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3. The Effects of Testosterone on Hypothalamic and Serum Oxytocin Levels Are Affected by the Estrogen Milieu in Female Rats.

Author

Arata, Moeka, Tamura, Kou, Aoki, Hidenori, Noguchi, Hiroki, Takeda, Asuka, Minato, Saki, Yamamoto, Shota, Kinouchi, Riyo, Yoshida, Kanako, Yamamoto, Yuri, Kaji, Takashi, and Iwasa, Takeshi

Abstract

Previous studies have suggested that the effects of androgens on body weight (BW) and appetite are affected by the estrogen milieu in females; however, the mechanism underlying these effects remains unclear. We hypothesized that androgens may affect endogenous oxytocin (OT), which is a hypothalamic anorectic factor, and that these effects of androgens may be altered by the estrogen milieu in females. To investigate this hypothesis, in the present study, we examined the effects of testosterone on peripheral and central OT levels in ovariectomized female rats that did or did not receive estradiol supplementation. Ovariectomized female rats were randomly divided into non-estradiol-supplemented or estradiol-supplemented groups, and half of the rats in each group were concurrently supplemented with testosterone (i.e., rats were divided into four groups, n = 7 per each group). We also measured peripheral and central OT receptor (OTR) gene expression levels. As a result, we found that testosterone increased serum and hypothalamic OT levels and OT receptor mRNA levels in non-estradiol-supplemented rats, whereas it had no effects on these factors in estradiol-supplemented rats. In addition, testosterone reduced food intake, BW gain, and fat weight in non-estradiol-supplemented rats, whereas it did not have any effects on BW, appetite, or fat weight in estradiol-supplemented rats. These findings indicate that the effects of androgens on OT may be affected by the estrogen milieu, and elevated OT levels may be related to the blunting of appetite and prevention of obesity under estrogen-deficient conditions. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Expression of SMADs in orthotopic human endometrium, ovarian endometriosis, and endometriotic lesions in a murine model

Author

Kadota, Yuri, primary, Kato, Takeshi, additional, Kasai, Kana, additional, Kawakita, Takako, additional, Murayama, Misaki, additional, Shinya, Akari, additional, Sasada, Hikari, additional, Katayama, Sachiko, additional, Nii, Mari, additional, Yamamoto, Shota, additional, Noguchi, Hiroki, additional, Tamura, Kou, additional, Aoki, Hidenori, additional, Taniguchi, Miyu, additional, Nakagawa, Tomotaka, additional, Kaji, Takashi, additional, Nishimura, Masato, additional, Kinouchi, Riyo, additional, Yoshida, Kanako, additional, and Iwasa, Takeshi, additional

Published
2024
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5. Oncologic, fertility, and obstetric outcomes with MPA therapy in women with endometrial cancer and atypical endometrial hyperplasia.

Author

Takeda, Asuka, Yamamoto, Yuri, Tamura, Kou, Aoki, Hidenori, Noguchi, Hiroki, Minato, Saki, Kamada, Shuhei, Arakaki, Ryosuke, Kaji, Takashi, and Iwasa, Takeshi

Subjects
CANCER relapse, MEDROXYPROGESTERONE, ANTINEOPLASTIC agents, PATHOLOGIC complete response, CANCER patient medical care, PSYCHOLOGY of women, TREATMENT effectiveness, PREGNANCY outcomes, RETROSPECTIVE studies, DESCRIPTIVE statistics, ENDOMETRIAL tumors, UTERINE diseases, FERTILITY preservation, DISEASE progression, PREGNANCY
Abstract

Aim: Medroxyprogesterone acetate (MPA) is one of the treatments of atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) to preserve the fertility. Efficacy of MPA therapy and fertility and obstetric outcomes after remission were evaluated in EC or AEH patients. Methods: Among patients diagnosed with EC or AEH at Tokushima University Hospital between January 2002 and October 2020, we retrospectively analyzed patients, ages range from 26 to 40, who underwent conservative management using MPA (400–600 mg/day). Results: In total, 19 patients underwent MPA therapy. The 18 (94%) patients achieved complete response (CR), and 1 (5%) patient achieved partial response (PR). Relapse occurred in 6 (32%) patients who had achieved CR. Of the patients who relapsed, 4 patients resumed MPA therapy and were in remission. Among 19 patients, 13 patients attempted pregnancy after CR. All of them underwent ovulation induction or assisted reproductive technology. As a result, 20 pregnancies in 10 (77%) patients and 12 live births in 9 (69%) patients were achieved. Rate of spontaneous abortion was 35% (7/20). Conclusions: MPA therapy can produce a high remission rate, and be considered an effective treatment for patients who wish fertility preservation. Around 70% patients who attempt to pregnancy can have at least one baby by infertility treatments. Because recurrence rate after MPA therapy is high, it may be desirable to aim for early pregnancy by active intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Age-Dependent Changes in the Effects of Androgens on Female Metabolic and Body Weight Regulation Systems in Humans and Laboratory Animals

