), Quinones-Delgado, P. (Pablo), Rolland, C. (Christine), Rodts, U. (Ulysse), Samolinski, B. (Boleslaw), Sanchez-Borges, M. (Mario), Schünemann, H.J. (Holger), Shamji, M. (Mohamed), Somekh, D. (David), Togias, A., Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Usmani, O. (Omar), Walker, S. (Samantha), Wallace, D. (D.), Valiulis, A. (Arunas), Van Der Kleij, R.M. (Rianne Mjj), Ventura, M.T. (Maria Teresa), Williams, S. (Sian), Yorgancioglu, A. (Arzu), and Zuberbier, T. (Torsten)
Published: 2019
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9. Prenatal Particulate Air Pollution and DNA Methylation in Newborns: An Epigenome-Wide Meta-Analysis

Author: Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Yousefi, P. (Paul), Relton, C.L. (Caroline), Merid, S.K. (Simon Kebede), Breton, C. (Carrie), Gao, L. (Lu), Volk, H.E. (Heather E.), Feinberg, J.I. (Jason I.), Ladd-Acosta, C. (Christine), Bakulski, K. (Kelly), Auffray, C. (C.), Lemonnier, N. (Nathanaël), Plusquin, M. (Michelle), Ghantous, A. (Akram), Herceg, Z. (Zdenko), Nawrot, T.S. (Tim S.), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Rusconi, F. (Franca), Vineis, P. (Paolo), Kogevinas, M. (Manolis), Felix, J.F. (Janine), Duijts, L. (Liesbeth), Dekker, H.T. (Herman) den, Jaddoe, V.W.V. (Vincent), Ruiz, J.L. (José L), Bustamante, M. (Mariona), Anto, J.M. (Josep), Sunyer, J. (Jordi), Vrijheid, M. (Martine), Gutzkow, K.B. (Kristine B.), Grazuleviciene, R. (Regina), Hernandez-Ferrer, C. (Carles), Annesi-Maesano, I. (Isabella), Lepeule, J. (Johanna), Bousquet, J. (Jean), Bergström, A. (Anna), Kull, C.A. (Christian), Söderhäll, C. (Cilla), Kere, J. (Juha), Gehring, U. (Ulrike), Brunekreef, B. (Bert), Just, A.C. (Allan C.), Wright, R.J. (Rosalind J.), Peng, C. (Cheng), Gold, D.R. (Diane), Kloog, I. (Itai), Demeo, D.L. (Dawn), Pershagen, G. (Göran), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Baccarelli, A.A. (Andrea), Melén, E. (Erik), Gruzieva, O. (Olena), Xu, C.-J. (Cheng-Jian), Yousefi, P. (Paul), Relton, C.L. (Caroline), Merid, S.K. (Simon Kebede), Breton, C. (Carrie), Gao, L. (Lu), Volk, H.E. (Heather E.), Feinberg, J.I. (Jason I.), Ladd-Acosta, C. (Christine), Bakulski, K. (Kelly), Auffray, C. (C.), Lemonnier, N. (Nathanaël), Plusquin, M. (Michelle), Ghantous, A. (Akram), Herceg, Z. (Zdenko), Nawrot, T.S. (Tim S.), Pizzi, C. (Costanza), Richiardi, L. (Lorenzo), Rusconi, F. (Franca), Vineis, P. (Paolo), Kogevinas, M. (Manolis), Felix, J.F. (Janine), Duijts, L. (Liesbeth), Dekker, H.T. (Herman) den, Jaddoe, V.W.V. (Vincent), Ruiz, J.L. (José L), Bustamante, M. (Mariona), Anto, J.M. (Josep), Sunyer, J. (Jordi), Vrijheid, M. (Martine), Gutzkow, K.B. (Kristine B.), Grazuleviciene, R. (Regina), Hernandez-Ferrer, C. (Carles), Annesi-Maesano, I. (Isabella), Lepeule, J. (Johanna), Bousquet, J. (Jean), Bergström, A. (Anna), Kull, C.A. (Christian), Söderhäll, C. (Cilla), Kere, J. (Juha), Gehring, U. (Ulrike), Brunekreef, B. (Bert), Just, A.C. (Allan C.), Wright, R.J. (Rosalind J.), Peng, C. (Cheng), Gold, D.R. (Diane), Kloog, I. (Itai), Demeo, D.L. (Dawn), Pershagen, G. (Göran), Koppelman, G.H. (Gerard), London, S.J. (Stephanie J.), Baccarelli, A.A. (Andrea), and Melén, E. (Erik)
Abstract: BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed to investigate associations between prenatal exposure to particulate matter (PM) with diameter [Formula: see text] ([Formula: see text]) or [Formula: see text] ([Formula: see text]) and DNA methylation in newborns and children. METHODS: We meta-analyzed associations between exposure to [Formula: see text] ([Formula: see text]) and [Formula: see text] ([Formula: see text]) at maternal home addresses during pregnancy and newborn DNA methylation assessed by Illumina Infinium HumanMethylation450K BeadChip in nine European and American studies, with replication in 688 independent newborns and look-up analyses in 2,118 older children. We used two approaches, one focusing on single cytosine-phosphate-guanine (CpG) sites and another on differentially methylated regions (DMRs). We also related PM exposures to blood mRNA expression. RESULTS: Six CpGs were significantly associa
Published: 2019
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10. Next-generation ARIA care pathways for rhinitis and asthma: A model for multimorbid chronic diseases

Author: Bousquet, J.J. (J. Jean), Schünemann, H.J. (Holger), Togias, A., Erhola, M. (Marina), Hellings, P.W. (Peter), Zuberbier, T. (Torsten), Agache, I. (Ioana), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Becker, S. (Sven), Bedolla-Barajas, M. (Martin), Bewick, M. (Michael), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Boulet, L.P., Bourrez, J.M. (Jean Marc), Brusselle, G.G. (Guy), Chavannes, N.H. (Nicolas), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Gaga, M. (Mina), Haahtela, T. (Tari), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Le, L.T., Larenas-Linnemann, D. (Désirée), Laune, D. (Daniel), Lourenço, O.M. (Olga M.), Menditto, E. (Enrica), Mullol, J. (Joaquin), Okamoto, Y. (Yashitaka), Papadopoulos, N., Pham-Thi, N. (Nhân), Picard, R. (Robert), Pinnock, H. (Hilary), Roche, N. (Nicolas), Roller-Wirnsberger, R.E. (Regina E.), Rolland, C. (Christine), Samolinski, B. (Boleslaw), Sheikh, A. (Aziz), Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Valiulis, A. (Arunas), Valovirta, E. (Erkka), Vasankari, T. (Tuula), Ventura, M.-T. (Maria-Teresa), Walker, S. (Samantha), Williams, S. (Sian), Akdis, C.A. (Cezmi A.), Annesi-Maesano, I. (Isabella), Arnavielhe, S. (Sylvie), Basagaña, X. (Xavier), Bateman, E.D. (Eric), Bedbrook, A. (Anna), Bennoor, K.S. (K.), Benveniste, S. (Samuel), Bergmann, K.-C. (Karl-Christian), Bialek, S. (Slawomir), Billo, N. (Nils), Bindslev-Jensen, C. (Carsten), Bjermer, L. (Leif), Blain, H. (Hubert), Bonini, M. (Matteo), Bonniaud, P. (Philippe), Bouchard, J. (Jacques), Briedis, V. (Vitalis), Brightling, C.E. (Christofer E.), Brozek, J., Buhl, R. (Roland), Buonaiuto, R. (Roland), Canonica, G.W. (Giorgo W.), Cardona, D. (Doris), Carriazo, A.M. (Ana M.), Carr, W.W. (Warner), Cartier, C. (Christine), Casale, T.B. (Thomas), Cecchi, L. (Lorenzo), Cepeda Sarabia, A.M. (Alfonso M.), Chkhartishvili, E. (Eka), Chu, D.K. (Derek K.), Cingi, C. (Cemal), Colgan, E. (Elaine), De Sousa, J.C. (Jaime Correia), Courbis, A.L. (Anne Lise), Custovic, A. (Adnan), Cvetkosvki, B. (Biljana), Damato, G. (Gennaro), Da Silva, J. (Jane), Dantas, C. (Carina), Dokic, D. (D.), Dauvilliers, Y. (Yves), Dedeu, A. (Antoni), De Feo, G. (Giulia), Devillier, P. (Philippe), Di Capua, S. (Stefania), Dykewickz, M. (Marc), Dubakiene, R. (R.), Ebisawa, M. (Motohiro), El-Gamal, Y. (Y.), Eller, E. (Esben), Emuzyte, R., Farrell, J. (John), Fink-Wagner, A. (Antjie), Fiocchi, A. (Alessandro), Fontaine, J.F. (Jean F.), Gemicioǧlu, B. (Bilun), Schmid-Grendelmeir, P. (Peter), Gamkrelidze, A. (Amiran), Garcia-Aymerich, J. (Judith), Gomez, M. (Maximiliano), Diaz, S.G. (Sandra González), Gotua, M. (M.), Guldemond, N. (Nick), Guzmán, M.A. (M.), Hajjam, J. (Jawad), O'Hourihane, J.B. (John B.), Humbert, M. (Marc), Iaccarino, G. (Guido), Ierodiakonou, D. (Despo), Ivancevich, J.C. (Juan), Joos, G.F. (Guy), Jung, K.-S. (Ki-Suck), Jutel, M. (M.), Kaidashev, I. (Igor), Kalayci, O. (Omer), Kardas, P. (Przemyslaw), Keil, M. (Mark), Khaitov, M. (Mussa), Khaltaev, N., Kleine-Tebbe, J. (Jörg), Kowalski, M.L., Kritikos, V. (Vicky), Kull, C.A. (Christian), Leonardini, L. (Lisa), Lieberman, A.P. (Andrew), Lipworth, B., Lødrup Carlsen, K.C. (K. C.), Loureiro, C.C. (Claudia C.), Louis, R. (Renaud), Mair, A. (Alpana), Marien, G. (Gert), Mahboub, B., Malva, J. (Joao), Manning, P. (Patrick), De Manuel Keenoy, E. (Esteban), Marshall, G.D., Masjedi, M.R. (Mohamed R.), Maspero, J.F. (Jorge F.), Mathieu-Dupas, E. (Eve), Matricardi, P.M. (Poalo M.), Melén, E. (Eric), Melo-Gomes, E. (Elisabete), Meltzer, E.O., Mercier, J. (Jacques), Miculinic, N. (Neven), Mihaltan, F. (Florin), Milenkovic, B. (Branislava), Moda, G. (Giuliana), Mogica-Martinez, M.-D. (Maria-Dolores), Mohammad, Y., Montefort, S. (Steve), Monti, R. (Ricardo), Morais-Almeida, M. (Mario), Mösges, R. (Ralph), Münter, L. (Lars), Muraro, A. (Antonella), Murray, R. (Ruth), Naclerio, R., Napoli, L. (Luigi), Namazova-Baranova, L. (Leila), Neffen, H. (Hugo), Nekam, K. (Kristoff), Neou, A. (A.), Novellino, E. (Enrico), Nyembue, D. (Dieudonné), O'Hehir, R. (Robin), Ohta, K., Okubo, K. (Kimi), Onorato, G. (Gabrielle), Ouedraogo, S., Pali-Schöll, I. (I.), Palkonen, S. (Susanna), Panzner, P. (P.), Park, H.-S. (Hae-Sim), Pépin, J.-L. (Jean-Louis), Pereira, A.-M. (Ana-Maria), Pfaar, O. (Oliver), Paulino, E. (Ema), Phillips, J. (Jim), Plavec, D. (Davor), Popov, T.A. (Ted A.), Portejoie, F. (Fabienne), Price, D. (David), Prokopakis, E.P. (Emmanuel P.), Pugin, B. (Benoit), Raciborski, F. (Filip), Rajabian-Söderlund, R. (Rojin), Reitsma, S. (Sietze), Rodo, X. (Xavier), Romano, A., Rosario, N. (Nelson), Rottem, M. (Menahenm), Ryan, D. (Dermot), Salimäki, J. (Johanna), Sanchez-Borges, M.M. (Mario M.), Sisul, J.C. (J.), Solé, D. (Dirceu), Somekh, D. (David), Sooronbaev, T. (Talant), Sova, M. (Milan), Spranger, O., Stellato, C. (Cristina), Stelmach, R. (Rafael), Ulrik, C.S., Thibaudon, M. (Michel), To, T. (Teresa), Todo Bom, A., Tomazic, P.V. (Peter V.), Valero, A.A. (Antonio A.), Valenta, R. (Rudolph), Valentin-Rostan, M. (Marylin), Van Der Kleij, R.M. (Rianne Mjj), Vandenplas, O. (Olivier), Vezzani, G. (Giorgio), Viart, F. (Frédéric), Viegi, G., Wallace, D. (D.), Wagenmann, M. (Martin), Wang, D.Y. (De Y.), Waserman, S. (Susan), Wickman, M. (Magnus), Williams, D., Wong, G. (G.), Wroczynski, P. (Piotr), Yiallouros, P.K. (P.), Yorgancioglu, A. (Arzu), Yusuf, O.M. (Osman), Zar, H.J. (Heahter J.), Zeng, S. (Stéphane), Zernotti, M., Zhang, L. (Luo), Zhong, N.S. (Nan S.), Zidarn, M. (Mihaela), Bousquet, J.J. (J. Jean), Schünemann, H.J. (Holger), Togias, A., Erhola, M. (Marina), Hellings, P.W. (Peter), Zuberbier, T. (Torsten), Agache, I. (Ioana), Ansotegui, I.J. (I.), Anto, J.M. (Josep), Bachert, C. (Claus), Becker, S. (Sven), Bedolla-Barajas, M. (Martin), Bewick, M. (Michael), Bosnic-Anticevich, S. (Sinthia), Bosse, I. (Isabelle), Boulet, L.P., Bourrez, J.M. (Jean Marc), Brusselle, G.G. (Guy), Chavannes, N.H. (Nicolas), Costa, E. (Elisio), Cruz, A.A. (Alvaro), Czarlewski, W. (Wienczyslawa), Fokkens, W.J. (Wytske), Fonseca, J.A. (Joao A.), Gaga, M. (Mina), Haahtela, T. (Tari), Illario, M. (Maddalena), Klimek, L. (Ludger), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Le, L.T., Larenas-Linnemann, D. (Désirée), Laune, D. (Daniel), Lourenço, O.M. (Olga M.), Menditto, E. (Enrica), Mullol, J. (Joaquin), Okamoto, Y. (Yashitaka), Papadopoulos, N., Pham-Thi, N. (Nhân), Picard, R. (Robert), Pinnock, H. (Hilary), Roche, N. (Nicolas), Roller-Wirnsberger, R.E. (Regina E.), Rolland, C. (Christine), Samolinski, B. (Boleslaw), Sheikh, A. (Aziz), Toppila-Salmi, S. (Sanna), Tsiligianni, I.G. (Ioanna G), Valiulis, A. (Arunas), Valovirta, E. (Erkka), Vasankari, T. (Tuula), Ventura, M.-T. (Maria-Teresa), Walker, S. (Samantha), Williams, S. (Sian), Akdis, C.A. (Cezmi A.), Annesi-Maesano, I. (Isabella), Arnavielhe, S. (Sylvie), Basagaña, X. (Xavier), Bateman, E.D. (Eric), Bedbrook, A. (Anna), Bennoor, K.S. (K.), Benveniste, S. (Samuel), Bergmann, K.-C. (Karl-Christian), Bialek, S. (Slawomir), Billo, N. (Nils), Bindslev-Jensen, C. (Carsten), Bjermer, L. (Leif), Blain, H. (Hubert), Bonini, M. (Matteo), Bonniaud, P. (Philippe), Bouchard, J. (Jacques), Briedis, V. (Vitalis), Brightling, C.E. (Christofer E.), Brozek, J., Buhl, R. (Roland), Buonaiuto, R. (Roland), Canonica, G.W. (Giorgo W.), Cardona, D. (Doris), Carriazo, A.M. (Ana M.), Carr, W.W. (Warner), Cartier, C. (Christine), Casale, T.B. (Thomas), Cecchi, L. (Lorenzo), Cepeda Sarabia, A.M. (Alfonso M.), Chkhartishvili, E. (Eka), Chu, D.K. (Derek K.), Cingi, C. (Cemal), Colgan, E. (Elaine), De Sousa, J.C. (Jaime Correia), Courbis, A.L. (Anne Lise), Custovic, A. (Adnan), Cvetkosvki, B. (Biljana), Damato, G. (Gennaro), Da Silva, J. (Jane), Dantas, C. (Carina), Dokic, D. (D.), Dauvilliers, Y. (Yves), Dedeu, A. (Antoni), De Feo, G. (Giulia), Devillier, P. (Philippe), Di Capua, S. (Stefania), Dykewickz, M. (Marc), Dubakiene, R. (R.), Ebisawa, M. (Motohiro), El-Gamal, Y. (Y.), Eller, E. (Esben), Emuzyte, R., Farrell, J. (John), Fink-Wagner, A. (Antjie), Fiocchi, A. (Alessandro), Fontaine, J.F. (Jean F.), Gemicioǧlu, B. (Bilun), Schmid-Grendelmeir, P. (Peter), Gamkrelidze, A. (Amiran), Garcia-Aymerich, J. (Judith), Gomez, M. (Maximiliano), Diaz, S.G. (Sandra González), Gotua, M. (M.), Guldemond, N. (Nick), Guzmán, M.A. (M.), Hajjam, J. (Jawad), O'Hourihane, J.B. (John B.), Humbert, M. (Marc), Iaccarino, G. (Guido), Ierodiakonou, D. (Despo), Ivancevich, J.C. (Juan), Joos, G.F. (Guy), Jung, K.-S. (Ki-Suck), Jutel, M. (M.), Kaidashev, I. (Igor), Kalayci, O. (Omer), Kardas, P. (Przemyslaw), Keil, M. (Mark), Khaitov, M. (Mussa), Khaltaev, N., Kleine-Tebbe, J. (Jörg), Kowalski, M.L., Kritikos, V. (Vicky), Kull, C.A. (Christian), Leonardini, L. (Lisa), Lieberman, A.P. (Andrew), Lipworth, B., Lødrup Carlsen, K.C. (K. C.), Loureiro, C.C. (Claudia C.), Louis, R. (Renaud), Mair, A. (Alpana), Marien, G. (Gert), Mahboub, B., Malva, J. (Joao), Manning, P. (Patrick), De Manuel Keenoy, E. (Esteban), Marshall, G.D., Masjedi, M.R. (Mohamed R.), Maspero, J.F. (Jorge F.), Mathieu-Dupas, E. (Eve), Matricardi, P.M. (Poalo M.), Melén, E. (Eric), Melo-Gomes, E. (Elisabete), Meltzer, E.O., Mercier, J. (Jacques), Miculinic, N. (Neven), Mihaltan, F. (Florin), Milenkovic, B. (Branislava), Moda, G. (Giuliana), Mogica-Martinez, M.-D. (Maria-Dolores), Mohammad, Y., Montefort, S. (Steve), Monti, R. (Ricardo), Morais-Almeida, M. (Mario), Mösges, R. (Ralph), Münter, L. (Lars), Muraro, A. (Antonella), Murray, R. (Ruth), Naclerio, R., Napoli, L. (Luigi), Namazova-Baranova, L. (Leila), Neffen, H. (Hugo), Nekam, K. (Kristoff), Neou, A. (A.), Novellino, E. (Enrico), Nyembue, D. (Dieudonné), O'Hehir, R. (Robin), Ohta, K., Okubo, K. (Kimi), Onorato, G. (Gabrielle), Ouedraogo, S., Pali-Schöll, I. (I.), Palkonen, S. (Susanna), Panzner, P. (P.), Park, H.-S. (Hae-Sim), Pépin, J.-L. (Jean-Louis), Pereira, A.-M. (Ana-Maria), Pfaar, O. (Oliver), Paulino, E. (Ema), Phillips, J. (Jim), Plavec, D. (Davor), Popov, T.A. (Ted A.), Portejoie, F. (Fabienne), Price, D. (David), Prokopakis, E.P. (Emmanuel P.), Pugin, B. (Benoit), Raciborski, F. (Filip), Rajabian-Söderlund, R. (Rojin), Reitsma, S. (Sietze), Rodo, X. (Xavier), Romano, A., Rosario, N. (Nelson), Rottem, M. (Menahenm), Ryan, D. (Dermot), Salimäki, J. (Johanna), Sanchez-Borges, M.M. (Mario M.), Sisul, J.C. (J.), Solé, D. (Dirceu), Somekh, D. (David), Sooronbaev, T. (Talant), Sova, M. (Milan), Spranger, O., Stellato, C. (Cristina), Stelmach, R. (Rafael), Ulrik, C.S., Thibaudon, M. (Michel), To, T. (Teresa), Todo Bom, A., Tomazic, P.V. (Peter V.), Valero, A.A. (Antonio A.), Valenta, R. (Rudolph), Valentin-Rostan, M. (Marylin), Van Der Kleij, R.M. (Rianne Mjj), Vandenplas, O. (Olivier), Vezzani, G. (Giorgio), Viart, F. (Frédéric), Viegi, G., Wallace, D. (D.), Wagenmann, M. (Martin), Wang, D.Y. (De Y.), Waserman, S. (Susan), Wickman, M. (Magnus), Williams, D., Wong, G. (G.), Wroczynski, P. (Piotr), Yiallouros, P.K. (P.), Yorgancioglu, A. (Arzu), Yusuf, O.M. (Osman), Zar, H.J. (Heahter J.), Zeng, S. (Stéphane), Zernotti, M., Zhang, L. (Luo), Zhong, N.S. (Nan S.), and Zidarn, M. (Mihaela)
Abstract: Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy. Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhi-nitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Santé as a Good Practice in the field of digitally-enabled, integrated, person-centred care. Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
Published: 2019
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11. MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence

