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11 results on '"Antonenko, Yury N."'

2. Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs)

Author

Skulachev, Vladimir P., Antonenko, Yury N., Cherepanov, Dmitry A., Chernyak, Boris V., Izyumov, Denis S., Khailova, Ludmila S., Klishin, Sergey S., Korshunova, Galina A., Lyamzaev, Konstantin G., Pletjushkina, Olga Yu., Roginsky, Vitaly A., Rokitskaya, Tatiana I., Severin, Fedor F., Severina, Inna I., Simonyan, Ruben A., Skulachev, Maxim V., Sumbatyan, Natalia V., Sukhanova, Evgeniya I., Tashlitsky, Vadim N., Trendeleva, Tatyana A., Vyssokikh, Mikhail Yu., and Zvyagilskaya, Renata A.

Published
2010
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4. Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore

Author

Severin, Fedor F., primary, Severina, Inna I., additional, Antonenko, Yury N., additional, Rokitskaya, Tatiana I., additional, Cherepanov, Dmitry A., additional, Mokhova, Elena N., additional, Vyssokikh, Mikhail Yu., additional, Pustovidko, Antonina V., additional, Markova, Olga V., additional, Yaguzhinsky, Lev S., additional, Korshunova, Galina A., additional, Sumbatyan, Nataliya V., additional, Skulachev, Maxim V., additional, and Skulachev, Vladimir P., additional

Published
2009
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5. A new method of the measurement of the electrically neutral fluxes of cations through lipid bilayer membranes induced by Me n+ / nH +-exchangers

Author

Antonenko, Yury N. and Yaguzhinsky, Lev S.

Abstract

Electrically neutral ionophores (nigericin, monencin) incorporated into a planar bilayer lipid membrane (BLM) bring about hydrogen ion gradient formation in the unstirred layers of BLM if a metal ion gradient on the membrane is prepared. Under these conditions a diffusion potential of a hydrogen ion is generated after addition of a protonophore. Cation selectivity of nigericin, monencin and A23187 has been studied by means of electrical potential measurements in the presence of a protonophore and Me n+ / nH +-exchangers mentioned above. The data on cation selectivity are in a good agreement with the well known results of the direct measurements of metal ion fluxes. This shows that the effect of generation of the potential on BLM in the presence of a protonophore and a Me n+ / nH +-exchanger can be used for the estimation of electrically neutral ion fluxes through BLM.

Published
1983
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6. A new method of the measurement of the electrically neutral fluxes of cations through lipid bilayer membranes induced by Men+/nH+‐exchangers

Author

Antonenko, Yury N. and Yaguzhinsky, Lev S.

Abstract

Electrically neutral ionophores (nigericin, monencin) incorporated into a planar bilayer lipid membrane (BLM) bring about hydrogen ion gradient formation in the unstirred layers of BLM if a metal ion gradient on the membrane is prepared. Under these conditions a diffusion potential of a hydrogen ion is generated after addition of a protonophore. Cation selectivity of nigericin, monencin and A23187 has been studied by means of electrical potential measurements in the presence of a protonophore and Men+/nH+‐exchangers mentioned above. The data on cation selectivity are in a good agreement with the well known results of the direct measurements of metal ion fluxes. This shows that the effect of generation of the potential on BLM in the presence of a protonophore and a Men+/nH+‐exchanger can be used for the estimation of electrically neutral ion fluxes through BLM.

Published
1983
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11. Methodology for use of mitochondria-targeted cations in the field of oxidative stress-related research.

Author

Vyssokikh MY, Antonenko YN, Lyamzaev KG, Rokitskaya TI, and Skulachev VP

Subjects
Cations pharmacology, Cell Culture Techniques, Cell Membrane Permeability, Fluoresceins administration & dosage, Fluoresceins chemistry, Hydrogen Peroxide pharmacology, Hydrogen-Ion Concentration, Lipid Bilayers chemistry, Lipid Bilayers isolation & purification, Liposomes chemistry, Mitochondria drug effects, Organophosphorus Compounds metabolism, Oxidation-Reduction, Cations metabolism, Mitochondria metabolism, Oxidative Stress drug effects
Abstract

For many pathological conditions, reactive oxygen species (ROS) generated in mitochondria are considered to have a role as a trigger. When mitochondrial ROS (mROS) are formed in the inner mitochondrial membrane, they initiate free radical-mediated chain reactions of lipid peroxidation and are thus especially damaging. The consequences of membrane damage are decreased electrical resistance of the membrane, oxidative damage to cardiolipin (a mitochondria specific lipid essential for functioning of respiratory chain proteins and H(+)-ATP synthase), and damage to mitochondrial DNA localized in close vicinity to the inner membrane, with consequent mitochondrial dysfunction and induction of apoptotic cascade and cell death. To target the starting point of such undesirable events, antioxidants conjugated with mitochondria-targeted, membrane-penetrating cations can be used to scavenge ROS inside mitochondria. The most demonstrative indications favoring this conclusion originate from recent discoveries of the in vivo effects of such cations belonging to the MitoQ and SkQ groups. Here we describe some essential methodological aspects of the application of mitochondria-targeted cations promising in treating oxidative stress-related pathologies.

Published
2015
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