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6. Self‐Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy (Adv. Sci. 7/2024)

Author

Gao, Shan, primary, Miura, Yutaka, additional, Sumiyoshi, Akira, additional, Ohno, Satoshi, additional, Ogata, Keisuke, additional, Nomoto, Takahiro, additional, Matsui, Makoto, additional, Honda, Yuto, additional, Suzuki, Minoru, additional, Iiyama, Megumi, additional, Osada, Kensuke, additional, Aoki, Ichio, additional, and Nishiyama, Nobuhiro, additional

Published
2024
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8. Adnexal masses characterized on 3 tesla magnetic resonance imaging – added value of diffusion techniques

Author

Dimova Julia, Zlatareva Dora, Bakalova Rumiana, Aoki Ichio, and Hadjidekov George

Subjects
adnexal masses, 3 tesla mr, diagnosis, malignancy, ovarian neoplasms, diffusion restriction, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

To assess different types of adnexal masses as identified by 3T MRI and to discuss the added value of diffusion techniques compared with conventional sequences.

Published
2020
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9. Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis

Author

Grandjean, Joanes, Canella, Carola, Anckaerts, Cynthia, Ayrancı, Gülebru, Bougacha, Salma, Bienert, Thomas, Buehlmann, David, Coletta, Ludovico, Gallino, Daniel, Gass, Natalia, Garin, Clément M., Nadkarni, Nachiket Abhay, Hübner, Neele S., Karatas, Meltem, Komaki, Yuji, Kreitz, Silke, Mandino, Francesca, Mechling, Anna E., Sato, Chika, Sauer, Katja, Shah, Disha, Strobelt, Sandra, Takata, Norio, Wank, Isabel, Wu, Tong, Yahata, Noriaki, Yeow, Ling Yun, Yee, Yohan, Aoki, Ichio, Chakravarty, M. Mallar, Chang, Wei-Tang, Dhenain, Marc, von Elverfeldt, Dominik, Harsan, Laura-Adela, Hess, Andreas, Jiang, Tianzi, Keliris, Georgios A., Lerch, Jason P., Meyer-Lindenberg, Andreas, Okano, Hideyuki, Rudin, Markus, Sartorius, Alexander, Van der Linden, Annemie, Verhoye, Marleen, Weber-Fahr, Wolfgang, Wenderoth, Nicole, Zerbi, Valerio, and Gozzi, Alessandro

Published
2020
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10. Self‐Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy

Author

Gao, Shan, primary, Miura, Yutaka, additional, Sumiyoshi, Akira, additional, Ohno, Satoshi, additional, Ogata, Keisuke, additional, Nomoto, Takahiro, additional, Matsui, Makoto, additional, Honda, Yuto, additional, Suzuki, Minoru, additional, Iiyama, Megumi, additional, Osada, Kensuke, additional, Aoki, Ichio, additional, and Nishiyama, Nobuhiro, additional

Published
2023
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16. Block Copolymer‐Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near‐Infrared Photothermal Therapy.

Author

Li, Shang-Wei, Hsieh, Ming-Feng, Hong, Taehun, Chen, Pengwen, Osada, Kensuke, Liu, Xueying, Aoki, Ichio, Yu, Jiashing, Wu, Kevin C.-W., and Cabral, Horacio

Subjects
METAL-organic frameworks, BLOCK copolymers, PHOTOTHERMAL conversion, ETHYLENE glycol, BLOOD circulation
Abstract

Metal–organic frameworks (MOFs), such as the magnetic resonance imaging‐fit MIL‐100 based on Fe, are gaining significant attention as versatile theranostics with high‐loading capability. Moreover, as MOFs can be engineered to target tumors, there is much interest in applying them for precise pin‐point treatment of cancer. Herein, Pd nanoparticles within MIL‐100(Fe) are generated to create MOFs with remarkable photothermal conversion properties for cancer therapy. The Pd‐loaded MIL‐100(Fe) (Pd@MIL‐100(Fe)) are stabilized with biocompatible block copolymers to generate MOFs with PEGylated surfaces. This is achieved by directly mixing poly(ethylene glycol)‐poly(L‐aspartic acid) (PEG‐p(Asp)) or dopamine‐modified PEG‐p(Asp) (PEG‐p(Asp‐Dopa)) block copolymers with the MOFs in aqueous conditions. The resulting block copolymer‐stabilized MOF hybrids are stable in physiological conditions. Particularly, the Pd@MIL‐100(Fe)/PEG‐p(Asp‐Dopa) hybrids show enhanced blood circulation and increased accumulation in B16F10 melanoma. Furthermore, when irradiated with 808 nm light, the Pd@MIL‐100(Fe)/PEG‐p(Asp‐Dopa) hybrids rapidly increase the temperature to 50 °C, enabling tumor remission. The surface‐stabilized Pd@MIL‐100(Fe)/polymer hybrids open viable opportunities for innovating MOF/polymer hybrid‐based approaches for drug delivery. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Development of an MRI contrast agent for both detection and inhibition of the amyloid-b fibrillation process