Author: Bousquet, J. (Jean), Arnavielhe, S, Bedbrook, A. (Anna), Bewick, M, Laune, D, Mathieu-Dupas, E., Murray, R., Onorato, G.L., Pépin, J.L., Picard, R., Portejoie, F, Costa, E., Fonseca, J., Lourenço, O., Morais-Almeida, M. (Mario), Todo Bom, A., Cruz, A.A. (Alvaro), Silva, J.D., Serpa, F.S., Illario, M., Menditto, E., Cecchi, L., Monti, R., Napoli, L., Ventura, M. T., De Feo, G., Larenas-Linnemann, D. (Désirée), Perez, M, Huerta Villabolos, Y.R., Rivero-yeverino, D., Rodriguez-zagal, E., Amat, F., Annesi-Maesano, I. (Isabella), Bosse, I, Demoly, P., Devillier, P. (Philippe), Fontaine, J.F., Just, P.M., Kuna, T.P., Samolinski, B. (Boleslaw), Valiulis, A. (Arunas), Emuzyte, R., Kvedariene, V. (Violeta), Ryan, D. (Dermot), Sheikh, A. (Aziz), Schmidt-grendelmeier, P., Klimek, L., Pfaar, O, Bergmann, K.-C. (Karl-Christian), Mösges, R., Zuberbier, T. (Torsten), Roller-Wirnsberger, R.E., Tomazic, P., Fokkens, WJ, Chavannes, N.H. (Nicolas), Reitsma, S., Anto, JM, Cardona, V, Dedeu, T, Mullol, J., Haahtela, T. (Tari), Salimäki, J., Toppila-Salmi, S., Valovirta, E. (Erkka), Gemicioğlu, B., Yorgancioglu, A., Papadopoulos, N., Prokopakis, E.P., Bosnic-Anticevich, S, O’hehir, R., Ivancevich, J.C. (Juan), Neffen, H, Zernotti, E., Kull, C.A. (Christian), Melén, E. (Erik), Wickman, M., Bachert, C. (Claus), Hellings, P, Palkonen, S., Bindslev-Jensen, C. (Carsten), Eller, E., Waserman, S., Sova, M., Vries, G. (Gerard) de, Eerd, M. (Maarten) van, Agache, I., Casale, T, Dykewickz, M., Naclerio, RN, Okamoto, Y., Wallace, D.V., Hellings, P.W. (Peter), Aberer, W. (W.), Akdis, C.A., Alberti, M.R., Almeida, R., Angles, R., Ansotegui, I.J. (I.), Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H, Avolio, F., Bacci, E., Baiardini, I. (Ilaria), Barbara, C, Barbagallo, M., Baroni, I., Barreto, B.A., Basagaña, X. (Xavier), Bateman, E.D. (Eric), Bedolla-Barajas, M., Beghé, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M. (Martin), Bertorello, L., Białoszewski, A.Z., Bieber, T. (Thomas), Bialek, S., Bjermer, L. (Leif), Blain, H, Blasi, F, Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosnic-Anticevich, C.S., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R, Braido, F. (Fulvio), Briedis, V., Brightling, C.E. (C.), Brozek, J., Bucca, C., Buhl, R, Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M.T., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F, Caillot, D. (Denis), Caimmi, D, Calderon, MA, Camargos, PAM, Camuzat, T, Canfora, G., Canonica, G.W., Carlsen, K.H. (Karin), Carreiro-Martins, P., Carriazo, A.M., Carr, W.W. (Warner), Cartier, C., Castellano, G., Cepeda, F., Chen, Y., Chiron, R, Chivato, T., Chkhartishvili, E. (E.), Chuchalin, A.G., Chung, K.F., Ciaravolo, M.M., Ciceran, A., Cingi, C., Ciprandi, G. (G.), Carvalho Coehlo, A.C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R.M., Corti, F. (Fabiola), Costa-Dominguez, M.C., Courbis, A.L., Cox, L. (Linda), Crescenzo, M., Custovic, A. (Adnan), Czarlewski, W., Dahlen, S.E., Dario, C., da Silva, J, Dauvilliers, Y. (Yves), Darsow, U. (U.), Blay, F. de, De Carlo, G, de Fátima Emerson, M., De Martino, B., de Paula Motta Rubini, N., Deleanu, D. (D.), Denburg, J., Di Capua Ercolano, S., Di Carluccio, N., Didier, A, Dokic, D. (D.), Dominguez-Silva, M.G., Douagui, H., Dray, G, Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G, Dykewicz, M.S. (M.), El-Gamal, Y. (Y.), Eklund, P., Farrell, J., Farsi, A., Ferreira de Mello, J., Jr., Ferrero, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fonseca, J.A. (J.), Forti, S., Fuentes-Perez, J.M., Gálvez-Romero, J.L., Gamkrelidze, A. (Amiran), Garcia-Aymerich, J. (Judith), García-Cobas, C.Y., Garcia-Cruz, M.H., Genova, S., George, C., Gereda, JE, Gerth van Wijk, R. (Roy), Gomez, R. M., Gómez-Vera, J., González Diaz, S., Gotua, M. (M.), Grisle, I, Guidacci, M., Guldemond, N. (Nick), Gutter, Z., Guzmán, M.A., Hajjam, J., Hernández, L., Hourihane, JOB, Huerta-Villalobos, Y.R., Humbert, M., Iaccarino, G. (Guido), Jares, EJ, Jassem, E., Johnston, S.L., Joos, G.F. (Guy), Jung, KS, Jutel, M. (M.), Kaidashev, I, Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Karjalainen, J. (Juha), Kardas, P., Keil, M. (Mark), Keith, P.K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Kowalski, M.L., Kuitunen, M., Kuna, P. (Piotr), Kupczyk, M, Krzych-Fałta, E., Lacwik, P., Lauri, D., Lavrut, J., Le, L.T., Lessa, M., Levato, G., Li, J., Lieberman, A.P. (Andrew), Lipiec, A., Lipworth, B., Lodrup Carlsen, K.C., Louis, R, Luna-Pech, J.A., Maciej, K., Magnan, A, Mahboub, B., Maier, D., Mair, A., Majer, I.M. (Istvan), Malva, J., Mandajieva, E., Manning, P, De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Maspero, JF, Matta Campos, J.J., Matos, A.L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M.A., Melén, E., Melo-Gomes, E, Meltzer, E.O., Mercier, J, Miculinic, N, Mihaltan, F. (F.), Milenkovic, B, Moda, G., Mogica-Martinez, M.D., Mohammad, Y., Momas, I. (I.), Montefort, S., Mora Bogado, D., Morato-Castro, F.F., Mota-Pinto, A., Moura Santo, P., Münter, L., Murarol, A. (Antonella), Naclerio, R., Nadif, R. (Rachel), Nalin, M., Namazova-Baranova, L. (L.), Niedeberger, V., Nekam, K., Neou, A. (A.), Nieto, A. (Antonio), Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T.D. (T.), O’hehir, R.E., Odzhakova, C., Ohta, K. (Ken), Okubo, K. (K.), Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Panzner, P. (P.), Park, H.S. (H.), Papi, A, Passalacqua, G. (Giovanni), Paulino, E., Pawankar, R. (Ruby), Pedersen, S., Pereira, A.M. (A.), Persico, M., Phillips, J., Pigearias, B. (B.), Pin, I. (Isabelle), Pitsios, C, Plavec, D, Pohl, W. (W.), Popov, T.A., Potter, P., Pozzi, A.C., Price, D., Puy, R., Pugin, B., Pulido Ross, R.E., Przemecka, M., Rabe, K.F. (Klaus F.), Raciborski, F, Rajabian-Soderlund, R., Ribeirinho, I., Rimmer, J., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C, Rodenas, F, Rodo, X., González, M. (Marcos), Rodriguez-Mañas, L., Rolland, C, Rodrigues Valle, S., Rodriguez, M.M. (M. Mirta), Romano, A., Rolla, G., Romano, M. (Matteo), Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M. (M.), Sagara, H., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Schunemann, HJ, Scichilone, N., Schmid-Grendelmeier, P, Shamai, S., Sierra, M., Simons, F.E.R., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I, Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T, Sørensen, M. (Mette), Sorlini, M., Spranger, O., Stellato, C., Stelmach, R, Stukas, R., Sunyer, J. (Jordi), Strozek, J., Szylling, A., Tebyriçá, J.N., Thibaudon, M., To, M.S., Tomazic, P.V., Trama, U., Triggiani, M. (M.), Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Ganse, E. (Éric), Van Hague, M., Vandenplas, O. (Olivier), Vezzani, G, Vasankari, T, Vatrella, A., Verissimo, M.T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M, Walker, S., Wallace, D. (D.), Wang, D.Y. (De Yun), Werfel, T., Westman, M. (Mina), Williams, DM, Williams, S. (Stephanie), Wilson, N., Wright, J. (Juliet), Wroczynski, P., Yakovliev, P., Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zar, H.J., Zhang, L. (Lingling), Zhong, N., Zernotti, M., Zidarn, M. (M.), Zubrinich, C., Zurkuhlen, A., Bousquet, J. (Jean), Arnavielhe, S, Bedbrook, A. (Anna), Bewick, M, Laune, D, Mathieu-Dupas, E., Murray, R., Onorato, G.L., Pépin, J.L., Picard, R., Portejoie, F, Costa, E., Fonseca, J., Lourenço, O., Morais-Almeida, M. (Mario), Todo Bom, A., Cruz, A.A. (Alvaro), Silva, J.D., Serpa, F.S., Illario, M., Menditto, E., Cecchi, L., Monti, R., Napoli, L., Ventura, M. T., De Feo, G., Larenas-Linnemann, D. (Désirée), Perez, M, Huerta Villabolos, Y.R., Rivero-yeverino, D., Rodriguez-zagal, E., Amat, F., Annesi-Maesano, I. (Isabella), Bosse, I, Demoly, P., Devillier, P. (Philippe), Fontaine, J.F., Just, P.M., Kuna, T.P., Samolinski, B. (Boleslaw), Valiulis, A. (Arunas), Emuzyte, R., Kvedariene, V. (Violeta), Ryan, D. (Dermot), Sheikh, A. (Aziz), Schmidt-grendelmeier, P., Klimek, L., Pfaar, O, Bergmann, K.-C. (Karl-Christian), Mösges, R., Zuberbier, T. (Torsten), Roller-Wirnsberger, R.E., Tomazic, P., Fokkens, WJ, Chavannes, N.H. (Nicolas), Reitsma, S., Anto, JM, Cardona, V, Dedeu, T, Mullol, J., Haahtela, T. (Tari), Salimäki, J., Toppila-Salmi, S., Valovirta, E. (Erkka), Gemicioğlu, B., Yorgancioglu, A., Papadopoulos, N., Prokopakis, E.P., Bosnic-Anticevich, S, O’hehir, R., Ivancevich, J.C. (Juan), Neffen, H, Zernotti, E., Kull, C.A. (Christian), Melén, E. (Erik), Wickman, M., Bachert, C. (Claus), Hellings, P, Palkonen, S., Bindslev-Jensen, C. (Carsten), Eller, E., Waserman, S., Sova, M., Vries, G. (Gerard) de, Eerd, M. (Maarten) van, Agache, I., Casale, T, Dykewickz, M., Naclerio, RN, Okamoto, Y., Wallace, D.V., Hellings, P.W. (Peter), Aberer, W. (W.), Akdis, C.A., Alberti, M.R., Almeida, R., Angles, R., Ansotegui, I.J. (I.), Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H, Avolio, F., Bacci, E., Baiardini, I. (Ilaria), Barbara, C, Barbagallo, M., Baroni, I., Barreto, B.A., Basagaña, X. (Xavier), Bateman, E.D. (Eric), Bedolla-Barajas, M., Beghé, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M. (Martin), Bertorello, L., Białoszewski, A.Z., Bieber, T. (Thomas), Bialek, S., Bjermer, L. (Leif), Blain, H, Blasi, F, Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosnic-Anticevich, C.S., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R, Braido, F. (Fulvio), Briedis, V., Brightling, C.E. (C.), Brozek, J., Bucca, C., Buhl, R, Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M.T., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F, Caillot, D. (Denis), Caimmi, D, Calderon, MA, Camargos, PAM, Camuzat, T, Canfora, G., Canonica, G.W., Carlsen, K.H. (Karin), Carreiro-Martins, P., Carriazo, A.M., Carr, W.W. (Warner), Cartier, C., Castellano, G., Cepeda, F., Chen, Y., Chiron, R, Chivato, T., Chkhartishvili, E. (E.), Chuchalin, A.G., Chung, K.F., Ciaravolo, M.M., Ciceran, A., Cingi, C., Ciprandi, G. (G.), Carvalho Coehlo, A.C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R.M., Corti, F. (Fabiola), Costa-Dominguez, M.C., Courbis, A.L., Cox, L. (Linda), Crescenzo, M., Custovic, A. (Adnan), Czarlewski, W., Dahlen, S.E., Dario, C., da Silva, J, Dauvilliers, Y. (Yves), Darsow, U. (U.), Blay, F. de, De Carlo, G, de Fátima Emerson, M., De Martino, B., de Paula Motta Rubini, N., Deleanu, D. (D.), Denburg, J., Di Capua Ercolano, S., Di Carluccio, N., Didier, A, Dokic, D. (D.), Dominguez-Silva, M.G., Douagui, H., Dray, G, Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G, Dykewicz, M.S. (M.), El-Gamal, Y. (Y.), Eklund, P., Farrell, J., Farsi, A., Ferreira de Mello, J., Jr., Ferrero, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fonseca, J.A. (J.), Forti, S., Fuentes-Perez, J.M., Gálvez-Romero, J.L., Gamkrelidze, A. (Amiran), Garcia-Aymerich, J. (Judith), García-Cobas, C.Y., Garcia-Cruz, M.H., Genova, S., George, C., Gereda, JE, Gerth van Wijk, R. (Roy), Gomez, R. M., Gómez-Vera, J., González Diaz, S., Gotua, M. (M.), Grisle, I, Guidacci, M., Guldemond, N. (Nick), Gutter, Z., Guzmán, M.A., Hajjam, J., Hernández, L., Hourihane, JOB, Huerta-Villalobos, Y.R., Humbert, M., Iaccarino, G. (Guido), Jares, EJ, Jassem, E., Johnston, S.L., Joos, G.F. (Guy), Jung, KS, Jutel, M. (M.), Kaidashev, I, Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Karjalainen, J. (Juha), Kardas, P., Keil, M. (Mark), Keith, P.K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Kowalski, M.L., Kuitunen, M., Kuna, P. (Piotr), Kupczyk, M, Krzych-Fałta, E., Lacwik, P., Lauri, D., Lavrut, J., Le, L.T., Lessa, M., Levato, G., Li, J., Lieberman, A.P. (Andrew), Lipiec, A., Lipworth, B., Lodrup Carlsen, K.C., Louis, R, Luna-Pech, J.A., Maciej, K., Magnan, A, Mahboub, B., Maier, D., Mair, A., Majer, I.M. (Istvan), Malva, J., Mandajieva, E., Manning, P, De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Maspero, JF, Matta Campos, J.J., Matos, A.L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M.A., Melén, E., Melo-Gomes, E, Meltzer, E.O., Mercier, J, Miculinic, N, Mihaltan, F. (F.), Milenkovic, B, Moda, G., Mogica-Martinez, M.D., Mohammad, Y., Momas, I. (I.), Montefort, S., Mora Bogado, D., Morato-Castro, F.F., Mota-Pinto, A., Moura Santo, P., Münter, L., Murarol, A. (Antonella), Naclerio, R., Nadif, R. (Rachel), Nalin, M., Namazova-Baranova, L. (L.), Niedeberger, V., Nekam, K., Neou, A. (A.), Nieto, A. (Antonio), Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T.D. (T.), O’hehir, R.E., Odzhakova, C., Ohta, K. (Ken), Okubo, K. (K.), Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Panzner, P. (P.), Park, H.S. (H.), Papi, A, Passalacqua, G. (Giovanni), Paulino, E., Pawankar, R. (Ruby), Pedersen, S., Pereira, A.M. (A.), Persico, M., Phillips, J., Pigearias, B. (B.), Pin, I. (Isabelle), Pitsios, C, Plavec, D, Pohl, W. (W.), Popov, T.A., Potter, P., Pozzi, A.C., Price, D., Puy, R., Pugin, B., Pulido Ross, R.E., Przemecka, M., Rabe, K.F. (Klaus F.), Raciborski, F, Rajabian-Soderlund, R., Ribeirinho, I., Rimmer, J., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C, Rodenas, F, Rodo, X., González, M. (Marcos), Rodriguez-Mañas, L., Rolland, C, Rodrigues Valle, S., Rodriguez, M.M. (M. Mirta), Romano, A., Rolla, G., Romano, M. (Matteo), Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M. (M.), Sagara, H., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Schunemann, HJ, Scichilone, N., Schmid-Grendelmeier, P, Shamai, S., Sierra, M., Simons, F.E.R., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I, Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T, Sørensen, M. (Mette), Sorlini, M., Spranger, O., Stellato, C., Stelmach, R, Stukas, R., Sunyer, J. (Jordi), Strozek, J., Szylling, A., Tebyriçá, J.N., Thibaudon, M., To, M.S., Tomazic, P.V., Trama, U., Triggiani, M. (M.), Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Ganse, E. (Éric), Van Hague, M., Vandenplas, O. (Olivier), Vezzani, G, Vasankari, T, Vatrella, A., Verissimo, M.T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M, Walker, S., Wallace, D. (D.), Wang, D.Y. (De Yun), Werfel, T., Westman, M. (Mina), Williams, DM, Williams, S. (Stephanie), Wilson, N., Wright, J. (Juliet), Wroczynski, P., Yakovliev, P., Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zar, H.J., Zhang, L. (Lingling), Zhong, N., Zernotti, M., Zidarn, M. (M.), Zubrinich, C., and Zurkuhlen, A.
Abstract: mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly afect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on self-management should be the norm. Mobile Airways Sentinel networK (MASK), the Phase 3 ARIA initiative, is based on the freely available MASK app (the Allergy Diary, Android and iOS platforms). MASK is available in 16 languages and deployed in 23 countries. The present paper provides an over‑ view of the methods used in MASK and the key results obtained to date. These include a novel phenotypic charac‑ terization of the patients, confrmation of the impact of allergic rhinitis on work productivity and treatment patterns in real life. Most patients appear to self-medicate, are often non-adherent and do not follow guidelines. Moreover, the Allergy Diary is able to distinguish between AR medications. The potential usefulness of MASK will be further explored by POLLAR (Impact of Air Pollution on Asthma and Rhinitis), a new Horizon 2020 project using the Allergy Diary.
Published: 2018
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12. Geolocation with respect to personal privacy for the Allergy Diary app - A MASK study

