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28 results on '"Ao, Jian-Yang"'

4. Supplementary figure legends from Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma

Author

Ao, Jian-Yang, primary, Zhu, Xiao-Dong, primary, Chai, Zong-Tao, primary, Cai, Hao, primary, Zhang, Yuan-Yuan, primary, Zhang, Ke-Zhi, primary, Kong, Ling-Qun, primary, Zhang, Ning, primary, Ye, Bo-Gen, primary, Ma, De-Ning, primary, and Sun, Hui-Chuan, primary

Published
2023
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5. Supplementary figures S1-9 from Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma

Author

Ao, Jian-Yang, primary, Zhu, Xiao-Dong, primary, Chai, Zong-Tao, primary, Cai, Hao, primary, Zhang, Yuan-Yuan, primary, Zhang, Ke-Zhi, primary, Kong, Ling-Qun, primary, Zhang, Ning, primary, Ye, Bo-Gen, primary, Ma, De-Ning, primary, and Sun, Hui-Chuan, primary

Published
2023
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6. Supplementary Tables S1-3 from Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma

Author

Ao, Jian-Yang, primary, Zhu, Xiao-Dong, primary, Chai, Zong-Tao, primary, Cai, Hao, primary, Zhang, Yuan-Yuan, primary, Zhang, Ke-Zhi, primary, Kong, Ling-Qun, primary, Zhang, Ning, primary, Ye, Bo-Gen, primary, Ma, De-Ning, primary, and Sun, Hui-Chuan, primary

Published
2023
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7. Exploring the constitutive activation mechanism of the class A orphan GPR20

Author

Zhang, Ming-yang, Ao, Jian-yang, Liu, Ning, Chen, Ting, and Lu, Shao-yong

Abstract

GPR20, an orphan G protein-coupled receptor (GPCR), shows significant expression in intestinal tissue and represents a potential therapeutic target to treat gastrointestinal stromal tumors. GPR20 performs high constitutive activity when coupling with Gi. Despite the pharmacological importance of GPCR constitutive activation, determining the mechanism has long remained unclear. In this study, we explored the constitutive activation mechanism of GPR20 through large-scale unbiased molecular dynamics simulations. Our results unveil the allosteric nature of constitutively activated GPCR signal transduction involving extracellular and intracellular domains. Moreover, the constitutively active state of the GPR20 requires both the N-terminal cap and Giprotein. The N-terminal cap of GPR20 functions like an agonist and mediates long-range activated conformational shift. Together with the previous study, this study enhances our knowledge of the self-activation mechanism of the orphan receptor, facilitates the drug discovery efforts that target GPR20.

Published
2024
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11. Impact of splenomegaly and splenectomy on prognosis in hepatocellular carcinoma with portal vein tumor thrombus treated with hepatectomy

Author

Chai, Zong-Tao, primary, Zhang, Xiu-Ping, additional, Shao, Min, additional, Ao, Jian-Yang, additional, Chen, Zhen-Hua, additional, Zhang, Fan, additional, Hu, Yi-Ren, additional, Zhong, Cheng-Qian, additional, Lin, Jian-Hua, additional, Fang, Kun-Peng, additional, Wu, Meng-Chao, additional, Lau, Wan Yee, additional, and Cheng, Shu-Qun, additional

Published
2021
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13. CD31 regulates metastasis by inducing epithelial–mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway

Author

Zhang, Yuan-Yuan, primary, Kong, Ling-Qun, additional, Zhu, Xiao-Dong, additional, Cai, Hao, additional, Wang, Cheng-Hao, additional, Shi, Wen-Kai, additional, Cao, Man-Qing, additional, Li, Xiao-Long, additional, Li, Kang-Shuai, additional, Zhang, Shi-Zhe, additional, Chai, Zong-Tao, additional, Ao, Jian-Yang, additional, Ye, Bo-Gen, additional, and Sun, Hui-Chuan, additional

Published
2018
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14. Colony-Stimulating Factor 1 Receptor Blockade Inhibits Tumor Growth by Altering the Polarization of Tumor-Associated Macrophages in Hepatocellular Carcinoma

Author

Ao, Jian-Yang, primary, Zhu, Xiao-Dong, additional, Chai, Zong-Tao, additional, Cai, Hao, additional, Zhang, Yuan-Yuan, additional, Zhang, Ke-Zhi, additional, Kong, Ling-Qun, additional, Zhang, Ning, additional, Ye, Bo-Gen, additional, Ma, De-Ning, additional, and Sun, Hui-Chuan, additional

Published
2017
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17. Reduced expression of CD109 in tumor-associated endothelial cells promotes tumor progression by paracrine interleukin-8 in hepatocellular carcinoma

