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244 results on '"Arcidiacono, Paolo G"'

1. Evaluating no fixation, endoscopic suture fixation, and an over-the-scope clip for anchoring fully covered self-expanding metal stents in benign upper gastrointestinal conditions: a comparative multicenter international study (With Video)

Author

Mehta, Amit, Ashhab, Ashraf, Shrigiriwar, Apurva, Assefa, Redeat, Canakis, Andrew, Frohlinger, Michael, Bouvette, Christopher A., Matus, Gregus, Punkenhofer, Paul, Mandarino, Francesco Vito, Azzolini, Francesco, Samaan, Jamil S., Advani, Rashmi, Desai, Shivani K., Confer, Bradley, Sangwan, Vikas K., Pineda-Bonilla, Jonh J., Lee, David P., Modi, Kinnari, Eke, Chiemeziem, Schiemer, Moritz, Rondini, Elena, Dolak, Werner, Agarunov, Emil, Duku, Margaret, Telese, Andrea, Pawa, Rishi, Pawa, Swati, Velasco, Natividad Zaragoza, Farha, Jad, Berrien-Lopez, Rickisha, Abu, Sherifatu, McLean-Powell, Charlee K., Kim, Raymond E., Rumman, Amir, Spaun, Georg O., Arcidiacono, Paolo G., Park, Kenneth H., Khara, Harshit S., Diehl, David L., Kedia, Prashant, Kuellmer, Armin, Manta, Raffaele, Gonda, Tamas A., Sehgal, Vinay, Haidry, Rehan, and Khashab, Mouen A.

Published
2024
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2. Routine Molecular Profiling in Both Resectable and Unresectable Pancreatic Adenocarcinoma: Relevance of Cytologic Samples

Author

Redegalli, Miriam, Grassini, Greta, Magliacane, Gilda, Pecciarini, Lorenza, Schiavo Lena, Marco, Smart, Chanel E., Johnston, Rebecca L., Waddell, Nicola, Maestro, Roberta, Macchini, Marina, Orsi, Giulia, Petrone, Maria Chiara, Rossi, Gemma, Balzano, Gianpaolo, Falconi, Massimo, Arcidiacono, Paolo G., Reni, Michele, Doglioni, Claudio, and Cangi, Maria Giulia

Published
2023
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3. EUS-Guided Biliary Drainage Versus ERCP in Malignant Biliary Obstruction Before Hepatobiliary Surgery: An International Multicenter Comparative Study

Author

Tyberg, Amy, Sarkar, Avik, Shahid, Haroon M., Shah-Khan, Sardar M., Gaidhane, Monica, Simon, Alexa, Eisenberg, Ian A., Lajin, Michael, Karagyozov, Petko, Liao, Kelvin, Patel, Roohi, Zhao, Eric, Martínez, Ma Guadalupe, Artifon, Everson L., Lino, André D., Vanella, Giuseppe, Arcidiacono, Paolo G., and Kahaleh, Michel

Published
2022
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4. Infection Control Practices and Outcomes of Endoscopy Units in the Lombardy Region of Italy: A Survey From the Italian Society of Digestive Endoscopy During COVID-19 Spread

Author

Capurso, Gabriele, Archibugi, Livia, Vanella, Giuseppe, Testoni, Sabrina G.G., Petrone, Maria C., Fanti, Lorella, Greco, Salvatore, Cavenati, Sergio, Gaffuri, Nicola, Lella, Fausto, Pace, Fabio, Cengia, Gianpaolo, Spada, Cristiano, Lovera, Mauro, Missale, Guido, Rosato, Stenio, Radaelli, Franco, Buscarini, Elisabetta, Parente, Fabrizio, Pilati, Stefano, Luigiano, Carmelo, Passoni, Giovanni R., Salerno, Raffaele, Bargiggia, Stefano, Penagini, Roberto, Cantù, Paolo, Fregoni, Fiorenza, Giannetti, Aurora, Devani, Massimo, Manes, Gianpiero, Fiori, Giancarla, Fontana, Paola, Gambitta, Pietro, Masci, Enzo, Mutignani, Massimiliano, Gatti, Mario, Canani, Marcella B., Vailati, Cristian, Dinelli, Marco Emilio, Marzo, Vincenza, Alvisi, Costanza, Caramia, Vitantonio, Di Sabatino, Antonio, Mauro, Aurelio, De Grazia, Federico, Balzarini, Marco, Segato, Sergio, Nella, Giovanni A., Giannini, Patrizia, Leoni, Piera, Testoni, Pier A., Mariani, Alberto, and Arcidiacono, Paolo G.

