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179 results on '"Antohe, Felicia"'

4. Dihydrotestosterone Augments the Angiogenic and Migratory Potential of Human Endothelial Progenitor Cells by an Androgen Receptor-Dependent Mechanism.

Author

Popa, Mirel Adrian, Mihai, Cristina Maria, Șuică, Viorel Iulian, Antohe, Felicia, Dubey, Raghvendra K., Leeners, Brigitte, and Simionescu, Maya

Subjects
PROGENITOR cells, ENDOTHELIAL cells, STANOLONE, CELL migration, ANDROGEN receptors, CARDIOVASCULAR system
Abstract

Endothelial progenitor cells (EPCs) play a critical role in cardiovascular regeneration. Enhancement of their native properties would be highly beneficial to ensuring the proper functioning of the cardiovascular system. As androgens have a positive effect on the cardiovascular system, we hypothesized that dihydrotestosterone (DHT) could also influence EPC-mediated repair processes. To evaluate this hypothesis, we investigated the effects of DHT on cultured human EPCs' proliferation, viability, morphology, migration, angiogenesis, gene and protein expression, and ability to integrate into cardiac tissue. The results showed that DHT at different concentrations had no cytotoxic effect on EPCs, significantly enhanced the cell proliferation and viability and induces fast, androgen-receptor-dependent formation of capillary-like structures. DHT treatment of EPCs regulated gene expression of androgen receptors and the genes and proteins involved in cell migration and angiogenesis. Importantly, DHT stimulation promoted EPC migration and the cells' ability to adhere and integrate into murine cardiac slices, suggesting it has a role in promoting tissue regeneration. Mass spectrometry analysis further highlighted the impact of DHT on EPCs' functioning. In conclusion, DHT increases the proliferation, migration, and androgen-receptor-dependent angiogenesis of EPCs; enhances the cells' secretion of key factors involved in angiogenesis; and significantly potentiates cellular integration into heart tissue. The data offer support for potential therapeutic applications of DHT in cardiovascular regeneration and repair processes. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Prevalence of virulence markers and pHS-2-like plasmids among Shigella sonnei and Shigella flexneri isolates originating from shigellosis cases in Romania

Author

Cristea Daniela, Oprea Mihaela, Ciontea Adriana Simona, Antohe Felicia, and Usein Codruta-Romanita

Subjects
shigella, virulence genes, phs-2 plasmid, Medicine
Abstract

The surveillance of shigellosis is carried out under the auspice of the European Centre for Disease Prevention and Control which requires a reliable laboratory-based surveillance at national level. To date, little information is published about the members of Shigella spp. responsible for Romanian cases of shigellosis which hinders the understanding of the current epidemiology of shigellosis. Consequently, this retrospective study aimed to assess the diversity of virulence profiles displayed by the strains circulating in our region, by using key chromosome- and plasmid-associated markers, and to document the prevalence of pHS-2-like plasmid previously proposed as a potential marker for reactive arthritis.

Published
2016
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10. New born macrosomia in gestational diabetes mellitus

Author

Bernea, Elena, primary, Uyy, Elena, additional, Mihai, Doina-Andrada, additional, Ceausu, Iuliana, additional, Ionescu‑tirgoviste, Constantin, additional, Suica, Viorel-Iulian, additional, Ivan, Luminita, additional, and Antohe, Felicia, additional

Published
2022
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12. Exosome Proteomics Reveals the Deregulation of Coagulation, Complement and Lipid Metabolism Proteins in Gestational Diabetes Mellitus

Author

Bernea, Elena G., primary, Suica, Viorel I., additional, Uyy, Elena, additional, Cerveanu-Hogas, Aurel, additional, Boteanu, Raluca M., additional, Ivan, Luminita, additional, Ceausu, Iuliana, additional, Mihai, Doina A., additional, Ionescu-Tîrgoviște, Constantin, additional, and Antohe, Felicia, additional

Published
2022
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14. Short-Term Blockade of Pro-Inflammatory Alarmin S100A9 Favorably Modulates Left Ventricle Proteome and Related Signaling Pathways Involved in Post-Myocardial Infarction Recovery

Author

Boteanu, Raluca Maria, primary, Suica, Viorel-Iulian, additional, Uyy, Elena, additional, Ivan, Luminita, additional, Cerveanu-Hogas, Aurel, additional, Mares, Razvan Gheorghita, additional, Simionescu, Maya, additional, Schiopu, Alexandru, additional, and Antohe, Felicia, additional

Published
2022
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19. Surface functionalization with anticorrosive and antimicrobial biodegradable polymeric implants

