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2. Acute kidney injury in children hospitalised for febrile urinary tract infection.

Author

Marzuillo, Pierluigi, Guarino, Stefano, Alfiero, Salvatore, Annicchiarico Petruzzelli, Luigi, Arenella, Mattia, Baccelli, Francesco, Brugnara, Milena, Corrado, Ciro, Delcaro, Giulia, Di Sessa, Anna, Gallotta, Giulia, Lanari, Marcello, Lorenzi, Maya, Malgieri, Gabriele, Miraglia del Giudice, Emanuele, Pecoraro, Carmine, Pennesi, Marco, Picassi, Sara, Pierantoni, Luca, and Puccio, Giuseppe

Subjects
ACUTE kidney failure, URINARY organs, MULTIPLE regression analysis, URINARY tract infections, LOGISTIC regression analysis, CONGENITAL disorders
Abstract

Aim: To determine (i) prevalence and the risk factors for acute kidney injury (AKI) in children hospitalised for febrile urinary tract infection (fUTI) and (ii) role of AKI as indicator of an underlying VUR. AKI, in fact, is favoured by a reduced nephron mass, often associated to VUR. Methods: This retrospective Italian multicentre study enrolled children aged 18 years or younger (median age = 0.5 years) discharged with a primary diagnosis of fUTI. AKI was defined using Kidney Disease/Improving Global Outcomes serum creatinine criteria. Results: Of 849 children hospitalised for fUTI (44.2% females, median age 0.5 years; IQR = 1.8), 124 (14.6%) developed AKI. AKI prevalence rose to 30% in the presence of underlying congenital anomalies of the kidney and urinary tract (CAKUT). The strongest AKI predictors were presence of CAKUT (OR = 7.5; 95%CI: 3.8–15.2; p = 9.4e‐09) and neutrophils levels (OR = 1.13; 95%CI: 1.08–1.2; p = 6.8e‐07). At multiple logistic regression analysis, AKI during fUTI episode was a significant indicator of VUR (OR = 3.4; 95%CI: 1.7–6.9; p = 0.001) despite correction for the diagnostic covariates usually used to assess the risk of VUR after the first fUTI episode. Moreover, AKI showed the best positive likelihood ratio, positive predictive value, negative predictive value and specificity for VUR. Conclusion: AKI occurs in 14.6% of children hospitalised for fUTI and is a significant indicator of VUR. [ABSTRACT FROM AUTHOR]

Published
2024
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3. De Novo Large Deletions in the PHEX Gene Caused X-Linked Hypophosphataemic Rickets in Two Italian Female Infants Successfully Treated with Burosumab

Author

Pecoraro, Carmine, primary, Fioretti, Tiziana, additional, Perruno, Assunta, additional, Klain, Antonella, additional, Cioffi, Daniela, additional, Ambrosio, Adelaide, additional, Passaro, Diego, additional, Annicchiarico Petruzzelli, Luigi, additional, Di Domenico, Carmela, additional, de Girolamo, Domenico, additional, Vallone, Sabrina, additional, Cattaneo, Fabio, additional, Ammendola, Rosario, additional, and Esposito, Gabriella, additional

Published
2023
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6. Collateral effects of COVID‐19 pandemic in pediatric hematooncology: Fatalities caused by diagnostic delay

Author

Parasole, Rosanna, primary, Stellato, Pio, additional, Conter, Valentino, additional, De Matteo, Antonia, additional, D'Amato, Luigia, additional, Colombini, Antonella, additional, Pecoraro, Carmine, additional, Bencivenga, Carmela, additional, Raimondo, Marta, additional, Silvestri, Susanna, additional, Tipo, Vincenzo, additional, Annicchiarico Petruzzelli, Luigi, additional, Giagnuolo, Giovanna, additional, Curatolo, Agostino, additional, Biondi, Andrea, additional, and Menna, Giuseppe, additional

Published
2020
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14. Prevalence of SARS-CoV-2-IgG Antibodies in Children with CKD or Immunosuppression

Author

Morello, William, Mastrangelo, Antonio, Guzzo, Isabella, Cusinato, Lisa, Annicchiarico Petruzzelli, Luigi, Benevenuta, Chiara, Martelli, Laura, Dall’Amico, Roberto, Vianello, Federica Alessandra, Puccio, Giuseppe, Massella, Laura, Benetti, Elisa, Pecoraro, Carmine, Peruzzi, Licia, Montini, Giovanni, Peruzzi, Licia, Petruzzelli, Luigi Annicchiarico, Becherucci, Francesca, Benetti, Elisa, Benevenuta, Chiara, Brugnara, Milena, Casadio, Luca, Chimenz, Roberto, Conti, Giovanni, Corrado, Ciro, D’Agostino, Viviana, Dall’Amico, Roberto, Gianoglio, Bruno, Giordano, Mario, Gualeni, Chiara, Guarino, Stefano, Guzzo, Isabella, La Manna, Angela, La Scola, Claudio, Martelli, Laura, Massella, Laura, Mastrangelo, Antonio, Materassi, Marco, Montini, Giovanni, Morello, William, Pani, Antonello, Papalia, Teresa, Pasini, Andrea, Pecoraro, Carmine, Pelliccia, Piernicola, Pennesi, Marco, Pugliese, Fabrizio, Ratsch, Ilse Maria, Romagnani, Paola, Roperto, Rosa Maria, Tamburello, Chiara, Vergine, Gianluca, Vergori, Antonio, Vianello, Federica Alessandra, and Vidal, Enrico

