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1. The neurophysiological brain-fingerprint of Parkinson’s disease

Author

Breitner, John, Poirier, Judes, Baillet, Sylvain, Bellec, Pierre, Bohbot, Véronique, Chakravarty, Mallar, Collins, Louis, Etienne, Pierre, Evans, Alan, Gauthier, Serge, Hoge, Rick, Ituria-Medina, Yasser, Multhaup, Gerhard, Münter, Lisa-Marie, Rajah, Natasha, Rosa-Neto, Pedro, Soucy, Jean-Paul, Vachon-Presseau, Etienne, Villeneuve, Sylvia, Amouyel, Philippe, Appleby, Melissa, Ashton, Nicholas, Auld, Daniel, Ayranci, Gülebru, Bedetti, Christophe, Beland, Marie-Lise, Blennow, Kaj, Westman, Ann Brinkmalm, Cuello, Claudio, Dadar, Mahsa, Daoust, Leslie-Ann, Das, Samir, Dauar-Tedeschi, Marina, De Beaumont, Louis, Dea, Doris, Descoteaux, Maxime, Dufour, Marianne, Farzin, Sarah, Ferdinand, Fabiola, Fonov, Vladimir, Gonneaud, Julie, Kat, Justin, Kazazian, Christina, Labonté, Anne, Lafaille-Magnan, Marie-Elyse, Lalancette, Marc, Lambert, Jean-Charles, Leoutsakos, Jeannie-Marie, Mahar, Laura, Mathieu, Axel, McSweeney, Melissa, Meyer, Pierre-François, Miron, Justin, Near, Jamie, NewboldFox, Holly, Nilsson, Nathalie, Orban, Pierre, Picard, Cynthia, Binette, Alexa Pichet, Poline, Jean-Baptiste, Rabipour, Sheida, Salaciak, Alyssa, Settimi, Matthew, Subramaniapillai, Sivaniya, Tam, Angela, Tardif, Christine, Théroux, Louise, Tremblay-Mercier, Jennifer, Tullo, Stephanie, Ulku, Irem, Vallée, Isabelle, Zetterberg, Henrik, Nair, Vasavan, Pruessner, Jens, Aisen, Paul, Anthal, Elena, Barkun, Alan, Beaudry, Thomas, Benbouhoud, Fatiha, Brandt, Jason, Carmo, Leopoldina, Carrier, Charles Edouard, Cheewakriengkrai, Laksanun, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Dansereau, Christian, Debacker, Clément, Desautels, René, Dubuc, Sylvie, Duclair, Guerda, Eisenberg, Mark, El-Khoury, Rana, Faubert, Anne-Marie, Fontaine, David, Frappier, Josée, Frenette, Joanne, Gagné, Guylaine, Gervais, Valérie, Giles, Renuka, Gordon, Renee, Jack, Clifford, Jutras, Benoit, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Lapalme, Félix, Lee, Tanya, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Maillet, David, Maltais, Jean-Robert, Mathotaarachchi, Sulantha, Mayrand, Ginette, Michaud, Diane, Montine, Thomas, Morris, John, Pagé, Véronique, Pascoal, Tharick, Peillieux, Sandra, Petkova, Mirela, Pogossova, Galina, Rioux, Pierre, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tariot, Pierre, Teigner, Eduard, Thomas, Ronald, Toussaint, Paule-Joanne, Tuwaig, Miranda, Venugopalan, Vinod, Verfaillie, Sander, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Beaulieu-Boire, Isabelle, Blanchet, Pierre, Bogard, Sarah, Bouchard, Manon, Chouinard, Sylvain, Cicchetti, Francesca, Cloutier, Martin, Dagher, Alain, Degroot, Clotilde, Desautels, Alex, Dion, Marie Hélène, Drouin-Ouellet, Janelle, Dufresne, Anne-Marie, Dupré, Nicolas, Duquette, Antoine, Durcan, Thomas, Fellows, Lesley K., Fon, Edward, Gagnon, Jean-François, Gan-Or, Ziv, Genge, Angela, Jodoin, Nicolas, Karamchandani, Jason, Lafontaine, Anne-Louise, Langlois, Mélanie, Leveille, Etienne, Lévesque, Martin, Melmed, Calvin, Monchi, Oury, Montplaisir, Jacques, Panisset, Michel, Parent, Martin, Pham-An, Minh-Thy, Postuma, Ronald, Pourcher, Emmanuelle, Rao, Trisha, Rivest, Jean, Rouleau, Guy, Sharp, Madeleine, Soland, Valérie, Sidel, Michael, Wing Sun, Sonia Lai, Thiel, Alexander, Vitali, Paolo, da Silva Castanheira, Jason, Wiesman, Alex I., Hansen, Justine Y., and Misic, Bratislav

