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7. Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation

Author

Aoki, Tomoaki, Wong, Vanessa, Hayashida, Kei, Becker, Lance B., Shinozaki, Koichiro, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Scholkmann, Felix, editor, LaManna, Joseph, editor, and Wolf, Ursula, editor

Published
2023
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8. Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer Is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats

Author

Okuma, Yu, Shinozaki, Koichiro, Yagi, Tsukasa, Hayashida, Kei, Aoki, Tomoaki, Yin, Tai, Kiguchi, Takeyuki, Iwami, Taku, Becker, Lance B., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Scholkmann, Felix, editor, LaManna, Joseph, editor, and Wolf, Ursula, editor

Published
2022
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12. An Automation System Equivalent to the Douglas Bag Technique Enables Continuous and Repeat Metabolic Measurements in Patients Undergoing Mechanical Ventilation

Author

Shinozaki, Koichiro, Yu, Pey-Jen, Zhou, Qiuping, Cassiere, Hugh A., Stanley, John, Rolston, Daniel M., Garg, Nidhi, Li, Timmy, Johnson, Jennifer, Saeki, Kota, Goto, Taiki, Okuma, Yu, Miyara, Santiago J., Hayashida, Kei, Aoki, Tomoaki, Wong, Vanessa, Molmenti, Ernesto P., Lampe, Joshua W., and Becker, Lance B.

Published
2022
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13. The interplay between bystander cardiopulmonary resuscitation and ambient temperature on neurological outcome after cardiac arrest: A nationwide observational cohort study

Author

Hayashida, Kei, Takegawa, Ryosuke, Nishikimi, Mitsuaki, Aoki, Tomoaki, Emoto, Ryo, Shinozaki, Koichiro, Miyara, Santiago J., Rolston, Daniel M., Li, Timmy, Shoaib, Muhammad, Fukuda, Tatsuma, Molmenti, Ernesto P., Suzuki, Masaru, Sasaki, Junichi, Matsui, Shigeyuki, and Becker, Lance B.

Published
2021
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14. Immune cell expression patterns of CD39/CD73 ectonucleotidases in rodent models of cardiac arrest and resuscitation

Author

Aoki, Tomoaki, primary, Wong, Vanessa, additional, Yin, Tai, additional, Nakamura, Eriko, additional, Endo, Yusuke, additional, Hayashida, Kei, additional, Robson, Simon C., additional, Nandurkar, Harshal, additional, Diamond, Betty, additional, Kim, Sun Jung, additional, Murao, Atsushi, additional, Wang, Ping, additional, Becker, Lance B., additional, and Shinozaki, Koichiro, additional

Published
2024
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17. Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats

Author

Yin, Tai, Becker, Lance B., Choudhary, Rishabh C., Takegawa, Ryosuke, Shoaib, Muhammad, Shinozaki, Koichiro, Endo, Yusuke, Homma, Koichiro, Rolston, Daniel M., Eguchi, Shuhei, Ariyoshi, Tadashi, Matsumoto, Asami, Oka, Kentaro, Takahashi, Motomichi, Aoki, Tomoaki, Miyara, Santiago J., Nishikimi, Mitsuaki, Sasaki, Junichi, Kim, Junhwan, Molmenti, Ernesto P., and Hayashida, Kei

Published
2021
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20. Organ-Specific Mitochondrial Alterations Following Ischemia–Reperfusion Injury in Post-Cardiac Arrest Syndrome: A Comprehensive Review.