Author: Bousquet, J. (Jean), Agache, I., Almeida, R., Angles, R., Annesi-Maesano, I. (Isabella), Anto, JM, Arnavielhe, S, Asayag, E., Bacci, E., Bachert, C. (Claus), Baiardini, I. (Ilaria), Baroni, I., Barreto, B.A., Basagaña, X. (Xavier), Bedbrook, A. (Anna), Bedolla-Barajas, M., Bergmann, K.-C. (Karl-Christian), Bertorello, L., Bewick, M, Bialek, S., Bieber, T. (Thomas), Bindslev-Jensen, C. (Carsten), Bjermer, L. (Leif), Blua, A., Marciniak, M.B., Bogus-Buczynska, I., Bosnic-Anticevich, S, Bosse, I, Bouchard, J. (Jacques), Bourret, R, Briedis, V., Bucca, C., Buonaiuto, R., Cabanas, M.T.B., Caiazza, D., Caillot, D. (Denis), Caimmi, D, Camargos, P., Canfora, G., Cardona, V, Carriazo, A.M., Cartier, C., Coelho, A.C.C., Castellano, G., Cecchi, L., Chavannes, N.H. (Nicolas), Ciaravolo, M.M., Cingi, C., Ciceran, A., Colas, L., Colgan, E., Coll, J., Conforti, D., de Sousa, JC, Cortés-Grimaldo, R.M., Corti, F. (Fabiola), Costa, D.J., Dominguez, M.C.C., Courbis, A.L., Cruz, A.A. (Alvaro), Custovic, A. (Adnan), Czarlewski, W., Dario, C., Silva, J.D., Dauvilliers, Y. (Yves), Carlo, G.D., Blay, F.D., Dedeu, T, Emerson, M.F., Feo, G.D., Cruz, M.H.G., Martino, B.D., Demoly, P., Rubini, N.P.M., Devillier, P. (Philippe), Vries, G. (Gerard) de, Ercolano, S.D., Di Carluccio, N., Dray, G, Dubakiene, R. (R.), Eller, E., Emuzyte, R., Espinoza-Contreras, J.M., Estrada-Cardona, A., Farrell, J., Farsi, A., de Mello, J.F., Jr., Ferrero, J., Fokkens, WJ, Fonseca, J., Fontaine, J.F., Forti, S., Garcia-Aymerich, J. (Judith), Gálvez-Romero, J.L., García-Cobas, C.I., Gemicioğlu, B., Gerth van Wijk, R. (Roy), Guidacci, M., Gómez-Vera, J., Guldemond, N. (Nick), Gutter, Z., Haahtela, T. (Tari), Hajjam, J., Hellings, P.W. (Peter), Hernández, L., Illario, M., Ivancevich, J.C. (Juan), Jares, E., Joos, G.F. (Guy), Just, P.M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Karjalainen, J. (Juha), Keil, M. (Mark), Khaltaev, N., Klimek, L., Kowalski, M.L., Kull, C.A. (Christian), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Kolek, V, Krzych-Fałta, E., Kupczyk, M, Lacwik, P., Larenas-Linnemann, D. (Désirée), Laune, D, Lauri, D., Lavrut, J., Lessa, M.A., Levato, G., Lewis, L., Lieten, I., Lipiec, A., Louis, R, Luna-Pech, J.A., Maciej, K., Magnan, A, Malva, J., Maspero, JF, Mathieu-Dupas, E., Matos, A.L., Mayora, O., Medina-ávalos, M.A., Melén, E. (Erik), Menditto, E., Millot-Keurinck, J., Mizani, M.A., Moda, G., Morais-Almeida, M. (Mario), Morato-Castro, F.F., Santo, P.M., Mösges, R., Mota-Pinto, A., Mullol, J., Murraro, A., Murray, R., Nalin, M., Noguès, M., Novellino, E., Napoli, L., Neffen, H, O’hehir, R.E., Onorato, G.L., Palkonen, S., Papadopoulos, N., Passalacqua, G. (Giovanni), Pépin, J.L., Pereira, A.M. (A.), Persico, M., Pfaar, O, Picard, R., Poncelet, P., Portejoie, F, Pozzi, A.C., Price, D., Prokopakis, E.P., Puy, R., Pugin, B., Przemecka-Green, M., Raciborski, F, Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C, Rodo, X., Valle, S.R., Rodríguez-González, M., Rolla, G., Roller-Wirnsberger, R.E., Romano, A., Romano, M. (Matteo), Rosario, K. (Karyna), Ryan, D. (Dermot), Salimäki, J., Samolinski, B. (Boleslaw), Samreth, D., Shamai, S., Sheikh, A. (Aziz), Sierra, M., Simons, F.E.R., Solé, D., Sorlini, M., Spranger, O., Stellato, C., Stelmach, A.R., Strozek, J., Stukas, R., Sutherland, M, Szylling, A., Tebyriçá, J.N., Thibaudon, M., Tibaldi, V., Todo Bom, A., Toppila-Salmi, S., Tomazic, P., Trama, U., Triggiani, M. (M.), Urrutia-Pereira, M., Valero, A., Valovirta, E. (Erkka), Valiulis, A. (Arunas), Vandenplas, O. (Olivier), Eerd, M. (Maarten) van, Vasankari, T, Vatrella, A., Ventura, M. T., Verissimo, M.T., Viart, F., Williams, S. (Stephanie), Wagenmann, M, Westman, M. (Mina), Wickman, M., Wroczynski, P., Yorgancioglu, A., Zernotti, E., Zurbierber, T., Zubrinich, C., Zurkuhlen, A., Ingenrieth, F., Costa, E., Fuentes-Pérez, J.M., Huerta-Villalobos, Y.R., da Silva, J, Tomazic, P.V., Makris, M. (M.), Psarros, F., Sova, M., Wehner, K., Wittmann, J., Bousquet, J. (Jean), Agache, I., Almeida, R., Angles, R., Annesi-Maesano, I. (Isabella), Anto, JM, Arnavielhe, S, Asayag, E., Bacci, E., Bachert, C. (Claus), Baiardini, I. (Ilaria), Baroni, I., Barreto, B.A., Basagaña, X. (Xavier), Bedbrook, A. (Anna), Bedolla-Barajas, M., Bergmann, K.-C. (Karl-Christian), Bertorello, L., Bewick, M, Bialek, S., Bieber, T. (Thomas), Bindslev-Jensen, C. (Carsten), Bjermer, L. (Leif), Blua, A., Marciniak, M.B., Bogus-Buczynska, I., Bosnic-Anticevich, S, Bosse, I, Bouchard, J. (Jacques), Bourret, R, Briedis, V., Bucca, C., Buonaiuto, R., Cabanas, M.T.B., Caiazza, D., Caillot, D. (Denis), Caimmi, D, Camargos, P., Canfora, G., Cardona, V, Carriazo, A.M., Cartier, C., Coelho, A.C.C., Castellano, G., Cecchi, L., Chavannes, N.H. (Nicolas), Ciaravolo, M.M., Cingi, C., Ciceran, A., Colas, L., Colgan, E., Coll, J., Conforti, D., de Sousa, JC, Cortés-Grimaldo, R.M., Corti, F. (Fabiola), Costa, D.J., Dominguez, M.C.C., Courbis, A.L., Cruz, A.A. (Alvaro), Custovic, A. (Adnan), Czarlewski, W., Dario, C., Silva, J.D., Dauvilliers, Y. (Yves), Carlo, G.D., Blay, F.D., Dedeu, T, Emerson, M.F., Feo, G.D., Cruz, M.H.G., Martino, B.D., Demoly, P., Rubini, N.P.M., Devillier, P. (Philippe), Vries, G. (Gerard) de, Ercolano, S.D., Di Carluccio, N., Dray, G, Dubakiene, R. (R.), Eller, E., Emuzyte, R., Espinoza-Contreras, J.M., Estrada-Cardona, A., Farrell, J., Farsi, A., de Mello, J.F., Jr., Ferrero, J., Fokkens, WJ, Fonseca, J., Fontaine, J.F., Forti, S., Garcia-Aymerich, J. (Judith), Gálvez-Romero, J.L., García-Cobas, C.I., Gemicioğlu, B., Gerth van Wijk, R. (Roy), Guidacci, M., Gómez-Vera, J., Guldemond, N. (Nick), Gutter, Z., Haahtela, T. (Tari), Hajjam, J., Hellings, P.W. (Peter), Hernández, L., Illario, M., Ivancevich, J.C. (Juan), Jares, E., Joos, G.F. (Guy), Just, P.M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Karjalainen, J. (Juha), Keil, M. (Mark), Khaltaev, N., Klimek, L., Kowalski, M.L., Kull, C.A. (Christian), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Kolek, V, Krzych-Fałta, E., Kupczyk, M, Lacwik, P., Larenas-Linnemann, D. (Désirée), Laune, D, Lauri, D., Lavrut, J., Lessa, M.A., Levato, G., Lewis, L., Lieten, I., Lipiec, A., Louis, R, Luna-Pech, J.A., Maciej, K., Magnan, A, Malva, J., Maspero, JF, Mathieu-Dupas, E., Matos, A.L., Mayora, O., Medina-ávalos, M.A., Melén, E. (Erik), Menditto, E., Millot-Keurinck, J., Mizani, M.A., Moda, G., Morais-Almeida, M. (Mario), Morato-Castro, F.F., Santo, P.M., Mösges, R., Mota-Pinto, A., Mullol, J., Murraro, A., Murray, R., Nalin, M., Noguès, M., Novellino, E., Napoli, L., Neffen, H, O’hehir, R.E., Onorato, G.L., Palkonen, S., Papadopoulos, N., Passalacqua, G. (Giovanni), Pépin, J.L., Pereira, A.M. (A.), Persico, M., Pfaar, O, Picard, R., Poncelet, P., Portejoie, F, Pozzi, A.C., Price, D., Prokopakis, E.P., Puy, R., Pugin, B., Przemecka-Green, M., Raciborski, F, Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rizzo, J.A., Rizzo, M.C., Robalo-Cordeiro, C, Rodo, X., Valle, S.R., Rodríguez-González, M., Rolla, G., Roller-Wirnsberger, R.E., Romano, A., Romano, M. (Matteo), Rosario, K. (Karyna), Ryan, D. (Dermot), Salimäki, J., Samolinski, B. (Boleslaw), Samreth, D., Shamai, S., Sheikh, A. (Aziz), Sierra, M., Simons, F.E.R., Solé, D., Sorlini, M., Spranger, O., Stellato, C., Stelmach, A.R., Strozek, J., Stukas, R., Sutherland, M, Szylling, A., Tebyriçá, J.N., Thibaudon, M., Tibaldi, V., Todo Bom, A., Toppila-Salmi, S., Tomazic, P., Trama, U., Triggiani, M. (M.), Urrutia-Pereira, M., Valero, A., Valovirta, E. (Erkka), Valiulis, A. (Arunas), Vandenplas, O. (Olivier), Eerd, M. (Maarten) van, Vasankari, T, Vatrella, A., Ventura, M. T., Verissimo, M.T., Viart, F., Williams, S. (Stephanie), Wagenmann, M, Westman, M. (Mina), Wickman, M., Wroczynski, P., Yorgancioglu, A., Zernotti, E., Zurbierber, T., Zubrinich, C., Zurkuhlen, A., Ingenrieth, F., Costa, E., Fuentes-Pérez, J.M., Huerta-Villalobos, Y.R., da Silva, J, Tomazic, P.V., Makris, M. (M.), Psarros, F., Sova, M., Wehner, K., and Wittmann, J.
Abstract: Background: Collecting data on the localization of users is a key issue for the MASK (Mobile Airways Sentinel networK: the Allergy Diary) App. Data anonymization is a method of sanitization for privacy. The European Commission’s Article 29 Working Party stated that geolocation information is personal data. To assess geolocation using the MASK method and to compare two anonymization methods in the MASK database to find an optimal privacy method. Methods: Geolocation was studied for all people who used the Allergy Diary App from December 2015 to November 2017 and who reported medical outcomes. Two different anonymization methods have been evaluated: Noise addition (randomization) and k-anonymity (generalization). Results: Ninety-three thousand one hundred and sixteen days of VAS were collected from 8535 users and 54,500 (58. 5%) were geolocalized, corresponding to 5428 users. Noise addition was found to be less accurate than k-anonymity using MASK data to protect the users’ life privacy. Discussion: k-anonymity is an acceptable method for the anonymization of MASK data and results can be used for other databases.
Published: 2018
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13. Cohort profile: Pregnancy and childhood epigenetics (PACE) consortium

