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1. Fostering diffusion of scientific contents of National Society Cardiovascular Journals: The new ESC search engine

Author

Antoniades, Loizos, Apetrei, Eduard, Aschermann, Michael, Bolognese, Leonardo, Dilic, Mirza, Edes, Istvan, Filipiak, Krzysztof J., Guliyev, Faig, Haouala, Habib, Hassanein, Mahmoud Mohamed, Heras, Magda, Höglund, Christer, Hulin, Ivan, Huber, Kurt, Ivanusa, Mario, Marinskis, Germanas, Masic, Izet, Ostojic, Miodrag, Pachinger, Otmar, Raev, Dimitar, Rogava, Mamanti, Rødevand, Olaf, Sansoy, Vedat, Shlyakhto, Evgeny, Shumakov, Valentin A., Van der Wall, Ernst, Videbæk, Jørgen, Lüscher, Thomas F., Alfonso, Fernando, Gonçalves, Lino, Pinto, Fausto, Timmis, Adam, Ector, Hugo, Ambrosio, Giuseppe, and Vardas, Panos

Published
2015
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3. International External Validation Study of the 2014 European Society of Cardiology Guidelines on Sudden Cardiac Death Prevention in Hypertrophic Cardiomyopathy (EVIDENCE-HCM)

Author

O’Mahony, Constantinos, Jichi, Fatima, Ommen, Steve R., Christiaans, Imke, Arbustini, Eloisa, Garcia-Pavia, Pablo, Cecchi, Franco, Olivotto, Iacopo, Kitaoka, Hiroaki, Gotsman, Israel, Carr-White, Gerald, Mogensen, Jens, Antoniades, Loizos, Mohiddin, Saidi A., Maurer, Mathew S., Tang, Hak Chiaw, Geske, Jeffrey B., Siontis, Konstantinos C., Mahmoud, Karim D., Vermeer, Alexa, Wilde, Arthur, Favalli, Valentina, Guttmann, Oliver P., Gallego-Delgado, Maria, Dominguez, Fernando, Tanini, Ilaria, Kubo, Toru, Keren, Andre, Bueser, Teofila, Waters, Sarah, Issa, Issa F., Malcolmson, James, Burns, Tom, Sekhri, Neha, Hoeger, Christopher W., Omar, Rumana Z., and Elliott, Perry M.

Published
2018
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5. Conflict of interest policies and disclosure requirements among European Society of Cardiology National Cardiovascular Journals

Author

Alfonso, Fernando, Timmis, Adam, Pinto, Fausto J., Ambrosio, Giuseppe, Ector, Hugo, Kulakowski, Piotr, Vardas, Panos, Editors’ Network members, Antoniades, Loizos, Ahmad, Mansoor, Apetrei, Eduard, Arai, Kaduo, Artigou, Jean-Yves, Aschermann, Michael, Böhm, Michael, Bolognese, Leonardo, Bugiardini, Raffaele, Cohen, Ariel, Edes, Istvan, Elias, Joseph, Galeano, Javier, Guarda, Eduardo, Haouala, Habib, Heras, Magda, Höglund, Christer, Huber, Kurt, Hulin, Ivan, Ivanusa, Mario, Krittayaphong, Rungroj, Kuo, Chi-Tai, Lau, Chu-Pak, Lyusov, Victor A., Marinskis, Germanas, Márquez, Manlio F., Masic, Izet, Pinho Moreira, Luiz Felipe, Mrochek, Alexander, Oganov, Rafael G., Raev, Dimitar, Rogava, Mamanti, Rødevand, Olaf, Sansoy, Vedat, Shimokawa, Hiroaki, Shumakov, Valentin A., Tajer, Carlos Daniel, van der Wall, Ernst E., Stefanadis, Christodoulos, Videbæk, Jørgen, and Lüscher, Thomas F.

Published
2012
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6. Importance of genotype for risk stratification in arrhythmogenic right ventricular cardiomyopathy using the 2019 ARVC risk calculator

Author

Protonotarios, Alexandros, primary, Bariani, Riccardo, additional, Cappelletto, Chiara, additional, Pavlou, Menelaos, additional, García-García, Alba, additional, Cipriani, Alberto, additional, Protonotarios, Ioannis, additional, Rivas, Adrian, additional, Wittenberg, Regitze, additional, Graziosi, Maddalena, additional, Xylouri, Zafeirenia, additional, Larrañaga-Moreira, José M, additional, de Luca, Antonio, additional, Celeghin, Rudy, additional, Pilichou, Kalliopi, additional, Bakalakos, Athanasios, additional, Lopes, Luis Rocha, additional, Savvatis, Konstantinos, additional, Stolfo, Davide, additional, Dal Ferro, Matteo, additional, Merlo, Marco, additional, Basso, Cristina, additional, Freire, Javier Limeres, additional, Rodriguez-Palomares, Jose F, additional, Kubo, Toru, additional, Ripoll-Vera, Tomas, additional, Barriales-Villa, Roberto, additional, Antoniades, Loizos, additional, Mogensen, Jens, additional, Garcia-Pavia, Pablo, additional, Wahbi, Karim, additional, Biagini, Elena, additional, Anastasakis, Aris, additional, Tsatsopoulou, Adalena, additional, Zorio, Esther, additional, Gimeno, Juan R, additional, Garcia-Pinilla, Jose Manuel, additional, Syrris, Petros, additional, Sinagra, Gianfranco, additional, Bauce, Barbara, additional, and Elliott, Perry M, additional

Published
2022
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9. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries

Author

Kristensen, Steen D., Laut, Kristina G., Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F., De Boer, Menko-Jan, Claeys, Marc J., Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hansen, Kim Wadt, Huber, Kurt, James, Stefan, Janota, Tomáš, Jennings, Siobhan, Kajander, Olli, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kornowski, Ran, Ludman, Peter F., Merkely, Béla, Milicic, Davor, Najafov, Ruslan, Nicolini, Francesca A., Noč, Marko, Ostojic, Miodrag, Pereira, Hélder, Radovanovic, Dragana, Sabaté, Manel, Sobhy, Mohamed, Sokolov, Maxim, Studencan, Martin, Terzic, Ibrahim, Wahler, Steffen, Widimsky, Petr, Mühlberger, Volker, Najafov, Ruslan, Legrand, V., Spuzic, M., Hajric, R., Markota, D., Srdic, S., Jorgova, Julia, Velchev, Vassil, Petrov, Ivo, Nikolic Heitzler, V., Babic, Z., Nicolaides, Evagoras, Christodulides, Theodoros, Georgiou, Panagiota, Jansky, Petr, Stasek, Josef, Terkelsen, Christian Juhl, Galatius, Søren, Sørensen, Rikke, Sobhy, Mohamed, Shal, Ahmed El, Romppanen, Hannu, Müller, Alfred, Rustige, Jörg, Alexopoulos, Dimitrios, Kallikazaros, Ioannis, Papaioannou, Georgios, Becker, David, Ungi, Imre, Kiss, Robert Gabor, Skuladottir, Frida Bjork, Bjornsdottir, Thora K., Cavanagh, Brendan, Twomey, Kathleen, Daly, Kieran, Matetzky, Shlomi, De Luca, Leonardo, Cremonesi, Alberto, Bovenzi, Francesco, Zakke, IIja, Maca, Aija, Narbute, Inga, Antov, S., Koch, Karel T., Mimoso, Jorge, Almeida, Manuel, Pereira, Ernesto, Tatu, Gabriel, Vinereanu, Dragos, DʼAngeli, Cinzia, Nedeljkovic, Milan, Vukcevic, Vladan, Dobric, Milan, Hricak, V., Kovař, F., Kurray, P., Peral, Vincente, Tresserras, Ricard, Regueiro, Ander, Erne, Paul, Rickli, Hans, Windecker, Stephan, Kozan, Omer, Ertas, Gokhan, Kervan, Umit, Birkhead, John, and Sokolov, Yuriy

Published
2014
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11. Fostering diffusion of scientific contents of National Society Cardiovascular Journals: the new ESC search engine

