Search

Your search keyword '"Arai, Tomio"' showing total 1,364 results
Start Over Author "Arai, Tomio"
1,364 results on '"Arai, Tomio"'

3. Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy

Author

Matsubara, Tomoyasu, Ishii, Kenji, Saito, Yoko, Tokumaru, Aya Midori, Arakawa, Akira, Hara, Manato, Kurihara, Masanori, Sengoku, Renpei, Kanemaru, Kazutomi, Iwata, Atsushi, Arai, Tomio, Miyashita, Akinori, Ikeuchi, Takeshi, Hasegawa, Masato, Murayama, Shigeo, and Saito, Yuko

Published
2024
Full Text
View/download PDF

13. Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models.

Author

Shinji, Seiichi, Ogawa, Yutaro, Yamada, Takeshi, Matsuda, Akihisa, Uehara, Kay, Yokoyama, Yasuyuki, Takahashi, Goro, Iwai, Takuma, Miyasaka, Toshimitsu, Kanaka, Shintaro, Hayashi, Koki, Shichi, Yuuki, Fujiwara, Masakazu, Takahashi, Kimimasa, Arai, Tomio, Ishiwata, Toshiyuki, and Yoshida, Hiroshi

Subjects
SCANNING transmission electron microscopy, CANCER cell analysis, TRANSMISSION electron microscopy, CELL lines, EPITHELIAL cells
Abstract

The epithelial and mesenchymal features of colorectal adenocarcinoma (CRAC) cell lines were compared in two-dimensional (2D) and three-dimensional (3D) cultures. In 2D cultures, the three CRAC cell lines exhibited epithelial characteristics with high E-cadherin and low vimentin levels, whereas two exhibited mesenchymal traits with opposite expression patterns. In 3D cultures using low-attachment plates, mesenchymal cells from 2D cultures showed reduced vimentin mRNA levels. Morphologically, the five CRAC cell lines appeared similarly shaped in 2D culture but formed different structures in 3D culture. Epithelial DLD-1 and mesenchymal COLO-320 cells produced large granular spheres, whereas epithelial HCT-15 cells formed small solid spheres. Tubular structures were observed in epithelial CACO-2 and mesenchymal SW480 spheres. Desmosome-like structures developed in epithelial CRAC cells, whereas entosis was observed in CACO-2, HCT-15, and SW480 cells. The Ki-67-positive proliferating cell count varied in 2D and 3D cultures of epithelial cells but remained high and unchanged in mesenchymal cells. These findings suggest that while CRAC cells display distinct epithelial and mesenchymal properties in 2D cultures, they form diverse 3D structures, irrespective of these traits. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

20. Clinicopathological importance of Bcl‐2 and p53 in postmenopausal triple‐negative breast carcinoma and association with age.

Author

Ito, Kei, Honma, Naoko, Ogata, Hideaki, Yamada, Akimitsu, Miyashita, Mika, Arai, Tomio, Sasaki, Eiichi, Shibuya, Kazutoshi, Mikami, Tetuo, and Sawaki, Masataka

Subjects
ANDROGEN receptors, BREAST cancer, TREATMENT effectiveness, ESTROGEN receptors, TRIPLE-negative breast cancer
Abstract

Appropriate biomarkers are required to predict the clinical outcome of triple‐negative breast cancer (TNBC). In this study, we focused on the clinical importance of two representative tumor‐associated proteins, Bcl‐2 and p53. Bcl‐2 expression is usually related to estrogen receptor expression and a favorable outcome in breast cancer. TNBC has been reported to show a high frequency of p53 positivity suggesting TP53 mutations. The expressions of Bcl‐2 and p53 were immunohistochemically examined in TNBC involving two age groups of postmenopausal women (≥75 y/o, n = 75; 55–64 y/o, n = 47), who underwent surgery without neoadjuvant therapy. We examined their associations with each other, or with clinicopathological factors including the outcome. Bcl‐2 expression was inversely correlated with androgen receptor, apocrine morphology, and p53 expressions, and was an independent predictor of a poor outcome in total or in younger women. p53 positivity was associated with a more favorable outcome than p53 negativity in the younger group. In combined analyzes, none of the twenty Bcl‐2‐negative/p53‐positive cases in the younger group exhibited recurrence, resulting in the independent favorable predictive value of Bcl‐2‐negative/p53‐positive. The anti‐apoptotic nature of Bcl‐2 may be apparent in TNBC. The excellent outcome of Bcl‐2‐negative/p53‐positive cases in the younger group warrants further combined investigation of Bcl‐2/p53 in TNBC. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Concordance between microsatellite instability testing and immunohistochemistry for mismatch repair proteins and efficient screening of mismatch repair deficient gastric cancer

Author

Yamamoto, Gou, primary, Ito, Tetsuya, additional, Suzuki, Okihide, additional, Kamae, Nao, additional, Kakuta, Miho, additional, Takahashi, Akemi, additional, Iuchi, Katsuya, additional, Arai, Tomio, additional, Ishida, Hideyuki, additional, and Akagi, Kiwamu, additional

Published
2023
Full Text
View/download PDF

30. Both MLH1 deficiency and BRAFV600E mutation are a unique characteristic of colorectal medullary carcinoma: An observational study