Published
2021
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7. Consensus guidelines on severe acute pancreatitis

Author

Pezzilli, Raffaele, Zerbi, Alessandro, Campra, Donata, Capurso, Gabriele, Golfieri, Rita, Arcidiacono, Paolo G., Billi, Paola, Butturini, Giovanni, Calculli, Lucia, Cannizzaro, Renato, Carrara, Silvia, Crippa, Stefano, De Gaudio, Raffaele, De Rai, Paolo, Frulloni, Luca, Mazza, Ernesto, Mutignani, Massimiliano, Pagano, Nico, Rabitti, Piergiorgio, and Balzano, Gianpaolo

Published
2015
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9. ENDOSCOPIC ULTRASOUND GUIDED GALLBLADDER DRAINAGE VERSUS PERCUTANEOUS DRAINAGE IN PATIENTS WITH ACUTE CHOLECYSTITIS UNDERGOING ELECTIVE CHOLECYSTECTOMY

Author

Tyberg Amy, Duarte-Chavez Rodrigo, Shahid Haroon M, Sarkar Avik, Simon Alexa, Shah-Khan Sardar M, Gaidhane Monica, Mohammad Tayyaba F, Nosher John, Wise Susannah S, Needham Victoria, Kheng Marin, Lajin Michael, Sojitra Badal, Wey Bryan, Dorwat Shivangi, Raina Hameed, Ansari Jaseem, Gandhi Ashish, Bapaye Amol, Krafft Matthew R, Thakkar Shyam, Singh Shailendra, Bane Janele R, Nasr John Y, Lee David P, Kedia Prashant, Arevalo-Mora Martha, Del Valle Raquel S, Robles-Medranda Carlos, Puga-Tejada Miguel, Vanella Giuseppe, Ardengh Jose Celso, Bilal Mohammad, Giuseppe Dell'Anna, Arcidiacono Paolo G, and Kahaleh Michel

Subjects
Gastroenterology
Published
2023
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10. EUS-Guided Biliary Drainage Versus ERCP in Malignant Biliary Obstruction Before Hepatobiliary Surgery: An International Multicenter Comparative Study.

Author

Tyberg, Amy, Sarkar, Avik, Shahid, Haroon M., Shah-Khan, Sardar M., Gaidhane, Monica, Simon, Alexa, Eisenberg, Ian A., Lajin, Michael, Karagyozov, Petko, Liao, Kelvin, Patel, Roohi, Zhao, Eric, Martínez, Maria Guadalupe, Artifon, Everson L., Lino, André D., Vanella, Giuseppe, Arcidiacono, Paolo G., and Kahaleh, Michel

Published
2023
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12. ENDOSCOPIC ULTRASOUND GUIDED GALLBLADDER DRAINAGE VERSUS PERCUTANEOUS DRAINAGE IN PATIENTS WITH ACUTE CHOLECYSTITIS UNDERGOING ELECTIVE CHOLECYSTECTOMY

Author

Tyberg, Amy, primary, Duarte-Chavez, Rodrigo, additional, Shahid, Haroon M., additional, Sarkar, Avik, additional, Simon, Alexa, additional, Shah-Khan, Sardar M., additional, Gaidhane, Monica, additional, Mohammad, Tayyaba F., additional, Nosher, John, additional, Wise, Susannah S., additional, Needham, Victoria, additional, Kheng, Marin, additional, Lajin, Michael, additional, Sojitra, Badal, additional, Dorwat, Shivangi, additional, Raina, Hameed, additional, Ansari, Jaseem, additional, Gandhi, Ashish, additional, Bapaye, Amol, additional, Krafft, Matthew R., additional, Thakkar, Shyam, additional, Singh, Shailendra, additional, Bane, Janele R., additional, Nasr, John Y., additional, Lee, David P., additional, Kedia, Prashant, additional, Arevalo-Mora, Martha, additional, Del Valle, Raquel S., additional, Robles-Medranda, Carlos, additional, Puga-Tejada, Miguel, additional, Vanella, Giuseppe, additional, Ardengh, Jose Celso, additional, Bilal, Mohammad, additional, Giuseppe, Dell'Anna, additional, Arcidiacono, Paolo G., additional, and Kahaleh, Michel, additional

Published
2022
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15. OUTCOMES OF COMBINED MANAGEMENT BILIARY AND GASTRIC OUTLET OBSTRUCTION (CABRIOLET STUDY): A MULTICENTRE RETROSPECTIVE ANALYSIS