Published
2024
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2. Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease

Author

Aisen, Paul, Anthal, Elena, Appleby, Melissa, Ayranci, Gülebru, Barkun, Alan, Beaudry, Thomas, Bellec, Pierre, Benbouhoud, Fatiha, Bohbot, Veronique, Brandt, Jason, Breitner, John, Carmo, Leopoldina, Carrier Charles, Edouard, Chakravarty, Mallar, Cheewakriengkrai, Laksanun, Collins, Louis, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Cuello, Claudio, Dadar, Mahsa, Dansereau, Christian, DasSamir, Marina, Dauar-Tedeschi, Dea, Doris, Debacker, Clement, Desautels, Rene, Dubuc, Sylvie, Duclair, Guerda, Dufour, Marianne, Eisenberg, Mark, El-Khoury, Rana, Etienne, Pierre, Evans, Alan, Faubert, Anne-Marie, Ferdinand, Fabiola, Fonov, Vladimir, Fontaine, David, Frappier, Josée, Joanne, Frenette, Gagne, Guylaine, Gauthier, Serge, Gervais, Valérie, Giles, Renuka, Gonneaud, Julie, Gordon, Renee, Hoge, Rick, Hyman, Bradley, Ituria-Medina, Yasser, Jack, Clifford, Kat, Justin, Kazazian, Christina, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Labonte, Anne, Lafaille-Magnan, Marie-Elyse, Lee, Tanya, Leoutsakos, Jeannie-Marie, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Mahar, Laura, Maillet, David, Maltais, Jean-Robert, Mathieu, Axel, Mathotaarachchi, Sulantha, Maultaup, Gerhard, Mayrand, Ginette, Meyer, Pierre-François, Michaud, Diane, Miron, Justin, Montine, Thomas, Morris, John, Münter, Lisa-Marie, Nair, Vasavan, Near, Jamie, Newbold-Fox, Holly, Orban, Pierre, Page, Véronique, Pascoal, Tharick, Petkova, Mirela, Picard, Cynthia, Pichet Binette, Alexa, Pogossova, Galina, Poirier, Judes, Pruessner, Jens, Rajah, Natasha, Rioux, Pierre, Rosa-Neto, Pedro, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tam, Angela, Tardif, Christine, Tariot, Pierre, Teigner, Eduard, Theroux, Louise, Thomas, Ronald, Toussaint, Paule-Joanne, Tremblay-Mercier, Jennifer, Tuwaig, Miranda, Vallee, Isabelle, Venugopalan, Vinod, Verfaillie, Sander, Villeneuve, Sylvia, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Verfaillie, Sander C.J., Vachon-Presseau, Etienne, Ossenkoppele, Rik, Scheltens, Philip, van der Flier, Wiesje M., and Breitner, John C.S.

Published
2018
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3. Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.

