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136 results on '"Appukkuttan, Prasad"'

4. High-speed microwave-promoted hetero-Diels-Alder reactions of 2(1H)-pyrazinones in ionic liquid doped solvents

Author

Eycken, Erik van der, Appukkuttan, Prasad, De Borggraeve, Wim, Dehaen, Wim, Dallinger, Doris, and Kappe, C. Oliver

Subjects
Chemistry, Organic -- Research, Diels-Alder reaction -- Usage, Pyridazine, Microwaves, Ionic solutions, Biological sciences, Chemistry
Abstract

Research has been conducted on 2(1H)-pyrazinones. The study of the inter- and intramolecular hetero-Diels-Alder reactions carried out under controlled microwave irradiation in a series of functionalized 2(1H)-pyrazinones is presented.

Published
2002

6. Diversity oriented microwave-assisted synthesis of (-)-steganacin aza-analogues

Author

Mont, Nuria, Mehta, Vaibhav Pravinchandra, Appukkuttan, Prasad, Beryozkina, Tetyana, Toppet, Suzzane, Hecke, Kristof Van, Meervelt, Luc Van, Voet, Arnout, and DeMaeyer, Marc

Subjects
Ring formation (Chemistry) -- Analysis, Lactones -- Chemical properties, Microwaves -- Usage, Polymerization -- Analysis, Biological sciences, Chemistry
Abstract

The development of a novel microwave-assisted synthetic protocol for the formation of hitherto unknown aza-analogues of (-)-steganacin is reported. The obtained product is a naturally occurring bisbenzocyclooctadiene lignan lactone with potent antileukemic and tubulin polymerization inhibitory activity.

Published
2008

7. Microwave-assisted, Mo(CO)(6)-mediated, palladium-catalyzed amino-carbonylation of aryl halides using allylamine : from exploration to scale-up

Author

Appukkuttan, Prasad, Axelsson, Linda, Van der Eycken, Erik, Larhed, Mats, Appukkuttan, Prasad, Axelsson, Linda, Van der Eycken, Erik, and Larhed, Mats

Abstract

Palladium-catalyzed aminocarbonylations of various (hetero)aryl halides with allylamine using Mo(CO)(6) as a solid, in situ CO source, were explored. Microwave-enhanced conditions proved to be highly useful in promoting the conversions in a mere 10-20 min with various (hetero)aryl iodides, bromides and chlorides. The scale-up of a microwave-enhanced aminocarbonylation to 25 mmol scale was performed successfully. (C) 2008 Elsevier Ltd. All rights reserved.

Published
2008
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8. Recent developments in microwave-assisted, transition-metal-catalysed C-C and C-N bond-forming reactions

Author

Appukkuttan, Prasad, Van der Eycken, Erik, Appukkuttan, Prasad, and Van der Eycken, Erik

Abstract

A selective over-view of the recent developments of microwave-assisted, transition-metal-catalysed C-C and C-N bond-forming reactions is presented. Microwave-assisted chemistry is a comparatively novel technique in the present-day synthetic world and has recently grown in an exponential manner, stretching from academia to a widely practiced technique in industry. Transition-metal-catalysed C-C and C-N bond-forming reactions represent one of the most interesting and well-investigated type of microwave-assisted reactions, evident from the plethora of available literature and patents in this area. Given the large number of articles published on the subject, we have made a very concise selection from the recent literature, covering manuscripts dealing with the subject from the period of the end 2004 until the first part of 2007.

Published
2008
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9. Microwave-assisted transition-metal-catalyzed synthesis of N-shifted and ring-expanded buflavine analogues

Author

Appukkuttan, Prasad, Dehaen, Wim, Van der Eycken, Erik, Appukkuttan, Prasad, Dehaen, Wim, and Van der Eycken, Erik

Abstract

Two novel and efficient strategies for the synthesis of hitherto unknown N-shifted and ring-expanded buflavine analogues are presented. Construction of the medium-sized ring system of the title molecules, a difficult task due to the high activation energy needed for the ring-closure with the additional rigidity imposed by the biaryl skeleton, was achieved by using Suzuki-Miyaura biaryl coupling and a ring-closing metathesis reaction as the key steps. The combination of a second-generation Grubbs catalyst and microwave irradiation proved to be highly useful in generating the otherwise difficult to obtain medium-sized ring system of the buflavine analogues.

Published
2007
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50. Microwave-Assisted Natural Product Chemistry.

Author

Larhed, Mats, Olofssonq, Kristofer, Appukkuttan, Prasad, and Eycken, Erik

Abstract

An overview of the application of microwave irradiation in natural product synthesis is presented, focusing on the developments in the last 5-10 years. This contribution covers the literature concerning the total synthesis of natural products and their analogues, the synthesis of alkaloids and the construction of building blocks of interest for natural product synthesis. As microwave irradiation appeared on the scene only recently, we are at an early stage of its application in natural product chemistry, even though some nice examples have been communicated recently. The application of dedicated microwave instruments as well as domestic microwave ovens is discussed, giving emphasis to the microwave-enhanced transformations. [ABSTRACT FROM AUTHOR]

Published
2006
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