Author

Vanella, Giuseppe, primary, Bronswijk, Michiel J., additional, Wanrooij, Roy V., additional, Dell'Anna, Giuseppe, additional, Laleman, Wim, additional, Van Malenstein, Hannah, additional, Voermans, Rogier P., additional, Fockens, Paul, additional, Van Der Merwe, Schalk, additional, and Arcidiacono, Paolo G., additional

Published
2022
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16. EUS-GUIDED BILIARY DRAINAGE VERSUS ERCP IN MALIGNANT BILIARY OBSTRUCTION PRIOR TO HEPATOBILIARY SURGERY: AN INTERNATIONAL MULTICENTER COMPARATIVE STUDY

Author

Tyberg, Amy, primary, Sarkar, Avik, additional, Shahid, Haroon M., additional, Shah-Khan, Sardar M., additional, Gaidhane, Monica, additional, Simon, Alexa, additional, Eisenberg, Ian A., additional, Lajin, Michael, additional, Karagyozov, Petko, additional, Liao, Kelvin, additional, Zhao, Eric, additional, Martínez, Ma Guadalupe, additional, Artifon, Everson L., additional, Lino, André D., additional, Vanella, Giuseppe, additional, Arcidiacono, Paolo G., additional, and Kahaleh, Michel, additional

Published
2022
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17. DIGITAL SINGLE-OPERATOR CHOLANGIOSCOPY IN DIAGNOSTIC AND THERAPEUTIC BILIO-PANCREATIC DISEASES: A PROSPECTIVE, MULTICENTER STUDY

Author

Fugazza, Alessandro, primary, Gabbiadini, Roberto, additional, Tringali, Andrea, additional, De Angelis, Claudio, additional, Mosca, Piergiorgio, additional, Maurano, Attilio, additional, Di Mitri, Roberto, additional, Manno, Mauro, additional, Mariani, Alberto, additional, Cereatti, Fabrizio, additional, Bertani, Helga, additional, Sferrazza, Sandro, additional, Donato, Giulio, additional, Tarantino, Ilaria, additional, Cugia, Luigi, additional, Aragona, Giovanni, additional, Cantù, Paolo, additional, Mazzocchi, Alessandro, additional, Canfora, Maria Laura, additional, Venezia, Ludovica, additional, Bendia, Emanuele, additional, Maroni, Luca, additional, Zulli, Claudio, additional, Conte, Elisabetta, additional, Soriani, Paola, additional, Ligresti, Dario, additional, Vilardo, Emanuelle, additional, Penagini, Roberto, additional, Benedetti, Antonio, additional, Arcidiacono, Paolo G., additional, Khalaf, Kareem, additional, Troncone, Edoardo, additional, Costamagna, Guido, additional, Repici, Alessandro, additional, and Anderloni, Andrea A., additional

Published
2022
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18. EUS-GUIDED GASTROJEJUNOSTOMY SHOWS HIGHER CLINICAL SUCCESS AND LOWER DYSFUNCTION RATE IN COMPARISON WITH DUODENAL STENTS IN MALIGNANT GASTRIC OUTLET OBSTRUCTION: AN INTERNATIONAL MULTICENTER PROPENSITY SCORE MATCHED COMPARISON

Author

de Gooyer, Peter, primary, Vanella, Giuseppe, additional, Bronswijk, Michiel, additional, Mandarino, Francesco Vito, additional, Fockens, Paul, additional, Laleman, Wim, additional, Van Malenstein, Hannah, additional, Dell'Anna, Giuseppe, additional, Wanrooij, Roy V., additional, Arcidiacono, Paolo G., additional, Van Der Merwe, Schalk, additional, and Voermans, Rogier P., additional

Published
2022
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20. Mo1243: RNA-SEQUENCING OF PANCREATIC CANCER FROM EUS-ACQUIRED TISSUE IS USEFUL TO DEFINE MOLECULAR SUBTYPES AND PROGNOSIS

Author

Archibugi, Livia, primary, Ruta, Veronica, additional, Panzeri, Valentina, additional, Zaccari, Piera, additional, Tacelli, Matteo, additional, Petrone, Maria, additional, Falconi, Massimo, additional, Reni, Michele, additional, Sette, Claudio, additional, Arcidiacono, Paolo G., additional, and Capurso, Gabriele, additional

Published
2022
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21. Endoscopic ultrasound-guided gastroenterostomy versus duodenal stenting for malignant gastric outlet obstruction: an international, multicenter, propensity score-matched comparison