Author

Ai, Meishan, Morris, Timothy P., Zhang, Jiahe, de la Colina, Adrián Noriega, Tremblay-Mercier, Jennifer, Villeneuve, Sylvia, Whitfield-Gabrieli, Susan, Kramer, Arthur F., Geddes, Maiya R., Aisen, Paul, Anthal, Elena, Appleby, Melissa, Bellec, Pierre, Benbouhoud, Fatiha, Bohbot, Véronique, Brandt, Jason, Breitner, John C. S., Brunelle, Céline, Chakravarty, Mallar, and Cheewakriengkrai, Laksanun

Subjects
DISEASE risk factors, FUNCTIONAL magnetic resonance imaging, OLDER people, FUNCTIONAL connectivity, LARGE-scale brain networks
Abstract

Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. Therefore, understanding the neural mechanisms underlying multidomain lifestyle engagement, particularly in older adults at risk for Alzheimer's disease (AD), gives valuable insights into providing lifestyle advice and intervention for those in need. The current study included 139 healthy older adults with familial risk for AD from the Prevent-AD longitudinal aging cohort. Self-reported exercise engagement, cognitive activity engagement, healthy diet adherence, and social activity engagement were included to examine potential phenotypes of an individual's lifestyle adherence. Two adherence profiles were discovered using data-driven clustering methodology [i.e., Adherence to healthy lifestyle (AL) group and Non-adherence to healthy lifestyle group]. Resting-state functional connectivity matrices and grey matter brain features obtained from magnetic resonance imaging were used to classify the two groups using a support vector machine (SVM). The SVM classifier was 75% accurate in separating groups. The features that show consistently high importance to the classification model were functional connectivity mainly between nodes located in different prior-defined functional networks. Most nodes were located in the default mode network, dorsal attention network, and visual network. Our results provide preliminary evidence of neurobiological characteristics underlying multidomain healthy lifestyle choices. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease

Author

Pichet Binette, Alexa, primary, Vachon-Presseau, Étienne, additional, Morris, John, additional, Bateman, Randall, additional, Benzinger, Tammie, additional, Collins, D. Louis, additional, Poirier, Judes, additional, Breitner, John C.S., additional, Villeneuve, Sylvia, additional, Allegri, Ricardo, additional, Amtashar, Fatima, additional, Bateman, Randy, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William (Bill), additional, Buck, Jill, additional, Buckles, Virginia, additional, Chea, Sochenda, additional, Chhatwal, Jasmeer, additional, Chrem, Patricio, additional, Chui, Helena, additional, Cinco, Jake, additional, Clifford, Jack, additional, Cruchaga, Carlos, additional, D‘Mello, Mirelle, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Edigo, Noelia, additional, Erekin-Taner, Nilufer, additional, Fagan, Anne, additional, Farlow, Marty, additional, Farrar, Angela, additional, Feldman, Howard, additional, Flynn, Gigi, additional, Fox, Nick, additional, Franklin, Erin, additional, Fujii, Hisako, additional, Gant, Cortaiga, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldman, Jill, additional, Gordon, Brian, additional, Graff-Radford, Neill, additional, Gray, Julia, additional, Gurney, Jenny, additional, Hassenstab, Jason, additional, Hirohara, Mie, additional, Holtzman, David, additional, Hornbeck, Russ, additional, DiBari, Siri Houeland, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Jerome, Gina, additional, Jucker, Mathias, additional, Karch, Celeste, additional, Kasuga, Kensaku, additional, Kawarabayashi, Takeshi, additional, Klunk, William (Bill), additional, Koeppe, Robert, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Lee, Jae-Hong, additional, Levin, Johannes, additional, Marcus, Daniel, additional, Martins, Ralph, additional, Mason, Neal Scott, additional, Masters, Colin, additional, Maue-Dreyfus, Denise, additional, McDade, Eric, additional, Montoya, Lucy, additional, Mori, Hiroshi, additional, Nagamatsu, Akem, additional, Neimeyer, Katie, additional, Noble, James, additional, Norton, Joanne, additional, Perrin, Richard, additional, Raichle, Marc, additional, Ringman, John, additional, Roh, Jee Hoon, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Shimada, Hiroyuki, additional, Shiroto, Tomoyo, additional, Shoji, Mikio, additional, Sigurdson, Wendy, additional, Sohrabi, Hamid, additional, Sparks, Paige, additional, Suzuki, Kazushi, additional, Swisher, Laura, additional, Taddei, Kevin, additional, Wang, Jen, additional, Wang, Peter, additional, Weiner, Mike, additional, Wolfsberger, Mary, additional, Xiong, Chengjie, additional, Xu, Xiong, additional, Tam, Angela, additional, Labonté, Anne, additional, Pichet Binette, Alexa, additional, Faubert, Anne-Marie, additional, Mathieu, Axel, additional, Madjar, Cécile, additional, Carrier, Charles Edouard, additional, Dansereau, Christian, additional, Kazazian, Christina, additional, Lepage, Claude, additional, Picard, Cynthia, additional, Maillet, David, additional, Michaud, Diane, additional, Couture, Doris, additional, Dea, Doris, additional, Cuello, Claudio, additional, Barkun, Alan, additional, Evans, Alan, additional, Courcot, Blandine, additional, Tardif, Christine, additional, Debacker, Clément, additional, Jack, Clifford R., additional, Fontaine, David, additional, Knopman, David S., additional, Maultaup, Gerhard, additional, Near, Jamie, additional, Leoutsakos, Jeannie-Marie, additional, Maltais, Jean-Robert, additional, Brandt, Jason, additional, Pruessner, Jens, additional, Morris, John C., additional, Cheewakriengkrai, Laksanun, additional, Münter, Lisa-Marie, additional, Collins, Louis, additional, Chakravarty, Mallar, additional, Sager, Mark A., additional, Dauar-Tedeschi, Marina, additional, Eisenberg, Mark, additional, Rajah, Natasha, additional, Aisen, Paul, additional, Toussaint, Joanne, additional, Rosa-Neto, Pedro, additional, Bellec, Pierre, additional, Kostopoulos, Penelope, additional, Etienne, Pierre, additional, Tariot, Pierre N., additional, Orban, Pierre, additional, Sperling, Reisa A., additional, Hoge, Rick, additional, Thomas, Ronald G., additional, Gauthier, Serge, additional, Craft, Suzanne, additional, Montine, Thomas J., additional, Nair, Vasavan, additional, Bohbot, Véronique, additional, Venugopalan, Vinod, additional, Fonov, Vladimir, additional, Ituria-Medina, Yasser, additional, Khachaturian, Zaven S., additional, Teigner, Eduard, additional, Anthal, Elena, additional, Yu, Elsa, additional, Ferdinand, Fabiola, additional, Pogossova, Galina, additional, Mayrand, Ginette, additional, Duclair, Guerda, additional, Gagné, Guylaine, additional, Newbold-Fox, Holly, additional, Leppert, Illana, additional, Vallée, Isabelle, additional, Vogel, Jacob W., additional, Tremblay-Mercier, Jennifer, additional, Frenette, Joanne, additional, Frappier, Josée, additional, Kat, Justin, additional, Miron, Justin, additional, Wan, Karen, additional, Mahar, Laura, additional, Carmo, Leopoldina, additional, Théroux, Louise, additional, Dadar, Mahsa, additional, Dufour, Marianne, additional, Lafaille-Magnan, Marie-Elyse, additional, Appleby, Melissa, additional, Savard, Mélissa, additional, Tuwaig, Miranda, additional, Petkova, Mirela, additional, Rioux, Pierre, additional, Meyer, Pierre-François, additional, El-Khoury, Rana, additional, Gordon, Renee, additional, Giles, Renuka, additional, Das, Samir, additional, Wang, Seqian, additional, Tabrizi, Shirin, additional, Mathotaarachchi, Sulantha, additional, Dubuc, Sylvie, additional, Lee, Tanya, additional, Beaudry, Thomas, additional, Gervais, Valérie, additional, Pagé, Véronique, additional, Gonneaud, Julie, additional, Ayranci, Gülebru, additional, Pascoal, Tharick A., additional, Desautels, René, additional, Benbouhoud, Fatiha, additional, Saint-Fort, Eunice Farah, additional, Verfaillie, Sander C.J., additional, Farzin, Sarah, additional, Salaciak, Alyssa, additional, Tullo, Stephanie, additional, Vachon-Presseau, Etienne, additional, Daoust, Leslie-Ann, additional, Köbe, Theresa, additional, Spreng, Nathan, additional, McSweeney, Melissa, additional, Nilsson, Nathalie, additional, Pishnamazi, Morteza, additional, and Bedetti, Christophe, additional

