1. Prevalence and Prognostic Significance of Right Ventricular Dysfunction in Patients With Severe Low-Flow, Low-Gradient Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.
- Author
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Bellino M, Ferruzzi GJ, Giordano A, Attisano T, Maiellaro F, Citro R, Baldi C, Corcione N, Morello A, Granata G, Turino S, Di Maio M, Silverio A, and Galasso G
- Subjects
- Humans, Male, Female, Aged, 80 and over, Prevalence, Aged, Italy epidemiology, Prognosis, Echocardiography, Risk Factors, Ventricular Function, Right physiology, Treatment Outcome, Risk Assessment methods, Retrospective Studies, Aortic Valve Stenosis surgery, Aortic Valve Stenosis mortality, Aortic Valve Stenosis complications, Aortic Valve Stenosis physiopathology, Aortic Valve Stenosis diagnostic imaging, Transcatheter Aortic Valve Replacement adverse effects, Ventricular Dysfunction, Right physiopathology, Ventricular Dysfunction, Right diagnostic imaging, Ventricular Dysfunction, Right epidemiology, Severity of Illness Index
- Abstract
Background: Whether the presence of right ventricular (RV) dysfunction may influence the clinical outcome of patients with low-flow, low-gradient aortic stenosis (LFLG-AS) undergoing transcatheter aortic valve replacement (TAVR) has not yet been established., Methods and Results: This study included consecutive patients with LFLG-AS undergoing TAVR at 2 high-volume Italian centers. RV dysfunction before TAVR procedure was defined as tricuspid annular plane systolic excursion assessed by transthoracic echocardiography lower than <17 mm. The primary outcome was all-cause death at 1 year. The propensity score weighting technique was implemented to account for potential selection bias between patients with and without RV dysfunction. A prespecified subgroup analysis was conducted to evaluate the consistency of the results in patients with classical and paradoxical LFLG-AS forms. This study included 392 patients; of them, 97 (24.7%) patients showed RV dysfunction before TAVR. At propensity score-weighted adjusted Cox regression analysis, RV dysfunction, according to dichotomous definition, was associated with an increased risk for the primary outcome (adjusted hazard ratio [HR], 3.11 [95% CI, 1.58-6.13]), cardiovascular death (adjusted HR, 3.26 [95% CI, 1.58-6.72]), and major adverse cardiovascular and cerebrovascular events (adjusted HR, 3.39 [95% CI, 1.76-6.53]). Conversely, no difference was detected for the risk of stroke and of permanent pacemaker implantation. No significant interaction of the classical and paradoxical LFLG-AS subgroups was detected for all the outcomes of interest., Conclusions: This study suggests that RV dysfunction echocardiographically assessed by tricuspid annular plane systolic excursion may improve the prognostic stratification of patients with LFLG-AS undergoing TAVR.
- Published
- 2024
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