Author

Alfonso, Fernando, Gonçalves, Lino, Pinto, Fausto, Timmis, Adam, Ector, Hugo, Ambrosio, Giuseppe, Vardas, Panos, Antoniades, Loizos, Apetrei, Eduard, Aschermann, Michael, Bolognese, Leonardo, Dilic, Mirza, Edes, Istvan, Filipiak, Krzysztof J., Guliyev, Faig, Haouala, Habib, Hassanein, Mahmoud Mohamed, Heras, Magda, Höglund, Christer, Hulin, Ivan, Ivanusa, Mario, Marinskis, Germanas, Masic, Izet, Monsuez, Jean-Jacques, Ostojic, Miodrag, Pachinger, Otmar, Raev, Dimitar, Rogava, Mamanti, Rødevand, Olaf, Sansoy, Vedat, Shlyakhto, Evgeny, Shumakov, Valentin A, Van der Wall, Ernst, Videbæk, Jørgen, and Lüscher, Thomas F

Published
2014
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12. The role of European national journals in education

Author

Mills, Peter, Timmis, Adam, Huber, Kurt, Ector, Hugo, Lancellotti, Patrizio, Masic, Izet, Ivanusa, Mario, Antoniades, Loizos, Aschermann, Michael, Laucevicius, Alexandras, Mustonen, Pirjo, Artigou, Jean-Yves, Vardas, Panos, Stefanadis, Christodoulos, Chiarello, Massimo, Bolognese, Leonardo, Ambrosio, Guiseppe, van der Wall, Ernst E, Kułakowski, Piotr, Pinto, Fausto J, Apetrei, Eduard, Oganov, Rafael G, Kamensky, Gabriel, Lüscher, Thomas F, Lerch, René, Haouala, Habib, Sansoy, Vedat, Shumakov, Valentin, Tajer, Carlos Daniel, Lau, Chu-Pak, Márquez, Manlio, Krittayaphong, Rungroj, Arai, Kaduo, and Alfonso, Fernando

Published
2009
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17. European Society of Cardiology: Cardiovascular Disease Statistics 2017

Author

Timmis, Adam, Townsend, Nick, Gale, Chris, Grobbee, Rick, Maniadakis, Nikos, Flather, Marcus, Wilkins, Elizabeth, Wright, Lucy, Vos, Rimke, Bax, Jeroen, Blum, Maxim, Logstrup, Susanne, Pinto, Fausto J., Vardas, Panos, Goda, Artan, Demiraj, Aurel F, Weidinger, Franz, Metzler, Bernard, Ibrahimov, Firdovsi, Pasquet, Agnes A, Claeys, Marc, Thorton, Yolanda, Kusljugic, Zumreta, Smajic, Elnur, Velchev, Vasil, Ivanov, Nikolay, Antoniades, Loizos, Agathangelou, Petros, Táborský, Miloš, Gerdes, Christian, Viigima, Margus, Juhani, Pietila Mikko, Juilliere, Yves, Cattan, Simon, Aladashvili, Alexander, Hamm, Christian, Kuck, Karl-Heinz, Papoutsis, Konstantinos, Bestehorn, Kurt, Foussas, Stefanos, Giannoulidou, Georgia, Varounis, Christos, Kallikazaros, Ioannis, Kiss, Robert Gabor, Czétényi, Tunde, Becker, Dávid, Gudnason, Thorarinn, Kearney, Peter, McDonald, Kenneth, Rozenman, Yoseph, Ziv, Batia, Bolognese, Leonardo, Luciolli, Paola, Boriani, Giuseppe, Berkinbayev, Salim, Rakisheva, Amina, Mirrakhimov, Erkin, Erglis, Andrejs, Jegere, Sandra, Marinskis, Germanas, Beissel, Jean, Marchal, Nathalie, Kedev, Sasko, Xuereb, Robert G, Tilney, Terence, Felice, Tiziana, Popovici, Mihail, Mulder, Barbara, Simoons, Maarten, Elsendoorn, Moniek, Steigen, Terje K, Atar, Dan, Kalarus, Zbigniew, Tendera, Michal, Cardoso, Jose Silva, Ribeiro, José, Mateus, Cristina, Tatu-Chitoiu, Gabriel, Seferovic, Petar, Beleslin, Branko, Simkova, Iveta, Durcikova, Petra, Belicova, Veronica, Fras, Zlatko, Radelj, Sasa, Gonzalez Juanatey, Jose Ramon, Legendre, Sharon, Braunschweig, Frieder, Kaufmann, Urs Philipp, Rudiger-Sturchler, Marjam, Tokgozoglu, Lale, Unver, Ahmet, Kovalenko, Volodymir, Nesukay, Elena, Naum, Anastasia, de Courtelary, Paola Thellung, Martin, Stephan, Sebastiao, David, Ghislain, Daval, Bardinet, Isabel, and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, Inequality, media_common.quotation_subject, Health infrastructure, Disease, 030204 cardiovascular system & hematology, European Society of Cardiology, 03 medical and health sciences, 0302 clinical medicine, Economic indicator, Internal medicine, Health care, Statistics, medicine, Cardiovascular disease, Morbidity, Mortality, Risk factors, Service provision, Cardiology and Cardiovascular Medicine, 030212 general & internal medicine, Disease burden, Cause of death, media_common, business.industry, medicine.disease, Obesity, Years of potential life lost, Cardiology, business
Abstract

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For permissions, please email: journals.permissions@oup.com., Aims: The European Society of Cardiology (ESC) Atlas has been compiled by the European Heart Agency to document cardiovascular disease (CVD) statistics of the 56 ESC member countries. A major aim of this 2017 data presentation has been to compare high-income and middle-income ESC member countries to identify inequalities in disease burden, outcomes, and service provision. Methods and results: The Atlas utilizes a variety of data sources, including the World Health Organization, the Institute for Health Metrics and Evaluation, and the World Bank to document risk factors, prevalence, and mortality of cardiovascular disease and national economic indicators. It also includes novel ESC-sponsored survey data of health infrastructure and cardiovascular service provision provided by the national societies of the ESC member countries. Data presentation is descriptive with no attempt to attach statistical significance to differences observed in stratified analyses. Important differences were identified between the high-income and middle-income member countries of the ESC with regard to CVD risk factors, disease incidence, and mortality. For both women and men, the age-standardized prevalence of hypertension was lower in high-income countries (18% and 27%) compared with middle-income countries (24% and 30%). Smoking prevalence in men (not women) was also lower (26% vs. 41%) and together these inequalities are likely to have contributed to the higher CVD mortality in middle-income countries. Declines in CVD mortality have seen cancer becoming a more common cause of death in a number of high-income member countries, but in middle-income countries declines in CVD mortality have been less consistent where CVD remains the leading cause of death. Inequalities in CVD mortality are emphasized by the smaller contribution they make to potential years of life lost in high-income countries compared with middle-income countries both for women (13% vs. 23%) and men (20% vs. 27%). The downward mortality trends for CVD may, however, be threatened by the emerging obesity epidemic that is seeing rates of diabetes increasing across all the ESC member countries. Survey data from the National Cardiac Societies showed that rates of cardiac catheterization and coronary artery bypass surgery, as well as the number of specialist centres required to deliver them, were greatest in the high-income member countries of the ESC. The Atlas confirmed that these ESC member countries, where the facilities for the contemporary treatment of coronary disease were best developed, were often those in which declines in coronary mortality have been most pronounced. Economic resources were not the only driver for delivery of equitable cardiovascular health care, as some middle-income ESC member countries reported rates for interventional procedures and device implantations that matched or exceeded the rates in wealthier member countries. Conclusion: In documenting national CVD statistics, the Atlas provides valuable insights into the inequalities in risk factors, health care delivery, and outcomes of CVD across the ESC member countries. The availability of these data will underpin the ESC’s ambitious mission ‘to reduce the burden of cardiovascular disease’ not only in its member countries but also in nation states around the world.

