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Your search keyword '"Arai, Chika"' showing total 18 results
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18 results on '"Arai, Chika"'

1. Ursoricin, a bacteriocin of Streptococcus ursoris , has potent activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci

Author

Wang, Chutian, primary, Le, Mi Nguyen-Tra, additional, Kawada-Matsuo, Miki, additional, Hisatsune, Junzo, additional, Sugawara, Yo, additional, Arai, Chika, additional, Nakanishi, Jun, additional, Takeda, Katsuhiro, additional, Shiba, Hideki, additional, Sugai, Motoyuki, additional, and Komatsuzawa, Hitoshi, additional

Published
2024
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2. Comprehensive Genomic Characterization of Staphylococcus aureus Isolated from Atopic Dermatitis Patients in Japan: Correlations with Disease Severity, Eruption Type, and Anatomical Site

Author

Obata, Shoko, primary, Hisatsune, Junzo, additional, Kawasaki, Hiroshi, additional, Fukushima-Nomura, Ayano, additional, Ebihara, Tamotsu, additional, Arai, Chika, additional, Masuda, Kanako, additional, Kutsuno, Shoko, additional, Iwao, Yasuhisa, additional, Sugai, Motoyuki, additional, Amagai, Masayuki, additional, and Tanese, Keiji, additional

Published
2023
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3. Disinfectant Susceptibility of Third-Generation-Cephalosporin/Carbapenem-Resistant Gram-Negative Bacteria Isolated from the Oral Cavity of Residents of Long-Term-Care Facilities

Author

Haruta, Azusa, primary, Kawada-Matsuo, Miki, additional, Le, Mi Nguyen-Tra, additional, Yoshikawa, Mineka, additional, Kajihara, Toshiki, additional, Yahara, Koji, additional, Kitamura, Norikazu, additional, Kutsuno, Shoko, additional, Arai, Chika, additional, Takeuchi, Maho, additional, Sugawara, Yo, additional, Hisatsune, Junzo, additional, Tsuga, Kazuhiro, additional, Ohge, Hiroki, additional, Sugai, Motoyuki, additional, and Komatsuzawa, Hitoshi, additional

Published
2023
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4. Oral and Rectal Colonization by Antimicrobial-Resistant Gram-Negative Bacteria and Their Association with Death among Residents of Long-Term Care Facilities: A Prospective, Multicenter, Observational, Cohort Study

Author

Kajihara, Toshiki, primary, Yahara, Koji, additional, Yoshikawa, Mineka, additional, Haruta, Azusa, additional, Kawada-Matsuo, Miki, additional, Le, Mi Nguyen-Tra, additional, Arai, Chika, additional, Takeuchi, Maho, additional, Kitamura, Norikazu, additional, Sugawara, Yo, additional, Hisatsune, Junzo, additional, Kayama, Shizuo, additional, Ohta, Kouji, additional, Tsuga, Kazuhiro, additional, Komatsuzawa, Hitoshi, additional, Ohge, Hiroki, additional, and Sugai, Motoyuki, additional

Published
2022
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5. Oral and Rectal Colonization by Antimicrobial-Resistant Gram-Negative Bacteria and Their Association with Death among Residents of Long-Term Care Facilities: A Prospective, Multicenter, Observational, Cohort Study.

Author

Kajihara, Toshiki, Yahara, Koji, Yoshikawa, Mineka, Haruta, Azusa, Kawada-Matsuo, Miki, Le, Mi Nguyen-Tra, Arai, Chika, Takeuchi, Maho, Kitamura, Norikazu, Sugawara, Yo, Hisatsune, Junzo, Kayama, Shizuo, Ohta, Kouji, Tsuga, Kazuhiro, Komatsuzawa, Hitoshi, Ohge, Hiroki, and Sugai, Motoyuki

Subjects
LONG-term care facilities, GRAM-negative bacteria, COHORT analysis, HEALTH facilities, DRUG resistance in microorganisms
Abstract

Introduction: The prevalence of antimicrobial-resistant bacteria (ARB) in long-term care facilities (LTCFs) remains unclear. Furthermore, the effect of ARB colonization on the clinical outcomes of LTCF residents has not been explored. Methods: We conducted a prospective multicenter cohort study and investigated the residents (N = 178) of six Japanese LTCFs (three Welfare Facilities for the Elderly Requiring Long-term Care and three Geriatric Health Service Facilities) for oral and rectal carriage of ARB. The clinical outcomes of the residents were evaluated based on isolating bacterial strains and subjecting them to whole-genome sequencing. Results: Of the 178 participants, 32 belonging to Geriatric Health Service Facilities with no information on their clinical outcome were excluded, and the remaining 146 were followed up for at most 21 months. Extended-spectrum β-lactamases (ESBL)-producing Enterobacterales and Pseudomonas aeruginosa were detected in 42.7% (n = 76) and 2.8% (n = 5) of the rectal swabs and 5.6% (n = 10) and 3.4% (n = 6) of the oral swabs, respectively. Detection of ARB in the oral and rectal cavities showed remarkable association with enteral nutrition. Further, P. aeruginosa was significantly associated with an increase in mortality of the residents, but there were not significant association between ESBL-producing Enterobacterales and mortality. Core-genome phylogeny of P. aeruginosa revealed a wide-spread distribution of the isolated strains across the phylogeny, which included a cluster of ST235 strains with substantially higher biofilm formation ability than the other isolated P. aeruginosa strains. Discussion/Conclusion: This study is the first to investigate the carriage of both oral and rectal ARB, genomic relatedness and determinants of antimicrobial resistance in isolated strains, and clinical outcomes of LTCF residents. Our study provides the first direct evidence for the burden of antimicrobial resistance in LTCFs. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Discovery of Novel Benzo[a]phenoxazine SSJ-183 as a Drug Candidate for Malaria

Author

Ge, Jian-Feng, primary, Arai, Chika, additional, Yang, Mei, additional, Bakar Md., Abu, additional, Lu, Jun, additional, Ismail, Nasser S. M., additional, Wittlin, Sergio, additional, Kaiser, Marcel, additional, Brun, Reto, additional, Charman, Susan A., additional, Nguyen, Tien, additional, Morizzi, Julia, additional, Itoh, Isamu, additional, and Ihara, Masataka, additional

Published
2010
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18. Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL).

Author

Yang M, Arai C, Bakar Md A, Lu J, Ge JF, Pudhom K, Takasu K, Kasai K, Kaiser M, Brun R, Yardley V, Itoh I, and Ihara M

Subjects
Animals, Antiprotozoal Agents chemistry, Benzothiazoles chemistry, Cell Line, Cell Survival drug effects, Female, Macrophages drug effects, Mice, Mice, Inbred BALB C, Parasitic Sensitivity Tests, Rats, Antiprotozoal Agents pharmacology, Benzothiazoles pharmacology, Leishmania donovani drug effects, Leishmaniasis, Visceral drug therapy
Abstract

Anti-Leishmania in vitro and in vivo activities of various rhodacyanine derivatives have been examined. Among them, the fluorinatied variant SJL-01 (8) showed IC(50) of 0.011 microM against Leishmania donovani strain MHOM/ET/67/L82 (selective index of >15000) and 95-97% inhibition against L. donovani strain MHOM/ET/67/HU in female BALB/c mice by 1.3-12.5 mg/kg x 5 iv administrations. Negative results on chromosomal aberration test and in vitro micronucleus test suggest that compound 8 is a hopeful candidate for visceral leishmaniasis (VL).

Published
2010
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