1. Clinical influences of anticentromere antibody on primary Sjögren’s syndrome in a prospective Korean cohort
- Author
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Ji-Min Kim, Shin-Seok Lee, Jung Hee Koh, Yoon-Kyoung Sung, Sung-Hwan Park, Youngjae Park, Seung-Ki Kwok, Jennifer Lee, and Jung Yoon Choe
- Subjects
medicine.medical_specialty ,Leukopenia ,business.industry ,phenotype ,Hypergammaglobulinemia ,medicine.disease ,anticentromere antibody ,Rheumatology ,eye diseases ,03 medical and health sciences ,stomatognathic diseases ,0302 clinical medicine ,Internal medicine ,Cohort ,medicine ,Rheumatoid factor ,Medicine ,030211 gastroenterology & hepatology ,medicine.symptom ,Prospective cohort study ,business ,sjogren’s syndrome ,Rheumatism ,Anti-SSA/Ro autoantibodies - Abstract
Background/Aims: This study was performed to clarify inf luences of anticentromere antibody (ACA) on clinical phenotypes of primary Sjögren’s syndrome (pSS) patients in Korea. Methods: We assessed 318 patients who met the 2016 American College of Rheumatology/ European League Against Rheumatism classification criteria for pSS. All patients were selected from the Korean Initiative of primary Sjögren’s Syndrome (KISS), a prospective cohort. Among them, 53 patients were positive for ACA, while another 265 patients were not. We compared various clinical data including demographic features, extra-glandular manifestations (EGMs), clinical indices, and laboratory values available from the KISS database between the two groups. Results: Patients in the ACA-positive pSS group were older (p = 0.042), and had higher xerostomia inventory scores (p = 0.040), whereas glandular dysfunction represented with Schirmer I test was more severe in the ACA-negative group. More frequent Raynaud’s phenomenon and liver involvement (both p < 0.001) and less articular involvement (p = 0.037) were observed among the EGMs in the ACA-positive group. Less frequency of leukopenia (p = 0.021), rheumatoid factor (p < 0.001), anti-Ro/SSA antibody positivity (p < 0.001), and hypergammaglobulinemia (p = 0.006), as well as higher positivity rates of anti-nuclear antibody and anti- topoisomerase antibody (p < 0.001 and p = 0.006, respectively) were found in the laboratory data in the ACA-positive pSS group. Conclusions: Considering distinct phenotypes in hematological and serological features and EGMs, we should monitor the occurrence of these clinical features among pSS patients with ACA in caution.
- Published
- 2021