Published
2018

18. Arrhythmic risk assessment in genotyped families with arrhythmogenic right ventricular cardiomyopathy

Author

Protonotarios, Alexandros Anastasakis, Aris Panagiotakos, Demosthenes B. Antoniades, Loizos Syrris, Petros Vouliotis, Apostolos Stefanadis, Christodoulos Tsatsopoulou, Adalena and McKenna, William J. Protonotarios, Nikos

Abstract

Arrhythmogenic right-ventricular cardiomyopathy (ARVC) is a genetically determined disorder, mostly caused by mutations in genes encoding desmosomal proteins. We evaluated phenotype/genotype characteristics to predict the risk for the first major arrhythmic event in desmosomal-mutation-associated ARVC families. A cohort of 105 desmosomal-mutation carriers belonging to 39 consecutive ARVC families was evaluated. Serial clinical work-up consisting of history, physical examination, 12-lead/signal-averaged/24 h ambulatory ECG, and two-dimensional echocardiography was performed every 6-12 months. The predictive value of gender and genotype for the first major arrhythmic event was investigated within the cohort using time-to-event analysis. ECG/echocardiographic features were evaluated at the time of event and associated with the outcome using an age-matched nested case-control study within the cohort. Forty-three (41%) participants experienced the primary arrhythmic outcome at median age of 29 (21-46) years. The first event was sustained ventricular tachycardia in 31 and sudden cardiac death in 12. Definite diagnosis according to the 2010 Task Force criteria, showed 57% positive and 100% negative predictive value for the occurrence of arrhythmic outcome. Male gender (hazard ratio = 3.26, 95%CI, 1.63-6.51), predicted the first major arrhythmic event, independently of genotype, on multivariable analysis. Repolarization abnormalities and left-ventricular dysfunction independently associated with clinical disease profile at the time of event. Male gender, independently of genotype is an arrhythmic risk predictor in ARVC-associated desmosomal-mutation carriers. Repolarization abnormalities and left-ventricular dysfunction are important components of the first event-associated clinical disease profile.

Published
2016

19. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries

Author

Kristensen, Steen D., Laut, Kristina G., Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F., De Boer, Menko-Jan, Claeys, Marc J., Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hansen, Kim Wadt, Huber, Kurt, James, Stefan, Janota, Tomáš, Jennings, Siobhan, Kajander, Olli, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kornowski, Ran, Ludman, Peter F., Merkely, Béla, Milicic, Davor, Najafov, Ruslan, Nicolini, Francesca A., Noč, Marko, Ostojic, Miodrag, Pereira, Hélder, Radovanovic, Dragana, Sabaté, Manel, Sobhy, Mohamed, Sokolov, Maxim, Studencan, Martin, Terzic, Ibrahim, Wahler, Steffen, Widimsky, Petr, Mühlberger, Volker, Legrand, V., Spuzic, M., Hajric, R., Markota, D., Srdic, S., Jorgova, Julia, Velchev, Vassil, Petrov, Ivo, Nikolic Heitzler, V., Babic, Z., Nicolaides, Evagoras, Christodulides, Theodoros, Georgiou, Panagiota, Jansky, Petr, Stasek, Josef, Terkelsen, Christian Juhl, Galatius, Søren, Sørensen, Rikke, Shal, Ahmed El, Romppanen, Hannu, Müller, Alfred, Rustige, Jörg, Alexopoulos, Dimitrios, Kallikazaros, Ioannis, Papaioannou, Georgios, Becker, David, Ungi, Imre, Kiss, Robert Gabor, Skuladottir, Frida Bjork, Bjornsdottir, Thora K., Cavanagh, Brendan, Twomey, Kathleen, Daly, Kieran, Matetzky, Shlomi, De Luca, Leonardo, Cremonesi, Alberto, Bovenzi, Francesco, Zakke, IIja, Maca, Aija, Narbute, Inga, Antov, S., Koch, Karel T., Mimoso, Jorge, Almeida, Manuel, Pereira, Ernesto, Tatu, Gabriel, Vinereanu, Dragos, D'Angeli, Cinzia, Nedeljkovic, Milan, Vukcevic, Vladan, Dobric, Milan, Hricak, V., Kovař, F., Kurray, P., Peral, Vincente, Tresserras, Ricard, Regueiro, Ander, Erne, Paul, Rickli, Hans, Windecker, Stephan, Kozan, Omer, Ertas, Gokhan, Kervan, Umit, Birkhead, John, Sokolov, Yuriy, Kristensen, Steen D., Laut, Kristina G., Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F., De Boer, Menko-Jan, Claeys, Marc J., Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hansen, Kim Wadt, Huber, Kurt, James, Stefan, Janota, Tomáš, Jennings, Siobhan, Kajander, Olli, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kornowski, Ran, Ludman, Peter F., Merkely, Béla, Milicic, Davor, Najafov, Ruslan, Nicolini, Francesca A., Noč, Marko, Ostojic, Miodrag, Pereira, Hélder, Radovanovic, Dragana, Sabaté, Manel, Sobhy, Mohamed, Sokolov, Maxim, Studencan, Martin, Terzic, Ibrahim, Wahler, Steffen, Widimsky, Petr, Mühlberger, Volker, Legrand, V., Spuzic, M., Hajric, R., Markota, D., Srdic, S., Jorgova, Julia, Velchev, Vassil, Petrov, Ivo, Nikolic Heitzler, V., Babic, Z., Nicolaides, Evagoras, Christodulides, Theodoros, Georgiou, Panagiota, Jansky, Petr, Stasek, Josef, Terkelsen, Christian Juhl, Galatius, Søren, Sørensen, Rikke, Shal, Ahmed El, Romppanen, Hannu, Müller, Alfred, Rustige, Jörg, Alexopoulos, Dimitrios, Kallikazaros, Ioannis, Papaioannou, Georgios, Becker, David, Ungi, Imre, Kiss, Robert Gabor, Skuladottir, Frida Bjork, Bjornsdottir, Thora K., Cavanagh, Brendan, Twomey, Kathleen, Daly, Kieran, Matetzky, Shlomi, De Luca, Leonardo, Cremonesi, Alberto, Bovenzi, Francesco, Zakke, IIja, Maca, Aija, Narbute, Inga, Antov, S., Koch, Karel T., Mimoso, Jorge, Almeida, Manuel, Pereira, Ernesto, Tatu, Gabriel, Vinereanu, Dragos, D'Angeli, Cinzia, Nedeljkovic, Milan, Vukcevic, Vladan, Dobric, Milan, Hricak, V., Kovař, F., Kurray, P., Peral, Vincente, Tresserras, Ricard, Regueiro, Ander, Erne, Paul, Rickli, Hans, Windecker, Stephan, Kozan, Omer, Ertas, Gokhan, Kervan, Umit, Birkhead, John, and Sokolov, Yuriy

Abstract

Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients admitted with STEMI in the European Society of Cardiology (ESC) member countries. Methods and results A cross-sectional descriptive study based on aggregated country-level data on the use of reperfusion therapy in patients admitted with STEMI during 2010 or 2011. Thirty-seven ESC countries were able to provide data from existing national or regional registries. In countries where no such registries exist, data were based on best expert estimates. Data were collected on the use of STEMI reperfusion treatment and mortality, the numbers of cardiologists, and the availability of PPCI facilities in each country. Our survey provides a brief data summary of the degree of variation in reperfusion therapy across Europe. The number of PPCI procedures varied between countries, ranging from 23 to 884 per million inhabitants. Primary percutaneous coronary intervention and thrombolysis were the dominant reperfusion strategy in 33 and 4 countries, respectively. The mean population served by a single PPCI centre with a 24-h service 7 days a week ranged from 31 300 inhabitants per centre to 6 533 000 inhabitants per centre. Twenty-seven of the total 37 countries participated in a former survey from 2007, and major increases in PPCI utilization were observed in 13 of these countries. Conclusion Large variations in reperfusion treatment are still present across Europe. Countries in Eastern and Southern Europe reported that a substantial number of STEMI patients are not receiving any reperfusion therapy. Implementation of the best reperfusion therapy as recommended in the guidelines should be encouraged

Published
2017

20. Clinical Significance of Epsilon Waves in Arrhythmogenic Cardiomyopathy

Author

Protonotarios, Alexandros Anastasakis, Aris Tsatsopoulou, Adalena Antoniades, Loizos Prappa, Efstathia Syrris, Petros and Tousoulis, Dimitrios McKenna, William J. Protonotarios, Nikos

