Search

Your search keyword '"Arbabi, Saman"' showing total 567 results
Start Over Author "Arbabi, Saman"
567 results on '"Arbabi, Saman"'

4. Chronic critical illness after hypothermia in trauma patients

Author

Miranda, David, Maine, Rebecca, Cook, Mackenzie, Brakenridge, Scott, Moldawer, Lyle, Arbabi, Saman, O'Keefe, Grant, Robinson, Bryce, Bulger, Eileen M, Maier, Ronald, and Cuschieri, Joseph

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Human Genome, Genetics, Physical Injury - Accidents and Adverse Effects, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, multiple trauma, multiple organ failure
Abstract

ObjectivesChronic critical illness (CCI) is a phenotype that occurs frequently in patients with severe injury. Previous work has suggested that inflammatory changes leading to CCI occur early following injury. However, the modifiable factors associated with CCI are unknown. We hypothesized that hypothermia, an early modifiable factor, is associated with CCI.MethodsTo determine the association of hypothermia and CCI, a secondary analysis of the Inflammation and Host Response to Injury database was performed, and subsequently validated on a similar cohort of patients from a single level 1 trauma center from January 2015 to December 2019. Hypothermia was defined as initial body temperature ≤34.5°C. CCI was defined as death or sustained multiorgan failure ≥14 days after injury. Data were analyzed using univariable analyses with Student's t-test and Pearson's χ2 test, and logistic regression. An arrayed genomic analysis of the transcriptome of circulating immune cells was performed in these patients.ResultsOf the initial 1675 patients, 254 had hypothermia and 1421 did not. On univariable analysis, 120/254 (47.2%) of patients with hypothermia had CCI, compared with 520/1421 (36.6%) without hypothermia who had CCI, p

Published
2021

5. Making your geriatric and palliative programs a strength: TQIP guideline implementation and the VRC perspective.

Author

Ho, Vanessa, Adams, Sasha, OConnell, Kathleen, Arbabi, Saman, Powelson, Elisabeth, Cooper, Zara, Stein, Deborah, and Cocanour, Christine

Subjects
clinical protocols, delivery of health care, geriatric, patient-centered care
Abstract

BACKGROUND: Older patients compose approximately 30% of trauma patients treated in the USA but make up nearly 50% of deaths from trauma. To help standardize and elevate care of these patients, the American College of Surgeons (ACS) Trauma Quality Improvement Programs best practice guidelines for geriatric trauma management was published in 2013 and that for palliative care was published in 2017. Here, we discuss how palliative care and geriatrics quality metrics can be tracked and used for performance improvement and leveraged as a strength for trauma verification. METHODS: We discuss the viewpoint of the ACS Verification, Review, and Consultation and three case studies, with practical tips and takeaways, of how these measures have been implemented at different institutions. RESULTS: We describe the use of (1) targeted educational initiatives, (2) development of a consultation tool based on institutional resources, and (3) application of a nurse-led frailty screen. DISCUSSION: Specialized care and attention to these vulnerable populations is recommended, but the implementation of these programs can take many shapes.Level of evidence V.

Published
2021

8. Patient-centered outcomes research and the injured patient: a summary of application

Author

Godat, Laura N, Jensen, Aaron R, Stein, Deborah M, Arbabi, Saman, Bulger, Eileen, Cohen, Mitchell J, Costantini, Todd W, Crandall, Marie M, Dicker, Rochelle A, Haut, Elliott R, Joseph, Bellal, Kozar, Rosemary A, Malhotra, Ajai K, Nathens, Avery B, Nirula, Raminder, Price, Michelle A, Smith, Jason W, and Zarzaur, Ben L

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Patient Safety, Physical Injury - Accidents and Adverse Effects, Clinical Research, Health Services, 8.1 Organisation and delivery of services, Health and social care services research, Good Health and Well Being, Coalition for National Trauma Research Scientific Advisory Council
Abstract

As trauma surgeons, we focus on the immediate care and needs of the injured patient every day. Historically, trauma and injury research has focused on outcomes such as mortality, complications, and length of stay; and process metrics such as time to CT scan, resuscitation checklist frequencies, or venous thromboembolism prophylaxis rates. These outcomes are perceived by healthcare providers to be important, but patients likely have different perceptions of what outcomes are most important to measure and improve. True patient-centered outcomes research involves the healthcare providers, and the entire team of stakeholders including patients and the community. Understanding the process of stakeholder engagement and the barriers trauma researchers must overcome to effectively enter this field of research is important. This summary aims to inform the trauma research community on the basics of patient-centered outcomes research, priorities for funding from the Patient-Centered Outcomes Research Institute, resources for collaboration around patient-centered outcomes research, and a unique career development and training opportunity for early career trauma surgeons to develop a skill set in patient-centered outcomes research.