Author

Kaneko, Masanao, primary, Nakashima, Mitsuko, additional, Sugiura, Kiichi, additional, Ishida, Natsuki, additional, Tamura, Satoshi, additional, Tani, Shinya, additional, Yamade, Mihoko, additional, Hamaya, Yasushi, additional, Osawa, Satoshi, additional, Tatsuta, Kyota, additional, Kurachi, Kiyotaka, additional, Baba, Satoshi, additional, Iwashita, Yuji, additional, Arai, Tomio, additional, Sugimura, Haruhiko, additional, Maekawa, Masato, additional, Sugimoto, Ken, additional, and Iwaizumi, Moriya, additional

Published
2023
Full Text
View/download PDF

43. Cardiac mucosa in neonates

Author

Takubo, Kaiyo, primary, Aida, Junko, additional, Vieth, Michael, additional, Fujiwara, Mutsunori, additional, Nemoto, Tetsuo, additional, Arai, Tomio, additional, Mukaisho, Ken-ichi, additional, Nakazawa, Atsuko, additional, and Ishiwata, Toshiyuki, additional

Published
2023
Full Text
View/download PDF

44. Supplementary Figure 2 from Chromosome 5q Loss in Colorectal Flat Adenomas

Author

Voorham, Quirinus J.M., primary, Carvalho, Beatriz, primary, Spiertz, Angela J., primary, van Grieken, Nicole C.T., primary, Mongera, Sandra, primary, Rondagh, Eveline J.A., primary, van de Wiel, Mark A., primary, Jordanova, Ekaterina S., primary, Ylstra, Bauke, primary, Kliment, Martin, primary, Grabsch, Heike, primary, Rembacken, Bjorn J., primary, Arai, Tomio, primary, de Bruïne, Adriaan P., primary, Sanduleanu, Silvia, primary, Quirke, Philip, primary, Mulder, Chris J.J., primary, van Engeland, Manon, primary, and Meijer, Gerrit A., primary

Published
2023
Full Text
View/download PDF

45. Supplementary Figure Legend from Chromosome 5q Loss in Colorectal Flat Adenomas

Author

Voorham, Quirinus J.M., primary, Carvalho, Beatriz, primary, Spiertz, Angela J., primary, van Grieken, Nicole C.T., primary, Mongera, Sandra, primary, Rondagh, Eveline J.A., primary, van de Wiel, Mark A., primary, Jordanova, Ekaterina S., primary, Ylstra, Bauke, primary, Kliment, Martin, primary, Grabsch, Heike, primary, Rembacken, Bjorn J., primary, Arai, Tomio, primary, de Bruïne, Adriaan P., primary, Sanduleanu, Silvia, primary, Quirke, Philip, primary, Mulder, Chris J.J., primary, van Engeland, Manon, primary, and Meijer, Gerrit A., primary

Published
2023
Full Text
View/download PDF

46. Supplementary Figure 3 from Chromosome 5q Loss in Colorectal Flat Adenomas

Author

Voorham, Quirinus J.M., primary, Carvalho, Beatriz, primary, Spiertz, Angela J., primary, van Grieken, Nicole C.T., primary, Mongera, Sandra, primary, Rondagh, Eveline J.A., primary, van de Wiel, Mark A., primary, Jordanova, Ekaterina S., primary, Ylstra, Bauke, primary, Kliment, Martin, primary, Grabsch, Heike, primary, Rembacken, Bjorn J., primary, Arai, Tomio, primary, de Bruïne, Adriaan P., primary, Sanduleanu, Silvia, primary, Quirke, Philip, primary, Mulder, Chris J.J., primary, van Engeland, Manon, primary, and Meijer, Gerrit A., primary

Published
2023
Full Text
View/download PDF

47. Supplementary Figure 1 from Chromosome 5q Loss in Colorectal Flat Adenomas

Author

Voorham, Quirinus J.M., primary, Carvalho, Beatriz, primary, Spiertz, Angela J., primary, van Grieken, Nicole C.T., primary, Mongera, Sandra, primary, Rondagh, Eveline J.A., primary, van de Wiel, Mark A., primary, Jordanova, Ekaterina S., primary, Ylstra, Bauke, primary, Kliment, Martin, primary, Grabsch, Heike, primary, Rembacken, Bjorn J., primary, Arai, Tomio, primary, de Bruïne, Adriaan P., primary, Sanduleanu, Silvia, primary, Quirke, Philip, primary, Mulder, Chris J.J., primary, van Engeland, Manon, primary, and Meijer, Gerrit A., primary

Published
2023
Full Text
View/download PDF

48. Supplementary Tables 1 - 4 from Chromosome 5q Loss in Colorectal Flat Adenomas

Author

Voorham, Quirinus J.M., primary, Carvalho, Beatriz, primary, Spiertz, Angela J., primary, van Grieken, Nicole C.T., primary, Mongera, Sandra, primary, Rondagh, Eveline J.A., primary, van de Wiel, Mark A., primary, Jordanova, Ekaterina S., primary, Ylstra, Bauke, primary, Kliment, Martin, primary, Grabsch, Heike, primary, Rembacken, Bjorn J., primary, Arai, Tomio, primary, de Bruïne, Adriaan P., primary, Sanduleanu, Silvia, primary, Quirke, Philip, primary, Mulder, Chris J.J., primary, van Engeland, Manon, primary, and Meijer, Gerrit A., primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results