Author

Visan, Anita Ioana, primary, Popescu-Pelin, Gianina, additional, Gherasim, Oana, additional, Mihailescu, Andreea, additional, Socol, Marcela, additional, Zgura, Irina, additional, Chiritoiu, Mari, additional, Sima, Livia, additional, Antohe, Felicia, additional, Radulescu, Luminita, additional, Vranceanu, Diana, additional, Cotrut, Cosmin, additional, Cristescu, Rodica, additional, and Socol, Gabriel, additional

Published
2021
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21. Analytical techniques for multiplex analysis of protein biomarkers

Author

European Cooperation in Science and Technology, Gool, Alain Van, Corrales, Fernando J., Čolović, Mirjana, Krstić, Danijela, Oliver-Martos, Begoña, Martínez-Cáceres, Eva, Jakasa, Ivone, Gajski, Goran, Brun, Virginie, Kyriacou, Kyriacos, Burzynska-Pedziwiatr, Izabela, Alicja Wozniak, Lucyna, Nierkens, Stephan, Pascual García, César, Katrlik, Jaroslav, Bojic-Trbojevic, Zanka, Vacek, Jan, Llorente, Alicia, Antohe, Felicia, Suica, Viorel, Suarez, Guillaume, t’Kindt, Ruben, Martin, Petra, Penque, Deborah, Lanca Martins, Ines, Bodok, Ede, Lacob, Bogdan-Cezar, Aydindogan, Eda, Timur, Suna, Allinson, John, Sutton, Christopher, Luider, Theo, Wittfooth, Saara, Sammar, Marei, European Cooperation in Science and Technology, Gool, Alain Van, Corrales, Fernando J., Čolović, Mirjana, Krstić, Danijela, Oliver-Martos, Begoña, Martínez-Cáceres, Eva, Jakasa, Ivone, Gajski, Goran, Brun, Virginie, Kyriacou, Kyriacos, Burzynska-Pedziwiatr, Izabela, Alicja Wozniak, Lucyna, Nierkens, Stephan, Pascual García, César, Katrlik, Jaroslav, Bojic-Trbojevic, Zanka, Vacek, Jan, Llorente, Alicia, Antohe, Felicia, Suica, Viorel, Suarez, Guillaume, t’Kindt, Ruben, Martin, Petra, Penque, Deborah, Lanca Martins, Ines, Bodok, Ede, Lacob, Bogdan-Cezar, Aydindogan, Eda, Timur, Suna, Allinson, John, Sutton, Christopher, Luider, Theo, Wittfooth, Saara, and Sammar, Marei

Abstract

[Introduction]: The importance of biomarkers for pharmaceutical drug development and clinical diagnostics is more significant than ever in the current shift toward personalized medicine. Biomarkers have taken a central position either as companion markers to support drug development and patient selection, or as indicators aiming to detect the earliest perturbations indicative of disease, minimizing therapeutic intervention or even enabling disease reversal. Protein biomarkers are of particular interest given their central role in biochemical pathways. Hence, capabilities to analyze multiple protein biomarkers in one assay are highly interesting for biomedical research. [Areas covered]: We here review multiple methods that are suitable for robust, high throughput, standardized, and affordable analysis of protein biomarkers in a multiplex format. We describe innovative developments in immunoassays, the vanguard of methods in clinical laboratories, and mass spectrometry, increasingly implemented for protein biomarker analysis. Moreover, emerging techniques are discussed with potentially improved protein capture, separation, and detection that will further boost multiplex analyses. [Expert commentary]: The development of clinically applied multiplex protein biomarker assays is essential as multi-protein signatures provide more comprehensive information about biological systems than single biomarkers, leading to improved insights in mechanisms of disease, diagnostics, and the effect of personalized medicine.

Published
2020

22. Analytical techniques for multiplex analysis of protein biomarkers

Author

Van Gool, Alain, Corrales, Fernado, Čolović, Mirjana B., Krstić, Danijela Z., Oliver-Martos, Begona, Martínez-Cáceres, Eva, Jakasa, Ivone, Gajski, Goran, Brun, Virginie, Kyriacou, Kyriacos, Burzynska-Pedziwiatr, Izabela, Wozniak, Lucyna Alicja, Nierkens, Stephan, Pascual García, César, Katrlik, Jaroslav, Bojić-Trbojević, Žanka, Vacek, Jan, Llorente, Alicia, Antohe, Felicia, Suica, Viorel, Suarez, Guillaume, T’Kindt, Ruben, Martin, Petra, Penque, Deborah, Martins, Ines Lanca, Bodoki, Ede, Iacob, Bogdan-Cezar, Aydindogan, Eda, Timur, Suna, Allinson, John, Sutton, Christopher, Luider, Theo, Wittfooth, Saara, Sammar, Marei, Van Gool, Alain, Corrales, Fernado, Čolović, Mirjana B., Krstić, Danijela Z., Oliver-Martos, Begona, Martínez-Cáceres, Eva, Jakasa, Ivone, Gajski, Goran, Brun, Virginie, Kyriacou, Kyriacos, Burzynska-Pedziwiatr, Izabela, Wozniak, Lucyna Alicja, Nierkens, Stephan, Pascual García, César, Katrlik, Jaroslav, Bojić-Trbojević, Žanka, Vacek, Jan, Llorente, Alicia, Antohe, Felicia, Suica, Viorel, Suarez, Guillaume, T’Kindt, Ruben, Martin, Petra, Penque, Deborah, Martins, Ines Lanca, Bodoki, Ede, Iacob, Bogdan-Cezar, Aydindogan, Eda, Timur, Suna, Allinson, John, Sutton, Christopher, Luider, Theo, Wittfooth, Saara, and Sammar, Marei