Published
2021
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5. Proximity to parental symptom onset and amyloid-β burden in sporadic Alzheimer disease

Author

Villeneuve, Sylvia, Vogel, Jacob W., Gonneaud, Julie, Pichet Binette, Alexa, Rosa-Neto, Pedro, Gauthier, Serge, Bateman, Randall J., Fagan, Anne M., Morris, John C., Benzinger, Tammie L. S., Johnson, Sterling C., Breitner, John C. S., Poirier, Judes, Barkun, Alan, Evans, Alan, Salaciak, Alyssa, Tam, Angela, Labonté, Anne, Faubert, Anne-Marie, Mathieu, Axel, Courcot, Blandine, Hyman, Bradley T., Madjar, C. cile, Carrier, Charles Edouard, Dansereau, Christian, Kazazian, Christina, Tardif, Christine, Lepage, Claude, Cuello, Claudio, Debacker, Clément, Jack, Clifford R., Picard, Cynthia, Maillet, David, Fontaine, David, Knopman, David S., Michaud, Diane, Couture, Doris, Dea, Doris, Teigner, Eduard, Anthal, Elena, Yu, Elsa, Vachon-Presseau, Etienne, Saint-Fort, Eunice Farah, Ferdinand, Fabiola, Benbouhoud, Fatiha, Pogossova, Galina, Maultaup, Gerhard, Mayrand, Ginette, Duclair, Guerda, Verfaillie, Sander C. J., and Neurology

Subjects
0301 basic medicine, Adult, Male, Parents, medicine.medical_specialty, Cross-sectional study, Apolipoprotein E4, Asymptomatic, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sex Factors, Alzheimer Disease, Internal medicine, medicine, Dementia, Humans, Aged, Original Investigation, Amyloid beta-Peptides, Aniline Compounds, business.industry, Middle Aged, medicine.disease, Peptide Fragments, Thiazoles, 030104 developmental biology, Cross-Sectional Studies, chemistry, Positron-Emission Tomography, Cohort, Asymptomatic Diseases, Biomarker (medicine), Female, Neurology (clinical), medicine.symptom, Alzheimer's disease, Pittsburgh compound B, business, 030217 neurology & neurosurgery, Cohort study
Abstract