Author

van Wanrooij, Roy L. J., additional, Vanella, Giuseppe, additional, Bronswijk, Michiel, additional, de Gooyer, Peter, additional, Laleman, Wim, additional, van Malenstein, Hannah, additional, Mandarino, Francesco Vito, additional, Dell’Anna, Giuseppe, additional, Fockens, Paul, additional, Arcidiacono, Paolo G., additional, van der Merwe, Schalk W., additional, and Voermans, Rogier P., additional

Published
2022
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22. Therapeutic endoscopic ultrasound: European Society of Gastrointestinal Endoscopy (ESGE) Guideline

Author

van der Merwe, Schalk W., additional, van Wanrooij, Roy L. J., additional, Bronswijk, Michiel, additional, Everett, Simon, additional, Lakhtakia, Sundeep, additional, Rimbas, Mihai, additional, Hucl, Tomas, additional, Kunda, Rastislav, additional, Badaoui, Abdenor, additional, Law, Ryan, additional, Arcidiacono, Paolo G., additional, Larghi, Alberto, additional, Giovannini, Marc, additional, Khashab, Mouen A., additional, Binmoeller, Kenneth F., additional, Barthet, Marc, additional, Perez-Miranda, Manuel, additional, and van Hooft, Jeanin E., additional

Published
2021
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23. Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk

Author

Lu, Ye, primary, Gentiluomo, Manuel, additional, Macauda, Angelica, additional, Gioffreda, Domenica, additional, Gazouli, Maria, additional, Petrone, Maria C., additional, Kelemen, Dezső, additional, Ginocchi, Laura, additional, Morelli, Luca, additional, Papiris, Konstantinos, additional, Greenhalf, William, additional, Izbicki, Jakob R., additional, Kiudelis, Vytautas, additional, Mohelníková-Duchoňová, Beatrice, additional, Bueno-de-Mesquita, Bas, additional, Vodicka, Pavel, additional, Brenner, Hermann, additional, Diener, Markus K., additional, Pezzilli, Raffaele, additional, Ivanauskas, Audrius, additional, Salvia, Roberto, additional, Szentesi, Andrea, additional, Aoki, Mateus Nóbrega, additional, Németh, Balázs C., additional, Sperti, Cosimo, additional, Jamroziak, Krzysztof, additional, Chammas, Roger, additional, Oliverius, Martin, additional, Archibugi, Livia, additional, Ermini, Stefano, additional, Novák, János, additional, Kupcinskas, Juozas, additional, Strouhal, Ondřej, additional, Souček, Pavel, additional, Cavestro, Giulia M., additional, Milanetto, Anna C., additional, Vanella, Giuseppe, additional, Neoptolemos, John P., additional, Theodoropoulos, George E., additional, van Laarhoven, Hanneke W. M., additional, Mambrini, Andrea, additional, Moz, Stefania, additional, Kala, Zdenek, additional, Loveček, Martin, additional, Basso, Daniela, additional, Uzunoglu, Faik G., additional, Hackert, Thilo, additional, Testoni, Sabrina G. G., additional, Hlaváč, Viktor, additional, Andriulli, Angelo, additional, Lucchesi, Maurizio, additional, Tavano, Francesca, additional, Carrara, Silvia, additional, Hegyi, Péter, additional, Arcidiacono, Paolo G., additional, Busch, Olivier R., additional, Lawlor, Rita T., additional, Puzzono, Marta, additional, Boggi, Ugo, additional, Guo, Feng, additional, Małecka-Panas, Ewa, additional, Capurso, Gabriele, additional, Landi, Stefano, additional, Talar-Wojnarowska, Renata, additional, Strobel, Oliver, additional, Gao, Xin, additional, Vashist, Yogesh, additional, Campa, Daniele, additional, and Canzian, Federico, additional

Published
2021
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24. Identification of Recessively Inherited Genetic Variants Potentially Linked to Pancreatic Cancer Risk