Published
2020

9. Building the future for national trauma research

Author

Price, Michelle A, Kozar, Rosemary A, Bulger, Eileen M, Jurkovich, Gregory J, Arbabi, Saman, Bulger, Eileen, Cohen, Mitchell J, Costantini, Todd W, Crandall, Marie M, Dicker, Rochelle A, Haut, Elliott R, Joseph, Bellal, Malhotra, Ajai K, Nathens, Avery B, Nirula, Raminder, Smith, Jason W, Stein, Deborah M, and Zarzaur, Ben L

Subjects
Commerce, Management, Tourism and Services, Marketing, Physical Injury - Accidents and Adverse Effects, Coalition for National Trauma Research Scientific Advisory Council
Abstract

This paper describes the current funding, infrastructure growth and future state of trauma research. It also introduces a group of review articles generated from The Future of Trauma Research: Innovations in Research Methodology conference hosted by the American College of Surgeons Committee on Trauma in July 2019.

Published
2020

13. The Role of Lipopolysaccharide Structure in Monocyte Activation and Cytokine Secretion

Author

Plevin, Rebecca E, Knoll, Megan, McKay, Meghan, Arbabi, Saman, and Cuschieri, Joseph

Subjects
Biomedical and Clinical Sciences, Immunology, Genetics, Underpinning research, Aetiology, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Inflammatory and immune system, Cells, Cultured, Cytokines, Humans, Interleukin-10, Leukocytes, Mononuclear, Lipid A, Lipopolysaccharide Receptors, Lipopolysaccharides, Male, Mitogen-Activated Protein Kinase Kinases, O Antigens, Phosphorylation, RNA, Messenger, Tumor Necrosis Factor-alpha, CD14, LPS, O-Antigen, sepsis, Clinical Sciences, Emergency & Critical Care Medicine, Clinical sciences
Abstract

BackgroundThe lipopolysaccharide (LPS) molecule is composed of a hydrophobic lipid region (Lipid A), an oligosaccharide core, and an O-Antigen chain. Lipid A has been described as the molecular region responsible for inducing activation of immune cells. We hypothesize that the O-Antigen plays a critical role in the activation and responsiveness of mononuclear cell immune function.MethodsPeripheral blood mononuclear cells (PBMCs) from healthy volunteers were stimulated with LPS, LPS with attenuated O-Antigen (RF5), or Lipid A (DPL), which lacks an O-Antigen. Selected cells were pretreated with a blocking antibody to CD14. Western blots were performed to determine activation of mitogen-activated protein kinases (MAPK) p38, ERK, and JNK at selected time-points. RNA was extracted for RT-PCR quantification of TNF-α and IL-10 gene transcription. Supernatants were harvested and analyzed by ELISA for tumor necrosis factor alpha (TNF-α) and interleukin 10 (IL-10).ResultsLPS elicited maximal response, including phosphorylation of p38, ERK, and JNK, synthesis of TNF-α and IL-10 mRNA, and secretion of TNF-α and IL-10. Stimulation with RF5 activated the same pathways to a lesser degree. DPL led to increased phosphorylation of p38 and ERK and increased secretion of IL-10. CD14 blockade was associated with a significant decrease in cytokine secretion by LPS, and abolished cytokine secretion in cells stimulated with RF5 or DPL.ConclusionsStructural variants of LPS activate monocytes differentially. The complete O-Antigen is important for maximal activation of MAPK, cytokine synthesis, and cytokine secretion. LPS with attenuated O-Antigen and Lipid A activate only certain components of these pathways. LPS with a complete O-Antigen stimulates cytokine secretion that is partially independent of CD14, but shortening or removal of the O-Antigen inhibits this secretion.

Published
2016

46. Blood product availability in the Washington state trauma system

Author

Ali, Mohamed, primary, Liu, Zhinan, additional, Taylor, Mark, additional, Orcutt, Tim, additional, Bledsoe, Anthony, additional, Phuong, Jimmy, additional, Stansbury, Lynn G., additional, Arbabi, Saman, additional, Robinson, Bryce R. H., additional, Bulger, Eileen, additional, Vavilala, Monica S., additional, and Hess, John R., additional

Published
2022
Full Text
View/download PDF

50. Blood component use and injury characteristics of acute trauma patients arriving from the scene of injury or as transfers to a large, mature US Level 1 trauma center serving a large, geographically diverse region

Author

Liu, Zhinan, primary, Ayyagari, Rajiv C., additional, Martinez Monegro, Edison Y., additional, Stansbury, Lynn G., additional, Arbabi, Saman, additional, Bulger, Eileen M., additional, Vavilala, Monica S., additional, and Hess, John R., additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results