Published
2021
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15. Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease

Author

Riccio, Eleonora, Sabbatini, Massimo, Bruzzese, Dario, Annicchiarico Petruzzelli, Luigi, Pellegrino, Angela, Spinelli, Letizia, Esposito, Roberta, Imbriaco, Massimo, Feriozzi, Sandro, and Pisani, Antonio

Abstract

Background and objectives:Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several studies, its prevalence is at present unknown. The focus of our study was to determine the prevalence of HF in a cohort of patients with FD and to identify the factors associated with a high risk of HF. Methods:To address this issue, a retrospective observational study of 87 patients with genetically confirmed FD was performed. HF was defined as an estimated glomerular filtration rate (eGFR) > 130 mL/min/1.73 m2corrected for age (> 40 years: –1 mL/min/1.73 m2/year). Results:HF occurred in 21 patients (24% of our population), and increased to 50% when only young adults were considered. Hyperfiltrating patients were younger and had lower proteinuria levels than those without HF. The prevalence of cardiovascular and other manifestations of FD was significantly lower in hyperfiltering patients. Conclusions:Our study showed a negative correlation between eGFR and age, and with proteinuria levels and the presence of cardiovascular and other manifestations of FD. These data favor the view that HF in Fabry patients could be related predominantly to a predisease state. Even in the absence of a “measured” GFR, HF should be regarded as an early marker of Fabry nephropathy, and its recognition and confirmation by true GFR seems a relevant feature to address the issue of the potential benefit of nephroprotective treatments at the early stage of Fabry nephropathy.

Published
2019
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18. Glomerular Hyperfiltration: An Early Marker of Nephropathy in Fabry Disease

Author

Sandro Feriozzi, Angela Maria Pellegrino, Letizia Spinelli, Massimo Sabbatini, Roberta Esposito, Dario Bruzzese, Eleonora Riccio, Luigi Annicchiarico Petruzzelli, Antonio Pisani, Massimo Imbriaco, Riccio, Eleonora, Sabbatini, Massimo, Bruzzese, Dario, ANNICCHIARICO PETRUZZELLI, Luigi, Pellegrino, Angela, Spinelli, Letizia, Esposito, Roberta, Imbriaco, Massimo, Feriozzi, Sandro, and Pisani, Antonio

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Physiology, Urology, Kidney Glomerulus, Population, 030232 urology & nephrology, Renal function, 030204 cardiovascular system & hematology, Gastroenterology, Nephropathy, Cohort Studies, Fabry nephropathy, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Physiology (medical), medicine, Humans, education, Aged, Retrospective Studies, education.field_of_study, Fabry disease, Proteinuria, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Early marker, Glomerular hyperfiltration, Nephrology, Cohort, Female, Kidney Diseases, medicine.symptom, Glomerular filtration rate, business, Biomarkers
Abstract

Background and objectives: Progressive nephropathy is one of the main features of Fabry disease (FD). It has been supposed that an early phase, clinically silent disease occurs in childhood and adolescence and is characterized by glomerular hyperfiltration (HF). Surprisingly, although HF has been reported in several studies, its prevalence is at present unknown. The focus of our study was to determine the prevalence of HF in a cohort of patients with FD and to identify the factors associated with a high risk of HF. Methods: To address this issue, a retrospective observational study of 87 patients with genetically confirmed FD was performed. HF was defined as an estimated glomerular filtration rate (eGFR) > 130 mL/min/1.73 m2 corrected for age (> 40 years: –1 mL/min/1.73 m2/year). Results: HF occurred in 21 patients (24% of our population), and increased to 50% when only young adults were considered. Hyperfiltrating patients were younger and had lower proteinuria levels than those without HF. The prevalence of cardiovascular and other manifestations of FD was significantly lower in hyperfiltering patients. Conclusions: Our study showed a negative correlation between eGFR and age, and with proteinuria levels and the presence of cardiovascular and other manifestations of FD. These data favor the view that HF in Fabry patients could be related predominantly to a predisease state. Even in the absence of a “measured” GFR, HF should be regarded as an early marker of Fabry nephropathy, and its recognition and confirmation by true GFR seems a relevant feature to address the issue of the potential benefit of nephroprotective treatments at the early stage of Fabry nephropathy.