Author

Nakamura, Eriko, Aoki, Tomoaki, Endo, Yusuke, Kazmi, Jacob, Hagiwara, Jun, Kuschner, Cyrus E., Yin, Tai, Kim, Junhwan, Becker, Lance B., and Hayashida, Kei

Subjects
*REPERFUSION injury, *REPERFUSION, *MITOCHONDRIA, *ACUTE kidney failure, *KNOWLEDGE gap theory, *BIOENERGETICS, *OXIDATIVE stress
Abstract

Background: Mitochondrial dysfunction, which is triggered by systemic ischemia–reperfusion (IR) injury and affects various organs, is a key factor in the development of post-cardiac arrest syndrome (PCAS). Current research on PCAS primarily addresses generalized mitochondrial responses, resulting in a knowledge gap regarding organ-specific mitochondrial dynamics. This review focuses on the organ-specific mitochondrial responses to IR injury, particularly examining the brain, heart, and kidneys, to highlight potential therapeutic strategies targeting mitochondrial dysfunction to enhance outcomes post-IR injury. Methods and Results: We conducted a narrative review examining recent advancements in mitochondrial research related to IR injury. Mitochondrial responses to IR injury exhibit considerable variation across different organ systems, influenced by unique mitochondrial structures, bioenergetics, and antioxidative capacities. Each organ demonstrates distinct mitochondrial behaviors that have evolved to fulfill specific metabolic and functional needs. For example, cerebral mitochondria display dynamic responses that can be both protective and detrimental to neuronal activity and function during ischemic events. Cardiac mitochondria show vulnerability to IR-induced oxidative stress, while renal mitochondria exhibit a unique pattern of fission and fusion, closely linked to their susceptibility to acute kidney injury. This organ-specific heterogeneity in mitochondrial responses requires the development of tailored interventions. Progress in mitochondrial medicine, especially in the realms of genomics and metabolomics, is paving the way for innovative strategies to combat mitochondrial dysfunction. Emerging techniques such as mitochondrial transplantation hold the potential to revolutionize the management of IR injury in resuscitation science. Conclusions: The investigation into organ-specific mitochondrial responses to IR injury is pivotal in the realm of resuscitation research, particularly within the context of PCAS. This nuanced understanding holds the promise of revolutionizing PCAS management, addressing the unique mitochondrial dysfunctions observed in critical organs affected by IR injury. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Low respiratory quotient correlates with high mortality in patients undergoing mechanical ventilation.

Author

Shinozaki, Koichiro, Yu, Pey-Jen, Zhou, Qiuping, Cassiere, Hugh A., John, Stanley, Rolston, Daniel M., Garg, Nidhi, Li, Timmy, Johnson, Jennifer, Saeki, Kota, Goto, Taiki, Okuma, Yu, Miyara, Santiago J., Hayashida, Kei, Aoki, Tomoaki, Wong, Vanessa K., Molmenti, Ernesto P., Lampe, Joshua W., and Becker, Lance B.

Abstract

Oxygen consumption (VO 2), carbon dioxide generation (VCO 2), and respiratory quotient (RQ), which is the ratio of VO 2 to VCO 2 , are critical indicators of human metabolism. To seek a link between the patient's metabolism and pathophysiology of critical illness, we investigated the correlation of these values with mortality in critical care patients. This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital. Age 18 years or older healthy volunteers and patients who underwent mechanical ventilation were enrolled. A high-fidelity automation device, which accuracy is equivalent to the gold standard Douglas Bag technique, was used to measure VO 2 , VCO 2 , and RQ at a wide range of fraction of inspired oxygen (F I O 2). We included a total of 21 subjects including 8 post-cardiothoracic surgery patients, 7 intensive care patients, 3 patients from the emergency room, and 3 healthy volunteers. This study included 10 critical care patients, whose metabolic measurements were performed in the ER and ICU, and 6 died. VO 2 , VCO 2 , and RQ of survivors were 282 +/− 95 mL/min, 202 +/− 81 mL/min, and 0.70 +/− 0.10, and those of non-survivors were 240 +/− 87 mL/min, 140 +/− 66 mL/min, and 0.57 +/− 0.08 (p = 0.34, p = 0.10, and p < 0.01), respectively. The difference of RQ was statistically significant (p < 0.01) and it remained significant when the subjects with F I O 2 < 0.5 were excluded (p < 0.05). Low RQ correlated with high mortality, which may potentially indicate a decompensation of the oxygen metabolism in critically ill patients. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Insufficient oxygen inhalation during cardiopulmonary resuscitation induces early changes in hemodynamics followed by late and unfavorable systemic responses in post‐cardiac arrest rats

