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1. LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer

Author

Anstee, Joanne E., Feehan, Karen T., Opzoomer, James W., Dean, Isaac, Muller, Henrike P., Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E., Lan, Guocheng, Zou, Xiangang, Watt, Fiona M., Ng, Tony, Burchell, Joy M., Kordasti, Shahram, Withers, David R., Lawrence, Toby, and Arnold, James N.

Published
2023
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3. LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.

Author

Anstee, Joanne E, Feehan, Karen T, Opzoomer, James W, Dean, Isaac, Muller, Henrike P, Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E, Lan, Guocheng, Zou, Xiangang, Watt, Fiona M, Ng, Tony, Burchell, Joy M, Kordasti, Shahram, Withers, David R, Lawrence, Toby, Arnold, James N, Anstee, Joanne E, Feehan, Karen T, Opzoomer, James W, Dean, Isaac, Muller, Henrike P, Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E, Lan, Guocheng, Zou, Xiangang, Watt, Fiona M, Ng, Tony, Burchell, Joy M, Kordasti, Shahram, Withers, David R, Lawrence, Toby, and Arnold, James N

Abstract

Tumor-associated macrophages (TAMs) are a heterogeneous population of cells that facilitate cancer progression. However, our knowledge of the niches of individual TAM subsets and their development and function remain incomplete. Here, we describe a population of lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)-expressing TAMs, which form coordinated multi-cellular "nest" structures that are heterogeneously distributed proximal to vasculature in tumors of a spontaneous murine model of breast cancer. We demonstrate that LYVE-1 + TAMs develop in response to IL-6, which induces their expression of the immune-suppressive enzyme heme oxygenase-1 and promotes a CCR5-dependent signaling axis, which guides their nest formation. Blocking the development of LYVE-1 + TAMs or their nest structures, using gene-targeted mice, results in an increase in CD8 + T cell recruitment to the tumor and enhanced response to chemotherapy. This study highlights an unappreciated collaboration of a TAM subset to form a coordinated niche linked to immune exclusion and resistance to anti-cancer therapy.

Published
2023

4. LYVE-1+ macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.

Author

Afd Pharmacology, Pharmacology, Anstee, Joanne E, Feehan, Karen T, Opzoomer, James W, Dean, Isaac, Muller, Henrike P, Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E, Lan, Guocheng, Zou, Xiangang, Watt, Fiona M, Ng, Tony, Burchell, Joy M, Kordasti, Shahram, Withers, David R, Lawrence, Toby, Arnold, James N, Afd Pharmacology, Pharmacology, Anstee, Joanne E, Feehan, Karen T, Opzoomer, James W, Dean, Isaac, Muller, Henrike P, Bahri, Meriem, Cheung, Tik Shing, Liakath-Ali, Kifayathullah, Liu, Ziyan, Choy, Desmond, Caron, Jonathan, Sosnowska, Dominika, Beatson, Richard, Muliaditan, Tamara, An, Zhengwen, Gillett, Cheryl E, Lan, Guocheng, Zou, Xiangang, Watt, Fiona M, Ng, Tony, Burchell, Joy M, Kordasti, Shahram, Withers, David R, Lawrence, Toby, and Arnold, James N

Published
2023

6. Perivascular macrophages collaborate to facilitate chemotherapy resistance in cancer

Author

Anstee, Joanne E., primary, Opzoomer, James W., additional, Dean, Isaac, additional, Muller, Henrike P., additional, Bahri, Meriem, additional, Liakath-Ali, Kifayathullah, additional, Liu, Ziyan, additional, Choy, Desmond, additional, Caron, Jonathan, additional, Sosnowska, Dominika, additional, Beatson, Richard, additional, Muliaditan, Tamara, additional, An, Zhengwen, additional, Gillett, Cheryl E., additional, Lan, Guocheng, additional, Zou, Xiangang, additional, Watt, Fiona M., additional, Ng, Tony, additional, Burchell, Joy M., additional, Kordasti, Shahram, additional, Withers, David R., additional, Lawrence, Toby, additional, and Arnold, James N., additional

