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137 results on '"Apostolidou, Eirini"'

1. Predictive Maintenance Under Absence of Sensor Data

Author

Pierros, Ioannis, Kochliaridis, Vasileios, Apostolidou, Eirini, Delimpasi, Eleni, Zygouris, Vasileios, Vlahavas, Ioannis, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Carette, Jacques, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Stettner, Lukasz, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Rettberg, Achim, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Maglogiannis, Ilias, editor, Iliadis, Lazaros, editor, Macintyre, John, editor, Avlonitis, Markos, editor, and Papaleonidas, Antonios, editor

Published
2024
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8. Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β–mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps

Author

Skendros, Panagiotis, Chrysanthopoulou, Akrivi, Rousset, François, Kambas, Konstantinos, Arampatzioglou, Athanasios, Mitsios, Alexandros, Bocly, Veronique, Konstantinidis, Theocharis, Pellet, Philippe, Angelidou, Iliana, Apostolidou, Eirini, Ritis, Dimitrios, Tsironidou, Victoria, Galtsidis, Sotiris, Papagoras, Charalampos, Stakos, Dimitrios, Kouklakis, Georgios, Dalla, Vasiliki, Koffa, Maria, Mitroulis, Ioannis, Theodorou, Ioannis, and Ritis, Konstantinos

Published
2017
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14. Hemodynamic effects of left atrial appendage occlusion

Author

Sharma, Esseim, primary, Apostolidou, Eirini, additional, Sheikh, Wasiq, additional, Parulkar, Anshul, additional, Ahmed, M. Bilal, additional, Lima, Fabio V., additional, McCauley, Brian D., additional, Kennedy, Kevin, additional, and Chu, Antony F., additional

Published
2021
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19. Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

Author

Kambas, Konstantinos, Chrysanthopoulou, Akrivi, Vassilopoulos, Dimitrios, Apostolidou, Eirini, Skendros, Panagiotis, Girod, Andreas, Arelaki, Stella, Froudarakis, Marios, Nakopoulou, Lydia, Giatromanolaki, Alexandra, Sidiropoulos, Prodromos, Koffa, Maria, Boumpas, Dimitrios T, Ritis, Konstantinos, and Mitroulis, Ioannis

Published
2014
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21. Institutional Red Blood Cell Transfusion Rates Are Correlated Following Endovascular and Surgical Cardiovascular Procedures: Evidence That Local Culture Influences Transfusion Decisions

Author

Apostolidou, Eirini, primary, Kolte, Dhaval, additional, Kennedy, Kevin F., additional, Beale, Charles E., additional, Abbott, J. Dawn, additional, Ehsan, Afshin, additional, Gurm, Hitinder S., additional, Carson, Jeffrey L., additional, Mamdani, Shafiq, additional, and Aronow, Herbert D., additional

Published
2020
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33. Growth, the Mediterranean diet and the buying power of adolescents in Greece

Author

Grammatikopoulou, Maria G., primary, Gkiouras, Konstantinos, additional, Daskalou, Efstratia, additional, Apostolidou, Eirini, additional, Theodoridis, Xenophon, additional, Stylianou, Charilaos, additional, Galli-Tsinopoulou, Assimina, additional, Tsigga, Maria, additional, Dardavessis, Theodore, additional, and Chourdakis, Michael, additional

Published
2018
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35. Efficacy and safety of prophylactic levetiracetam in supratentorial brain tumour surgery: a systematic review and meta‐analysis

Author

Pourzitaki, Chryssa, Tsaousi, Georgia, Apostolidou, Eirini, Karakoulas, Konstantinos, Kouvelas, Dimitrios, and Amaniti, Ekaterini

Subjects
Levetiracetam, Seizures, Phenytoin, Valproic Acid, Meta‐analysis, Humans, Supratentorial Neoplasms, Anticonvulsants, Piracetam, Craniotomy, Perioperative Care
Abstract