Author

Aoki, Tomoaki, primary, Wong, Vanessa, additional, Endo, Yusuke, additional, Hayashida, Kei, additional, Takegawa, Ryosuke, additional, Shoaib, Muhammad, additional, Miyara, Santiago J., additional, Choudhary, Rishabh C., additional, Yin, Tai, additional, Saeki, Kota, additional, Robson, Simon C., additional, Becker, Lance B., additional, and Shinozaki, Koichiro, additional

Published
2023
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25. Continuous and repeat metabolic measurements compared between post-cardiothoracic surgery and critical care patients

Author

Shinozaki, Koichiro, primary, Yu, Pey-Jen, additional, Zhou, Qiuping, additional, Cassiere, Hugh A., additional, John, Stanley, additional, Rolston, Daniel M., additional, Garg, Nidhi, additional, Li, Timmy, additional, Johnson, Jennifer, additional, Saeki, Kota, additional, Goto, Taiki, additional, Okuma, Yu, additional, Miyara, Santiago J., additional, Hayashida, Kei, additional, Aoki, Tomoaki, additional, Wong, Vanessa K., additional, Molmenti, Ernesto P., additional, Lampe, Joshua W., additional, and Becker, Lance B., additional

Published
2023
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26. Additional file 1 of Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest

Author

Hayashida, Kei, Takegawa, Ryosuke, Endo, Yusuke, Yin, Tai, Choudhary, Rishabh C., Aoki, Tomoaki, Nishikimi, Mitsuaki, Murao, Atsushi, Nakamura, Eriko, Shoaib, Muhammad, Kuschner, Cyrus, Miyara, Santiago J., Kim, Junhwan, Shinozaki, Koichiro, Wang, Ping, and Becker, Lance B.

Abstract

Additional file 1: Fig. S1. Arterial blood and metabolic measures sampled at pre-arrest baseline and at 15- and 120-min after resuscitation. Fig. S2. The cytochrome c oxidase (COX) activity in tissue homogenates from the brain and spleen of surviving animals at 72 h post-CA in the vehicle, frozen-thawed-, or fresh-mito group. Fig. S3. Confocal fluorescence imaging for the heart, liver, and lung at 24 h after CA resuscitation in rats treated with vehicle or fresh mitochondrial transplantation.

Published
2023
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27. Low Respiratory Quotient Correlates with High Mortality in Patients Undergoing Mechanical Ventilation

Author

Shinozaki, Koichiro, primary, Yu, Pey-Jen, additional, Zhou, Qiuping, additional, Cassiere, Hugh A., additional, John, Stanley, additional, Rolston, Daniel M., additional, Garg, Nidhi, additional, Li, Timmy, additional, Johnson, Jennifer, additional, Saeki, Kota, additional, Goto, Taiki, additional, Okuma, Yu, additional, Miyara, Santiago J., additional, Hayashida, Kei, additional, Aoki, Tomoaki, additional, Wong, Vanessa, additional, Molmenti, Ernesto P., additional, Lampe, Joshua, additional, and Becker, Lance, additional

Published
2023
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28. Upper-Extremity Deep Venous Thrombosis after Whole Blood Donation—A Case Report

Author

Abidoye, Oluseyi, additional, Johnson, Andrew, additional, Cho, Young Min, additional, Ogbuagu, Henry, additional, Choudhury, Hasan, additional, Takegawa, Ryosuke, additional, Hayashida, Kei, additional, Shinozaki, Koichiro, additional, Aoki, Tomoaki, additional, Okuma, Yu, additional, Zanos, Stavros, additional, Zafeiropoulos, Stefanos, additional, Giannis, Dimitrios, additional, Pipolo, Derek O., additional, Becker, Lance B., additional, Miyara, Santiago J., additional, Guevara, Sara, additional, and Molmenti, Ernesto P., additional