Author: Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), London, S.J. (Stephanie J.), Felix, J.F. (Janine F.), Joubert, B.R. (Bonnie), Baccarelli, A.A. (Andrea), Sharp, G.C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baïz, N. (Nour), Bakermans-Kranenburg, M.J. (Marian), Bakulski, K.M. (Kelly M.), Binder, E.B. (Elisabeth), Bouchard, L. (Luigi), Breton, C. (Carrie), Brunekreef, B. (Bert), Brunst, K.J. (Kelly J.), Burchard, E.G. (Esteban), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M.C. (Monica Cheng), Corpeleijn, W.E. (Willemijn), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G.D. (George Davey), Boever, P. (Patrick) de, Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (B.), Everson, T.M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M.D. (M. Daniele), Farchi, S. (Sara), Fernandez, M.F. (Mariana), Gao, L. (Lu), Gaunt, T.R. (Tom), Ghantous, A. (Akram), Gillman, M.W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Håberg, S.E. (Siri E), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J.W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D.D. (Dereje D.), Just, A.C. (Allan C.), Karagas, M.R. (Margaret), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K.J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G.H. (Gerard), Küpers, A.M. (Marlijn), Ladd-Acosta, C. (Christine), Lahti, J., Lambrechts, N. (Nathalie), Langie, S.A.S. (Sabine A.S.), Lie, R.T. (Rolv T.), Liu, A.H. (Andrew H.), Magnus, M.C. (Maria C.), Magnus, P. (Per), Maguire, R.L. (Rachel L.), Marsit, C.J. (Carmen J.), McArdle, W.L. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S.K. (Susan K.), Nawrot, T.S. (Tim S.), Nisticò, L. (Lorenza), Nohr, C. (Christian), Nordlund, B. (Björn), Nystad, W. (Wenche), Oh, S.S. (Sam S.), Oken, E. (Emily), Page, C.M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Göran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Räikkönen, K. (Katri), Reese, S.E. (Sarah E.), Reischl, G. (Gunilla), Richiardi, L. (Lorenzo), Ring, S.M. (Susan), Roy, R.P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D.A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sørensen, T.I.A. (Thorkild), Starling, A.P. (Anne P.), Sunyer, J. (Jordi), Taylor, J.A. (Jack A), Tiemeier, H.W. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), IJzendoorn, M.H. (Rien) van, Vonk, J.M. (Judith), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. (Joseph), Wilcox, A.J. (Allen), Wright, R.J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I.V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), and London, S.J. (Stephanie J.)
Published: 2018
Full Text: View/download PDF