Abstract

Epsilon Waves in ACM IntroductionEpsilon waves are hallmark features of arrhythmogenic cardiomyopathy (ACM) but information about their clinical significance is variable. We evaluated epsilon wave prevalence, characteristics, and their clinical significance in an ACM population. Methods and ResultsEighty-six unselected patients fulfilling the 2010 Task Force criteria were enrolled. Seventy-six of them were carriers of desmosomal mutations. All subjects were serially evaluated with standard 12-lead ECG and 2-dimensional echocardiography. Epsilon waves were evaluated in all precordial and inferior leads. Novel parameters assessed included their duration and precordial/inferior lead extension. Twenty-five subjects (29%) had epsilon waves that were present in lead V3 and beyond in 9, and in the inferior leads in 7. Epsilon waves were associated with right ventricular outflow tract (RVOT) (P = 0.001) but not RV posterior wall (P = 0.21), RV apex (P = 0.30), or left ventricular (P = 0.94) wall motion abnormalities. Patients with epsilon waves had increased RVOT diameter (P < 0.0001). Extension of epsilon waves in lead V3 and beyond was associated with increased epsilon wave duration (P = 0.002) and RVOT diameter (P = 0.04). The duration of epsilon waves was positively correlated with RVOT diameter (r = 0.70, P = 0.0001). Epsilon waves were also associated with episodes of sustained ventricular tachycardia (P = 0.004) but not with heart failure (P = 0.41) or sudden cardiac death (P = 0.31). ConclusionDetection of epsilon waves on 12-lead ECG reflects significant RVOT involvement, which was associated with episodes of sustained ventricular tachycardia but not sudden cardiac death.

Published
2015

21. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)

Author

Priori, Silvia G, Blomstrom Lundqvist, Carina, Mazzanti, Andrea, Bloma, Nico, Borggrefe, Martin, Camm, John, Elliott, Perry Mark, Fitzsimons, Donna, Hatala, Robert, Hindricks, Gerhard, Kirchhof, Paulus, Kjeldsen, Keld, Kuck, Karl Heinz, Hernandez Madrid, Antonio, Nikolaou, Nikolaos, Norekval, Tone M., Spaulding, Christian, Van Veldhuisen, Dirk J., Kolh, Philippe, Lip, Gregory Y. H., Agewall, Stefan, Barón Esquivias, Gonzalo, Boriani, Giuseppe, Budts, Werner, Bueno, Héctor, Capodanno, Davide, Carerj, Scipione, Crespo Leiro, Maria G., Czerny, Martin, Deaton, Christi, Dobrev, Dobromir, Erol, Çetin, Galderisi, Maurizio, Gorenek, Bulent, Kriebel, Thomas, Lambiase, Pier, Lancellotti, Patrizio, Lane, Deirdre A., Lang, Irene, Manolis, Athanasios J., Morais, Joao, Moreno, Javier, Piepoli, Massimo F., Rutten, Frans H., Sredniawa, Beata, Zamorano, Jose Luis, Zannad, Faiez, Aboyans, Victor, Achenbach, Stephan, Badimon, Lina, Baumgartner, Helmut, Bax, Jeroen J., Dean, Veronica, Gaemperli, Oliver, Nihoyannopoulos, Petros, Ponikowski, Piotr, Roffi, Marco, Torbicki, Adam, Vaz Carneiro, Antonio, Windecker, Stephan, Piruzyan, Armen, Roithinger, Franz Xaver, Mairesse, Georges H., Goronja, Boris, Shalganov, Tchavdar, Puljević, Davor, Antoniades, Loizos, Kautzner, Josef, Larsen, Jacob Moesgaard, Aboulmaaty, Mervat, Kampus, Priit, Hedman, Antti, Kamcevska Dobrkovic, Lidija, Piot, Olivier, Etsadashvili, Kakhaber, Eckardt, Lars, Deftereos, Spyridon, Gellér, László, Gizurarson, Sigfús, Keane, David, Haim, Moti, Della Bella, Paolo, Abdrakhmanov, Ayan, Mirrakhimov, Aibek, Kalejs, Oskars, Ben Lamin, Hisham, Marinskis, Germanas, Groben, Laurent, Sammut, Mark, Raducan, Aurica, Chaib, Ali, Tande, Pål Morten, Lenarczyk, Radoslaw, Morgado, Francisco Bello, Vatasescu, Radu, Mikhaylov, Evgeny N., Hlivak, Peter, Arenal, Angel, Jensen Urstad, Mats, Sticherling, Christian, Zeppenfeld, Katja, Chettaoui, Rafik, Demir, Mesut, Duncan, Edward, Parkhomenko, Alexander, Priori, Silvia G, Blomström Lundqvist, Carina, Mazzanti, Andrea, Bloma, Nico, Borggrefe, Martin, Camm, John, Elliott, Perry Mark, Fitzsimons, Donna, Hatala, Robert, Hindricks, Gerhard, Kirchhof, Paulu, Kjeldsen, Keld, Kuck, Karl Heinz, Hernandez Madrid, Antonio, Nikolaou, Nikolao, Norekvål, Tone M., Spaulding, Christian, Van Veldhuisen, Dirk J., Kolh, Philippe, Lip, Gregory Y. H., Agewall, Stefan, Barón Esquivias, Gonzalo, Boriani, Giuseppe, Budts, Werner, Bueno, Héctor, Capodanno, Davide, Carerj, Scipione, Crespo Leiro, Maria G., Czerny, Martin, Deaton, Christi, Dobrev, Dobromir, Erol, Çetin, Galderisi, Maurizio, Gorenek, Bulent, Kriebel, Thoma, Lambiase, Pier, Lancellotti, Patrizio, Lane, Deirdre A., Lang, Irene, Manolis, Athanasios J., Morais, Joao, Moreno, Javier, Piepoli, Massimo F., Rutten, Frans H., Sredniawa, Beata, Zamorano, Jose L., and Zannad, Faiez

Subjects
medicine.medical_treatment, Left, Myocardial Infarction, Coronary Artery Disease, Arrhythmias, Amiodarone, Cardiovascular, Ventricular Dysfunction, Left, Pregnancy, Implantable cardioverter defibrillator, Myocardial infarction, Child, Sleep Apnea, Obstructive, Terminal Care, Implantable cardioverter-defibrillator, Defibrillators, Implantable, Primary Prevention, Practice Guideline, Acute Disease, Ventricular arrhythmia, Catheter Ablation, Stable coronary artery disease, Drug Therapy, Combination, Acute coronary syndrome, Autopsy, Implantable, Cardiology and Cardiovascular Medicine, Cardiomyopathies, Cardiac, Human, Sports, Heart Defects, Congenital, medicine.medical_specialty, Sleep Apnea, Cardiotonic Agents, Electric Countershock, Heart failure, Guidelines, Risk Assessment, Drug Therapy, Physiology (medical), Humans, Emergency Treatment, Congenital heart disease, Aged, Cardiac arrhythmia, medicine.disease, Valvular heart disease, Pregnancy Complications, Sudden cardiac death, Death, Sudden, Cardiac, Early Diagnosis, Medizin, Heart Valve Diseases, Guideline, Coronary artery disease, Cardiac Resynchronization Therapy, Defibrillator, Congenital, Risk Factors, Tachycardia, Ventricular Dysfunction, Cardiac resynchronization therapy, Cardiomyopathy, Resuscitation, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Defibrillators, Female, Heart Transplantation, Mental Disorders, Myocarditis, Nervous System Diseases, Out-of-Hospital Cardiac Arrest, Pregnancy Complications, Cardiovascular, Quality of Life, Stroke Volume, Heart Defects, Atrial fibrillation, Combined Modality Therapy, Death, Treatment Outcome, Anti-Arrhythmia Agent, Combination, Cardiology, medicine.drug, Catheter ablation, Acute coronary syndrome † Cardiac resynchronization therapy † Cardiomyopathy † Congenital heart disease † Defibrillator † Guidelines † Heart failure † Implantable cardioverter defibrillator † Myocardial infarction † Resuscitation † Stable coronary artery disease † Sudden cardiac death † Tachycardia † Valvular heart disease † Ventricular arrhythmia, Internal medicine, medicine, Journal Article, cardiovascular diseases, business.industry, Obstructive, Risk Factor, Sudden, business
Abstract