Author

Yudi Utomo, Rohmad, Okada, Satoshi, Akira, Sumiyoshi, Asawa, Yasunobu, Seung Ban, Hyun, Yoshimori, Atsushi, Aoki, Ichio, Jürgen, Bajorath, Nakamura, Hiroyuki, and Ichio, Aoki

Abstract

A curcumin derivative conjugated with Gd-DO3A (Gd-DO3A-Comp.B) was synthesised as an MRI contrast agent for detecting the amyloid- (A) fibrillation process. Gd-DO3A-Comp.B inhibited Aß aggregation significantly and detected the fibril growth at 20 uM of AB with 10 uM of probe concentration by T1-weighted MR imaging.

Published
2022

24. Supplementary Table from A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma

Author

Tateishi, Kensuke, primary, Miyake, Yohei, primary, Kawazu, Masahito, primary, Sasaki, Nobuyoshi, primary, Nakamura, Taishi, primary, Sasame, Jo, primary, Yoshii, Yukie, primary, Ueno, Toshihide, primary, Miyake, Akio, primary, Watanabe, Jun, primary, Matsushita, Yuko, primary, Shiba, Norio, primary, Udaka, Naoko, primary, Ohki, Kentaro, primary, Fink, Alexandria L., primary, Tummala, Shilpa S., primary, Natsumeda, Manabu, primary, Ikegaya, Naoki, primary, Nishi, Mayuko, primary, Ohtake, Makoto, primary, Miyazaki, Ryohei, primary, Suenaga, Jun, primary, Murata, Hidetoshi, primary, Aoki, Ichio, primary, Miller, Julie J., primary, Fujii, Yukihiko, primary, Ryo, Akihide, primary, Yamanaka, Shoji, primary, Mano, Hiroyuki, primary, Cahill, Daniel P., primary, Wakimoto, Hiroaki, primary, Chi, Andrew S., primary, Batchelor, Tracy T., primary, Nagane, Motoo, primary, Ichimura, Koichi, primary, and Yamamoto, Tetsuya, primary

Published
2023
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25. Data from A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma

Author

Tateishi, Kensuke, primary, Miyake, Yohei, primary, Kawazu, Masahito, primary, Sasaki, Nobuyoshi, primary, Nakamura, Taishi, primary, Sasame, Jo, primary, Yoshii, Yukie, primary, Ueno, Toshihide, primary, Miyake, Akio, primary, Watanabe, Jun, primary, Matsushita, Yuko, primary, Shiba, Norio, primary, Udaka, Naoko, primary, Ohki, Kentaro, primary, Fink, Alexandria L., primary, Tummala, Shilpa S., primary, Natsumeda, Manabu, primary, Ikegaya, Naoki, primary, Nishi, Mayuko, primary, Ohtake, Makoto, primary, Miyazaki, Ryohei, primary, Suenaga, Jun, primary, Murata, Hidetoshi, primary, Aoki, Ichio, primary, Miller, Julie J., primary, Fujii, Yukihiko, primary, Ryo, Akihide, primary, Yamanaka, Shoji, primary, Mano, Hiroyuki, primary, Cahill, Daniel P., primary, Wakimoto, Hiroaki, primary, Chi, Andrew S., primary, Batchelor, Tracy T., primary, Nagane, Motoo, primary, Ichimura, Koichi, primary, and Yamamoto, Tetsuya, primary

Published
2023
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26. Supplementary Figure from A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma

Author

Tateishi, Kensuke, primary, Miyake, Yohei, primary, Kawazu, Masahito, primary, Sasaki, Nobuyoshi, primary, Nakamura, Taishi, primary, Sasame, Jo, primary, Yoshii, Yukie, primary, Ueno, Toshihide, primary, Miyake, Akio, primary, Watanabe, Jun, primary, Matsushita, Yuko, primary, Shiba, Norio, primary, Udaka, Naoko, primary, Ohki, Kentaro, primary, Fink, Alexandria L., primary, Tummala, Shilpa S., primary, Natsumeda, Manabu, primary, Ikegaya, Naoki, primary, Nishi, Mayuko, primary, Ohtake, Makoto, primary, Miyazaki, Ryohei, primary, Suenaga, Jun, primary, Murata, Hidetoshi, primary, Aoki, Ichio, primary, Miller, Julie J., primary, Fujii, Yukihiko, primary, Ryo, Akihide, primary, Yamanaka, Shoji, primary, Mano, Hiroyuki, primary, Cahill, Daniel P., primary, Wakimoto, Hiroaki, primary, Chi, Andrew S., primary, Batchelor, Tracy T., primary, Nagane, Motoo, primary, Ichimura, Koichi, primary, and Yamamoto, Tetsuya, primary