14. Cohort profile:pregnancy and childhood epigenetics (PACE) consortium

Author: Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), London, S. J. (Stephanie J.), Felix, J. F. (Janine F.), Joubert, B. R. (Bonnie R.), Baccarelli, A. A. (Andrea A.), Sharp, G. C. (Gemma C.), Almqvist, C. (Catarina), Annesi-Maesano, I. (Isabella), Arshad, H. (Hasan), Baiz, N. (Nour), Bakermans-Kranenburg, M. J. (Marian J.), Bakulski, K. M. (Kelly M.), Binder, E. B. (Elisabeth B.), Bouchard, L. (Luigi), Breton, C. V. (Carrie V.), Brunekreef, B. (Bert), Brunst, K. J. (Kelly J.), Burchard, E. G. (Esteban G.), Bustamante, M. (Mariona), Chatzi, L. (Leda), Munthe-Kaas, M. C. (Monica Cheng), Corpeleijn, E. (Eva), Czamara, D. (Darina), Dabelea, D. (Dana), Smith, G. D. (George Davey), De Boever, P. (Patrick), Duijts, L. (Liesbeth), Dwyer, T. (Terence), Eng, C. (Celeste), Eskenazi, B. (Brenda), Everson, T. M. (Todd M.), Falahi, F. (Fahimeh), Fallin, M. D. (M. Daniele), Farchi, S. (Sara), Fernandez, M. F. (Mariana F.), Gao, L. (Lu), Gaunt, T. R. (Tom R.), Ghantous, A. (Akram), Gillman, M. W. (Matthew W.), Gonseth, S. (Semira), Grote, V. (Veit), Gruzieva, O. (Olena), Haberg, S. E. (Siri E.), Herceg, Z. (Zdenko), Hivert, M.-F. (Marie-France), Holland, N. (Nina), Holloway, J. W. (John W.), Hoyo, C. (Cathrine), Hu, D. (Donglei), Huang, R.-C. (Rae-Chi), Huen, K. (Karen), Järvelin, M.-R. (Marjo-Riitta), Jima, D. D. (Dereje D.), Just, A. C. (Allan C.), Karagas, M. R. (Margaret R.), Karlsson, R. (Robert), Karmaus, W. (Wilfried), Kechris, K. J. (Katerina J.), Kere, J. (Juha), Kogevinas, M. (Manolis), Koletzko, B. (Berthold), Koppelman, G. H. (Gerard H.), Kupers, L. K. (Leanne K.), Ladd-Acosta, C. (Christine), Lahti, J. (Jari), Lambrechts, N. (Nathalie), Langie, S. A. (Sabine A. S.), Lie, R. T. (Rolv T.), Liu, A. H. (Andrew H.), Magnus, M. C. (Maria C.), Magnus, P. (Per), Maguire, R. L. (Rachel L.), Marsit, C. J. (Carmen J.), McArdle, W. (Wendy), Melen, E. (Erik), Melton, P. (Phillip), Murphy, S. K. (Susan K.), Nawrot, T. S. (Tim S.), Nistico, L. (Lorenza), Nohr, E. A. (Ellen A.), Nordlund, B. (Bjorn), Nystad, W. (Wenche), Oh, S. S. (Sam S.), Oken, E. (Emily), Page, C. M. (Christian M.), Perron, P. (Patrice), Pershagen, G. (Goran), Pizzi, C. (Costanza), Plusquin, M. (Michelle), Raikkonen, K. (Katri), Reese, S. E. (Sarah E.), Reischl, E. (Eva), Richiardi, L. (Lorenzo), Ring, S. (Susan), Roy, R. P. (Ritu P.), Rzehak, P. (Peter), Schoeters, G. (Greet), Schwartz, D. A. (David A.), Sebert, S. (Sylvain), Snieder, H. (Harold), Sorensen, T. I. (Thorkild I. A.), Starling, A. P. (Anne P.), Sunyer, J. (Jordi), ATaylor, J. (Jack), Tiemeier, H. (Henning), Ullemar, V. (Vilhelmina), Vafeiadi, M. (Marina), Van Ijzendoorn, M. H. (Marinus H.), Vonk, J. M. (Judith M.), Vriens, A. (Annette), Vrijheid, M. (Martine), Wang, P. (Pei), Wiemels, J. L. (Joseph L.), Wilcox, A. J. (Allen J.), Wright, R. J. (Rosalind J.), Xu, C.-J. (Cheng-Jian), Xu, Z. (Zongli), Yang, I. V. (Ivana V.), Yousefi, P. (Paul), Zhang, H. (Hongmei), Zhang, W. (Weiming), Zhao, S. (Shanshan), Agha, G. (Golareh), Relton, C. L. (Caroline L.), Jaddoe, V. W. (Vincent W. V.), and London, S. J. (Stephanie J.)
Published: 2018

15. CHRODIS criteria applied to the MASK (MACVIA-ARIA Sentinel NetworK) Good Practice in allergic rhinitis: a SUNFRAIL report

Author: Bousquet, J. (Jean), Onorato, G.L., Bachert, C. (Claus), Barbolini, M., Bedbrook, A. (Anna), Bjermer, L. (Leif), de Sousa, JC, Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), Keenoy, ED, Devillier, P. (Philippe), Fonseca, J, Hun, S., Kostka, T., Hellings, P.W. (Peter), Illario, M., Ivancevich, J.C. (Juan), Larenas-Linnemann, D. (Désirée), Millot-Keurinck, J., Ryan, D. (Dermot), Samolinski, B. (Boleslaw), Sheikh, A. (Aziz), Yorgancioglu, A., Agache, I., Arnavielhe, S, Bewick, M, Annesi-Maesano, I. (Isabella), Anto, JM, Bergmann, K.-C. (Karl-Christian), Bindslev-Jensen, C. (Carsten), Bosnic-Anticevich, S, Bouchard, J. (Jacques), Caimmi, D. P., Camargos, P., Canonica, G.W., Cardona, V, Carriazo, A.M., Cingi, C., Colgan, E., Custovic, A. (Adnan), Dahl, R., Demoly, P., Vries, G. (Gerard) de, Fokkens, WJ, Fontaine, J.F., Gemicioglu, B, Guldemond, N. (Nick), Gutter, Z., Haahtela, T. (Tari), Hellqvist-Dahl, B., Jares, E., Joos, G.F. (Guy), Just, P.M., Khaltaev, N., Keil, M. (Mark), Klimek, L., Kowalski, M.L., Kull, C.A. (Christian), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Laune, D, Louis, R, Magnan, A, Malva, J., Mathieu-Dupas, E., Melén, E. (Erik), Menditto, E., Morais-Almeida, M. (Mario), Mosges, R, Mullol, J., Murray, R., Neffen, H, O'Hehir, R, Palkonen, S., Papadopoulos, N., Passalacqua, G. (Giovanni), Pepin, J.L., Portejoie, F, Price, D., Pugin, B., Raciborski, F, Simons, F.E.R., Sova, M., Spranger, O., Stellato, C., Bom, AT, Tomazic, P.V., Triggiani, M. (M.), Valero, A., Valovirta, E. (Erkka), Vandenplas, O. (Olivier), Valiulis, A. (Arunas), Eerd, M. (Maarten) van, Ventura, M. T., Wickman, M., Young, I, Zuberbier, T. (Torsten), Zurkuhlen, A., Senn, A., Bousquet, J. (Jean), Onorato, G.L., Bachert, C. (Claus), Barbolini, M., Bedbrook, A. (Anna), Bjermer, L. (Leif), de Sousa, JC, Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), Keenoy, ED, Devillier, P. (Philippe), Fonseca, J, Hun, S., Kostka, T., Hellings, P.W. (Peter), Illario, M., Ivancevich, J.C. (Juan), Larenas-Linnemann, D. (Désirée), Millot-Keurinck, J., Ryan, D. (Dermot), Samolinski, B. (Boleslaw), Sheikh, A. (Aziz), Yorgancioglu, A., Agache, I., Arnavielhe, S, Bewick, M, Annesi-Maesano, I. (Isabella), Anto, JM, Bergmann, K.-C. (Karl-Christian), Bindslev-Jensen, C. (Carsten), Bosnic-Anticevich, S, Bouchard, J. (Jacques), Caimmi, D. P., Camargos, P., Canonica, G.W., Cardona, V, Carriazo, A.M., Cingi, C., Colgan, E., Custovic, A. (Adnan), Dahl, R., Demoly, P., Vries, G. (Gerard) de, Fokkens, WJ, Fontaine, J.F., Gemicioglu, B, Guldemond, N. (Nick), Gutter, Z., Haahtela, T. (Tari), Hellqvist-Dahl, B., Jares, E., Joos, G.F. (Guy), Just, P.M., Khaltaev, N., Keil, M. (Mark), Klimek, L., Kowalski, M.L., Kull, C.A. (Christian), Kuna, P. (Piotr), Kvedariene, V. (Violeta), Laune, D, Louis, R, Magnan, A, Malva, J., Mathieu-Dupas, E., Melén, E. (Erik), Menditto, E., Morais-Almeida, M. (Mario), Mosges, R, Mullol, J., Murray, R., Neffen, H, O'Hehir, R, Palkonen, S., Papadopoulos, N., Passalacqua, G. (Giovanni), Pepin, J.L., Portejoie, F, Price, D., Pugin, B., Raciborski, F, Simons, F.E.R., Sova, M., Spranger, O., Stellato, C., Bom, AT, Tomazic, P.V., Triggiani, M. (M.), Valero, A., Valovirta, E. (Erkka), Vandenplas, O. (Olivier), Valiulis, A. (Arunas), Eerd, M. (Maarten) van, Ventura, M. T., Wickman, M., Young, I, Zuberbier, T. (Torsten), Zurkuhlen, A., and Senn, A.
Abstract: A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life da
Published: 2017
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16. Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: Findings from the pregnancy and childhood epigenetics (PACE) consortium

