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5 results on '"Aprikian VS"'

1. [Myelopeptide-3 activates macrophage function].

Author

Aprikian VS, Mikhaĭlova AA, and Petrov RV

Subjects
Animals, Female, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred CBA, Salmonella typhimurium physiology, Macrophage Activation physiology, Macrophages, Peritoneal immunology, Oligopeptides physiology
Published
1999

3. [Changes in the phagocytic activity of macrophages under the action of different doses of antibiotics].

Author

Aprikian VS, Mikhaĭlova AA, and Petrov RV

Subjects
Animals, Dose-Response Relationship, Drug, Drug Synergism, Gentamicins pharmacology, Macrophages immunology, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Penicillin G pharmacology, Peritoneal Cavity cytology, Staphylococcus aureus, Streptomycin pharmacology, Time Factors, Anti-Bacterial Agents pharmacology, Macrophages drug effects, Phagocytosis drug effects
Abstract

Penicillin, streptomycin and gentamicin, when introduced into mice in a single injection in doses of 0.5-500,000 U/kg, produced different changes in the phagocytic activity of mouse peritoneal macrophages. Bactericidal doses of these antibiotics either suppressed the activity of macrophages or left it unchanged. Their sub-bactericidal doses enhanced the phagocytic activity of macrophages. Combined use of penicillin and streptomycin produced a synergic effect.

Published
1992

4. [Immunocorrecting properties of antibiotics in secondary immunodeficiency].

Author

Petrov RV, Aprikian VS, and Mikhaĭlova AA

Subjects
Animals, Anti-Bacterial Agents immunology, Antibody Formation, Cyclophosphamide immunology, Cyclophosphamide therapeutic use, Gentamicins immunology, Gentamicins therapeutic use, Immunity, Cellular, Immunologic Deficiency Syndromes immunology, Mice, Penicillin G immunology, Penicillin G therapeutic use, Streptomycin immunology, Streptomycin therapeutic use, Anti-Bacterial Agents therapeutic use, Immunologic Deficiency Syndromes drug therapy
Abstract

The study investigated immunocorrecting properties of penicillin G, streptomycin, gentamycin in cyclophosphamide--induced immunodeficiency in mice. It was determined, that antibiotics in sub-bactericidal doses possess pronounced immunocorrecting properties. This effect was observed in both humoral and cell-mediated immune response.

Published
1992

5. [The protective properties of myelopeptides in the development of infectious processes caused by bacteria of the genus Salmonella].

Author

Petrov RV, Aprikian VS, Sergeev IuO, Elkina SI, and Sergeev VV

Subjects
Animals, Body Weight drug effects, Drug Evaluation, Preclinical, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Salmonella Infections, Animal mortality, Salmonella typhimurium, Swine, Swine Diseases mortality, Swine Diseases prevention & control, Time Factors, Bone Marrow immunology, Oligopeptides, Peptides therapeutic use, Salmonella Infections, Animal prevention & control
Abstract

The protective properties of myelopeptides in the development of bacterial infection in mice and young pigs, caused by S. typhimurium 415, S. cholerae-suis 1422 and 370, have been studied. Myelopeptides have been found to possess protective properties when injected into animals infected with S. typhimurium and S. cholerae-suis in lethal doses. The best protective effect (survival rate of 100%) has been achieved by the injection of myelopeptides 24 hours before challenge. Myelopeptides have also been found to promote the weight gain of young pigs infected with S. cholerae-suis.

Published
1988

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