IMPORTANCE: Alzheimer disease (AD) develops during several decades. Presymptomatic individuals might be the best candidates for clinical trials, but their identification is challenging because they have no symptoms. OBJECTIVE: To assess whether a sporadic parental estimated years to symptom onset calculation could be used to identify information about amyloid-β (Aβ) levels in asymptomatic individuals with a parental history of AD dementia. DESIGN, SETTING, AND PARTICIPANTS: This cohort study analyzed Aβ1-42 in cerebrospinal fluid (CSF) specimens from 101 cognitively normal individuals who had a lumbar puncture as part of the Presymptomatic Evaluation of Novel or Experimental Treatments for Alzheimer Disease (PREVENT-AD) cohort from September 1, 2011, through November 30, 2016 (374 participants were enrolled in the cohort during this period). The study estimated each participant’s proximity to his/her parent’s symptom onset by subtracting the index relative’s onset age from his/her current age. The association between proximity to parental symptom onset and Aβ levels was then assessed using apolipoprotein E ε4 (APOE4) status and sex as interactive terms. These analyses were performed again in 2 independent cohorts using CSF and Pittsburgh compound B carbon 11–labeled positron emission tomography (PIB-PET) Aβ biomarkers: the Adult Children Study (ACS) and the Wisconsin Registry for Alzheimer Prevention (WRAP) cohorts. MAIN OUTCOMES AND MEASURES: The association between proximity to parental symptom onset and Aβ burden in asymptomatic individuals with a parental history of sporadic AD. RESULTS: The present analysis included a subset of 101 PREVENT-AD individuals (mean [SD] age, 61.8 [5.1] years; 30 [29.7%] male), 128 ACS participants (112 participants underwent CSF measurement: mean [SD] age, 63.4 [5.1] years; 31 [27.7%] male; and 107 underwent PIB-PET: mean [SD] age, 64.6 [5.3] years; 27 [25.2%] male), and 135 WRAP participants (85 participants underwent CSF measurement: mean [SD] age, 59.9 [6.0] years; 27 [31.8%] male; and 135 underwent PIB-PET: mean [SD] age, 59.6 [6.1] years; 43 [31.9%] male). In the PREVENT-AD cohort, individuals approaching their parent’s onset age had lower CSF Aβ1-42 levels (range, 402-1597; B = −9.09, P = .04). This association was stronger in APOE4 carriers (B = −17.9, P = .03) and women (B = −19.8, P = .02). In the ACS cohort, the main association was replicated using PIB-PET data, and the sex interaction was replicated using CSF and PIB-PET data. In the WRAP cohort, the results were not replicated using cross-sectional data, but the main association and the APOE interaction were replicated using PIB-PET longitudinal data. CONCLUSIONS AND RELEVANCE: These results suggest that proximity to parental symptom onset may help estimate Aβ biomarker changes in women or APOE4 carrier asymptomatic individuals with a parental history of sporadic AD.

Published
2018

6. Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease

Author

Verfaillie, Sander C.J., Pichet Binette, Alexa, Vachon-Presseau, Etienne, Tabrizi, Shirin, Savard, Mélissa, Bellec, Pierre, Ossenkoppele, Rik, Scheltens, Philip, van der Flier, Wiesje M., Breitner, John C.S., Villeneuve, Sylvia, Aisen, Paul, Anthal, Elena, Appleby, Melissa, Ayranci, Gülebru, Barkun, Alan, Beaudry, Thomas, Bellec, Pierre, Benbouhoud, Fatiha, Bohbot, Veronique, Brandt, Jason, Breitner, John, Carmo, Leopoldina, Carrier Charles, Edouard, Chakravarty, Mallar, Cheewakriengkrai, Laksanun, Collins, Louis, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Cuello, Claudio, Dadar, Mahsa, Dansereau, Christian, DasSamir, Marina, Dauar-Tedeschi, Dea, Doris, Debacker, Clement, Desautels, Rene, Dubuc, Sylvie, Duclair, Guerda, Dufour, Marianne, Eisenberg, Mark, El-Khoury, Rana, Etienne, Pierre, Evans, Alan, Faubert, Anne-Marie, Ferdinand, Fabiola, Fonov, Vladimir, Fontaine, David, Frappier, Josée, Joanne, Frenette, Gagne, Guylaine, Gauthier, Serge, Gervais, Valérie, Giles, Renuka, Gonneaud, Julie, Gordon, Renee, Hoge, Rick, Hyman, Bradley, Ituria-Medina, Yasser, Jack, Clifford, Kat, Justin, Kazazian, Christina, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Labonte, Anne, Lafaille-Magnan, Marie-Elyse, Lee, Tanya, Leoutsakos, Jeannie-Marie, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Mahar, Laura, Maillet, David, Maltais, Jean-Robert, Mathieu, Axel, Mathotaarachchi, Sulantha, Maultaup, Gerhard, Mayrand, Ginette, Meyer, Pierre-François, Michaud, Diane, Miron, Justin, Montine, Thomas, Morris, John, Münter, Lisa-Marie, Nair, Vasavan, Near, Jamie, Newbold-Fox, Holly, Orban, Pierre, Page, Véronique, Pascoal, Tharick, Petkova, Mirela, Picard, Cynthia, Pichet Binette, Alexa, Pogossova, Galina, Poirier, Judes, Pruessner, Jens, Rajah, Natasha, Rioux, Pierre, Rosa-Neto, Pedro, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tam, Angela, Tardif, Christine, Tariot, Pierre, Teigner, Eduard, Theroux, Louise, Thomas, Ronald, Toussaint, Paule-Joanne, Tremblay-Mercier, Jennifer, Tuwaig, Miranda, Vallee, Isabelle, Venugopalan, Vinod, Verfaillie, Sander, Villeneuve, Sylvia, Vogel, Jacob, Wan, Karen, Wang, Seqian, and Yu, Elsa