Author: Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Poppelaars-Monnereau, C. (Claire), Allard, C. (Catherine), Yousefi, P. (Paul), Everson, T.M. (Todd M.), Bohlin, J. (Jon), Xu, Z. (Zongli), Huang, R.-C. (Rae-Chi), Reese, S.E. (Sarah E.), Xu, C.-J. (Cheng-Jian), Baïz, N. (Nour), Hoyo, C. (Cathrine), Agha, G. (Golareh), Roy, R. (Ritu), Holloway, J. (John), Ghantous, A. (Akram), Merid, S.K. (Simon Kebede), Bakulski, K.M. (Kelly M.), Küpers, A.M. (Marlijn), Zhang, H. (Hongmei), Richmond, R.C. (Rebecca C.), Page, C.M. (Christian M.), Duijts, L. (Liesbeth), Lie, R.T. (Rolv T.), Melton, P.E. (Phillip E.), Vonk, J.M. (Judith), Nohr, C. (Christian), Williams-DeVane, C. (ClarLynda), Huen, K. (Karen), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Gonseth, S. (Semira), Rezwan, F.I. (Faisal I.), Herceg, Z. (Zdenko), Ekström, S. (Sandra), Croen, L. (Lisa), Falahi, F. (Fahimeh), Perron, P. (Patrice), Karagas, M.R. (Margaret), Quraishi, B.M. (Bilal M.), Suderman, M.J. (Matthew J.), Magnus, M.C. (Maria C.), Jaddoe, V.W.V. (Vincent), Taylor, J.A. (Jack A.), Anderson, D. (Denise), Zhao, S. (Shanshan), Smit, H.A. (Henriëtte), Josey, M.J. (Michele J.), Bradman, A. (Asa), Baccarelli, A.A. (Andrea), Bustamante, M. (Mariona), Håberg, S.E. (Siri E), Pershagen, G. (Göran), Hertz-Picciotto, I. (Irva), Newschaffer, C. (Craig), Corpeleijn, W.E. (Willemijn), Bouchard, L. (Luigi), Lawlor, D.A. (Debbie A.), Maguire, R.L. (Rachel L.), Barcellos, L.F. (Lisa), Smith, G.D. (George Davey), Eskenazi, B. (B.), Karmaus, W. (Wilfried), Marsit, C.J. (Carmen J.), Hivert, M.-F. (Marie-France), Snieder, H. (Harold), Fallin, M.D. (M. Daniele), Melén, E. (Erik), Munthe-Kaas, M.C. (Monica Cheng), Arshad, H. (Hasan), Wiemels, J. (Joseph), Annesi-Maesano, I. (Isabella), Vrijheid, M. (Martine), Oken, E. (Emily), Holland, N. (Nina), Murphy, S.K. (Susan K.), Sørensen, T.I.A. (Thorkild), Koppelman, G.H. (Gerard), Newnham, J.P. (John), Wilcox, A.J. (Allen), Nystad, W. (Wenche), London, S.J. (Stephanie J.), Felix, J.F. (Janine), Relton, C.L. (Caroline), Sharp, G.C. (Gemma C.), Salas, L.A. (Lucas A.), Poppelaars-Monnereau, C. (Claire), Allard, C. (Catherine), Yousefi, P. (Paul), Everson, T.M. (Todd M.), Bohlin, J. (Jon), Xu, Z. (Zongli), Huang, R.-C. (Rae-Chi), Reese, S.E. (Sarah E.), Xu, C.-J. (Cheng-Jian), Baïz, N. (Nour), Hoyo, C. (Cathrine), Agha, G. (Golareh), Roy, R. (Ritu), Holloway, J. (John), Ghantous, A. (Akram), Merid, S.K. (Simon Kebede), Bakulski, K.M. (Kelly M.), Küpers, A.M. (Marlijn), Zhang, H. (Hongmei), Richmond, R.C. (Rebecca C.), Page, C.M. (Christian M.), Duijts, L. (Liesbeth), Lie, R.T. (Rolv T.), Melton, P.E. (Phillip E.), Vonk, J.M. (Judith), Nohr, C. (Christian), Williams-DeVane, C. (ClarLynda), Huen, K. (Karen), Rifas-Shiman, S.L. (Sheryl), Ruiz-Arenas, C. (Carlos), Gonseth, S. (Semira), Rezwan, F.I. (Faisal I.), Herceg, Z. (Zdenko), Ekström, S. (Sandra), Croen, L. (Lisa), Falahi, F. (Fahimeh), Perron, P. (Patrice), Karagas, M.R. (Margaret), Quraishi, B.M. (Bilal M.), Suderman, M.J. (Matthew J.), Magnus, M.C. (Maria C.), Jaddoe, V.W.V. (Vincent), Taylor, J.A. (Jack A.), Anderson, D. (Denise), Zhao, S. (Shanshan), Smit, H.A. (Henriëtte), Josey, M.J. (Michele J.), Bradman, A. (Asa), Baccarelli, A.A. (Andrea), Bustamante, M. (Mariona), Håberg, S.E. (Siri E), Pershagen, G. (Göran), Hertz-Picciotto, I. (Irva), Newschaffer, C. (Craig), Corpeleijn, W.E. (Willemijn), Bouchard, L. (Luigi), Lawlor, D.A. (Debbie A.), Maguire, R.L. (Rachel L.), Barcellos, L.F. (Lisa), Smith, G.D. (George Davey), Eskenazi, B. (B.), Karmaus, W. (Wilfried), Marsit, C.J. (Carmen J.), Hivert, M.-F. (Marie-France), Snieder, H. (Harold), Fallin, M.D. (M. Daniele), Melén, E. (Erik), Munthe-Kaas, M.C. (Monica Cheng), Arshad, H. (Hasan), Wiemels, J. (Joseph), Annesi-Maesano, I. (Isabella), Vrijheid, M. (Martine), Oken, E. (Emily), Holland, N. (Nina), Murphy, S.K. (Susan K.), Sørensen, T.I.A. (Thorkild), Koppelman, G.H. (Gerard), Newnham, J.P. (John), Wilcox, A.J. (Allen), Nystad, W. (Wenche), London, S.J. (Stephanie J.), Felix, J.F. (Janine), and Relton, C.L. (Caroline)
Abstract: Pre-pregnancy maternal obesity is associated with adverse offspring outcomes at birth and later in life. Individual studies have shown that epigenetic modifications such as DNA methylation could contribute. Within the Pregnancy and Childhood Epigenetics (PACE) Consortium, we meta-analysed the association between pre-pregnancy maternal BMI and methylation at over 450,000 sites in newborn blood DNA, across 19 cohorts (9,340 mother-newborn pairs). We attempted to infer causality by comparing the effects of maternal versus paternal BMI and incorporating genetic variation. In four additional cohorts (1,817 mother-child pairs), we meta-analysed the association between maternal BMI at the start of pregnancy and blood methylation in adolescents. In newborns, maternal BMI was associated with small (<0.2% per BMI unit (1 kg/m2), P < 1.06 × 10-7) methylation variation at 9,044 sites throughout the genome. Adjustment for estimated cell proportions greatly attenuated the number of significant CpGs to 104, including 86 sites common to the unadjusted model. At 72/86 sites, the direction of the association was the same in newborns and adolescents, suggesting persistence of signals. However, we found evidence for a6causal intrauterine effect of maternal BMI on newborn methylation at just 8/86 sites. In conclusion, this well-powered analysis identified robust associations between maternal adiposity and variations in newborn blood DNA methylation, but these small effects may be better explained by genetic or lifestyle factors than a causal intrauterine mechanism. This highlights the need for large-scale collaborative approaches and the application of causal inference techniques in epigenetic epidemiology.
Published: 2017
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17. Mother’s education and offspring asthma risk in 10 European cohort studies

Author: Lewis, K. M. (Kate Marie), Ruiz, M. (Milagros), Goldblatt, P. (Peter), Morrison, J. (Joana), Porta, D. (Daniela), Forastiere, F. (Francesco), Hryhorczuk, D. (Daniel), Zvinchuk, O. (Oleksandr), Saurel-Cubizolles, M.-J. (Marie-Josephe), Lioret, S. (Sandrine), Annesi-Maesano, I. (Isabella), Vrijheid, M. (Martine), Torrent, M. (Maties), Iniguez, C. (Carmen), Larranaga, I. (Isabel), Harskamp-van Ginkel, M. W. (Margreet W.), Vrijkotte, T. G. (Tanja G. M.), Klanova, J. (Jana), Svancara, J. (Jan), Barross, H. (Henrique), Correia, S. (Sofia), Jarvelin, M.-R. (Marjo-Riitta), Taanila, A. (Anja), Ludvigsson, J. (Johnny), Faresjo, T. (Tomas), Marmot, M. (Michael), Pikhart, H. (Hynek), Lewis, K. M. (Kate Marie), Ruiz, M. (Milagros), Goldblatt, P. (Peter), Morrison, J. (Joana), Porta, D. (Daniela), Forastiere, F. (Francesco), Hryhorczuk, D. (Daniel), Zvinchuk, O. (Oleksandr), Saurel-Cubizolles, M.-J. (Marie-Josephe), Lioret, S. (Sandrine), Annesi-Maesano, I. (Isabella), Vrijheid, M. (Martine), Torrent, M. (Maties), Iniguez, C. (Carmen), Larranaga, I. (Isabel), Harskamp-van Ginkel, M. W. (Margreet W.), Vrijkotte, T. G. (Tanja G. M.), Klanova, J. (Jana), Svancara, J. (Jan), Barross, H. (Henrique), Correia, S. (Sofia), Jarvelin, M.-R. (Marjo-Riitta), Taanila, A. (Anja), Ludvigsson, J. (Johnny), Faresjo, T. (Tomas), Marmot, M. (Michael), and Pikhart, H. (Hynek)
Abstract: Highly prevalent and typically beginning in childhood, asthma is a burdensome disease, yet the risk factors for this condition are not clarified. To enhance understanding, this study assessed the cohort-specific and pooled risk of maternal education on asthma in children aged 3–8 across 10 European countries. Data on 47,099 children were obtained from prospective birth cohort studies across 10 European countries. We calculated cohort-specific prevalence difference in asthma outcomes using the relative index of inequality (RII) and slope index of inequality (SII). Results from all countries were pooled using random-effects meta-analysis procedures to obtain mean RII and SII scores at the European level. Final models were adjusted for child sex, smoking during pregnancy, parity, mother’s age and ethnicity. The higher the score the greater the magnitude of relative (RII, reference 1) and absolute (SII, reference 0) inequity. The pooled RII estimate for asthma risk across all cohorts was 1.46 (95% CI 1.26, 1.71) and the pooled SII estimate was 1.90 (95% CI 0.26, 3.54). Of the countries examined, France, the United Kingdom and the Netherlands had the highest prevalence’s of childhood asthma and the largest inequity in asthma risk. Smaller inverse associations were noted for all other countries except Italy, which presented contradictory scores, but with small effect sizes. Tests for heterogeneity yielded significant results for SII scores. Overall, offspring of mothers with a low level of education had an increased relative and absolute risk of asthma compared to offspring of high-educated mothers.
Published: 2017

18. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

Author: Bousquet, J. (Jean), Hellings, P.W. (Peter), Agache, I., Bedbrook, A. (Anna), Bachert, C. (Claus), Bergmann, K.-C. (Karl-Christian), Bewick, M., Bindslev-Jensen, C. (Carsten), Bosnic-Anticevitch, S., Bucca, C., Caimmi, D.P., Camargos, P., Canonica, G. (Gwalter), Casale, T.B. (Thomas), Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W.J. (Wytske), Guldemond, N.A., Haahtela, T. (Tari), Illario, M., Just, P.M., Keil, M. (Mark), Klimek, L. (Ludger), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Morais-Almeida, M. (Mario), Mullol, J., Murray, R., Naclerio, R., O'hehir, R.E., Papadopoulos, N., Pawankar, R. (Ruby), Potter, P., Ryan, D. (Dermot), Samolinski, B., Schünemann, H.J. (Holger), Sheikh, A. (Aziz), Simons, F.E.R., Stellato, C., Todo Bom, A., Tomazic, P.V., Valiulis, A. (Arunas), Valovirta, E. (Erkka), Ventura, M.T., Wickman, M. (Magnus), Young, I., Yorgancioglu, A., Zuberbier, T. (Torsten), Aberer, W. (W.), Akdis, C.A., Annesi-Maesano, I. (Isabella), Ankri, J., Ansotegui, I.J. (I.), Anto, J.M. (Josep), Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I. (Ilaria), Barbara, C., Barbagallo, M., Bateman, E.D. (Eric), Beghe, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M., Białoszewski, A.Z., Bieber, T. (Thomas), Bjermer, L. (Leif), Blain, H., Blasi, F. (Francesco), Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosse, I., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R., Braido, F. (Fulvio), Briggs, A. (Andrew), Brightling, C.E. (C.), Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F., Calderon, M. (Moises), Camuzat, T., Cardona, D. (Doris), Carreiro-Martins, P., Carriazo, A.M., Carlsen, K.H. (Karin), Carr, W.W. (Warner), Cepeda Sarabia, A.M., Cesari, M., Chatzi, L. (Leda), Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G. (G.), De Sousa, J.C. (J. Correia), Cox, L. (Linda), Crooks, G., Custovic, A. (Adnan), Dahlen, S.E., Darsow, U. (U.), Dedeu, T., Deleanu, D. (D.), Denburg, J., De Vries, G., Didier, A., Dinh-Xuan, A.T., Dokic, D. (D.), Douagui, H., Dray, G., Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G. (George), Dykewicz, M.S., Eklund, P., El-Gamal, Y. (Y.), Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fletcher, M. (M.), Forastiere, F., Gaga, M. (Mina), Gamkrelidze, A. (Amiran), Gemicioǧlu, B., Gereda, J.E. (J.), Van Wick, R.G. (R. Gerth), González Diaz, S. (S.), Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A. (M.), Hellquist-Dahl, B. (B.), Heinrich, J. (Joachim), Horak, F., Hourihane, J.O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E.J., Jeandel, C., Johnston, S.L., Joos, G.F. (Guy), Jonquet, O., Jung, K.S., Jutel, M. (M.), Kaidashev, I., Khaitov, M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Kardas, P., Keith, P.K., Kerkhof, M. (Marjan), Kerstjens, H.A.M. (Huib), Khaltaev, N., Kogevinas, M. (Manolis), Kolek, V., Koppelman, G.H. (Gerard), Kowalski, M.L., Kuitunen, M., Kull, C.A. (Christian), Kvedariene, V. (Violeta), Lambrecht, B.N.M. (Bart), Lau, S. (Susanne), Laune, D., Le, L.T., Lieberman, A.P. (Andrew), Lipworth, B., Li, J. (J.), Lødrup Carlsen, K.C. (K. C.), Louis, R. (Renaud), Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E. (Erik), Melo-Gomes, E., Meltzer, E.O., Mercier, J., Merk, J. (Jeroen), Miculinic, N., Mihaltan, F. (F.), Milenkovic, B. (Branislava), Millot-Keurinck, J., Mohammad, Y., Momas, I. (I.), Mösges, R. (Ralph), Muraro, A., Namazova-Baranova, L. (L.), Nadif, R. (Rachel), Neffen, H., Nekam, K., Nieto, A. (Antonio), Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T.D. (T.), Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. (Pierluigi), Pali-Schöll, I. (I.), Palkonen, S., Panzner, P. (P.), Papi, A., Park, H.S., Passalacqua, G. (Giovanni), Pedersen, S.E. (Soren E.), Pereira, A.M., Pfaar, O. (Oliver), Picard, R., Pigearias, B. (B.), Pin, I. (Isabelle), Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Postma, D.S. (Dirkje), Poulsen, L.K., Price, D. (David), Rabe, K.F. (Klaus F.), Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodríguez-Mañas, L. (Leocadio), Rolland, C., Roman Rodriguez, M. (M.), Romano, A., Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Scichilone, N., Schmid-Grendelmeier, P. (Peter), Serrano, E., Shields, M.D., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I., Smit, H.A. (Henriëtte), Solé, D. (D.), Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J. (Peter), Strandberg, T., Sunyer, J. (Jordi), Thijs, C. (Carel), Triggiani, M. (M.), Valenta, R., Valero, A.L. (A.), Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O. (Olivier), Varona, L.L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D.Y. (De Yun), Wahn, U. (Ulrich), Werfel, T., Whalley, B., Williams, D., Williams, S., Wilson, N., Wright, J. (Juliet), Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zaidi, A., Zar, H.J., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M. (M.), Bousquet, J. (Jean), Hellings, P.W. (Peter), Agache, I., Bedbrook, A. (Anna), Bachert, C. (Claus), Bergmann, K.-C. (Karl-Christian), Bewick, M., Bindslev-Jensen, C. (Carsten), Bosnic-Anticevitch, S., Bucca, C., Caimmi, D.P., Camargos, P., Canonica, G. (Gwalter), Casale, T.B. (Thomas), Chavannes, N.H. (Nicolas), Cruz, A.A. (Alvaro), De Carlo, G., Dahl, R., Demoly, P., Devillier, P., Fonseca, J., Fokkens, W.J. (Wytske), Guldemond, N.A., Haahtela, T. (Tari), Illario, M., Just, P.M., Keil, M. (Mark), Klimek, L. (Ludger), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Morais-Almeida, M. (Mario), Mullol, J., Murray, R., Naclerio, R., O'hehir, R.E., Papadopoulos, N., Pawankar, R. (Ruby), Potter, P., Ryan, D. (Dermot), Samolinski, B., Schünemann, H.J. (Holger), Sheikh, A. (Aziz), Simons, F.E.R., Stellato, C., Todo Bom, A., Tomazic, P.V., Valiulis, A. (Arunas), Valovirta, E. (Erkka), Ventura, M.T., Wickman, M. (Magnus), Young, I., Yorgancioglu, A., Zuberbier, T. (Torsten), Aberer, W. (W.), Akdis, C.A., Annesi-Maesano, I. (Isabella), Ankri, J., Ansotegui, I.J. (I.), Anto, J.M. (Josep), Arnavielhe, S., Asarnoj, A., Arshad, H., Avolio, F., Baiardini, I. (Ilaria), Barbara, C., Barbagallo, M., Bateman, E.D. (Eric), Beghe, B., Bel, E.H., Bennoor, K.S. (K.), Benson, M., Białoszewski, A.Z., Bieber, T. (Thomas), Bjermer, L. (Leif), Blain, H., Blasi, F. (Francesco), Boner, A.L., Bonini, M. (Matteo), Bonini, S. (Sergio), Bosse, I., Bouchard, J. (Jacques), Boulet, L.P., Bourret, R., Braido, F. (Fulvio), Briggs, A. (Andrew), Brightling, C.E. (C.), Brozek, J., Buhl, R., Bunu, C., Burte, E., Bush, A. (Andrew), Caballero-Fonseca, F., Calderon, M. (Moises), Camuzat, T., Cardona, D. (Doris), Carreiro-Martins, P., Carriazo, A.M., Carlsen, K.H. (Karin), Carr, W.W. (Warner), Cepeda Sarabia, A.M., Cesari, M., Chatzi, L. (Leda), Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A.G., Chung, K.F., Ciprandi, G. (G.), De Sousa, J.C. (J. Correia), Cox, L. (Linda), Crooks, G., Custovic, A. (Adnan), Dahlen, S.E., Darsow, U. (U.), Dedeu, T., Deleanu, D. (D.), Denburg, J., De Vries, G., Didier, A., Dinh-Xuan, A.T., Dokic, D. (D.), Douagui, H., Dray, G., Dubakiene, R. (R.), Durham, S.R. (Stephen), Du Toit, G. (George), Dykewicz, M.S., Eklund, P., El-Gamal, Y. (Y.), Ellers, E., Emuzyte, R., Farrell, J., Fink-Wagner, A. (A.), Fiocchi, A. (Alessandro), Fletcher, M. (M.), Forastiere, F., Gaga, M. (Mina), Gamkrelidze, A. (Amiran), Gemicioǧlu, B., Gereda, J.E. (J.), Van Wick, R.G. (R. Gerth), González Diaz, S. (S.), Grisle, I., Grouse, L., Gutter, Z., Guzmán, M.A. (M.), Hellquist-Dahl, B. (B.), Heinrich, J. (Joachim), Horak, F., Hourihane, J.O.B., Humbert, M., Hyland, M., Iaccarino, G., Jares, E.J., Jeandel, C., Johnston, S.L., Joos, G.F. (Guy), Jonquet, O., Jung, K.S., Jutel, M. (M.), Kaidashev, I., Khaitov, M., Kalayci, O. (Omer), Kalyoncu, A.F. (A.), Kardas, P., Keith, P.K., Kerkhof, M. (Marjan), Kerstjens, H.A.M. (Huib), Khaltaev, N., Kogevinas, M. (Manolis), Kolek, V., Koppelman, G.H. (Gerard), Kowalski, M.L., Kuitunen, M., Kull, C.A. (Christian), Kvedariene, V. (Violeta), Lambrecht, B.N.M. (Bart), Lau, S. (Susanne), Laune, D., Le, L.T., Lieberman, A.P. (Andrew), Lipworth, B., Li, J. (J.), Lødrup Carlsen, K.C. (K. C.), Louis, R. (Renaud), Lupinek, C., MacNee, W., Magar, Y., Magnan, A., Mahboub, B., Maier, D., Majer, I., Malva, J., Manning, P., De Manuel Keenoy, E., Marshall, G.D., Masjedi, M.R. (M.), Mathieu-Dupas, E., Maurer, M., Mavale-Manuel, S., Melén, E. (Erik), Melo-Gomes, E., Meltzer, E.O., Mercier, J., Merk, J. (Jeroen), Miculinic, N., Mihaltan, F. (F.), Milenkovic, B. (Branislava), Millot-Keurinck, J., Mohammad, Y., Momas, I. (I.), Mösges, R. (Ralph), Muraro, A., Namazova-Baranova, L. (L.), Nadif, R. (Rachel), Neffen, H., Nekam, K., Nieto, A. (Antonio), Niggemann, B., Nogueira-Silva, L., Nogues, M., Nyembue, T.D. (T.), Ohta, K., Okamoto, Y., Okubo, K., Olive-Elias, M., Ouedraogo, S., Paggiaro, P. (Pierluigi), Pali-Schöll, I. (I.), Palkonen, S., Panzner, P. (P.), Papi, A., Park, H.S., Passalacqua, G. (Giovanni), Pedersen, S.E. (Soren E.), Pereira, A.M., Pfaar, O. (Oliver), Picard, R., Pigearias, B. (B.), Pin, I. (Isabelle), Plavec, D., Pohl, W., Popov, T.A., Portejoie, F., Postma, D.S. (Dirkje), Poulsen, L.K., Price, D. (David), Rabe, K.F. (Klaus F.), Raciborski, F., Roberts, G., Robalo-Cordeiro, C., Rodenas, F., Rodríguez-Mañas, L. (Leocadio), Rolland, C., Roman Rodriguez, M. (M.), Romano, A., Rosado-Pinto, J., Rosario, K. (Karyna), Rottem, M., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G.K., Scichilone, N., Schmid-Grendelmeier, P. (Peter), Serrano, E., Shields, M.D., Siroux, V. (V.), Sisul, J.C. (J.), Skrindo, I., Smit, H.A. (Henriëtte), Solé, D. (D.), Sooronbaev, T., Spranger, O., Stelmach, R., Sterk, P.J. (Peter), Strandberg, T., Sunyer, J. (Jordi), Thijs, C. (Carel), Triggiani, M. (M.), Valenta, R., Valero, A.L. (A.), Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O. (Olivier), Varona, L.L., Vellas, B., Vezzani, G., Vazankari, T., Viegi, G., Vontetsianos, T., Wagenmann, M., Walker, S., Wang, D.Y. (De Yun), Wahn, U. (Ulrich), Werfel, T., Whalley, B., Williams, D., Williams, S., Wilson, N., Wright, J. (Juliet), Yawn, B.P. (Barbara), Yiallouros, P.K. (P.), Yusuf, O.M. (Osman), Zaidi, A., Zar, H.J., Zernotti, M., Zhang, L., Zhong, N., and Zidarn, M. (M.)
Abstract: The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA - disseminated and implemented in over 70 countries globally - is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social ine
Published: 2016
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19. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

Author: Joubert, B.R. (Bonnie), Felix, J.F. (Janine), Yousefi, P. (Paul), Bakulski, K.M. (Kelly M.), Just, A.C. (Allan C.), Breton, C. (Carrie), Reese, S.E. (Sarah E.), Markunas, C.A. (Christina A.), Richmond, R.C. (Rebecca C.), Xu, C.-J. (Cheng-Jian), Küpers, L.K. (Leanne), Oh, S.S. (Sam S.), Hoyo, C. (Cathrine), Gruzieva, O. (Olena), Söderhäll, C. (Cilla), Salas, L.A. (Lucas A.), Baïz, N. (Nour), Zhang, H. (Hongmei), Lepeule, J. (Johanna), Ruiz, C. (Carlos), Ligthart, S. (Symen), Wang, T. (Tianyuan), Taylor, J.A. (Jack A.), Duijts, L. (Liesbeth), Sharp, G.C. (Gemma C.), Jankipersadsing, S.A. (Soesma A.), Nilsen, R.M. (Roy M.), Vaez, A. (Ahmad), Fallin, M.D. (M. Daniele), Hu, D. (Donglei), Litonjua, A.A. (Augusto), Fuemmeler, B.F. (Bernard F.), Huen, K. (Karen), Kere, J. (Juha), Kull, C.A. (Christian), Munthe-Kaas, M.C. (Monica Cheng), Gehring, U. (Ulrike), Bustamante, M. (Mariona), Saurel-Coubizolles, M.J. (Marie José), Quraishi, B.M. (Bilal M.), Ren, J. (Jie), Tost, J. (Jörg), Gonzalez, J.R. (Juan R.), Peters, M.J. (Marjolein), Håberg, S.E. (Siri E), Xu, Z. (Zongli), Meurs, J.B.J. (Joyce) van, Gaunt, T.R. (Tom), Kerkhof, M. (Marjan), Corpeleijn, W.E. (Willemijn), Feinberg, A.P. (Andrew P.), Eng, C. (Celeste), Baccarelli, A.A. (Andrea), Benjamin Neelon, S.E. (Sara E.), Bradman, A. (Asa), Merid, S.K. (Simon Kebede), Bergström, A. (Anna), Herceg, Z. (Zdenko), Hernandez-Vargas, H. (Hector), Brunekreef, B. (Bert), Pinart, M. (Mariona), Heude, B. (Barbara), Ewart, S. (Susan), Yao, J. (Jin), Lemonnier, N. (Nathanaël), Franco, O.H. (Oscar), Wu, M.C. (Michael), Hofman, A. (Albert), McArdle, W.L. (Wendy), Vlies, P. (P.) van der, Falahi, F. (Fahimeh), Gillman, M.W. (Matthew W.), Barcellos, L.F. (Lisa), Kumar, A. (Ashish), Wickman, M. (Magnus), Guerra, S. (S.), Charles, M.-A. (Marie-Aline), Holloway, J. (John), Auffray, C. (C.), Tiemeier, H.W. (Henning), Smith, A.V. (Davey), Postma, D.S. (Dirkje), Hivert, M.-F. (Marie-France), Eskenazi, B. (Brenda), Vrijheid, M. (Martine), Arshad, H. (Hasan), Anto, J.M. (Josep), Dehghan, A. (Abbas), Karmaus, W. (Wilfried), Annesi-Maesano, I. (Isabella), Sunyer, J. (Jordi), Ghantous, A. (Akram), Pershagen, G. (Göran), Holland, N. (Nina), Murphy, S.K. (Susan K.), Demeo, D.L. (Dawn), Burchard, E.G. (Esteban), Ladd-Acosta, C. (Christine), Snieder, H. (Harold), Nystad, W. (Wenche), Koppelman, G.H. (Gerard), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), Wilcox, A.J. (Allen), Melén, E. (Erik), London, S.J. (Stephanie J.), Joubert, B.R. (Bonnie), Felix, J.F. (Janine), Yousefi, P. (Paul), Bakulski, K.M. (Kelly M.), Just, A.C. (Allan C.), Breton, C. (Carrie), Reese, S.E. (Sarah E.), Markunas, C.A. (Christina A.), Richmond, R.C. (Rebecca C.), Xu, C.-J. (Cheng-Jian), Küpers, L.K. (Leanne), Oh, S.S. (Sam S.), Hoyo, C. (Cathrine), Gruzieva, O. (Olena), Söderhäll, C. (Cilla), Salas, L.A. (Lucas A.), Baïz, N. (Nour), Zhang, H. (Hongmei), Lepeule, J. (Johanna), Ruiz, C. (Carlos), Ligthart, S. (Symen), Wang, T. (Tianyuan), Taylor, J.A. (Jack A.), Duijts, L. (Liesbeth), Sharp, G.C. (Gemma C.), Jankipersadsing, S.A. (Soesma A.), Nilsen, R.M. (Roy M.), Vaez, A. (Ahmad), Fallin, M.D. (M. Daniele), Hu, D. (Donglei), Litonjua, A.A. (Augusto), Fuemmeler, B.F. (Bernard F.), Huen, K. (Karen), Kere, J. (Juha), Kull, C.A. (Christian), Munthe-Kaas, M.C. (Monica Cheng), Gehring, U. (Ulrike), Bustamante, M. (Mariona), Saurel-Coubizolles, M.J. (Marie José), Quraishi, B.M. (Bilal M.), Ren, J. (Jie), Tost, J. (Jörg), Gonzalez, J.R. (Juan R.), Peters, M.J. (Marjolein), Håberg, S.E. (Siri E), Xu, Z. (Zongli), Meurs, J.B.J. (Joyce) van, Gaunt, T.R. (Tom), Kerkhof, M. (Marjan), Corpeleijn, W.E. (Willemijn), Feinberg, A.P. (Andrew P.), Eng, C. (Celeste), Baccarelli, A.A. (Andrea), Benjamin Neelon, S.E. (Sara E.), Bradman, A. (Asa), Merid, S.K. (Simon Kebede), Bergström, A. (Anna), Herceg, Z. (Zdenko), Hernandez-Vargas, H. (Hector), Brunekreef, B. (Bert), Pinart, M. (Mariona), Heude, B. (Barbara), Ewart, S. (Susan), Yao, J. (Jin), Lemonnier, N. (Nathanaël), Franco, O.H. (Oscar), Wu, M.C. (Michael), Hofman, A. (Albert), McArdle, W.L. (Wendy), Vlies, P. (P.) van der, Falahi, F. (Fahimeh), Gillman, M.W. (Matthew W.), Barcellos, L.F. (Lisa), Kumar, A. (Ashish), Wickman, M. (Magnus), Guerra, S. (S.), Charles, M.-A. (Marie-Aline), Holloway, J. (John), Auffray, C. (C.), Tiemeier, H.W. (Henning), Smith, A.V. (Davey), Postma, D.S. (Dirkje), Hivert, M.-F. (Marie-France), Eskenazi, B. (Brenda), Vrijheid, M. (Martine), Arshad, H. (Hasan), Anto, J.M. (Josep), Dehghan, A. (Abbas), Karmaus, W. (Wilfried), Annesi-Maesano, I. (Isabella), Sunyer, J. (Jordi), Ghantous, A. (Akram), Pershagen, G. (Göran), Holland, N. (Nina), Murphy, S.K. (Susan K.), Demeo, D.L. (Dawn), Burchard, E.G. (Esteban), Ladd-Acosta, C. (Christine), Snieder, H. (Harold), Nystad, W. (Wenche), Koppelman, G.H. (Gerard), Relton, C.L. (Caroline), Jaddoe, V.W.V. (Vincent), Wilcox, A.J. (Allen), Melén, E. (Erik), and London, S.J. (Stephanie J.)
Abstract: Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathwa
Published: 2016
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20. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author: Sonnenschein-Voort, A.M.M. (Agnes) van der, Arends, L.R. (Lidia), Jongste, J.C. (Johan) de, Annesi-Maesano, I. (Isabella), Arshad, S.H. (Syed), Barros, A.I. (Ana), Basterrechea, M. (Mikel), Bisgaard, H. (Hans), Chatzi, L. (Leda), Corpeleijn, W.E. (Willemijn), Correia, S. (Sofia), Craig, L.C.A. (Leone C.), Devereux, M.P. (Michael ), Dogaru, T. (Teodora), Dostal, M. (Miroslav), Duchen, K. (Karel), Eggesbø, M. (Merete), Ent, C.K. (Cornelis) van der, Fantini, M.P. (Maria), Forastiere, F. (Francesco), Frey, U. (Urs), Gehring, U. (Ulrike), Gori, D. (Davide), Gugten, A.C. (Anne) van der, Hanke, W. (Wojciech), Henderson, A. (Alex), Heude, B. (Barbara), Iñiguez, A. (Andrés), Inskip, H.M. (Hazel), Keil, M. (Mark), Kelleher, J.F. (Joseph), Kogevinas, M. (Manolis), Kreiner-Møller, E. (Eskil), Kuehni, C. (Claudia), Küpers, L.K. (Leanne), Lancz, K. (Kinga), Larsen, P.S. (Pernille), Lau, S. (Susanne), Ludvigsson, J., Mommers, M. (Monique), Nybo Andersen, A.-M. (Anne-Marie), Palkovicova, L. (Lubica), Pike, K.C. (Katharine), Pizzi, C. (Costanza), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Roberts, G., Schmidt, A. (Anne), Sram, R.J. (Radim), Sunyer, J. (Jordi), Thijs, C. (Carel), Torrent, M. (Maties), Viljoen, K. (Karien), Wijga, A.H. (Alet), Vrijheid, M. (Martine), Jaddoe, V.W.V. (Vincent), Duijts, L. (Liesbeth), Sonnenschein-Voort, A.M.M. (Agnes) van der, Arends, L.R. (Lidia), Jongste, J.C. (Johan) de, Annesi-Maesano, I. (Isabella), Arshad, S.H. (Syed), Barros, A.I. (Ana), Basterrechea, M. (Mikel), Bisgaard, H. (Hans), Chatzi, L. (Leda), Corpeleijn, W.E. (Willemijn), Correia, S. (Sofia), Craig, L.C.A. (Leone C.), Devereux, M.P. (Michael ), Dogaru, T. (Teodora), Dostal, M. (Miroslav), Duchen, K. (Karel), Eggesbø, M. (Merete), Ent, C.K. (Cornelis) van der, Fantini, M.P. (Maria), Forastiere, F. (Francesco), Frey, U. (Urs), Gehring, U. (Ulrike), Gori, D. (Davide), Gugten, A.C. (Anne) van der, Hanke, W. (Wojciech), Henderson, A. (Alex), Heude, B. (Barbara), Iñiguez, A. (Andrés), Inskip, H.M. (Hazel), Keil, M. (Mark), Kelleher, J.F. (Joseph), Kogevinas, M. (Manolis), Kreiner-Møller, E. (Eskil), Kuehni, C. (Claudia), Küpers, L.K. (Leanne), Lancz, K. (Kinga), Larsen, P.S. (Pernille), Lau, S. (Susanne), Ludvigsson, J., Mommers, M. (Monique), Nybo Andersen, A.-M. (Anne-Marie), Palkovicova, L. (Lubica), Pike, K.C. (Katharine), Pizzi, C. (Costanza), Polanska, K. (Kinga), Porta, D. (Daniela), Richiardi, L. (Lorenzo), Roberts, G., Schmidt, A. (Anne), Sram, R.J. (Radim), Sunyer, J. (Jordi), Thijs, C. (Carel), Torrent, M. (Maties), Viljoen, K. (Karien), Wijga, A.H. (Alet), Vrijheid, M. (Martine), Jaddoe, V.W.V. (Vincent), and Duijts, L. (Liesbeth)
Abstract: Background Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. Results Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P <.05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were lar
Published: 2014
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21. Research needs in allergy: An EAACI position paper, in collaboration with EFA