The aim of this study was to perform an up-to-date systematic review and meta-analysis on the efficacy and safety of prophylactic administration of levetiracetam in brain tumour patients.A systematic review of studies published until April 2015 was conducted using Scopus/Elsevier, EMBASE and MEDLINE. The search was limited to articles reporting results from adult patients, suffering from brain tumour, undergoing supratentorial craniotomy for tumour resection or biopsy and administered levetiracetam in the perioperative period for seizure prophylaxis. Outcomes included the efficacy and safety of levetiracetam, as well as the tolerability of the specific regimen, defined by the discontinuation of the treatment due to side effects.The systematic review included 1148 patients from 12 studies comparing levetiracetam with no treatment, phenytoin and valproate, while only 243 patients from three studies, comparing levetiracetam vs phenytoin efficacy and safety, were included in the meta-analysis. The combined results from the meta-analysis showed that levetiracetam administration was followed by significantly fewer seizures than treatment with phenytoin (OR = 0.12 [0.03-0.42]: χ(2) = 1.76: I(2) = 0%). Analysis also showed significantly fewer side effects in patients receiving levetiracetam, compared to other groups (P 0.05). The combined results showed fewer side effects in the levetiracetam group compared to the phenytoin group (OR = 0.65 [0.14-2.99]: χ(2) = 8.79: I(2) = 77%).The efficacy of prophylaxis with levetiracetam seems to be superior to that with phenytoin and valproate administration. Moreover, levetiracetam use demonstrates fewer side effects in brain tumour patients. Nevertheless, high risk of bias and moderate methodological quality must be taken into account when considering these results.

Published
2016

36. Neutrophil extracellular traps regulate IL-1 beta-mediated inflammation in familial Mediterranean fever

Author

Apostolidou, Eirini Skendros, Panagiotis Kambas, Konstantinos and Mitroulis, Ioannis Konstantinidis, Theocharis and Chrysanthopoulou, Akrivi Nakos, Konstantinos Tsironidou, Victoria Koffa, Maria Boumpas, Dimitrios T. Ritis, Konstantinos

Abstract

Objective Inflammatory attacks of familial Mediterranean fever (FMF) are characterised by circulation and influx of high number of polymorphonuclear neutrophils (PMN) in the affected sites and profound therapeutic effect of IL-1 beta inhibitors. We investigated the role of neutrophil extracellular traps (NET) in the pathogenesis of FMF, and their involvement in IL-1 beta production. Methods Blood samples were obtained from six FMF patients during remissions and from three patients during attacks. NET formation and NET components were studied by fluorescence techniques, immunobloting and MPO-DNA complex ELISA. Results PMNs from patients released NETs decorated with IL-1 beta during disease attacks. On the other hand, PMNs from patients during remission were resistant to inflammatory stimuli that induce NET release in PMNs from control subjects. Lower basal autophagy levels were identified in PMNs during remission, while induction of autophagy facilitated NET release, suggesting that autophagy is involved in the regulation of NET release. During the resolution of attacks, inhibition of NET formation by negative feedback mechanism was also observed. The anti-inflammatory agents, colchicine and DNAse I, inhibited IL-1 beta production in PMNs and IL-1 beta activity in NETs, respectively. Conclusions We suggest two additive events for triggering the FMF attack; the production of IL-1 beta by PMNs and its release through NETs. At the same time NETs, homeostatically, downregulate further NETosis, facilitating the resolution of attack. Compensatorly, lower basal autophagy of PMNs may protect from crises by attenuating the release of pro-inflammatory NETs.

Published
2016

38. Neutrophil extracellular traps promote differentiation and function of fibroblasts

Author

Chrysanthopoulou, Akrivi Mitroulis, Ioannis Apostolidou, Eirini and Arelaki, Stella Mikroulis, Dimitrios Konstantinidis, Theocharis Sivridis, Efthimios Koffa, Maria Giatromanolaki, Alexandra Boumpas, Dimitrios T. Ritis, Konstantinos Kambas, Konstantinos

Abstract

Neutrophil activation by inflammatory stimuli and the release of extracellular chromatin structures (neutrophil extracellular traps-NETs) have been implicated in inflammatory disorders. Herein, we demonstrate that NETs released by neutrophils treated either with fibrosis-related agents, such as cigarette smoke, magnesium silicate, bleomycin, or with generic NET inducers, such as phorbol 12-myristate 13-acetate, induced activation of lung fibroblasts (LFs) and differentiation into myofibroblast (MF) phenotype. Interestingly, the aforementioned agents or IL-17 (a primary initiator of inflammation/fibrosis) had no direct effect on LF activation and differentiation. MFs treated with NETs demonstrated increased connective tissue growth factor expression, collagen production, and proliferation/migration. These fibrotic effects were significantly decreased after degradation of NETs with DNase1, heparin or myeloperoxidase inhibitor, indicating the key role of NET-derived components in LF differentiation and function. Furthermore, IL-17 was expressed in NETs and promoted the fibrotic activity of differentiated LFs but not their differentiation, suggesting that priming by DNA and histones is essential for IL-17-driven fibrosis. Additionally, autophagy was identified as the orchestrator of NET formation, as shown by inhibition studies using bafilomycin A1 or wortmannin. The above findings were further supported by the detection of NETs in close proximity to alpha-smooth muscle actin (-SMA)-expressing fibroblasts in biopsies from patients with fibrotic interstitial lung disease or from skin scar tissue. Together, these data suggest that both autophagy and NETs are involved not only in inflammation but also in the ensuing fibrosis and thus may represent potential therapeutic targets in human fibrotic diseases. Copyright (c) 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd

Published
2014

40. Nonmedical Use of Prescription Medications Among Medical Students in Greece: Prevalence of and Motivation for Use.

Author

Papazisis, Georgios, Tsakiridis, Ioannis, Pourzitaki, Chryssa, Apostolidou, Eirini, Spachos, Dimitrios, and Kouvelas, Dimitrios

Subjects
ANALGESICS, DRUGS, PSYCHOLOGY of medical students, MOTIVATION (Psychology), NARCOTICS, SELF medication, SUBSTANCE abuse, SURVEYS, TRANQUILIZING drugs, SAMPLE size (Statistics), CENTRAL nervous system stimulants, DISEASE prevalence, DATA analysis software, DESCRIPTIVE statistics
Abstract

Background: Non-medical use of prescription medications has risen to unprecedented levels over the past decade worldwide; however, studies assessing misuse across medical students are sparse.Objectives: The purpose of this study was to1) estimate the lifetime and the past-year prevalence of non-medical use of prescription medications among medical students in Greece 2) identify the motivation for use.Methods: 591 medical students completed an anonymous, self-administered, web-based survey assessing lifetime and past-year prevalence of non-medical use of four classes of prescription drugs (opioid painkillers, tranquillizers, sleeping and stimulant medications). According to the motivation to use the responders were classified into three subtypes (selftreatment, recreational, and mixed).Results: The prevalence of lifetime use was 10.7% for at least one of the four prescription drug classes and 9% of the respondents reported lifetime misuse of multiple categories of prescription drugs. The past-year prevalence was approximately 7.7% for at least one of the four prescription drug classes, while the majority misused the drugs “1-2 times per year”. Senior students used tranquilizers more than junior students. Self-treatment and mixed subtypes of tranquillizers misuse was more prevalent among women than men while the self-treatment subtype was the most prevalent subtype in all the four drug classes.Conclusions: This is the first study investigating non-medical use of prescription medications among Greek medical students and indicates a high prevalence of misuse of some categories of prescription drugs, mostly for self-treatment purposes. [ABSTRACT FROM PUBLISHER]

Published
2018
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41. Primary mitral valve regurgitation: Update and review.

Author

Apostolidou, Eirini, Maslow, Andrew D., and Poppas, Athena

Subjects
*MITRAL valve insufficiency, *MITRAL valve surgery, *ETIOLOGY of diseases, *THERAPEUTICS
Abstract

Mitral regurgitation is the second most common valvular disorder requiring surgical intervention worldwide. This review summarizes the current understanding of primary, degenerative mitral regurgitation with respect to etiology, comprehensive assessment, natural history and management. The new concept of staging of the valvular disorders, newer predictors of adverse and controversy of "watchful waiting'' versus "early surgical intervention'' for severe, asymptomatic, primary mitral regurgitation are addressed. [ABSTRACT FROM AUTHOR]

Published
2017
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42. Neutrophil extracellular traps regulate IL-1β-mediated inflammation in familial Mediterranean fever

Author

Apostolidou, Eirini, primary, Skendros, Panagiotis, additional, Kambas, Konstantinos, additional, Mitroulis, Ioannis, additional, Konstantinidis, Theocharis, additional, Chrysanthopoulou, Akrivi, additional, Nakos, Konstantinos, additional, Tsironidou, Victoria, additional, Koffa, Maria, additional, Boumpas, Dimitrios T, additional, and Ritis, Konstantinos, additional

Published
2014
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43. Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

Author

Kambas, Konstantinos, Mitroulis, Ioannis, Apostolidou, Eirini, Girod, Andreas, Chrysanthopoulou, Akrivi, Pneumatikos, Ioannis, Skendros, Panagiotis, Kourtzelis, Ioannis, Koffa, Maria, Kotsianidis, Ioannis, Ritis, Konstantinos, Kambas, Konstantinos, Mitroulis, Ioannis, Apostolidou, Eirini, Girod, Andreas, Chrysanthopoulou, Akrivi, Pneumatikos, Ioannis, Skendros, Panagiotis, Kourtzelis, Ioannis, Koffa, Maria, Kotsianidis, Ioannis, and Ritis, Konstantinos