Author

Lu, Ye Gentiluomo, Manuel Macauda, Angelica Gioffreda, Domenica Gazouli, Maria Petrone, Maria C. Kelemen, Dezso and Ginocchi, Laura Morelli, Luca Papiris, Konstantinos and Greenhalf, William Izbicki, Jakob R. Kiudelis, Vytautas and Mohelnikova-Duchonova, Beatrice Bueno-de-Mesquita, Bas Vodicka, Pavel Brenner, Hermann Diener, Markus K. Pezzilli, Raffaele and Ivanauskas, Audrius Salvia, Roberto Szentesi, Andrea and Aoki, Mateus Nobrega Nemeth, Balazs C. Sperti, Cosimo and Jamroziak, Krzysztof Chammas, Roger Oliverius, Martin and Archibugi, Livia Ermini, Stefano Novak, Janos Kupcinskas, Juozas Strouhal, Ondrej Soucek, Pavel Cavestro, Giulia M. and Milanetto, Anna C. Vanella, Giuseppe Neoptolemos, John P. and Theodoropoulos, George E. van Laarhoven, Hanneke W. M. and Mambrini, Andrea Moz, Stefania Kala, Zdenek Lovecek, Martin and Basso, Daniela Uzunoglu, Faik G. Hackert, Thilo Testoni, Sabrina G. G. Hlavac, Viktor Andriulli, Angelo Lucchesi, Maurizio Tavano, Francesca Carrara, Silvia Hegyi, Peter and Arcidiacono, Paolo G. Busch, Olivier R. Lawlor, Rita T. and Puzzono, Marta Boggi, Ugo Guo, Feng Malecka-Panas, Ewa and Capurso, Gabriele Landi, Stefano Talar-Wojnarowska, Renata and Strobel, Oliver Gao, Xin Vashist, Yogesh Campa, Daniele and Canzian, Federico

Abstract

Although 21 pancreatic cancer susceptibility loci have been identified in individuals of European ancestry through genome-wide association studies (GWASs), much of the heritability of pancreatic cancer risk remains unidentified. A recessive genetic model could be a powerful tool for identifying additional risk variants. To discover recessively inherited pancreatic cancer risk loci, we performed a re-analysis of the largest pancreatic cancer GWAS, the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4), including 8,769 cases and 7,055 controls of European ancestry. Six single nucleotide polymorphisms (SNPs) showed associations with pancreatic cancer risk according to a recessive model of inheritance. We replicated these variants in 3,212 cases and 3,470 controls collected from the PANcreatic Disease ReseArch (PANDoRA) consortium. The results of the meta-analyses confirmed that rs4626538 (7q32.2), rs7008921 (8p23.2) and rs147904962 (17q21.31) showed specific recessive effects (p10(-3)), although none of the six SNPs reached the conventional threshold for genome-wide significance (p < 5x10(-8)). Additional bioinformatic analysis explored the functional annotations of the SNPs and indicated a possible relationship between rs36018702 and expression of the BCL2L11 and BUB1 genes, which are known to be involved in pancreatic biology. Our findings, while not conclusive, indicate the importance of considering non-additive genetic models when performing GWAS analysis. The SNPs associated with pancreatic cancer in this study could be used for further meta-analysis for recessive association of SNPs and pancreatic cancer risk and might be a useful addiction to improve the performance of polygenic risk scores.

Published
2021

25. Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk

Author

Lu, Ye Corradi, Chiara Gentiluomo, Manuel Lopez de Maturana, Evangelina Theodoropoulos, George E. Roth, Susanne Maiello, Evaristo Morelli, Luca Archibugi, Livia Izbicki, Jakob R. and Sarlos, Patricia Kiudelis, Vytautas Oliverius, Martin and Aoki, Mateus Nobrega Vashist, Yogesh van Eijck, Casper H. J. and Gazouli, Maria Talar-Wojnarowska, Renata Mambrini, Andrea and Pezzilli, Raffaele Bueno-de-Mesquita, Bas Hegyi, Peter and Soucek, Pavel Neoptolemos, John P. Di Franco, Gregorio and Sperti, Cosimo Kauffmann, Emanuele F. Hlavac, Viktor and Uzunoglu, Faik G. Ermini, Stefano Malecka-Panas, Ewa and Lucchesi, Maurizio Vanella, Giuseppe Dijk, Frederike and Mohelnikova-Duchonova, Beatrice Bambi, Franco Petrone, Maria Chiara Jamroziak, Krzysztof Guo, Feng Kolarova, Katerina and Capretti, Giovanni Milanetto, Anna Caterina Ginocchi, Laura and Lovecek, Martin Puzzono, Marta van Laarhoven, Hanneke W. M. and Carrara, Silvia Ivanauskas, Audrius Papiris, Konstantinos and Basso, Daniela Arcidiacono, Paolo G. Izbeki, Ferenc Chammas, Roger Vodicka, Pavel Hackert, Thilo Pasquali, Claudio and Piredda, Maria L. Costello-Goldring, Eithne Cavestro, Giulia Martina Szentesi, Andrea Tavano, Francesca Wlodarczyk, Barbara Brenner, Hermann Kreivenaite, Edita Gao, Xin and Bunduc, Stefania Vermeulen, Roel C. H. Schneider, Martin A. and Latiano, Anna Gioffreda, Domenica Testoni, Sabrina G. G. and Kupcinskas, Juozas Lawlor, Rita T. Capurso, Gabriele Malats, Nuria Campa, Daniele Canzian, Federico

