1. Casting a wider net: Immunosurveillance by nonclassical MHC molecules.
- Author
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D’Souza, M. Patricia, Adams, Erin, Altman, John D., Birnbaum, Michael E., Boggiano, Cesar, Casorati, Giulia, Chien, Yueh-hsiu, Conley, Anthony, Eckle, Sidonia Barbara Guiomar, Früh, Klaus, Gondré-Lewis, Timothy, Hassan, Namir, Huang, Huang, Jayashankar, Lakshmi, Kasmar, Anne G., Kunwar, Nina, Lavelle, Judith, Lewinsohn, David M., Moody, Branch, and Picker, Louis
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MAJOR histocompatibility complex , *OLIGOPEPTIDES , *T cells , *HIV , *IMMUNODEFICIENCY , *CLINICAL medicine - Abstract
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered “unconventional,” in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, “Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens,” sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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