Abstract

Introduction: The importance of biomarkers for pharmaceutical drug development and clinical diagnostics is more significant than ever in the current shift toward personalized medicine. Biomarkers have taken a central position either as companion markers to support drug development and patient selection, or as indicators aiming to detect the earliest perturbations indicative of disease, minimizing therapeutic intervention or even enabling disease reversal. Protein biomarkers are of particular interest given their central role in biochemical pathways. Hence, capabilities to analyze multiple protein biomarkers in one assay are highly interesting for biomedical research. Areas covered: We here review multiple methods that are suitable for robust, high throughput, standardized, and affordable analysis of protein biomarkers in a multiplex format. We describe innovative developments in immunoassays, the vanguard of methods in clinical laboratories, and mass spectrometry, increasingly implemented for protein biomarker analysis. Moreover, emerging techniques are discussed with potentially improved protein capture, separation, and detection that will further boost multiplex analyses. Expert commentary: The development of clinically applied multiplex protein biomarker assays is essential as multi-protein signatures provide more comprehensive information about biological systems than single biomarkers, leading to improved insights in mechanisms of disease, diagnostics, and the effect of personalized medicine.

Published
2020

23. Analytical techniques for multiplex analysis of protein biomarkers

Author

Cancer, CTI Research, CDL Patiëntenzorg MI, Infection & Immunity, Van Gool, Alain, Corrales, Fernado, Čolović, Mirjana, Krstić, Danijela, Oliver-Martos, Begona, Martínez-Cáceres, Eva, Jakasa, Ivone, Gajski, Goran, Brun, Virginie, Kyriacou, Kyriacos, Burzynska-Pedziwiatr, Izabela, Wozniak, Lucyna Alicja, Nierkens, Stephan, Pascual García, César, Katrlik, Jaroslav, Bojic-Trbojevic, Zanka, Vacek, Jan, Llorente, Alicia, Antohe, Felicia, Suica, Viorel, Suarez, Guillaume, t'Kindt, Ruben, Martin, Petra, Penque, Deborah, Martins, Ines Lanca, Bodoki, Ede, Iacob, Bogdan-Cezar, Aydindogan, Eda, Timur, Suna, Allinson, John, Sutton, Christopher, Luider, Theo, Wittfooth, Saara, Sammar, Marei, Cancer, CTI Research, CDL Patiëntenzorg MI, Infection & Immunity, Van Gool, Alain, Corrales, Fernado, Čolović, Mirjana, Krstić, Danijela, Oliver-Martos, Begona, Martínez-Cáceres, Eva, Jakasa, Ivone, Gajski, Goran, Brun, Virginie, Kyriacou, Kyriacos, Burzynska-Pedziwiatr, Izabela, Wozniak, Lucyna Alicja, Nierkens, Stephan, Pascual García, César, Katrlik, Jaroslav, Bojic-Trbojevic, Zanka, Vacek, Jan, Llorente, Alicia, Antohe, Felicia, Suica, Viorel, Suarez, Guillaume, t'Kindt, Ruben, Martin, Petra, Penque, Deborah, Martins, Ines Lanca, Bodoki, Ede, Iacob, Bogdan-Cezar, Aydindogan, Eda, Timur, Suna, Allinson, John, Sutton, Christopher, Luider, Theo, Wittfooth, Saara, and Sammar, Marei

Published
2020

26. Analytical techniques for multiplex analysis of protein biomarkers

Author

Van Gool, Alain, primary, Corrales, Fernado, additional, Čolović, Mirjana, additional, Krstić, Danijela, additional, Oliver-Martos, Begona, additional, Martínez-Cáceres, Eva, additional, Jakasa, Ivone, additional, Gajski, Goran, additional, Brun, Virginie, additional, Kyriacou, Kyriacos, additional, Burzynska-Pedziwiatr, Izabela, additional, Wozniak, Lucyna Alicja, additional, Nierkens, Stephan, additional, Pascual García, César, additional, Katrlik, Jaroslav, additional, Bojic-Trbojevic, Zanka, additional, Vacek, Jan, additional, Llorente, Alicia, additional, Antohe, Felicia, additional, Suica, Viorel, additional, Suarez, Guillaume, additional, t’Kindt, Ruben, additional, Martin, Petra, additional, Penque, Deborah, additional, Martins, Ines Lanca, additional, Bodoki, Ede, additional, Iacob, Bogdan-Cezar, additional, Celikbas, Eda, additional, Timur, Suna, additional, Allinson, John, additional, Sutton, Christopher, additional, Luider, Theo, additional, Wittfooth, Saara, additional, and Sammar, Marei, additional

