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Inflammation is a local protective response caused by tissue injury or damage that serves to destroy, reduce, or localize both injured and injured tissues. In Indonesia, especially in Bali famous for its traditional medicine is Usada Bali. One part of Usada Bali is Lontar UsadaTaruPramana which contains an explanation of medicinal ingredients derived from herbs as an external medicine in the form of boreh (parem). This study aims to determine the effectiveness of the formulation boreh usadatarupramana as anti-inflammatory therapy against male rats induced carrageenan. The method used was pre-test and post-test with control group design using 15 male white rats divided into 3 treatment groups. Group 1 (P1 or negative control) was given 15 mg placebo (cream base), Group 2 (P2 or positive control) was given 15 mg sodium diclofenac cream and Group 3 (P3or treatment group) was given 15 mg boreh formulation. The statistical analysis showed no significant difference of rat foot volume between positive control group and boreh formulation group with p-value = 0.444. This suggests that the boreh formulation group had the same effect as the positive control group as the anti-inflammatory therapy on decreased rat foot volume of edema. [ABSTRACT FROM AUTHOR]