Abstract

Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched in silico the genome for SNPs in miRNA seed sequences or 3 prime untranslated regions (3’UTRs) of miRNA target genes. Genome-wide association data of PC cases and controls from the Pancreatic Cancer Cohort (PanScan) Consortium and the Pancreatic Cancer Case-Control (PanC4) Consortium were re-analyzed for discovery, and genotyping data from two additional consortia (PanGenEU and PANDoRA) were used for replication, for a total of 14,062 cases and 11,261 controls. None of the SNPs reached genome-wide significance in the meta-analysis, but for three of them the associations were in the same direction in all the study populations and showed lower value of p in the meta-analyses than in the discovery phase. Specifically, rs7985480 was consistently associated with PC risk (OR = 1.12, 95% CI 1.07-1.17, p = 3.03 x 10(-6) in the meta-analysis). This SNP is in linkage disequilibrium (LD) with rs2274048, which modulates binding of various miRNAs to the 3’UTR of UCHL3, a gene involved in PC progression. In conclusion, our results expand the knowledge of the genetic PC risk through miRNA-related SNPs and show the usefulness of functional prioritization to identify genetic polymorphisms associated with PC risk.

Published
2021

26. Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk

Author

Lu, Ye, primary, Corradi, Chiara, additional, Gentiluomo, Manuel, additional, López de Maturana, Evangelina, additional, Theodoropoulos, George E., additional, Roth, Susanne, additional, Maiello, Evaristo, additional, Morelli, Luca, additional, Archibugi, Livia, additional, Izbicki, Jakob R., additional, Sarlós, Patricia, additional, Kiudelis, Vytautas, additional, Oliverius, Martin, additional, Aoki, Mateus Nóbrega, additional, Vashist, Yogesh, additional, van Eijck, Casper H. J., additional, Gazouli, Maria, additional, Talar-Wojnarowska, Renata, additional, Mambrini, Andrea, additional, Pezzilli, Raffaele, additional, Bueno-de-Mesquita, Bas, additional, Hegyi, Péter, additional, Souček, Pavel, additional, Neoptolemos, John P., additional, Di Franco, Gregorio, additional, Sperti, Cosimo, additional, Kauffmann, Emanuele F., additional, Hlaváč, Viktor, additional, Uzunoğlu, Faik G., additional, Ermini, Stefano, additional, Małecka-Panas, Ewa, additional, Lucchesi, Maurizio, additional, Vanella, Giuseppe, additional, Dijk, Frederike, additional, Mohelníková-Duchoňová, Beatrice, additional, Bambi, Franco, additional, Petrone, Maria Chiara, additional, Jamroziak, Krzysztof, additional, Guo, Feng, additional, Kolarova, Katerina, additional, Capretti, Giovanni, additional, Milanetto, Anna Caterina, additional, Ginocchi, Laura, additional, Loveček, Martin, additional, Puzzono, Marta, additional, van Laarhoven, Hanneke W. M., additional, Carrara, Silvia, additional, Ivanauskas, Audrius, additional, Papiris, Konstantinos, additional, Basso, Daniela, additional, Arcidiacono, Paolo G., additional, Izbéki, Ferenc, additional, Chammas, Roger, additional, Vodicka, Pavel, additional, Hackert, Thilo, additional, Pasquali, Claudio, additional, Piredda, Maria L., additional, Costello-Goldring, Eithne, additional, Cavestro, Giulia Martina, additional, Szentesi, Andrea, additional, Tavano, Francesca, additional, Włodarczyk, Barbara, additional, Brenner, Hermann, additional, Kreivenaite, Edita, additional, Gao, Xin, additional, Bunduc, Stefania, additional, Vermeulen, Roel C. H., additional, Schneider, Martin A., additional, Latiano, Anna, additional, Gioffreda, Domenica, additional, Testoni, Sabrina G. G., additional, Kupcinskas, Juozas, additional, Lawlor, Rita T., additional, Capurso, Gabriele, additional, Malats, Núria, additional, Campa, Daniele, additional, and Canzian, Federico, additional

