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24 results on '"Aquilina, Joseph W."'

9. Efficacy and safety of extended-release oxybutynin in combination with tamsulosin for treatment of lower urinary tract symptoms in men: randomized, double-blind, placebo-controlled study

Author

Macdiarmid, Scott A., Peters, Kenneth M., Chen, Andrew, Armstrong, Robert B., Orman, Camille, Aquilina, Joseph W., and Nitti, Victor W.

Subjects
Oxybutynin -- Dosage and administration, Tamsulosin hydrochloride -- Dosage and administration, Urinary tract infections -- Drug therapy, Urinary tract infections -- Patient outcomes, Drug therapy, Combination -- Usage, Drug therapy, Combination -- Patient outcomes
Abstract

OBJECTIVE: To evaluate the efficacy and tolerability of extended-release oxybutynin in combination with the [[alpha].sub.1]-blocker tamsulosin in reducing lower urinary tract symptoms in men. PATIENTS AND METHODS: In this multicenter, [...]

Published
2008

10. Dalteparin in combination with abciximab during percutaneous coronary intervention

Author

Kereiakes, Dean J., Kleiman, Neal S., Fry, Edward, Mwawasi, Grace, Lengerich, Rose, Maresh, Kelly, Burkert, Mary Lynn, Aquilina, Joseph W., DeLoof, Michael, Broderick, Thomas M., and Shimshak, Thomas M.

Subjects
Anticoagulants (Medicine) -- Evaluation, Heart attack -- Drug therapy, Unstable angina -- Drug therapy, Health
Published
2001

16. Pharmacokinetics and pharmacodynamic, pharmacokinetic, pharmacodynamic, and electrocardiographic effects of dapoxetine and moxifloxacin compared with placebo in healthy adult male subjects

Author

Modi, Nishit B., Nath, Rajneesh, Staehr, Peter, Gupta, Suneel K., Aquilina, Joseph W., and Rivas, David

Subjects
Men -- Health aspects, Moxifloxacin -- Dosage and administration, Moxifloxacin -- Research, Pharmacokinetics -- Analysis, Premature ejaculation -- Diagnosis, Premature ejaculation -- Care and treatment, Health
Published
2009

23. Pharmacokinetic, Pharmacodynamic, and Electrocardiographic Effects of Dapoxetine and Moxifloxacin Compared With Placebo in Healthy Adult Male Subjects.

Author

Modi, Nishit B., Nath, Rajneesh, Staehr, Peter, Gupta, Suneel K., Aquilina, Joseph W., and Rivas, David

Subjects
SEROTONIN uptake inhibitors, ELECTROCARDIOGRAPHY, MOXIFLOXACIN, PHARMACOKINETICS, PHARMACODYNAMICS, PLACEBOS, MEN, TREATMENT of sexual dysfunction, IMPOTENCE
Abstract

Selective serotonin reuptake inhibitors (SSRIs) may be associated with electrocardiographic effects. The electrocardiographic pharmacodynamics of dapoxetine, a short-acting SSRI being developed for the treatment of premature ejaculation, are compared with those of placebo and moxifloxacin (positive control) in 2 single-center, randomized, crossover studies in healthy men. In study 1, subjects receive 2 doses of dapoxetine 120 mg, given 3 hours apart; a single dose of moxifloxacin 400 mg; and 2 doses of placebo, given 3 hours apart. In study 2, subjects receive single doses of dapoxetine 60 mg, dapoxetine 120 mg, moxifloxacin 400 mg, and placebo. Moxifloxacin significantly increases QT and corrects QT intervals (QTc) compared with placebo in both studies (eg, Bazett-corrected QTc of 11.90 milliseconds [95% confidence interval, 2.68 to 21.11] and 5.06 [95% confidence interval, -2.26 to 12.38]). Dapoxetine 60,120, and 240 mg do not prolong the QT/QTc interval and have no clinically significant electrocardiographic effects. Dapoxetine and moxifloxacin pharmacokinetics are similar to previous reports. Adverse events are generally mild in severity; nausea is the most common. The results demonstrate that dapoxetine does not have electrocardiographic effects at doses of 60, 120, and 240 mg. [ABSTRACT FROM AUTHOR]

Published
2010
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