Abstract

Both subjective cognitive decline (SCD) and a family history of Alzheimer’s disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD.

Published
2018
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7. Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease

Author

Orban, Pierre, Madjar, Cécile, Savard, Mélissa, Dansereau, Christian, Tam, Angela, Das, Samir, Evans, Alan C., Rosa-Neto, Pedro, Breitner, John C.S., Bellec, Pierre, Aisen, Paul, Pascoal, Tharick Ali, Anthal, Elena, Appleby, Melissa, Barkun, Alan, Beaudry, Thomas, Benbouhoud, Fatiha, Bohbot, Veronique, Brandt, Jason, Breitner, John C. S., Brunelle, Céline, Carmo, Leopoldina, Cheewakriengkrai, Laksanaun, Collins, Louis, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Cuello, A. Claudio, Dadar, Mahsa, Dauar-Tedeschi, Marina, Dea, Dorothy, Debacker, Clément, Desautels, René, Desrochers, Nicole, Dubuc, Sylvie, Duclair, Guerda, Dufour, Marianne, Eisenberg, Mark, El-Khoury, Rana, Etienne, Pierre, Faubert, Anne Marie, Ferdinand, Fabiola, Fonov, Vladimir S., Fontaine, David, Francoeur, Renaud, Frappier, Josée, Frenette, Joanne, Gauthier, Serge, Gervais, Valérie, Giles, Renuka, Gordon, Renee, Hoge, Rick, Hyman, Bradley T., Iturria-Medina, Yasser, Jack, Clifford R., Kat, Justin, Khachaturian, Zaven S., Kliegman, Stephanie, Knopman, David S., Kostopoulos, Penelope, Labonté, Anne, Lafaille-Magnan, Marie-Elyse, Lee, Tanya, Lepage, Claude, Leppert, Ilana, Leoutsakos, Jeannie-Marie, Mahar, Laura, Maltais, Jean-Robert, Mathieu, Axel, Mathotaarachchi, Sulantha, Maultaup, Gerhard, Mayrand, Ginette, Michaud, Diane, Miron, Justin, Montine, Thomas J., Morris, John C., Münter, Lisa-Marie, Nair, Vasavan, Near, Jamie, Newbold-Fox, Holly, Pagé, Véronique, Petkova, Mirela, Picard, Cynthia, Pogossova, Galina, Poirier, Isabelle, Poirier, Judes, Pruessner, Jens, Rajah, Natasha, Rioux, Pierre, Sager, Mark A., Sperling, Reisa A., Tariot, Pierre N., Teigner, Eduard, Théroux, Louise, Thomas, Ronald G., Toussaint, Paule-Joanne, Tremblay-Mercier, Jennifer, Tuwaig, Miranda, Vallée, Isabelle, Venogopalan, Vinod, Wan, Karen, and Wang, Seqian

Subjects
Predictive markers, Alzheimer's disease, Brain imaging, Functional magnetic resonance imaging
Abstract

We present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the “Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease” (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ~3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease.

Published
2015
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