ACC : American College of Cardiology ACE : angiotensin-converting enzyme ACS : acute coronary syndrome AF : atrial fibrillation AGNES : Arrhythmia Genetics in the Netherlands AHA : American Heart Association AMIOVIRT : AMIOdarone Versus Implantable cardioverter-defibrillator

Published
2015
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22. Sudden unexplained death in the young: epidemiology, aetiology and value of the clinically guided genetic screening

Author

Anastasakis, Aris, primary, Papatheodorou, Efstathios, additional, Ritsatos, Konstantinos, additional, Protonotarios, Nikos, additional, Rentoumi, Vasiliki, additional, Gatzoulis, Konstantinos, additional, Antoniades, Loizos, additional, Agapitos, Emmanuel, additional, Koutsaftis, Philippos, additional, Spiliopoulou, Chara, additional, and Tousoulis, Dimitrios, additional

Published
2017
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23. Políticas de conflictos de intereses y requisitos para su declaración en las revistas cardiovasculares nacionales de la Sociedad Europea de Cardiología

Author

Alfonso, Fernando, Timmis, Adam, Pinto, Fausto J., Ambrosio, Giuseppe, Ector, Hugo, Kulakowski, Piotr, Vardas, Panos, Antoniades, Loizos, Ahmad, Mansoor, Apetrei, Eduard, Arai, Kaduo, Artigou, Jean-Yves, Aschermann, Michael, Böhm, Michael, Bolognese, Leonardo, Bugiardini, Raffaele, Cohen, Ariel, Edes, Istvan, Elias, Joseph, Galeano, Javier, Guarda, Eduardo, Haouala, Habib, Heras, Magda, Höglund, Christer, Huber, Kurt, Hulin, Ivan, Ivanusa, Mario, Krittayaphong, Rungroj, Kuo, Chi-Tai, Lau, Chu-Pak, Lyusov, Victor A., Marinskis, Germanas, Márquez, Manlio F., Masic, Izet, Pinho Moreira, Luiz Felipe, Mrochek, Alexander, Oganov, Rafael G., Raev, Dimitar, Rogava, Mamanti, Rødevand, Olaf, Sansoy, Vedat, Shimokawa, Hiroaki, Shumakov, Valentin A., Tajer, Carlos Daniel, van der Wall, Ernst E., Stefanadis, Christodoulos, Videbæk, Jørgen, and Lüscher, Thomas F.

Published
2012
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24. Fostering diffusion of scientific contents of National Society Cardiovascular Journals: The new ESC search engine

Author

Alfonso, Fernando, primary, Gonçalves, Lino, additional, Pinto, Fausto, additional, Timmis, Adam, additional, Ector, Hugo, additional, Ambrosio, Giuseppe, additional, Vardas, Panos, additional, Antoniades, Loizos, additional, Apetrei, Eduard, additional, Aschermann, Michael, additional, Bolognese, Leonardo, additional, Dilic, Mirza, additional, Edes, Istvan, additional, Filipiak, Krzysztof J., additional, Guliyev, Faig, additional, Haouala, Habib, additional, Hassanein, Mahmoud Mohamed, additional, Heras, Magda, additional, Höglund, Christer, additional, Hulin, Ivan, additional, Huber, Kurt, additional, Ivanusa, Mario, additional, Marinskis, Germanas, additional, Masic, Izet, additional, Ostojic, Miodrag, additional, Pachinger, Otmar, additional, Raev, Dimitar, additional, Rogava, Mamanti, additional, Rødevand, Olaf, additional, Sansoy, Vedat, additional, Shlyakhto, Evgeny, additional, Shumakov, Valentin A., additional, Van der Wall, Ernst, additional, Videbæk, Jørgen, additional, and Lüscher, Thomas F., additional

Published
2015
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25. Arrhythmic risk assessment in genotyped families with arrhythmogenic right ventricular cardiomyopathy

Author

Protonotarios, Alexandros, primary, Anastasakis, Aris, additional, Panagiotakos, Demosthenes B., additional, Antoniades, Loizos, additional, Syrris, Petros, additional, Vouliotis, Apostolos, additional, Stefanadis, Christodoulos, additional, Tsatsopoulou, Adalena, additional, McKenna, William J., additional, and Protonotarios, Nikos, additional

Published
2015
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26. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011:current status in 37 ESC countries

Author

Kristensen, Steen D, Laut, Kristina G, Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F, De Boer, Menko-Jan, Claeys, Marc J, Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hansen, Kim Wadt, Huber, Kurt, James, Stefan, Janota, Tomáš, Jennings, Siobhan, Kajander, Olli, Kanakakis, John, Karamfiloff, Kiril K, Kedev, Sasko, Kornowski, Ran, Ludman, Peter F, Merkely, Béla, Milicic, Davor, Najafov, Ruslan, Nicolini, Francesca A, Noč, Marko, Ostojic, Miodrag, Pereira, Hélder, Radovanovic, Dragana, Sabaté, Manel, Sobhy, Mohamed, Sokolov, Maxim, Studencan, Martin, Terzic, Ibrahim, Wahler, Steffen, Widimsky, Petr, Kristensen, Steen D, Laut, Kristina G, Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F, De Boer, Menko-Jan, Claeys, Marc J, Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hansen, Kim Wadt, Huber, Kurt, James, Stefan, Janota, Tomáš, Jennings, Siobhan, Kajander, Olli, Kanakakis, John, Karamfiloff, Kiril K, Kedev, Sasko, Kornowski, Ran, Ludman, Peter F, Merkely, Béla, Milicic, Davor, Najafov, Ruslan, Nicolini, Francesca A, Noč, Marko, Ostojic, Miodrag, Pereira, Hélder, Radovanovic, Dragana, Sabaté, Manel, Sobhy, Mohamed, Sokolov, Maxim, Studencan, Martin, Terzic, Ibrahim, Wahler, Steffen, and Widimsky, Petr

Abstract

AIMS: Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients admitted with STEMI in the European Society of Cardiology (ESC) member countries.METHODS AND RESULTS: A cross-sectional descriptive study based on aggregated country-level data on the use of reperfusion therapy in patients admitted with STEMI during 2010 or 2011. Thirty-seven ESC countries were able to provide data from existing national or regional registries. In countries where no such registries exist, data were based on best expert estimates. Data were collected on the use of STEMI reperfusion treatment and mortality, the numbers of cardiologists, and the availability of PPCI facilities in each country. Our survey provides a brief data summary of the degree of variation in reperfusion therapy across Europe. The number of PPCI procedures varied between countries, ranging from 23 to 884 per million inhabitants. Primary percutaneous coronary intervention and thrombolysis were the dominant reperfusion strategy in 33 and 4 countries, respectively. The mean population served by a single PPCI centre with a 24-h service 7 days a week ranged from 31 300 inhabitants per centre to 6 533 000 inhabitants per centre. Twenty-seven of the total 37 countries participated in a former survey from 2007, and major increases in PPCI utilization were observed in 13 of these countries.CONCLUSION: Large variations in reperfusion treatment are still present across Europe. Countries in Eastern and Southern Europe reported that a substantial number of STEMI patients are not receiving any reperfusion therapy. Implementation of the best reperfusion therapy as recommended in the guidelines should be encouraged.