Published
2021
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27. ID: 3523404 EUS-GUIDED CHOLEDOCHODUODENOSTOMY VERSUS ERCP WITH COVERED METALLIC STENTS IN PATIENTS WITH UNRESECTABLE MALIGNANT DISTAL BILIARY OBSTRUCTION. A MULTI-CENTERED RANDOMIZED CONTROLLED TRIAL (DRA-MBO TRIAL)

Author

Teoh, Anthony Y., primary, Napoleon, Bertrand, additional, Kunda, Rastislav, additional, Arcidiacono, Paolo G., additional, Kongkam, Pradermchai, additional, Larghi, Alberto, additional, Van Der Merwe, Schalk, additional, Jacques, Jérémie, additional, Legros, Romain, additional, Ratanachu-Ek, Thawee, additional, Kaffes, Arthur, additional, Aerts, Maridi, additional, Chan, Shannon M., additional, Yan W. Chiu, Philip Wai, additional, Fumex, Fabien, additional, Messaoudi, Nouredin, additional, Ng, Kelvin K., additional, Ng, Enders K., additional, Rizzatti, Gianenrico, additional, Saxena, Payal, additional, and Lau, James, additional

Published
2021
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28. ID: 3523918 A CORE CURRICULUM FOR BASIC EUS SKILLS - AN INTERNATIONAL CONSENSUS USING THE DELPHI METHODOLOGY

Author

Gásdal Karstensen, John, primary, Nayahangan, Leizl Joy, additional, Saftoiu, Adrian, additional, Epshtein, Aleksei, additional, Sahai, Anand, additional, Wang, Andrew Y., additional, Teoh, Anthony Y., additional, Burmester, Elke, additional, Gonen, Can, additional, Dietrich, Christoph F., additional, Jenssen, Christian, additional, Vazquez-Sequeiros, Enrique, additional, van der Heijden, Erik H., additional, Bories, Erwan, additional, Santo, Erwin, additional, Kalaitzakis, Evangelos, additional, Artifon, Everson, additional, Maluf-Filho, Fauze, additional, Mishra, Girish, additional, Aslanian, Harry R., additional, Scheiman, James, additional, Poley, Jan-Werner, additional, van Hooft, Jeanin E., additional, Dewitt, John M., additional, Iglesias-Garcia, Julio, additional, Do-Cong Pham, Khanh, additional, Aabakken, Lars, additional, Brink, Lene, additional, Sosa-Valencia, Leonardo, additional, Lee, Linda S., additional, Bhutani, Manoop S., additional, Perez-Miranda, Manuel, additional, Lahav, Maor, additional, Petrone, Maria, additional, Jinga, Mariana, additional, Topazian, Mark, additional, Kimmey, Michael B., additional, Mortensen, Michael B., additional, Larsen, Michael Hareskov, additional, Hocke, Michael, additional, Levy, Michael J., additional, Al-Haddad, Mohammad A., additional, Palazzo, Laurent, additional, Palazzo, Maxime, additional, Arcidiacono, Paolo G., additional, Fockens, Paul, additional, Clementsen, Paul Frost, additional, Deprez, Pierre H., additional, Fusaroli, Pietro, additional, Garg, Pramod, additional, Watson, Rabindra, additional, Keswani, Rajesh N., additional, Sadik, Riadh, additional, Havre, Roald F., additional, Kilincalp, Serta, additional, Tang, Shou-Jiang, additional, Sun, Siyu, additional, Hollerbach, Stephan, additional, Pereira, Stephen P., additional, Lakhtakia, Sundeep, additional, Rana, Surinder S., additional, Haque, Saad, additional, Itoi, Takao, additional, Woodward, Timothy A., additional, Baron, Todd H., additional, Siddiqui, Uzma D., additional, Shami, Vanessa M., additional, Sharma, Vijay, additional, Bhatia, Vikram, additional, Dhir, Vinay, additional, Arantes, Vitor N., additional, Konge, Lars, additional, and Vilmann, Peter, additional

Published
2021
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29. ID: 3522469 RISK OF COVID-19 TRANSMISSION AND OUTCOMES IN HEALTHCARE WORKERS PRESENT DURING GASTROINTESTINAL ENDOSCOPIC PROCEDURES: AN INTERNATIONAL MULTICENTER STUDY