Published
2023
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27. Supplementary Data from A Hyperactive RelA/p65-Hexokinase 2 Signaling Axis Drives Primary Central Nervous System Lymphoma

Author

Tateishi, Kensuke, primary, Miyake, Yohei, primary, Kawazu, Masahito, primary, Sasaki, Nobuyoshi, primary, Nakamura, Taishi, primary, Sasame, Jo, primary, Yoshii, Yukie, primary, Ueno, Toshihide, primary, Miyake, Akio, primary, Watanabe, Jun, primary, Matsushita, Yuko, primary, Shiba, Norio, primary, Udaka, Naoko, primary, Ohki, Kentaro, primary, Fink, Alexandria L., primary, Tummala, Shilpa S., primary, Natsumeda, Manabu, primary, Ikegaya, Naoki, primary, Nishi, Mayuko, primary, Ohtake, Makoto, primary, Miyazaki, Ryohei, primary, Suenaga, Jun, primary, Murata, Hidetoshi, primary, Aoki, Ichio, primary, Miller, Julie J., primary, Fujii, Yukihiko, primary, Ryo, Akihide, primary, Yamanaka, Shoji, primary, Mano, Hiroyuki, primary, Cahill, Daniel P., primary, Wakimoto, Hiroaki, primary, Chi, Andrew S., primary, Batchelor, Tracy T., primary, Nagane, Motoo, primary, Ichimura, Koichi, primary, and Yamamoto, Tetsuya, primary

Published
2023
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37. Effect of Alpha-tocopheryl Succinate on the Cytotoxicity of Anticancer Drugs Towards Leukemia Lymphocytes

Author

Ivanova, Donika, Zhelev, Zhivko, Zlateva, Genoveva, Lazarova, Dessislava, Yaneva, Zvezdelina, Panovska, Radmila, Aoki, Ichio, Bakalova, Rumiana, and Ichio, Aoki

Abstract

Background/aim: This study analysed the effect of α-tocopheryl succinate (α-TS) on the redox-state of leukemia and normal lymphocytes, as well as their sensitization to fifteen anticancer drugs. Materials and methods: Cell viability was analyzed by trypan blue staining and automated counting of live and dead cells. Apoptosis was analyzed by FITC-Annexin V test. Oxidative stress was evaluated by the intracellular levels of reactive oxygen species (ROS) and protein-carbonyl products. Results: Most combinations (α-TS plus anticancer drug) exerted additive or antagonistic effects on the proliferation and viability of leukemia lymphocytes. α-TS combined with barasertib, bortezomib or lonafarnib showed a strong synergistic cytotoxic effect, which was best expressed in the case of barasestib. It was accompanied by impressive induction of apoptosis and increased production of ROS, but insignificant changes in protein-carbonyl levels. α-TS plus barasertib did not alter the viability and did not induce oxidative stress and apoptosis in normal lymphocytes. Conclusion: α-TS could be a promising adjuvant in second-line anticancer therapy, particularly in acute lymphoblastic leukemia, to reduce the therapeutic doses of barasertib, bortezomib, and lonafarnib, increasing their effectiveness and minimizing their side effects.

Published
2022

45. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging

Author

Kenichiro, Matsumoto, Nakanishi, Ikuo, Zhelev, Zhivko, Bakalova, Rumiana, Aoki, Ichio, Ikuo, Nakanishi, and Ichio, Aoki

Abstract

Significance: In vivo assessment of paramagnetic and diamagnetic conversions of nitroxyl radicals based on cyclic redox mechanism can be an index of tissue redox status. The redox mechanism of nitroxyl radicals, which enables their use as a normal tissue-selective radioprotector, is seen as being attractive on planning radiation therapy. Recent Advances: In vivo redox imaging using nitroxyl radicals as redox-sensitive contrast agents has been developed to assess tissue redox status. Chemical and biological behaviors depending on chemical structures of nitroxyl radical compounds have been understood in detail. Polymer types of nitroxyl radical contrast agents and/or nitroxyl radical-labeled drugs were designed for approaching theranostics. Critical Issues: Nitroxyl radicals as magnetic resonance imaging (MRI) contrast agents have several advantages compared with those used in electron paramagnetic resonance (EPR) imaging, while support by EPR spectroscopy is important to understand information from MRI. Redox-sensitive paramagnetic contrast agents having a medicinal benefit, that is, nitroxyl-labeled drug, have been developed and proposed. Future Directions: A development of suitable nitroxyl contrast agent for translational theranostic applications with high reaction specificity and low normal tissue toxicity is under progress. Nitroxyl radicals as redox-sensitive magnetic resonance contrast agents can be a useful tool to detect an abnormal tissue redox status such as disordered oxidative stress.

Published
2021

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