Author

Iwasa, Takeshi, primary, Noguchi, Hiroki, additional, Tanano, Risa, additional, Yamanaka, Erika, additional, Takeda, Asuka, additional, Tamura, Kou, additional, Aoki, Hidenori, additional, Sugimoto, Tatsuro, additional, Sasada, Hikari, additional, Maeda, Takaaki, additional, Minato, Saki, additional, Yamamoto, Shota, additional, Inui, Hiroaki, additional, Kagawa, Tomohiro, additional, Yoshida, Atsuko, additional, Mineda, Ayuka, additional, Nii, Mari, additional, Kinouchi, Riyo, additional, Yoshida, Kanako, additional, Yamamoto, Yuri, additional, and Kaji, Takashi, additional

Published
2023
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7. すべての胚移植に全胚凍結法が必要か。プロゲステロン上昇を伴わない新鮮胚移植は、凍結融解胚移植と同等の妊娠率をもたらす

Author

Abe, Masami, Yamamoto, Yuri, Noguchi, Hiroki, Tamura, Kou, Aoki, Hidenori, Takeda, Asuka, Minato, Saki, Kamada, Shuhei, Tachibana, Ayaka, and Iwasa, Takeshi

Subjects
fresh embryo transfer, progesterone level, freeze-all
Abstract

Objectives : It has been suggested that the clinical outcomes of frozen-thawed embryo transfer (ET) are superior to those of fresh embryo transfer. We examined whether a freeze-all strategy is necessary for all embryo transfers, and, if not, to evaluate the conditions in which the pregnancy rates of fresh embryo transfer and frozen-thawed ET did not differ. Methods : Patients who underwent blastocyst transfer at Tokushima University Hospital between 2008 and 2019 were enrolled. The clinical outcomes and clinical characteristics of 1,022 patients that underwent fresh embryo transfer and 1,728 patients that underwent frozen-thawed ET were examined retrospectively. We considered the factors that influenced the pregnancy outcomes of fresh embryo transfer. Results : The frozen-thawed ET group exhibited significantly higher pregnancy, live-birth, and miscarriage rates than the fresh embryo transfer group. In the fresh embryo transfer group, a high progesterone level on the day of the human chorionic gonadotropin (hCG) trigger and lower grade embryos were risk factors for a low pregnancy rate. However, in the cases in which the progesterone level was < 1.0 ng / mL the pregnancy rate was equal to that of frozen-thawed ET. Conclusions : A freeze-all strategy is not necessary for embryo transfers, but should be employed in cases involving pre-ovulatory progesterone elevation.

Published
2022

10. Progesterone Treatment Reduces Food Intake and Body Weight in Ovariectomized Female Rats

Author

Uchishiba, Maimi, primary, Yamamoto, Shota, additional, Takeda, Asuka, additional, Arakaki, Ryosuke, additional, Arata, Moeka, additional, Noguchi, Hiroki, additional, Tamura, Kou, additional, Aoki, Hidenori, additional, Maeda, Takaaki, additional, Minato, Saki, additional, Nii, Mari, additional, Inui, Hiroaki, additional, Kamada, Shuhei, additional, Kinouchi, Riyo, additional, Yamamoto, Yuri, additional, Yoshida, Kanako, additional, Yagi, Shigetaka, additional, Kato, Takeshi, additional, Kaji, Takashi, additional, Nishimurra, Masato, additional, Ino, Kazuhiko, additional, and Iwasa, Takeshi, additional

Published
2023
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11. Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients

Author

Yanagihara, Rie, Yamamoto, Yuri, Kawakita, Takako, Noguchi, Hiroki, Yano, Yuya, Hayashi, Noriko, Ohta, Chiaki, Minato, Saki, Kamada, Shuhei, Aoki, Hidenori, Tamura, Kou, Masaki, Rie, Tachibana, Ayaka, Arakaki, Ryosuke, Yoshida, Kanako, Kato, Takeshi, Irahara, Minoru, and Iwasa, Takeshi

Subjects
endocrine system, biotin, IVF/ICSI, pregnancy, follicular fluid
Abstract

It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.