Published
2022
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7. LYVE-1 + Macrophages Form a Collaborative CCR5-Dependent Perivascular Niche That Influences Chemotherapy Responses in Cancer

Author

Anstee, Joanne E., primary, Opzoomer, James W., additional, Dean, Isaac, additional, Muller, Henrike P., additional, Bahri, Meriem, additional, Liakath-Ali, Kifayathullah, additional, Liu, Ziyan, additional, Choy, Desmond, additional, Caron, Jonathan, additional, Sosnowska, Dominika, additional, Beatson, Richard, additional, Muliaditan, Tamara, additional, An, Zhengwen, additional, Gillett, Cheryl E., additional, Lan, Guocheng, additional, Zou, Xiangang, additional, Watt, Fiona M., additional, Ng, Tony, additional, Burchell, Joy M., additional, Kordasti, Shahram, additional, Withers, David R., additional, Lawrence, Toby, additional, and Arnold, James N., additional

Published
2022
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8. Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression

Author

Opzoomer, James W., primary, Anstee, Joanne E., additional, Dean, Isaac, additional, Hill, Emily J., additional, Bouybayoune, Ihssane, additional, Caron, Jonathan, additional, Muliaditan, Tamara, additional, Gordon, Peter, additional, Sosnowska, Dominika, additional, Nuamah, Rosamond, additional, Pinder, Sarah E., additional, Ng, Tony, additional, Dazzi, Francesco, additional, Kordasti, Shahram, additional, Withers, David R., additional, Lawrence, Toby, additional, and Arnold, James N., additional

Published
2021
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9. Abstract 113: Lyve-1 expressing macrophages direct the expansion of pericytes within the perivascular niche to support angiogenesis in cancer

Author

Opzoomer, James W., primary, Anstee, Joanne E., additional, Dean, Isaac, additional, Hill, Emily J., additional, Bouybayoune, Ihssane, additional, Caron, Jonathan, additional, Muliaditan, Tamara, additional, Gordon, Peter, additional, Nuamah, Rosamond, additional, Pinder, Sarah E., additional, Ng, Tony, additional, Dazzi, Francesco, additional, Kordasti, Shahram, additional, Withers, David R., additional, Lawrence, Toby, additional, and Arnold, James N., additional

Published
2021
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10. Macrophages orchestrate the expansion of a proangiogenic perivascular niche during cancer progression

Author

Afd Pharmacology, Pharmacology, Opzoomer, James W, Anstee, Joanne E, Dean, Isaac, Hill, Emily J, Bouybayoune, Ihssane, Caron, Jonathan, Muliaditan, Tamara, Gordon, Peter, Sosnowska, Dominika, Nuamah, Rosamond, Pinder, Sarah E, Ng, Tony, Dazzi, Francesco, Kordasti, Shahram, Withers, David R, Lawrence, Toby, Arnold, James N, Afd Pharmacology, Pharmacology, Opzoomer, James W, Anstee, Joanne E, Dean, Isaac, Hill, Emily J, Bouybayoune, Ihssane, Caron, Jonathan, Muliaditan, Tamara, Gordon, Peter, Sosnowska, Dominika, Nuamah, Rosamond, Pinder, Sarah E, Ng, Tony, Dazzi, Francesco, Kordasti, Shahram, Withers, David R, Lawrence, Toby, and Arnold, James N

Published
2021

12. Macrophages orchestrate the expansion of a pro-angiogenic perivascular niche during cancer progression

Author

Opzoomer, James W., primary, Anstee, Joanne E., additional, Dean, Isaac, additional, Hill, Emily J., additional, Bouybayoune, Ihssane, additional, Caron, Jonathan, additional, Muliaditan, Tamara, additional, Gordon, Peter, additional, Sosnowska, Dominika, additional, Nuamah, Rosamond, additional, Pinder, Sarah E., additional, Ng, Tony, additional, Dazzi, Francesco, additional, Kordasti, Shahram, additional, Withers, David R., additional, Lawrence, Toby, additional, and Arnold, James N., additional

Published
2020
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