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Background. Interest in electroencephalographic (EEG) coronavirus disease 2019 (COVID-19) findings has been growing, especially in the search for a specific-features EEG of encephalopathy. Methods. We made a retrospective analysis of 29 EEGs recorded in 15 patients with COVID-19 and neurological symptoms. We classified the EEGs as “Acute EEG” and “follow-up EEG.” We did a statistical analysis between voltage and respiratory status of the patient, stay or not in the intensive care unit (ICU), days of stay in the ICU, sedative drugs, pharmacological treatment, type of symptoms predominating, and outcome. Results. We found EEG abnormalities in all patients studied. We observed the amplitude of background

Objective We report a kindred with a genetic form of REM behaviour disorder (RBD) with autosomal dominant transmission. Patients and methods Clinical, polysomnography study, genetic study and brain MRI were performed to evaluate the index patients. The genetic study included exome sequencing of the index cases that detected 60,869 variants in the individuals examined. Results The kindred has a RBD with autosomal dominant transmission starting in second decade of life. After filtering out the exome variants shared by two affected cases the pool of variants could be reduced to thirteen; one of them is in PVALB, a calcium-binding albumin protein present in gabaergic interneurons in the nervous system that inhibit the pyramidal cell during REM sleep. Conclusions RBD can have a genetic origin. The results of the exome study in this kindred suggest that gabaergic circuits may be altered in patients with RBD. Further studies in this family or in other pedigrees with familial RBD may clear the role of this gene in this disorder.

Introduction Postanoxic coma after cardiac arrest is one of the most serious acute cerebral conditions and a frequent cause of admission to critical care units, wherefore is necessary the use of accurate methods for diagnosis and prognosis. In addition to the classic neurologic examination, EEG is increasingly emerging as an important tool to assess cerebral functions in a non-invasive way because is a sensitive method for evaluating patients with anoxic-ischaemic encephalopathy due to cardiorrespiratory arrest (CRA) and provides accurate prognostic information in the early phase of coma however, its specificity is affected by the action of sedative drugs and the variability inter-observers. The EEG shows several patterns that may be useful for the prognosis and possible progression of patients with post-CRA coma. The aim of this study is to describe the morphology and analyze the prognostic value of the EEG patterns and reactivity to stimuli in post-CRA coma patients. Methods 45 patients with CRA were analyzed. The variables established in the study included age, sex, pathological history, time of CRA, cause of CRA, therapeutic hypothermia, EEG (pattern and reactivity) and clinical development. All EEG studies were done without sedation drugs at least for 8 h and 24 h after therapeutic hypothermia (TH). Results The initial EEG and the control EEGs in the patients were analyzed and an attempt was made to establish a correlation between the various EEG patterns and the clinical evolution of the patients. Surprisingly, the EEG reactivity was the parameter that, in isolation, presented greater specificity in our series. Conclusion The EEG provides early information on brain function and prognosis in the context of a multimodal assessment of coma patients with recovered CRA. The standardization in the nomenclature of the EEG patterns following the terminology of the ACNS helps the easy recognition of these patterns and their correlation with the prognosis. It is essential to evaluate reactivity in this patients, given that this seems to be the most relevant data when estimating a prognosis.