Published
2022

12. Changes in Serum Oxytocin Levels under Physiological and Supraphysiological Gonadal Steroid Hormone Conditions in Women of Reproductive Age: A Preliminary Study

Author

Tachibana, Ayaka, primary, Yamamoto, Yuri, additional, Noguchi, Hiroki, additional, Takeda, Asuka, additional, Tamura, Kou, additional, Aoki, Hidenori, additional, Minato, Saki, additional, Uchishiba, Maimi, additional, Yamamoto, Shota, additional, Kamada, Shuhei, additional, Yoshida, Atsuko, additional, Kinouchi, Riyo, additional, Yoshida, Kanako, additional, and Iwasa, Takeshi, additional

Published
2022
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14. Compatible cut‐off values for luteinizing hormone and the luteinizing hormone/follicle‐stimulating hormone ratio in diagnostic criteria of the Japan Society of Obstetrics and Gynecology for polycystic ovary syndrome

Author

Yanagihara, Rie, primary, Matsuzaki, Toshiya, additional, Aoki, Hidenori, additional, Tamura, Kou, additional, Nagashima, Mao, additional, Minato, Saki, additional, Kamada, Shuhei, additional, Yamamoto, Yuri, additional, Irahara, Minoru, additional, and Iwasa, Takeshi, additional

Published
2022
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16. Compatible cut‐off values for luteinizing hormone and the luteinizing hormone/follicle‐stimulating hormone ratio in diagnostic criteria of the Japan Society of Obstetrics and Gynecology for polycystic ovary syndrome.

Author

Yanagihara, Rie, Matsuzaki, Toshiya, Aoki, Hidenori, Tamura, Kou, Nagashima, Mao, Minato, Saki, Kamada, Shuhei, Yamamoto, Yuri, Irahara, Minoru, and Iwasa, Takeshi

Subjects
OBESITY, STATISTICS, FOLLICLE-stimulating hormone, POLYCYSTIC ovary syndrome, GYNECOLOGY, OBSTETRICS, IMMUNOASSAY, LUTEINIZING hormone, RESEARCH funding, DESCRIPTIVE statistics, LUMINESCENCE spectroscopy
Abstract

Aim: The abnormal secretion of luteinizing hormone (LH) is one of the typical features of polycystic ovary syndrome (PCOS) and adopted in the diagnostic criteria of the Japan Society of Obstetrics and Gynecology (JSOG). We investigated cut‐off values for LH and the LH/follicle‐stimulating hormone (FSH) ratio in resent two measurement systems for the diagnosis of PCOS. Methods: Ninety‐nine controls and 106 patients with PCOS were enrolled. Serum LH and FSH levels were measured using an electrochemiluminescence immunoassay (ARCHITECT) and chemiluminescence immunoassay (ECLusys). We examined the distribution of the measured levels, selected the conversion closest to the standard normal distribution in the control group, and calculated mean + 1 SD values for LH and the LH/FSH ratio as candidates. Cut‐off values coincided with the medians of the candidates in the two assay systems using a regression equation. We calculated the endocrinological abnormality rate in PCOS according to the JSOG criteria by abnormal LH secretion and elevated T. Results: Cut‐off values for LH (mIU/mL) and the LH/FSH ratio were 7.1 and 1.21, respectively, in ARCHITECT, and 9.9 and 1.51, respectively, in ECLusys. The detection rates of endocrinological abnormalities in PCOS were 72.2% and 70.6% in the nonoverweight/obese PCOS group and overweight/obese PCOS group, respectively, in ARCHITECT, and 69.4% and 73.5%, respectively, in ECLusys. Conclusion: We obtained cut‐off values of LH and the LH/FSH ratio for diagnostic criteria of JSOG criteria for PCOS, that were highly compatible between two major assay systems. These cut‐off values will contribute to the diagnosis of PCOS in Japan and presumably in women of Asian ethnicities. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Is a freeze-all strategy necessary for all embryo transfers : Fresh embryo transfer without progesterone elevation results in an equivalent pregnancy rate to cryopreserved embryo transfer

Author

Abe, Masami, primary, Yamamoto, Yuri, additional, Noguchi, Hiroki, additional, Tamura, Kou, additional, Aoki, Hidenori, additional, Takeda, Asuka, additional, Minato, Saki, additional, Kamada, Shuhei, additional, Tachibana, Ayaka, additional, and Iwasa, Takeshi, additional

Published
2022
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18. Effects of undernutrition and low energy availability on reproductive functions and their underlying neuroendocrine mechanisms