Abstract

Background: Sepsis is associated with systemic inflammatory responses and induction of coagulation system. Neutrophil extracellular traps (NETs) constitute an antimicrobial mechanism, recently implicated in thrombosis via platelet entrapment and aggregation. Methodology/Principal Findings: In this study, we demonstrate for the first time the localization of thrombogenic tissue factor (TF) in NETs released by neutrophils derived from patients with gram-negative sepsis and normal neutrophils treated with either serum from septic patients or inflammatory mediators involved in the pathogenesis of sepsis. Localization of TF in acidified autophagosomes was observed during this process, as indicated by positive LC3B and LysoTracker staining. Moreover, phosphatidylinositol 3-kinase inhibition with 3-MA or inhibition of endosomal acidification with bafilomycin A1 hindered the release of TF-bearing NETs. TF present in NETs induced thrombin generation in culture supernatants, which further resulted in protease activated receptor-1 signaling. Conclusions/Significance: This study demonstrates the involvement of autophagic machinery in the extracellular delivery of TF in NETs and the subsequent activation of coagulation cascade, providing evidence for the implication of this process in coagulopathy and inflammatory response in sepsis. © 2012 Kambas et al.

Published
2012

46. Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboinflammation and the thrombophilic state associated with the disease

Author

Kambas, Konstantinos, primary, Chrysanthopoulou, Akrivi, additional, Vassilopoulos, Dimitrios, additional, Apostolidou, Eirini, additional, Skendros, Panagiotis, additional, Girod, Andreas, additional, Arelaki, Stella, additional, Froudarakis, Marios, additional, Nakopoulou, Lydia, additional, Giatromanolaki, Alexandra, additional, Sidiropoulos, Prodromos, additional, Koffa, Maria, additional, Boumpas, Dimitrios T, additional, Ritis, Konstantinos, additional, and Mitroulis, Ioannis, additional

Published
2013
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47. Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

Author

Kambas, Konstantinos, primary, Mitroulis, Ioannis, additional, Apostolidou, Eirini, additional, Girod, Andreas, additional, Chrysanthopoulou, Akrivi, additional, Pneumatikos, Ioannis, additional, Skendros, Panagiotis, additional, Kourtzelis, Ioannis, additional, Koffa, Maria, additional, Kotsianidis, Ioannis, additional, and Ritis, Konstantinos, additional

Published
2012
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50. Tissue factor expression in neutrophil extracellular traps and neutrophil derived microparticles in antineutrophil cytoplasmic antibody associated vasculitis may promote thromboin ammation and the thrombophilic state associated with the disease.

Author

Kambas, Konstantinos, Chrysanthopoulou, Akrivi, Vassilopoulos, Dimitrios, Apostolidou, Eirini, Skendros, Panagiotis, Girod, Andreas, Arelaki, Stella, Froudarakis, Marios, Nakopoulou, Lydia, Giatromanolaki, Alexandra, Sidiropoulos, Prodromos, Koffa, Maria, Boumpas, Dimitrios T., Ritis, Konstantinos, and Mitroulis, Ioannis

Abstract

Objectives Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is characterised by neutrophil activation. An elevated prevalence of venous thromboembolic events has been reported in AAV. Because of the critical role of neutrophils in inflammation associated thrombosis, we asked whether neutrophil tissue factor (TF) may be implicated in the thrombotic diathesis in AAV. Methods Neutrophils from four patients and sera from 17 patients with ANCA associated vasculitis with active disease and remission were studied. TF expression was assessed by immunoblotting and confocal microscopy. Circulating DNA levels were evaluated. TF expressing microparticles (MPs) were measured by flow cytometry and thrombin--antithrombin complex levels by ELISA. Results Peripheral blood neutrophils from four patients with active disease expressed elevated TF levels and released TF expressing neutrophil extracellular traps (NETs) and MPs. TF positive NETs were released by neutrophils isolated from the bronchoalveolar lavage an were detected in nasal and renal biopsy specimens. Elevated levels of circulating DNA and TF expressing neutrophil derived MPs were further observed in sera from patients with active disease. Induction of remission attenuated the aforementioned effects. Control neutrophils treated with sera from patients with active disease released TF bearing NETs and MPs which were abolished after IgG depletion. Treatment of control neutrophils with isolated IgG from sera from patients with active disease also resulted in the release of TF bearing NETs. TF implication in MP dependent thrombin generation was demonstrated by antibody neutralisation studies. Conclusions Expression of TF in NETs and neutrophil derived MPs proposes a novel mechanism for the induction of thrombosis and inflammation in active AAV. [ABSTRACT FROM AUTHOR]

Published
2014
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