Published
2014

27. El papel de las revistas nacionales europeas en la formación médica

Author

Mills, Peter, Timmis, Adam, Huber, Kurt, Ector, Hugo, Lancellotti, Patrizio, Masic, Izet, Ivanusa, Mario, Antoniades, Loizos, Aschermann, Michael, Videvæk, Jørgen, Laucevicius, Aleksandras, Mustonen, Pirjo, Artigou, Jean-Yves, Vardas, Panos, Stefanadis, Christodoulos, Chiariello, Massimo, Bolognese, Leonardo, Ambrosio, Guiseppe, van der Wall, Ernst E., Kulakowski, Piotr, Pinto, Fausto J., Apetrei, Eduard, Oganov, Rafael G., Kamensky, Gabriel, Lüscher, Thomas F., Lerch, René, Haouala, Habib, Sansoy, Vedat, Shumakov, Valentin, Tajer, Carlos Daniel, Lau, Chu-Pak, Márquez, Manlio, Krittayaphong, Rungroj, Arai, Kaduo, and Alfonso, Fernando

Published
2009
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28. Arrhythmogenic right ventricular cardiomyopathy/dysplasia on the basis of the revised diagnostic criteria in affected families with desmosomal mutations

Author

Protonotarios, Nikos, primary, Anastasakis, Aris, additional, Antoniades, Loizos, additional, Chlouverakis, Gregory, additional, Syrris, Petros, additional, Basso, Cristina, additional, Asimaki, Angeliki, additional, Theopistou, Artemisia, additional, Stefanadis, Christodoulos, additional, Thiene, Gaetano, additional, McKenna, William J., additional, and Tsatsopoulou, Adalena, additional

Published
2011
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29. The role of European national journals in education

Author

Mills, Peter, primary, Timmis, Adam, additional, Huber, Kurt, additional, Ector, Hugo, additional, Lancellotti, Patrizio, additional, Masic, Izet, additional, Ivanusa, Mario, additional, Antoniades, Loizos, additional, Aschermann, Michael, additional, Laucevicius, Alexandras, additional, Mustonen, Pirjo, additional, Artigou, Jean-Yves, additional, Vardas, Panos, additional, Stefanadis, Christodoulos, additional, Chiarello, Massimo, additional, Bolognese, Leonardo, additional, Ambrosio, Guiseppe, additional, van der Wall, Ernst E, additional, Kułakowski, Piotr, additional, Pinto, Fausto J, additional, Apetrei, Eduard, additional, Oganov, Rafael G, additional, Kamensky, Gabriel, additional, Lüscher, Thomas F, additional, Lerch, René, additional, Haouala, Habib, additional, Sansoy, Vedat, additional, Shumakov, Valentin, additional, Tajer, Carlos D, additional, Lau, Chu-Pak, additional, Márquez, Manlio, additional, Krittayaphong, Rungroj, additional, Arai, Kaduo, additional, and Alfonso, Fernando, additional

Published
2010
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30. The Role of European National Journals in Education

Author

Mills, Peter, primary, Timmis, Adam, additional, Huber, Kurt, additional, Ector, Hugo, additional, Lancellotti, Patrizio, additional, Masic, Izet, additional, Ivanusa, Mario, additional, Antoniades, Loizos, additional, Aschermann, Michael, additional, Videvæk, Jørgen, additional, Laucevicius, Aleksandras, additional, Mustonen, Pirjo, additional, Artigou, Jean-Yves, additional, Vardas, Panos, additional, Stefanadis, Christodoulos, additional, Chiariello, Massimo, additional, Bolognese, Leonardo, additional, Ambrosio, Guiseppe, additional, van der Wall, Ernst E., additional, Kulakowski, Piotr, additional, Pinto, Fausto J., additional, Apetrei, Eduard, additional, Oganov, Rafael G., additional, Kamensky, Gabriel, additional, Lüscher, Thomas F., additional, Lerch, René, additional, Haouala, Habib, additional, Sansoy, Vedat, additional, Shumakov, Valentin, additional, Tajer, Carlos Daniel, additional, Lau, Chu-Pak, additional, Márquez, Manlio, additional, Krittayaphong, Rungroj, additional, Arai, Kaduo, additional, and Alfonso, Fernando, additional

Published
2009
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33. Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries

Author

Kristensen, Steen D., Laut, Kristina G., Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F., De Boer, Menko-Jan, Claeys, Marc J., Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hansen, Kim Wadt, Huber, Kurt, James, Stefan, Janota, Tomáš, Jennings, Siobhan, Kajander, Olli, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kornowski, Ran, Ludman, Peter F., Merkely, Béla, Milicic, Davor, Najafov, Ruslan, Nicolini, Francesca A., Noč, Marko, Ostojic, Miodrag, Pereira, Hélder, Radovanovic, Dragana, Sabaté, Manel, Sobhy, Mohamed, Sokolov, Maxim, Studencan, Martin, Terzic, Ibrahim, Wahler, Steffen, Widimsky, Petr, Mühlberger, Volker, Legrand, V., Spuzic, M., Hajric, R., Markota, D., Srdic, S., Jorgova, Julia, Velchev, Vassil, Petrov, Ivo, Nikolic Heitzler, V., Babic, Z., Nicolaides, Evagoras, Christodulides, Theodoros, Georgiou, Panagiota, Jansky, Petr, Stasek, Josef, Terkelsen, Christian Juhl, Galatius, Søren, Sørensen, Rikke, Shal, Ahmed El, Romppanen, Hannu, Müller, Alfred, Rustige, Jörg, Alexopoulos, Dimitrios, Kallikazaros, Ioannis, Papaioannou, Georgios, Becker, David, Ungi, Imre, Kiss, Robert Gabor, Skuladottir, Frida Bjork, Bjornsdottir, Thora K., Cavanagh, Brendan, Twomey, Kathleen, Daly, Kieran, Matetzky, Shlomi, De Luca, Leonardo, Cremonesi, Alberto, Bovenzi, Francesco, Zakke, IIja, Maca, Aija, Narbute, Inga, Antov, S., Koch, Karel T., Mimoso, Jorge, Almeida, Manuel, Pereira, Ernesto, Tatu, Gabriel, Vinereanu, Dragos, D'Angeli, Cinzia, Nedeljkovic, Milan, Vukcevic, Vladan, Dobric, Milan, Hricak, V., Kovař, F., Kurray, P., Peral, Vincente, Tresserras, Ricard, Regueiro, Ander, Erne, Paul, Rickli, Hans, Windecker, Stephan, Kozan, Omer, Ertas, Gokhan, Kervan, Umit, Birkhead, John, Sokolov, Yuriy, Kristensen, Steen D., Laut, Kristina G., Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F., De Boer, Menko-Jan, Claeys, Marc J., Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, Gudnason, Thorarinn, Hansen, Kim Wadt, Huber, Kurt, James, Stefan, Janota, Tomáš, Jennings, Siobhan, Kajander, Olli, Kanakakis, John, Karamfiloff, Kiril K., Kedev, Sasko, Kornowski, Ran, Ludman, Peter F., Merkely, Béla, Milicic, Davor, Najafov, Ruslan, Nicolini, Francesca A., Noč, Marko, Ostojic, Miodrag, Pereira, Hélder, Radovanovic, Dragana, Sabaté, Manel, Sobhy, Mohamed, Sokolov, Maxim, Studencan, Martin, Terzic, Ibrahim, Wahler, Steffen, Widimsky, Petr, Mühlberger, Volker, Legrand, V., Spuzic, M., Hajric, R., Markota, D., Srdic, S., Jorgova, Julia, Velchev, Vassil, Petrov, Ivo, Nikolic Heitzler, V., Babic, Z., Nicolaides, Evagoras, Christodulides, Theodoros, Georgiou, Panagiota, Jansky, Petr, Stasek, Josef, Terkelsen, Christian Juhl, Galatius, Søren, Sørensen, Rikke, Shal, Ahmed El, Romppanen, Hannu, Müller, Alfred, Rustige, Jörg, Alexopoulos, Dimitrios, Kallikazaros, Ioannis, Papaioannou, Georgios, Becker, David, Ungi, Imre, Kiss, Robert Gabor, Skuladottir, Frida Bjork, Bjornsdottir, Thora K., Cavanagh, Brendan, Twomey, Kathleen, Daly, Kieran, Matetzky, Shlomi, De Luca, Leonardo, Cremonesi, Alberto, Bovenzi, Francesco, Zakke, IIja, Maca, Aija, Narbute, Inga, Antov, S., Koch, Karel T., Mimoso, Jorge, Almeida, Manuel, Pereira, Ernesto, Tatu, Gabriel, Vinereanu, Dragos, D'Angeli, Cinzia, Nedeljkovic, Milan, Vukcevic, Vladan, Dobric, Milan, Hricak, V., Kovař, F., Kurray, P., Peral, Vincente, Tresserras, Ricard, Regueiro, Ander, Erne, Paul, Rickli, Hans, Windecker, Stephan, Kozan, Omer, Ertas, Gokhan, Kervan, Umit, Birkhead, John, and Sokolov, Yuriy