Author

Iwasa, Takeshi, primary, Noguchi, Hiroki, additional, Aoki, Hidenori, additional, Tamura, Kou, additional, Maeda, Takaaki, additional, Takeda, Asuka, additional, Uchishiba, Maimi, additional, Arakaki, Ryosuke, additional, Minato, Saki, additional, Kamada, Shuhei, additional, Yamamoto, Shota, additional, Imaizumi, Junki, additional, Kagawa, Tomohiro, additional, Yoshida, Atsuko, additional, Fukui, Rijin, additional, Daizumoto, Kei, additional, Kon, Masafumi, additional, Shinohara, Nobuo, additional, Yoshida, Kanako, additional, and Yamamoto, Yuri, additional

Published
2022
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19. 生後早期の心理的ストレスが雌雄ラットの性成熟、性行動に与える影響

Author

Yano, Kiyohito, Matsuzaki, Toshiya, Iwasa, Takeshi, Mayila, Yiliyasi, Yanagihara, Rie, Tungalagsuvd, Altankhuu, Munkhzaya, Munkhsaihan, Tokui, Takako, Kamada, Shuhei, Hayashi, Aki, Masaki, Rie, Aoki, Hidenori, Tamura, Kou, and Irahara, Minoru

Subjects
neonatal period, sexual behavior, early life stress, maternal separation, sexual maturation, psychological stress
Abstract

Purpose: We studied the influence of psychological stress during the early neonatal period on sexual maturation and sexual behavior in rats. Methods: Neonatal male and female rats were divided into control (C) and maternal separation (MS) groups (n = 20‐24 per group). The pups in the MS groups were placed in isolation cages for 240 minutes/d from postnatal days 2‐11. Vaginal opening (VO) in females and preputial separation (PS) in males (indicators of sexual maturation) were monitored, as was the estrous cycle in females. Thereafter, sexual behavior was monitored twice at 13 and 15 weeks of age. Results: As for sexual maturation, the onset of PS occurred significantly earlier in the MS group than in the C group, whereas the onset of VO did not differ between the groups. The length of the estrous cycle did not differ between the groups. The frequencies of sexual behaviors did not differ between the groups in either sex. Conclusions: In conclusion, early‐life psychological stress induced by MS advanced sexual maturation in male rats, whereas it did not affect sexual maturation in female rats. On the other hand, early‐life psychological stress might not affect sexual behavior in adulthood in either sex.

Published
2019

20. A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes

Author

Kamada, Shuhei, primary, Yamamoto, Yuri, additional, Aoki, Hidenori, additional, Tamura, Kou, additional, Takeda, Asuka, additional, Minato, Saki, additional, Masaki, Rie, additional, Yanagihara, Rie, additional, Hayashi, Noriko, additional, Yano, Yuya, additional, Imaizumi, Junki, additional, Kagawa, Tomohiro, additional, Yoshida, Atsuko, additional, Kawakita, Takako, additional, Irahara, Minoru, additional, and Iwasa, Takeshi, additional

Published
2021
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21. The influence of psychological stress in early life on sexual maturation and sexual behavior in male and female rats

Author

Yano, Kiyohito, primary, Matsuzaki, Toshiya, additional, Iwasa, Takeshi, additional, Mayila, Yiliyasi, additional, Yanagihara, Rie, additional, Tungalagsuvd, Altankhuu, additional, Munkhzaya, Munkhsaihan, additional, Tokui, Takako, additional, Kamada, Shuhei, additional, Hayashi, Aki, additional, Masaki, Rie, additional, Aoki, Hidenori, additional, Tamura, Kou, additional, and Irahara, Minoru, additional

Published
2020
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24. Study on problems and effects of voltage and reactive power control in mass introduction of photo-voltaic (PV) generation towards power system

Author

Sokna Sor, Aoki Hidenori, and Mohammad Farhan Bin Mohd Fauzi

Subjects
Electric power system, Stand-alone power system, Engineering, Switched-mode power supply, business.industry, Electronic engineering, Grid-connected photovoltaic power system, Power-flow study, Voltage regulation, Voltage optimisation, business, Maximum power point tracking
Abstract

This paper presents the latest discovery on problems at distribution and transmission system when mass Photo-Voltaic (PV) generations were introduced into distributed system with three different cases applied. Implementation of Genetic Algorithm (GA) in Voltage and Reactive Power Control (VQC) is proposed to overcome the voltage instability and to maintain the reliability of the power system, stability of voltage in the power system and reduce the system loss. The research is demonstrated by implementing Modified IEEE 14 buses Power Model System.

Published
2015

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