Published
2022
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33. Abstract 14580: Methodological Challenges Conducting In Vitro Ischemia and Reperfusion: A Fundamental Problem in Cell Viability Determination

Author

Miyara, Santiago J, primary, Shoaib, Muhammad, additional, Endo, Yusuke, additional, Choudhary, Rishabh C, additional, Hayashida, Kei, additional, Shinozaki, Koichiro, additional, Aoki, Tomoaki, additional, Kim, Junhwan, additional, Nishikimi, Mitsuaki, additional, Guevara, Sara, additional, Molmenti, Ernesto P, additional, Shore-lesserson, Linda, additional, Aronsohn, Judith, additional, and Becker, Lance B, additional

Published
2021
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34. Additional file 1 of Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats

Author

Yin, Tai, Becker, Lance B., Choudhary, Rishabh C., Takegawa, Ryosuke, Shoaib, Muhammad, Shinozaki, Koichiro, Endo, Yusuke, Homma, Koichiro, Rolston, Daniel M., Eguchi, Shuhei, Ariyoshi, Tadashi, Matsumoto, Asami, Oka, Kentaro, Takahashi, Motomichi, Aoki, Tomoaki, Miyara, Santiago J., Nishikimi, Mitsuaki, Sasaki, Junichi, Kim, Junhwan, Molmenti, Ernesto P., and Hayashida, Kei

Subjects
circulatory and respiratory physiology
Abstract

Additional file 1: Figure S1. Scheme of the rat ECPR model using cardiopulmonary bypass and an extracorporeal membrane. The experimental gas (placebo or H2) was administered via a ventilator and an extracorporeal oxygenator. 1, capnograph; 2, oxygen saturation and hematocrit; 3, pump speed (mL/min); 4, temperature, PO2, and system pressure of arterial return; 5, rectal temperature; 6, arterial pressure and central venous pressure and arterial blood gas analysis; 7; electrocardiogram; 8; esophageal temperature. Figure S2. Changes in arterial lactate, PaO2, PaCO2, pH, base excess, and HCO3��� during CA and ECPR. Data are presented as the mean �� SEM. BL, baseline. *P

Published
2021
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35. Additional file 2 of Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats

Author

Yin, Tai, Becker, Lance B., Choudhary, Rishabh C., Takegawa, Ryosuke, Shoaib, Muhammad, Shinozaki, Koichiro, Endo, Yusuke, Homma, Koichiro, Rolston, Daniel M., Eguchi, Shuhei, Ariyoshi, Tadashi, Matsumoto, Asami, Oka, Kentaro, Takahashi, Motomichi, Aoki, Tomoaki, Miyara, Santiago J., Nishikimi, Mitsuaki, Sasaki, Junichi, Kim, Junhwan, Molmenti, Ernesto P., and Hayashida, Kei

Abstract

Additional file 2: Table S1. Group characteristics before resuscitation in rats of placebo and H2 group. Table S2. Physiological and interventional variables during ECPR in rats of placebo and H2 group. Table S3. Detailed information of perturbed metabolites (VIP > 1.0) among the groups (Placebo vs. Pre-CA, or H2 vs. Placebo). Table S4. Result from metabolite set enrichment analysis (MSEA).

Published
2021
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36. Additional file 1 of Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies

Author

Hayashida, Kei, Takegawa, Ryosuke, Shoaib, Muhammad, Aoki, Tomoaki, Rishabh C. Choudhary, Kuschner, Cyrus E., Nishikimi, Mitsuaki, Miyara, Santiago J., Rolston, Daniel M., Guevara, Sara, Junhwan Kim, Shinozaki, Koichiro, Molmenti, Ernesto P., and Becker, Lance B.

