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645 results on '"Appelman, Henry D."'

1. Non-IBD Noninfectious Colitis

Author

Lin, Jingmei, Appelman, Henry D., Lin, Fan, Series Editor, Yang, Ximing J., Series Editor, Wang, Hanlin L., editor, and Chen, Zongming Eric, editor

Published
2021
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2. Epigenetic Reprogramming of Autophagy Drives Mutant IDH1 Glioma Progression and Response to Radiation

Author

Núñez, Felipe J, primary, Banerjee, Kaushik, additional, Mujeeb, Anzar A., additional, Mauser, Ava, additional, Tronrud, Claire E., additional, Zhu, Ziwen, additional, Taher, Ayman, additional, Kadiyala, Padma, additional, Carney, Stephen V., additional, Garcia-Fabiani, Maria B., additional, Comba, Andrea, additional, Alghamri, Mahmoud S., additional, McClellan, Brandon L., additional, Faisal, Syed M., additional, Nwosu, Zeribe C., additional, Hong, Hanna S., additional, Qin, Tingting, additional, Sartor, Maureen A., additional, Ljungman, Mats, additional, Cheng, Shi-Yuan, additional, Appelman, Henry D., additional, Lowenstein, Pedro R., additional, Lahann, Joerg, additional, Lyssiotis, Costas A., additional, and Castro, Maria G., additional

Published
2024
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7. Autoimmune Gastritis

Author

Hall, Sara N. and Appelman, Henry D.

Subjects
Diagnosis, Anemia -- Diagnosis, Gastritis -- Diagnosis, Gastrointestinal diseases, Intelligence gathering, Epithelium, Hyperplasia, Pernicious anemia, Diagnostic errors
Abstract

PATHOGENESIS Autoimmune gastritis (AG) is an immune-mediated disease, restricted to oxyntic (acid-producing) mucosa in the corpus (anatomic body and fundus) of the stomach. (1) Normally, the parietal cells in the [...], * Context.--Autoimmune gastritis (AG) is a corpus-restricted chronic atrophic gastritis associated with intrinsic factor deficiency, either with or without pernicious anemia. Autoimmune gastritis is a microscopic disease because patients present with no or vague symptoms, and clinicians rarely find endoscopic changes. Autoimmune gastritis only becomes a clinical disease when pathologists diagnose it in gastric biopsies performed for a variety of clinical indications. Unfamiliarity with this disease can result in misdiagnosis of patients, and thus inadequate patient management. Objective.--To review the pathogenesis, clinical features, diagnostic criteria, differential diagnoses, sequelae, and surveillance recommendations for AG. Data Sources.--The sources of the study include a review of the pertinent literature for AG. Conclusions.--Autoimmune gastritis is an important disease characterized by a loss of oxyntic mucosa and presence of metaplastic epithelium and enterochromaffin-like cell hyperplasia. Awareness and proper diagnosis are critical to prevent mismanagement of patients. (Arch Pathol Lab Med. 2019;143:1327-1331; doi: 10.5858/arpa.2019-0345-RA)

Published
2019
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14. Gastric Metastases

Author

Owens, Scott R., Appelman, Henry D., Cheng, Liang, Series editor, Owens, Scott R., and Appelman, Henry D.

Published
2014
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36. Approach to the Liver Biopsy in the Patient With Chronic Low-Level Aminotransferase Elevations

Author

Ettel, Mark G. and Appelman, Henry D.

Subjects
Research, Enzymes -- Research, Liver -- Research
Abstract

There is extensive literature addressing both the histopathologic and clinical characteristics of every liver disease entity that presents with specific clinical and/or laboratory findings. Many patients, however, are biopsied not [...], Pathologists sometimes encounter a liver biopsy from an asymptomatic patient with unexplained low-level parenchymal liver enzyme elevations. These biopsies often have minor histologic changes but are otherwise almost entirely normal. This can lead to the quandary of whether or not the features are clinically meaningful and how one must formulate a diagnosis from the possibly nonspecific findings of a near-normal biopsy. The following discussion focuses on the histologic changes that can be seen in these biopsies and the practical issues involved in making a diagnosis that provides useful information to the clinician. The literature and textbooks addressing the histologic and clinical features of these cases are reviewed with an emphasis on the clinical implications of finding nonspecific histologic alterations in these patients. doi: 10.5858/arpa.2018-0214-RA

Published
2018
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