Author: Papadopoulos, N., Agache, I., Bavbek, S. (Sevim), Bilo, B.M. (Beatrice M.), Braido, F. (Fulvio), Cardona, D. (Doris), Custovic, A. (Adnan), DeMonchy, J. (Jan), Demoly, P., Eigenmann, P.A. (Philippe), Gayraud, J. (J.), Grattan, C., Heffler, E. (E.), Hellings, P.W. (Peter), Jutel, M. (M.), Knol, E.F. (Edward Frank), Lötvall, J. (Jan), Murarol, A. (Antonella), Poulsen, L.K., Roberts, G., Schmid-Grendelmeier, P. (Peter), Skevaki, C. (Chrysanthi), Triggiani, M. (M.), VanRee, R. (Ronald), Werfel, T., Flood, B. (Breda), Palkonen, S., Savli, R. (Roberta), Allegri, P. (Pia), Annesi-Maesano, I. (Isabella), Annunziato, F. (Francesco), Antolin-Amerigo, D. (Dario), Apfelbacher, M. (Manuela), Blanca, M. (Miguel), Bogacka, E. (Ewa), Bonadonna, P. (Patrizia), Bonini, M. (Matteo), Boyman, O. (Onur), Brockow, K. (Knut), Burney, P. (Peter), Buters, J. (Jeroen), Butiene, I. (Indre), Calderon, M. (Moises), Cardell, L.O., Caubet, J.-C. (Jean-Christoph), Celenk, S. (Sevcan), Cichocka-Jarosz, E., Cingi, C. (Cemal), Couto, M. (Mariana), DeJong, N. (Nicolette), Del Giacco, S. (Stefano), Douladiris, N. (Nikolaos), Fassio, F. (Filippo), Fauquert, J.-L. (Jean-Luc), Fernandez, J. (Javier), Rivas, M.F. (Montserrat Fernandez), Ferrer, M. (Marta), Flohr, C. (Carsten), Gardner, J. (James), Genuneit, J. (Jon), Gevaert, P. (P.), Groblewska, A. (Anna), Hamelmann, E. (Eckard), Hoffmann, H.J. (Hans Jürgen), Hoffmann-Sommergruber, K. (K.), Hovhannisyan, L. (Lilit), Hox, V. (Valérie), Jahnsen, F.L. (Frode L.), Kalayci, O. (Omer), Kalpaklioglu, A.F. (Ayse Füsun), Kleine-Tebbe, J. (Jörg), Konstantinou, G. (George), Kurowski, M. (Marcin), Lau, S. (Susanne), Lauener, R. (Roger), Lauerma, A. (Antti), Logan, K. (K.), Magnan, A. (Antoine), Makowska, J. (Joanna), Makrinioti, H. (Heidi), Mangina, P. (Paraskevi), Manole, F. (Felicia), Mari, A. (A.), Mazón, A., Mills, C. (Clare), Mingomataj, E.Ç. (Ervin Ç), Niggemann, B., Nilsson, G. (Gunnar), Ollert, M. (Markus), O'Mahony, L. (Liam), O'Neil, S. (Serena), Pala, G. (Gianni), Papi, A. (Alberto), Passalacqua, G. (Giovanni), Perkin, M. (Michael), Pfaar, O. (Oliver), Pitsios, C., Quirce, S. (S.), Raap, U., Raulf-Heimsoth, M., Rhyner, C. (Claudio), Robson-Ansley, P. (Paula), Alves, R.R. (Rodrigo Rodrigues), Roje, Z. (Zeljka), Rondon, C. (Carmen), Rudzeviciene, O. (Odilija), Rueff, F. (Franziska), Rukhadze, M. (Maia), Rumi, G. (Gabriele), Sackesen, C. (Cansin), Santos, A.F. (Alexandra F.), Santucci, A. (Annalisa), Scharf, C. (Christian), Schmidt-Weber, C.B., Schnyder, B. (Benno), Schwarze, J. (Jürgen), Senna, G.E. (Gianenrico), Sergejeva, S. (Svetlana), Seys, S. (Sven), Siracusa, A. (Andrea), Skypala, I. (I.), Sokolowska, M. (Milena), Spertini, F. (Francois), Spiewak, R. (Radoslaw), Sprikkelman, A.B. (Aline), Sturm, G.J., Swoboda, I., Terreehorst, I., Toskala, E., Traidl-Hoffmann, C. (Claudia), Venter, C. (C.), Vlieg-Boerstra, B.J., Whitacker, P. (Paul), Worm, M. (M.), Xepapadaki, P. (Paraskevi), Akdis, C.A., Papadopoulos, N., Agache, I., Bavbek, S. (Sevim), Bilo, B.M. (Beatrice M.), Braido, F. (Fulvio), Cardona, D. (Doris), Custovic, A. (Adnan), DeMonchy, J. (Jan), Demoly, P., Eigenmann, P.A. (Philippe), Gayraud, J. (J.), Grattan, C., Heffler, E. (E.), Hellings, P.W. (Peter), Jutel, M. (M.), Knol, E.F. (Edward Frank), Lötvall, J. (Jan), Murarol, A. (Antonella), Poulsen, L.K., Roberts, G., Schmid-Grendelmeier, P. (Peter), Skevaki, C. (Chrysanthi), Triggiani, M. (M.), VanRee, R. (Ronald), Werfel, T., Flood, B. (Breda), Palkonen, S., Savli, R. (Roberta), Allegri, P. (Pia), Annesi-Maesano, I. (Isabella), Annunziato, F. (Francesco), Antolin-Amerigo, D. (Dario), Apfelbacher, M. (Manuela), Blanca, M. (Miguel), Bogacka, E. (Ewa), Bonadonna, P. (Patrizia), Bonini, M. (Matteo), Boyman, O. (Onur), Brockow, K. (Knut), Burney, P. (Peter), Buters, J. (Jeroen), Butiene, I. (Indre), Calderon, M. (Moises), Cardell, L.O., Caubet, J.-C. (Jean-Christoph), Celenk, S. (Sevcan), Cichocka-Jarosz, E., Cingi, C. (Cemal), Couto, M. (Mariana), DeJong, N. (Nicolette), Del Giacco, S. (Stefano), Douladiris, N. (Nikolaos), Fassio, F. (Filippo), Fauquert, J.-L. (Jean-Luc), Fernandez, J. (Javier), Rivas, M.F. (Montserrat Fernandez), Ferrer, M. (Marta), Flohr, C. (Carsten), Gardner, J. (James), Genuneit, J. (Jon), Gevaert, P. (P.), Groblewska, A. (Anna), Hamelmann, E. (Eckard), Hoffmann, H.J. (Hans Jürgen), Hoffmann-Sommergruber, K. (K.), Hovhannisyan, L. (Lilit), Hox, V. (Valérie), Jahnsen, F.L. (Frode L.), Kalayci, O. (Omer), Kalpaklioglu, A.F. (Ayse Füsun), Kleine-Tebbe, J. (Jörg), Konstantinou, G. (George), Kurowski, M. (Marcin), Lau, S. (Susanne), Lauener, R. (Roger), Lauerma, A. (Antti), Logan, K. (K.), Magnan, A. (Antoine), Makowska, J. (Joanna), Makrinioti, H. (Heidi), Mangina, P. (Paraskevi), Manole, F. (Felicia), Mari, A. (A.), Mazón, A., Mills, C. (Clare), Mingomataj, E.Ç. (Ervin Ç), Niggemann, B., Nilsson, G. (Gunnar), Ollert, M. (Markus), O'Mahony, L. (Liam), O'Neil, S. (Serena), Pala, G. (Gianni), Papi, A. (Alberto), Passalacqua, G. (Giovanni), Perkin, M. (Michael), Pfaar, O. (Oliver), Pitsios, C., Quirce, S. (S.), Raap, U., Raulf-Heimsoth, M., Rhyner, C. (Claudio), Robson-Ansley, P. (Paula), Alves, R.R. (Rodrigo Rodrigues), Roje, Z. (Zeljka), Rondon, C. (Carmen), Rudzeviciene, O. (Odilija), Rueff, F. (Franziska), Rukhadze, M. (Maia), Rumi, G. (Gabriele), Sackesen, C. (Cansin), Santos, A.F. (Alexandra F.), Santucci, A. (Annalisa), Scharf, C. (Christian), Schmidt-Weber, C.B., Schnyder, B. (Benno), Schwarze, J. (Jürgen), Senna, G.E. (Gianenrico), Sergejeva, S. (Svetlana), Seys, S. (Sven), Siracusa, A. (Andrea), Skypala, I. (I.), Sokolowska, M. (Milena), Spertini, F. (Francois), Spiewak, R. (Radoslaw), Sprikkelman, A.B. (Aline), Sturm, G.J., Swoboda, I., Terreehorst, I., Toskala, E., Traidl-Hoffmann, C. (Claudia), Venter, C. (C.), Vlieg-Boerstra, B.J., Whitacker, P. (Paul), Worm, M. (M.), Xepapadaki, P. (Paraskevi), and Akdis, C.A.
Abstract: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century. The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels. Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and tre
Published: 2012
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21 results on '"Annesi-Maesano, I. (Isabella)"'

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18. ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

19. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis

20. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

21. Research needs in allergy: An EAACI position paper, in collaboration with EFA

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21 results on '"Annesi-Maesano, I. (Isabella)"'

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