Abstract

Additional file 1. PRISMA 2009 checklist RT.

Published
2021
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37. Right Ventricle Embolization of IVC Filter Fragments: An Incidental Finding

Author

Miyara, Santiago J., additional, Guevara, Sara, additional, Shore-Lesserson, Linda, additional, Shoaib, Muhammad, additional, Kirsch, Claudia, additional, Metz, Christine N., additional, Nair, Vinay, additional, Lau, Lawrence, additional, Choudhary, Rishabh C., additional, McCann-Molmenti, Alexia, additional, Baez, Anthony M., additional, Hayashida, Kei, additional, Takegawa, Ryosuke, additional, Shinozaki, Koichiro, additional, Aoki, Tomoaki, additional, Nishikimi, Mitsuaki, additional, Cho, Young Min, additional, Morell, Alexis, additional, Zafeiropoulos, Stefanos, additional, Zanos, Stavros, additional, Watt, Stacey, additional, Montorfano, Lisandro, additional, Bartoc, Cristian D., additional, Lumermann, Claudio M., additional, Aronsohn, Judith, additional, Becker, Lance B., additional, and Molmenti, Ernesto P., additional

Published
2021
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38. Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New York

Author

Miyara, Santiago J., primary, Becker, Lance B., additional, Guevara, Sara, additional, Kirsch, Claudia, additional, Metz, Christine N., additional, Shoaib, Muhammad, additional, Grodstein, Elliot, additional, Nair, Vinay V., additional, Jandovitz, Nicholas, additional, McCann-Molmenti, Alexia, additional, Hayashida, Kei, additional, Takegawa, Ryosuke, additional, Shinozaki, Koichiro, additional, Yagi, Tsukasa, additional, Aoki, Tomoaki, additional, Nishikimi, Mitsuaki, additional, Choudhary, Rishabh C., additional, Cho, Young Min, additional, Zanos, Stavros, additional, Zafeiropoulos, Stefanos, additional, Hoffman, Hannah B., additional, Watt, Stacey, additional, Lumermann, Claudio M., additional, Aronsohn, Judith, additional, Shore-Lesserson, Linda, additional, and Molmenti, Ernesto P., additional

Published
2021
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49. [Current Status and Future Prospects of Chemoradiotherapy for Esophageal Cancer].

Author

Aoki T, Nakamura T, and Kakeji Y

Subjects
Esophageal Neoplasms pathology, Esophagectomy, Female, Humans, Male, Neoplasm Staging, Neoplasm, Residual, Recurrence, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemoradiotherapy, Esophageal Neoplasms therapy
Abstract

Chemoradiotherapy is a very important factor and one of the 2 pillars of esophageal cancer treatment. Although esophagectomy is the standard treatment for clinical stage Ⅰ(T1N0M0)esophageal cancer, chemoradiotherapy is reported to be effective. Currently, a phaseⅢ clinical trial is underway to compare patients who undergo esophagectomy and those who receive radical chemoradiotherapy. Esophagectomy after neoadjuvant chemotherapy is the standard treatment for clinical stageⅡ/Ⅲ(except for T4) esophageal cancer, whereas chemoradiotherapy is regarded as the standard treatment for patients who wish to preserve their esophagus, those who refuse surgery, and those with inoperable disease. Chemoradiotherapy, rather than surgical treatment, is usually selected for clinical stageⅣ (T4/M1LYM) esophageal cancer. While curability increases with chemoradiotherapy, late adverse events such as cardiopulmonary toxicity and safety problems with salvage treatment of cases with residual tumor or recurrent cancer have been observed. New irradiation techniques using radiation technology are being developed, such as intensity-modulated radiation therapy (IMRT). These innovations are expected to improve treatment results by avoiding irradiation of at-risk organs, without reducing the target radiation volume. New treatments, including salvage protocols, introduction of new radiotherapy equipment such as IMRT, and new drugs, are being developed, and further advances are anticipated.

Published
2015

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