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16. Neutral gadolinium(III) complexes of bulky octadentate dtpa derivatives as potential contrast agents for magnetic resonance imaging

Author

Annie Bligh, S.W., Chowdhury, Anwar H.M.S., McPartlin, Mary, Scowen, Ian J., Bulman, Robert A., Annie Bligh, S.W., Chowdhury, Anwar H.M.S., McPartlin, Mary, Scowen, Ian J., and Bulman, Robert A.

Abstract

A series of bulky and neutral gadolinium complexes of [bis(R-amide)dtpaH3] (where R = Pri,, Bui,, Bz and phenylethyl, L1--L4)) with potential application as contrast agents for magnetic resonance imaging has been prepared and characterized ; the relaxivity of these complexes is comparable to the contrast agent [Gd(dtpa)(H2OO)]; which is which is currently used in clinics; the X-ray structure analysis of the gadolinium(III) complex of L3 reveals a neutral nine-coordinate complex featuring a water molecule in the tricapped trigonal prismatic metal coordination sphere.

17. 1H NMR study of monocrotaline and its metabolites in human blood

Author

Yang, Yi-Cheng, Crowder, John, Wardle, Nicholas J., Yang, Li, White, Kenneth N., Wang, Zheng-Tao, and Annie Bligh, S.W.

Subjects
*MONOCROTALINE, *METABOLITES, *BLOOD testing, *SERUM albumin, *PYRROLIZIDINES, *NUCLEAR magnetic resonance spectroscopy, *CHEMICAL composition of plants, *LACTONES, *BLOOD plasma
Abstract

Abstract: Monocrotaline (MCT) is a naturally occurring hepatotoxic pyrrolizidine alkaloid found in plants. This investigation is aimed at furthering the understanding of the role of blood in mediating the transport of MCT and its reactive metabolites in humans. Reactions of monocrotaline and its metabolites, dehydromonocrotaline (DHM), retronecine (RET) and dehydroretronecine (DHR) with human blood plasma, red blood cells (RBCs), and whole blood were studied in vitro by proton nuclear magnetic resonance spectroscopy. In plasma MCT remained intact and weakly associated with plasma proteins, and DHM was rapidly hydrolyzed releasing necic and lactone acids, and the reactive pyrrolic metabolite. MCT and its metabolite DHM were internalized in RBCs to the extent of 46.0% and 48.9% respectively in 30min. No polymerization of DHR was observed when incubated with plasma and RBCs. The data clearly showed that both human plasma and RBCs could be the carriers for the transportation of MCT and its metabolites, DHM, RET and DHR between organs and could stabilise the reactive MCT metabolite DHR. [Copyright &y& Elsevier]

Published
2011
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