Published
2020
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27. Long-Term Evaluation of Dip-Coated PCL-Blend-PEG Coatings in Simulated Conditions

Author

Visan, Anita Ioana, primary, Popescu-Pelin, Gianina, additional, Gherasim, Oana, additional, Mihailescu, Andreea, additional, Socol, Marcela, additional, Zgura, Irina, additional, Chiritoiu, Mari, additional, Elena Sima, Livia, additional, Antohe, Felicia, additional, Ivan, Luminita, additional, M. Vranceanu, Diana, additional, M. Cotruț, Cosmin, additional, Cristescu, Rodica, additional, and Socol, Gabriel, additional

Published
2020
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35. Additional file 3: Figure S1. of Alteration of actin dependent signaling pathways associated with membrane microdomains in hyperlipidemia

Author

Viorel-Iulian Suica, Uyy, Elena, Boteanu, Raluca, Luminita Ivan, and Antohe, Felicia

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

Base peak chromatographic alignment. Representative biological replicates of the three groups are shown: C - control group (blue base peak chromatograms), A - ApoE KO mice fed hyperlipidemic diet (green base peak chromatograms) and At - ApoE KO mice that received hyperlipidemic diet and statin treatment (red base peak chromatograms). (DOCX 277Â kb)

Published
2015
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36. Additional file 4: Figure S2. of Alteration of actin dependent signaling pathways associated with membrane microdomains in hyperlipidemia

Author

Viorel-Iulian Suica, Uyy, Elena, Boteanu, Raluca, Luminita Ivan, and Antohe, Felicia

Abstract

Gene ontology details of detergent resistant membrane microdomains proteins. Data distribution based on: Cellular Component (a), Biological Process (b) and Molecular Function (c). Data expressed as mean values ± SD, following the analysis of the biological replicates. (DOCX 654 kb)

Published
2015
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39. EVALUATION OF THE IMMUNOGENICITY OF REVERSE-VACCINOLOGY DERIVED STAPHYLOCOCCUS AUREUS PROTEINS ON EXPERIMENTAL ENDOCARDITIS MODEL.

Author

Oprea, Mihaela, Cordoş, Bogdan, Străuţ, Monica, Costache, Adriana, Antohe, Felicia, and Onu, Adrian

Subjects
STAPHYLOCOCCUS aureus, RECOMBINANT proteins, CELL surface antigens, ENDOCARDITIS, INFECTIVE endocarditis
Abstract

Copyright of Romanian Archives of Microbiology & Immunology is the property of Institutul Cantacuzino and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019

42. S100A4 and ERBB2 as Co-Factors in Pancreatic Cancer

Author

Nastase, Anca, primary, Dima, Simona, primary, Tica, Valeria, primary, Florea, Raluca, primary, Sorop, Andrei, primary, Ilie, Veronica, primary, Eftimie, Mihai, primary, Paslaru, Liliana, primary, Herlea, Vlad, primary, Bacalbaşa, Nicolae, primary, Ivan, Luminita, primary, Uyy, Elena, primary, Iulian Suica, Viorel, primary, Antohe, Felicia, primary, V Iancu, Iulia, primary, Plesa, Adriana, primary, Botezatu, Anca, primary, G Duda, Dan, primary, and Diaconu, Carmen C, primary

Published
2016
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44. Carbapenemase-Producing Klebsiella pneumoniae in Romania: A Six-Month Survey

Author

Lixandru, Brandusa Elena, primary, Cotar, Ani Ioana, additional, Straut, Monica, additional, Usein, Codruta Romanita, additional, Cristea, Dana, additional, Ciontea, Simona, additional, Tatu-Chitoiu, Dorina, additional, Codita, Irina, additional, Rafila, Alexandru, additional, Nica, Maria, additional, Buzea, Mariana, additional, Baicus, Anda, additional, Ghita, Mihaela Camelia, additional, Nistor, Irina, additional, Tuchiluş, Cristina, additional, Indreas, Marina, additional, Antohe, Felicia, additional, Glasner, Corinna, additional, Grundmann, Hajo, additional, Jasir, Aftab, additional, and Damian, Maria, additional

Published
2015
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