Author

Ye, Bo-Gen, primary, Sun, Hui-Chuan, additional, Zhu, Xiao-Dong, additional, Chai, Zong-Tao, additional, Zhang, Yuan-Yuan, additional, Ao, Jian-Yang, additional, Cai, Hao, additional, Ma, De-Ning, additional, Wang, Cheng-Hao, additional, Qin, Cheng-Dong, additional, Gao, Dong-Mei, additional, and Tang, Zhao-You, additional

Published
2016
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19. microRNA-26a suppresses recruitment of macrophages by down-regulating macrophage colony-stimulating factor expression through the PI3K/Akt pathway in hepatocellular carcinoma

Author

Chai, Zong-Tao, primary, Zhu, Xiao-Dong, additional, Ao, Jian-Yang, additional, Wang, Wen-Quan, additional, Gao, Dong-Mei, additional, Kong, Jian, additional, Zhang, Ning, additional, Zhang, Yuan-Yuan, additional, Ye, Bo-Gen, additional, Ma, De-Ning, additional, Cai, Hao, additional, and Sun, Hui-Chuan, additional

Published
2015
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20. Incomplete Radiofrequency Ablation Enhances Invasiveness and Metastasis of Residual Cancer of Hepatocellular Carcinoma Cell HCCLM3 via Activating β-Catenin Signaling

Author

Zhang, Ning, primary, Wang, Lu, additional, Chai, Zong-Tao, additional, Zhu, Zi-Man, additional, Zhu, Xiao-Dong, additional, Ma, De-Ning, additional, Zhang, Qiang-Bo, additional, Zhao, Yi-Ming, additional, Wang, Miao, additional, Ao, Jian-Yang, additional, Ren, Zheng-Gang, additional, Gao, Dong-Mei, additional, Sun, Hui-Chuan, additional, and Tang, Zhao-You, additional

Published
2014
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22. Arsenic trioxide induces differentiation of CD133+ hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse model

Author

Zhang, Ke-Zhi, primary, Zhang, Qiang-Bo, additional, Zhang, Quan-Bao, additional, Sun, Hui-Chuan, additional, Ao, Jian-Yang, additional, Chai, Zong-Tao, additional, Zhu, Xiao-Dong, additional, Lu, Lu, additional, Zhang, Yuan-Yuan, additional, Bu, Yang, additional, Kong, Ling-Qun, additional, and Tang, Zhao-You, additional

Published
2014
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23. MicroRNA-26a Inhibits Angiogenesis by Down-Regulating VEGFA through the PIK3C2α/Akt/HIF-1α Pathway in Hepatocellular Carcinoma

Author

Chai, Zong-Tao, primary, Kong, Jian, additional, Zhu, Xiao-Dong, additional, Zhang, Yuan-Yuan, additional, Lu, Lu, additional, Zhou, Jia-Min, additional, Wang, Long-Rong, additional, Zhang, Ke-Zhi, additional, Zhang, Qiang-Bo, additional, Ao, Jian-Yang, additional, Wang, Miao, additional, Wu, Wei-Zhong, additional, Wang, Lu, additional, Tang, Zhao-You, additional, and Sun, Hui-Chuan, additional

Published
2013
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24. Aspirin Minimized the Pro-Metastasis Effect of Sorafenib and Improved Survival by Up-Regulating HTATIP2 in Hepatocellular Carcinoma

Author

Lu, Lu, primary, Sun, Hui-Chuan, additional, Zhang, Wei, additional, Chai, Zong-Tao, additional, Zhu, Xiao-Dong, additional, Kong, Ling-Qun, additional, Wang, Wen-Quan, additional, Zhang, Ke-Zhi, additional, Zhang, Yuan-Yuan, additional, Zhang, Qiang-Bo, additional, Ao, Jian-Yang, additional, Li, Jia-Qi, additional, Wang, Lu, additional, Wu, Wei-Zhong, additional, and Tang, Zhao-You, additional

Published
2013
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26. Aspirin Minimized the Pro-Metastasis Effect of Sorafenib and Improved Survival by Up-Regulating HTATIP2 in Hepatocellular Carcinoma

Author

Lu, Lu, Sun, Hui-Chuan, Zhang, Wei, Chai, Zong-Tao, Zhu, Xiao-Dong, Kong, Ling-Qun, Wang, Wen-Quan, Zhang, Ke-Zhi, Zhang, Yuan-Yuan, Zhang, Qiang-Bo, Ao, Jian-Yang, Li, Jia-Qi, Wang, Lu, Wu, Wei-Zhong, and Tang, Zhao-You

Subjects
ASPIRIN, METASTASIS, CARBOXAMIDES, GENETIC regulation, LIVER cancer, TUMOR suppressor genes, CYCLOOXYGENASE genetics, LABORATORY mice, PREVENTION
Abstract