Abstract

Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in patients admitted with STEMI in the European Society of Cardiology (ESC) member countries. Methods and results A cross-sectional descriptive study based on aggregated country-level data on the use of reperfusion therapy in patients admitted with STEMI during 2010 or 2011. Thirty-seven ESC countries were able to provide data from existing national or regional registries. In countries where no such registries exist, data were based on best expert estimates. Data were collected on the use of STEMI reperfusion treatment and mortality, the numbers of cardiologists, and the availability of PPCI facilities in each country. Our survey provides a brief data summary of the degree of variation in reperfusion therapy across Europe. The number of PPCI procedures varied between countries, ranging from 23 to 884 per million inhabitants. Primary percutaneous coronary intervention and thrombolysis were the dominant reperfusion strategy in 33 and 4 countries, respectively. The mean population served by a single PPCI centre with a 24-h service 7 days a week ranged from 31 300 inhabitants per centre to 6 533 000 inhabitants per centre. Twenty-seven of the total 37 countries participated in a former survey from 2007, and major increases in PPCI utilization were observed in 13 of these countries. Conclusion Large variations in reperfusion treatment are still present across Europe. Countries in Eastern and Southern Europe reported that a substantial number of STEMI patients are not receiving any reperfusion therapy. Implementation of the best reperfusion therapy as recommended in the guidelines should be encouraged

34. Corrigendum to: Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries.

Author

Kristensen, Steen D., Laut, Kristina G., Fajadet, Jean, Kaifoszova, Zuzana, Kala, Petr, Di Mario, Carlo, Wijns, William, Clemmensen, Peter, Agladze, Vaja, Antoniades, Loizos, Alhabib, Khalid F., De Boer, Menko-Jan, Claeys, Marc J., Deleanu, Dan, Dudek, Dariusz, Erglis, Andrejs, Gilard, Martine, Goktekin, Omer, Guagliumi, Giulio, and Gudnason, Thorarinn

Published
2014

35. Naxos Disease and Related Cardio-Cutaneous Syndromes.

Author

Protonotarios A, Asimaki A, Basso C, Xylouri Z, Monda E, Protonotarios I, Crisci G, Abrahms DJ, Anastasakis A, Antoniades L, Bakalakos A, Carbone A, S Coonar A, Gimeno JR, Lazaros G, Lerakis S, Mestroni L, Papadopoulos G, Pecchia L, Prandi FR, Syrris P, Cadrin-Turigny J, Vasilakis A, Saffitz JE, Gaetano Thiene S, Elliott PM, Kaski JP, McKenna WJ, Bossone E, Limongelli G, and Tsatsopoulou A

Abstract

Naxos disease is a rare autosomal recessive condition combining arrhythmogenic right ventricular cardiomyopathy, woolly hair, and palmoplantar keratoderma. The first identified causative variant was in the gene encoding the desmosomal protein plakoglobin. Naxos disease exhibits fibro-fatty myocardial replacement with immunohistological abnormalities in cardiac protein and signaling pathways, highlighting the role of inflammation and potential anti-inflammatory treatments. Childhood cutaneous signs precede cardiac features, which are diagnosed by familial and genetic evaluation, electrocardiography and cardiac imaging. Disease progression necessitates holistic care with risk management and lifestyle adjustments, often needing treatment for arrhythmia and heart failure. Similar phenotypes have been linked to desmoplakin and rarely desmocollin2 gene variants, highlighting the importance of familial and genetic evaluation. This document summarizes current knowledge on Naxos disease and related cardiocutaneous syndromes and initiates an international endeavor to collect and study all global cases, aiming to improve understanding, treatment, and patient care through shared data and research., Competing Interests: Dr Protonotarios holds consulting agreements with Tenaya Therapeutics and Avidity Biosciences. Dr Crisci has received a research grant by the CardioPath program from Federico II University of Naples, Italy. Dr Abrams is a consultant/scientific advisory board for Thryv Therapeutics, Rockets Pharmaceuticals, Solid Biosciences. Dr Anastasakis is on the advisory board of Pfizer, Genesis, Takeda, Sanofi, and BMS. Dr Mestroni has received grant support from Tenaya Therapeutics, Pfizer, AstraZeneca, Owkin, Greenstone Bioscience, and Bristol Myers Squibb; and is a member of the scientific advisory board of Tenaya Therapeutics. Dr Saffitz is consultant for Implicit Bioscience and Rocket Pharmaceuticals. Dr McKenna is a scientific advisor to Health in Code and to Tenaya Therapeutics. Dr Elliott holds consultancies in Biomarin, Pfizer, BMS, and the Patent: US Pat No 62/903,103: GENE THERAPY COMPOSITIONS AND TREATMENT OF RIGHT VENTRICULAR ARRYTHMOGENIC CARDIOMYOPATHY. Dr Kaski has consultancy/advisory board activities with Tenaya Therapeutics, Cytokinetics, Lexeo, Avidity Biosciences, and Accord Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (© 2025 The Authors.)

Published
2025
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36. Sudden unexplained death in the young: epidemiology, aetiology and value of the clinically guided genetic screening.

Author

Anastasakis A, Papatheodorou E, Ritsatos K, Protonotarios N, Rentoumi V, Gatzoulis K, Antoniades L, Agapitos E, Koutsaftis P, Spiliopoulou C, and Tousoulis D

Subjects
Adolescent, Adult, Age of Onset, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac physiopathology, Autopsy, Cause of Death, Child, Child, Preschool, Echocardiography, Electrocardiography, Female, Genetic Markers, Genetic Predisposition to Disease, Greece epidemiology, Heredity, Humans, Incidence, Infant, Male, Pedigree, Phenotype, Predictive Value of Tests, Prospective Studies, Risk Factors, Young Adult, Arrhythmias, Cardiac genetics, Arrhythmias, Cardiac mortality, DNA Mutational Analysis, Death, Sudden, Cardiac epidemiology, Genetic Testing methods, Mutation
Abstract

Aims: To determine the incidence and the causes of sudden death (SD) in persons aged 1-35 years old and the diagnostic yield of clinically guided genetic screening in the sudden arrhythmic death syndrome (SADS) victims' families., Methods and Results: Incidence and causes of SD in the Attica region of Greece in 2002-10 were determined using death certificates and autopsy reports. We evaluated clinically consecutive families of SADS victims and if a clinical diagnosis was established, we proceeded to targeted genetic analysis. Out of 6030 deaths, 56% were due to traumatic or violent causes, 40.5% were natural deaths, and 3.3% were of undetermined cause. There were 349 SD cases. Cardiovascular causes accounted for 65%, non-cardiovascular causes for 17%, and SADS for 18%. Clinical evaluation identified an inherited heart disease in 5/20 SADS families (25%). Targeted genetic analysis identified a causative mutation in all of the five screened families and reconfirmed the diagnosis in three of five proband victims. Clinical and genetic evaluation of 28 family members identified eight affected carriers and eight non-affected carriers. Molecular autopsy failed to identify any of these families., Conclusion: Sudden death in the young is of cardiovascular origin in the majority of cases. A considerable rate of SD cases remains of unknown cause on post-mortem. Apart from channelopathies, subclinical forms of inherited structural heart diseases would appear to be implicated in SADS. Clinically guided genetic screening has a significant diagnostic yield and identifies affected families that would have been missed by the current suggested molecular autopsy panel., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For Permissions, please email: journals.permissions@oup.com.)

Published
2018
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37. Epidemiology of acute coronary syndromes in the Mediterranean island of Cyprus (CYPACS study, Cyprus study of acute coronary syndromes).