Published
2019

19. Crosstalk between intestine and kidney. Revival of an ancient link

Author

Antonella Caiazza, Bernadette Scognamiglio, Antonietta Ascione, Francesco Cappellaio, Luigi Annicchiarico Petruzzelli, Domenico Russo, Laura Pirro, Angela Maria Pellegrino, Andrea Memoli, Luigi Russo, Pellegrino, Angela Maria, ANNICCHIARICO PETRUZZELLI, Luigi, Ascione, Antonietta, Caiazza, Antonella, Cappellaio, Francesco, Memoli, Andrea, Pirro, Laura, Russo, Luigi, Scognamiglio, Bernadette, and Russo, Domenico

Subjects
Crosstalk (biology), Kidney, Inflammation, Intestine, Bacterial microflora, Prebiotics, Intestinal sorbents, medicine.anatomical_structure, business.industry, medicine, General Medicine, Anatomy, business, Neuroscience
Abstract

Chronic kidney disease (CKD) is associated with systemic inflammation. The latter accelerates comorbidities that are associated with CKD (cardiovascular disease, anemia, infections, cachexia and several other conditions), shortens life span and greatly impairs the quality of life. Recently the attention has been focused intestine and intestinal microbiota as sources of systemic inflammation. On one hand, the microbiota promotes the production of uraemic solute with a biological impact on the progression of kidney failure and vascular diseases. On the other hand, the uraemic status alters the composition of the intestinal microbiota and the structure of the epithelial barrier, causing the translocation of both microbiota and uraemic toxins into the blood stream. Several approaches have recently been tested, including dietary measures, prebiotics, synbiotics and intestinal sorbents in order to reduce the generation and serum concentration of uraemic toxins.

Published
2015

20. An infant with hypercalcemia: answers

Author

Luigi Annicchiarico Petruzzelli, Angela La Manna, Andrea Apicella, Stefano Guarino, Pierluigi Marzuillo, Guarino, Stefano, Marzuillo, Pierluigi, Apicella, Andrea, Annicchiarico Petruzzelli, Luigi, and La Manna, Angela

Subjects
Nephrology, medicine.medical_specialty, Pediatrics, business.industry, MEDLINE, medicine.disease, Endocrinology, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Vitamin D intoxication, Hypercalcemia, Nephrocalcinosis, business, Human
Published
2014

21. Pediatric Minimal Change Disease and AKI following the Pfizer-BioNTech COVID-19 Vaccine: causal or incidental correlation?

Author

Annicchiarico Petruzzelli L, Minale B, Serio V, De Luca A, Marino Marsilia G, Campione S, Diomedi Camassei F, D'Arcangelo R, Luongo I, Lepore L, Giannattasio P, Molino D, Pirro L, Lonardo MC, Malgieri G, and Pecoraro C

Subjects
Adult, Child, Humans, Male, BNT162 Vaccine, Steroids, Vaccination, Acute Kidney Injury chemically induced, COVID-19 prevention & control, COVID-19 Vaccines adverse effects, Nephrosis, Lipoid chemically induced, Nephrotic Syndrome
Abstract

The global coronavirus 2019 (COVID-19) pandemic required vaccination even in children to reduce infection. We report on the development of acute kidney injury (AKI) and minimal change disease (MCD) nephrotic syndrome (NS), shortly after the first injection BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). A 12-year-old previously healthy boy was referred to our hospital with complaints of peripheral edema and nephrotic range proteinuria. Nine days earlier he had received his first injection BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). Seven days after injection, he developed leg edema, which rapidly progressed to anasarca with significant weight gain. On admission, serum creatinine was 1.3 mg/dL and 24-hour urinary protein excretion was 4 grams with fluid overload. As kidney function continued to decline over the next days, empirical steroid treatment and renal replacement therapy with ultrafiltration were started and kidney biopsy was performed. Seven days after steroid therapy, kidney function began to improve, gradually returning to normal. The association of MCD, nephrotic syndrome and AKI hasn't been previously described following the Pfizer-BioNTech COVID-19 vaccine in pediatric population, but this triad has been reported in adults. We need further similar case reports to establish the real incidence of this possible vaccine side effect., (Copyright by Società Italiana di Nefrologia SIN, Rome, Italy.)

Published
2022

22. Impact of COVID-19 Pandemic in Children with CKD or Immunosuppression.

Author

Mastrangelo A, Morello W, Vidal E, Guzzo I, Annicchiarico Petruzzelli L, Benetti E, Materassi M, Giordano M, Pasini A, Corrado C, Puccio G, Chimenz R, Pecoraro C, Massella L, Peruzzi L, and Montini G

Subjects
Adolescent, Age Factors, Child, Child, Preschool, Comorbidity, Female, Humans, Infant, Italy, Male, Renal Insufficiency, Chronic diagnosis, Renal Insufficiency, Chronic immunology, Renal Insufficiency, Chronic mortality, Risk Assessment, Risk Factors, COVID-19 diagnosis, COVID-19 immunology, COVID-19 mortality, COVID-19 therapy, Immunocompromised Host, Kidney Transplantation adverse effects, Renal Dialysis adverse effects, Renal Insufficiency, Chronic therapy
Published
2021
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