Background & Aims: We previously demonstrated the pro-metastasis effect of sorafenib in hepatocellular carcinoma (HCC), which is mediated by down-regulation of tumor suppressor HTATIP2. The aim of the present study was to determine whether aspirin minimizes this effect and improves survival. Methods: The effects of sorafenib, aspirin, and combined sorafenib and aspirin were observed in HCCLM3 and HepG2 xenograft nude mice. Tumor growth, intrahepatic metastasis (IHM), lung metastasis, and survival were assessed. Polymerase chain reaction (PCR) array, real-time (RT)-PCR, and Western blotting were used to examine gene expression. The anti-invasion and anti-metastasis effects of aspirin were studied in HTATIP2-knockdown and HTATIP2-overexpressing HCC cell lines. The molecular mechanism of HTATIP2 regulation by aspirin was explored. Results: Aspirin suppressed the pro-invasion and pro-metastasis effects of sorafenib in HCC and up-regulated HTATIP2 expression. Aspirin did not inhibit the proliferation of HCC cells, but it decreased the invasiveness of HCC with lower expression of HTATIP2 and increased expression of a set of markers, indicating a mesenchymal-to-epithelial transition in tumor cells. The up-regulation of HTATPI2 expression by aspirin is most likely mediated through inhibition of cyclooxygenase (COX) 2 expression. Conclusions: Aspirin minimized the pro-metastasis effect of sorafenib by up-regulating the tumor suppressor HTATIP2; this mechanism is mediated through inhibition of COX2. [ABSTRACT FROM AUTHOR]

Published
2013
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27. [Contrast-enhanced ultrasonography in diagnosis of inflammatory pseudotumor of liver].

Author

Chen Y, Jiang TA, Ao JY, Huang M, Chen F, and Zhao QY

Subjects
Adult, Female, Humans, Liver diagnostic imaging, Male, Middle Aged, Retrospective Studies, Ultrasonography, Young Adult, Granuloma, Plasma Cell diagnostic imaging, Liver Diseases diagnostic imaging
Abstract

Objective: To evaluate the application of contrast-enhanced ultrasonography (CEUS) in diagnosis of inflammatory pseudotumor of liver (IPL)., Methods: The contrast-enhanced untrasonography was performed in 32 cases of IPL and the results were retrospectively analyzed., Result: Among total 32 cases, 21 had absent contrast enhancement (type I); 6 had rimlike or stringlike enhancement during arterial phase and presented hypoechoic lesions during the late phase (type II); 2 had diffuse and homogeneous enhancement during early arterial phase,persisting hyperechoic during the late phase (type III); 3 had enhancement during arterial phases and washed out more quickly than liver parenchymal (type IV)., Conclusion: The perfusion pattern of IPL with CEUS varies, the predominant type is no contrast enhancement; type IV may be confused with atypical hepatic carcinoma, in that case the needle biopsy is necessary.

Published
2010
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28. Diagnostic analysis of hepatic angiomyolipoma.

Author

Jiang TA, Zhao QY, Chen MY, Wang LJ, and Ao JY

Subjects
Angiomyolipoma surgery, Biopsy, Needle, Follow-Up Studies, Hepatectomy methods, Humans, Immunohistochemistry, Liver Neoplasms surgery, Male, Middle Aged, Neoplasm Staging, Risk Assessment, Sensitivity and Specificity, Tomography, X-Ray Computed, Treatment Outcome, Ultrasonography, Doppler, Color, Angiomyolipoma diagnosis, Diagnostic Imaging methods, Liver Neoplasms diagnosis
Abstract

Background: Hepatic angiomyolipoma (HAML) is a rare tumor containing a variable amount of fat, vessels and smooth muscle. We report the image findings on ultrasonography and computed tomography (CT) of huge HAML., Method: The clinical, imaging and pathological data of a case of HAML were retrospectively collected and analyzed., Results: A huge heterogeneous hyperecho mass with anecho and hypoecho areas inside was found in the left hepatic lobe on ultrasonography. Color Doppler showed blood flow and arterial spectrum in it. CT scan showed a huge heterogeneous solid mass in the left lobe of the liver, with a low density and hypervascular area in arterial phase. The serum tumor marks were all negative. Ultrasound-guided biopsy was taken twice before resection and both showed necrosis tissue and reaction of inflammatory cells. Postoperative pathological results showed that the tumor was composed of epithelioid smooth muscle cells, thick-walled blood vessels and a few adipose cells with necrosis. The immunohistochemistry results showed appearance of typical HAML, with HMB-45 positive and alpha fetoprotein (AFP) negative., Conclusions: Preoperative diagnosis of HAML relies on combination of CT, MRI and ultrasonography. Our case of HAML showed heterogeneous hyperecho image on ultrasonography. Ultrasound-guided biopsy combined with morphological manifestation and specimen examination for HMB-45 may be helpful in the diagnosis of HAML.

Published
2005

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