Author

Antoniades L, Christodoulides T, Georgiou P, Hadjilouca C, Christodoulou E, Papasavas E, Nicolaides E, Panagiotakos D, and Pitsavos C

Subjects
Aged, Comorbidity, Cyprus epidemiology, Disease Management, Female, Hospital Mortality, Hospitalization statistics & numerical data, Humans, Incidence, Male, Middle Aged, Risk Factors, Sex Factors, Acute Coronary Syndrome diagnosis, Acute Coronary Syndrome mortality, Acute Coronary Syndrome therapy, Cardiovascular Agents therapeutic use, Hypertension epidemiology, Myocardial Revascularization methods, Myocardial Revascularization statistics & numerical data, Tobacco Smoke Pollution statistics & numerical data
Abstract

Introduction: So far, no studies have been performed regarding the epidemiology and management of acute coronary syndromes (ACS) in Cyprus. The aim of the present study was to enroll a representative sample of patients in order to study the epidemiology and management of ACS in the Mediterranean island of Cyprus., Methods: For a period of 12 months, all patients admitted to Nicosia General Hospital with an ACS were studied. The calculation of the annual incidence of ACS was based on the number of all ACS cases registered during one year in the Nicosia district. The results from the province of Nicosia can be considered as representative of the whole ACS profile in Cyprus., Results: The annual incidence of ACS in the Nicosia district was 160 per 100,000 inhabitants (41 per 100,000 women and 282 per 100,000 men). This percentage translates into 1342 ACS episodes annually among the Cypriot population. The ratio of men to women was 6.8:1. More female ACS patients than men had hypertension (67.3% vs. 46.3%, p=0.005) and were passive smokers (53.8% vs. 47.7%, p=0.4), while male patients with ACS included a significantly greater percentage of smokers compared to women (51.3% vs. 13.5%, p<0.001). Regarding the type of ACS, 45% of patients were diagnosed with STEMI, 41.3% with NSTEMI and 13.7% with unstable angina. The majority of patients with STEMI were treated with medical reperfusion. The in-hospital mortality rate was 3.5%., Conclusions: The annual incidence of ACS in Cyprus is below the European average. The management of ACS is similar to that in southern Europe. The majority of patients with STEMI are treated with pharmacological reperfusion. The small geographical area of the island provides the advantage of early reperfusion to the majority of patients, which results in very low in-hospital mortality.

Published
2014

38. Homocysteine levels and MTHFR polymorphisms in young patients with acute myocardial infarction: a case control study.

Author

Eftychiou C, Antoniades L, Makri L, Koumas L, Costeas PA, Kyriakou E, Nicolaides E, and Papadogiannis D

Subjects
Adult, Case-Control Studies, Cyprus, Humans, Hyperhomocysteinemia genetics, Male, Middle Aged, Myocardial Infarction blood, Myocardial Infarction etiology, Polymerase Chain Reaction, Polymorphism, Genetic, Risk Factors, Young Adult, Homocysteine blood, Hyperhomocysteinemia complications, Methylenetetrahydrofolate Reductase (NADPH2) genetics, Myocardial Infarction genetics
Abstract

Introduction: Increased levels of homocysteine are known to be associated with coronary artery disease (CAD). The most common form of genetic hyperhomocysteinemia results from MTHFR polymorphisms. To examine the role of homocysteine levels and MTHFR polymorphisms in premature CAD and acute myocardial infarction (MI) in the Cypriot population, a case control study was performed in Nicosia General Hospital., Methods: Sixty-three male patients less than 50 years old who presented with MI in Nicosia General Hospital were compared with 54 controls without CAD. Fasting homocysteine and lipids were tested within 24 hrs from admission, while MTHFR C677T and A1298C polymorphisms were also tested., Results: Mean homocysteine levels were 14.5 mol/L in patients and 12.3 mol/L in controls (p=0.017). Mutant homozygous MTHFR C677T was present in 17.7% of the patients and 19.2% of the controls (p=0.838), while mutant homozygous MTHFR A1298C was found in 16.1% of patients and 13.5% of controls (p=0.690). Mean homocysteine levels were 12.6 mol/L in patients with single-vessel CAD and 15.5 mol/L in patients with multi-vessel CAD (p=0.025). Lower HDL appeared to be associated with higher levels of homocysteine with an odds ratio of 0.901, indicating that for each unit increase in HDL, the expected odds of having high homocysteine levels decreased by approximately 10%., Conclusions: Higher levels of homocysteine are associated with acute MI and multi-vessel disease in Cypriot patients under the age of 50. The existence and extent of disease are not associated with MTHFR polymorphisms. Lower HDL is associated with higher levels of homocysteine.

Published
2012

39. [Conflict of interest policies and disclosure requirements among European Society of Cardiology national cardiovascular journals].

Author

Alfonso F, Timmis A, Pinto FJ, Ambrosio G, Ector H, Kulakowski P, Vardas P, Antoniades L, Ahmad M, Apetrei E, Arai K, Artigou JY, Aschermann M, Böhm M, Bolognese L, Bugiardini R, Cohen A, Edes I, Elias J, Galeano J, Guarda E, Haouala H, Heras M, Höglund C, Huber K, Hulin I, Ivanusa M, Krittayaphong R, Kuo CT, Lau CP, Lyusov VA, Marinskis G, Márquez MF, Masic I, Pinho-Moreira LF, Mrochek A, Oganov RG, Raev D, Rogava M, Rødevand O, Sansoy V, Shimokawa H, Shumakov VA, Tajer CD, van der Wall EE, Stefanadis C, Videbæk J, and Lüscher TF

Subjects
Cardiology, Conflict of Interest, Disclosure standards, Periodicals as Topic standards, Societies, Medical
Abstract

Disclosure of potential conflicts of interest is used by biomedical journals to guarantee credibility and transparency of the scientific process. Conflict of interest disclosure, however, is not systematically nor consistently dealt with by journals. Recent joint editorial efforts paved the way towards the implementation of uniform vehicles for conflicts of interest disclosure. This paper provides a comprehensive editorial perspective on classical conflict of interest-related issues. New insights into current conflicts of interest policies and practices among European Society of Cardiology national cardiovascular journals, as derived from a cross-sectional survey using a standardized questionnaire, are discussed.

Published
2012

40. A penetrating heart injury resulting in ventricular septal defect.

Author

Antoniades L, Petrou PM, Eftychiou C, and Nicolaides E

Subjects
Echocardiography, Transesophageal, Electrocardiography, Female, Heart Injuries psychology, Heart Septal Defects, Ventricular diagnostic imaging, Heart Septal Defects, Ventricular surgery, Humans, Middle Aged, Suicide, Attempted, Wounds, Penetrating psychology, Heart Injuries complications, Heart Septal Defects, Ventricular etiology, Wounds, Penetrating complications
Abstract

Penetrating heart injuries can be lethal. Here we report a case of self-inflicted cardiac injury with glass fragments by a psychiatric patient. The patient presented with cardiogenic shock and was initially treated surgically for a large pneumothorax and cardiac tamponade. A few days later she presented with dyspnoea and hypotension. An echo-Doppler study was performed and an acquired post-traumatic ventricular septal defect (VSD) with left-to-right shunt was diagnosed. The patient was transferred to theatre where the defect was successfully repaired. Post-traumatic VSD is a rare complication of penetrating heart injuries and has a tendency to present late. Follow up of such cases is recommended with repeat echocardiography.

Published
2011

41. Recommendations for the cardiovascular screening of athletes.

Author

Deligiannis A, Anastasakis A, Antoniades L, Bobotis G, Geleris P, Goudevenos J, Hahalis G, Kouidi E, Kranidis A, Kremastinos D, Lekakis J, Parcharidis G, Pyrgakis V, Rontogiannis G, Stefanadis C, Styliadis I, and Vardas P

Subjects
Adaptation, Physiological, Clinical Protocols, Death, Sudden, Cardiac epidemiology, Echocardiography, Doppler, Electrocardiography, Exercise physiology, Heart physiology, Heart physiopathology, Humans, Mass Screening, Risk Assessment, Cardiovascular Diseases diagnosis, Death, Sudden, Cardiac prevention & control, Sports physiology, Sports statistics & numerical data
Published
2010

42. The role of European National Journals in education.

Author

Mills P, Timmis A, Huber K, Ector H, Masic I, Ivanusa M, Antoniades L, Aschermann M, Laucevicius A, Mustonen P, Artigou JY, Vardas P, Stefanadis C, Chiarello M, Bolognese L, Ambrosio G, van der Wall EE, Kułakowski P, Pinto FJ, Apetrei E, Oganov RG, Kamensky G, Lüscher TF, Lerch R, Haouala H, Sansoy V, Shumakov V, Tajer CD, Lau CP, Márquez MF, Krittayaphong R, Arai K, and Alfonso F

Subjects
Europe, Cardiology education, Education, Medical, Continuing methods, Periodicals as Topic
Published
2009

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