Author

Krishna Kumar Nair, Govind, primary, Woo (Gene) Yoo, Jin, additional, Vanella, Giuseppe, additional, Angeletti, Stefano, additional, Mauro, Aurelio, additional, Zingone, Fabiana, additional, Toma, Antonella, additional, Pouillon, Lieven, additional, Papanikolaou, Ioannis S., additional, Boskoski, Ivo, additional, Bronswijk, Michiel J., additional, Capurso, Gabriele, additional, Dilaghi, Emanuele, additional, Di Sabatino, Antonio, additional, Savarino, Edoardo, additional, Fracasso, Pierluigi, additional, Matteo, Maria Valeria, additional, Van Der Merwe, Schalk, additional, Petrone, Maria, additional, Di Giulio, Emilio, additional, Roelandt, Philip, additional, Arcidiacono, Paolo G., additional, Costamagna, Guido, additional, and Farrell, James J., additional

Published
2021
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30. Infection Control Practices and Outcomes of Endoscopy Units in the Lombardy Region of Italy

Author

Capurso, Gabriele, Archibugi, Livia, Vanella, Giuseppe, Testoni, Sabrina G.G., Petrone, Maria C., Fanti, Lorella, Greco, Salvatore, Cavenati, Sergio, Gaffuri, Nicola, Lella, Fausto, Pace, Fabio, Cengia, Gianpaolo, Spada, Cristiano, Lovera, Mauro, Missale, Guido, Rosato, Stenio, Radaelli, Franco, Buscarini, Elisabetta, Parente, Fabrizio, Pilati, Stefano, Luigiano, Carmelo, Passoni, Giovanni R., Salerno, Raffaele, Bargiggia, Stefano, Penagini, Roberto, Cantù, Paolo, Fregoni, Fiorenza, Giannetti, Aurora, Devani, Massimo, Manes, Gianpiero, Fiori, Giancarla, Fontana, Paola, Gambitta, Pietro, Masci, Enzo, Mutignani, Massimiliano, Gatti, Mario, Canani, Marcella B., Vailati, Cristian, Dinelli, Marco Emilio, Marzo, Vincenza, Alvisi, Costanza, Caramia, Vitantonio, Di Sabatino, Antonio, Mauro, Aurelio, De Grazia, Federico, Balzarini, Marco, Segato, Sergio, Nella, Giovanni A., Giannini, Patrizia, Leoni, Piera, Testoni, Pier A., Mariani, Alberto, and Arcidiacono, Paolo G.

Subjects
Gastroenterology
Published
2020
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31. Therapeutic endoscopic ultrasound: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, van der Merwe, Schalk W, van Wanrooij, Roy L J, Bronswijk, Michiel, Everett, Simon, Lakhtakia, Sundeep, Rimbas, Mihai, Hucl, Tomas, Kunda, Rastislav, Badaoui, Abdenor, Law, Ryan, Arcidiacono, Paolo G, Larghi, Alberto, Giovannini, Marc, Khashab, Mouen A, Binmoeller, Kenneth F, Barthet, Marc, Perez-Miranda, Manuel, van Hooft, Jeanin E, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de gastro-entérologie, van der Merwe, Schalk W, van Wanrooij, Roy L J, Bronswijk, Michiel, Everett, Simon, Lakhtakia, Sundeep, Rimbas, Mihai, Hucl, Tomas, Kunda, Rastislav, Badaoui, Abdenor, Law, Ryan, Arcidiacono, Paolo G, Larghi, Alberto, Giovannini, Marc, Khashab, Mouen A, Binmoeller, Kenneth F, Barthet, Marc, Perez-Miranda, Manuel, and van Hooft, Jeanin E

Abstract

1: ESGE recommends the use of endoscopic ultrasound-guided biliary drainage (EUS-BD) over percutaneous transhepatic biliary drainage (PTBD) after failed endoscopic retrograde cholangiopancreatography (ERCP) in malignant distal biliary obstruction when local expertise is available.Strong recommendation, moderate quality evidence. 2: ESGE suggests EUS-BD with hepaticogastrostomy only for malignant inoperable hilar biliary obstruction with a dilated left hepatic duct when inadequately drained by ERCP and/or PTBD in high volume expert centers.Weak recommendation, moderate quality evidence. 3: ESGE recommends that EUS-guided pancreatic duct (PD) drainage should only be considered in symptomatic patients with an obstructed PD when retrograde endoscopic intervention fails or is not possible.Strong recommendation, low quality evidence. 4: ESGE recommends rendezvous EUS techniques over transmural PD drainage in patients with favorable anatomy owing to its lower rate of adverse events.Strong recommendation, low quality evidence. 5: ESGE recommends that, in patients at high surgical risk, EUS-guided gallbladder drainage (GBD) should be favored over percutaneous gallbladder drainage where both techniques are available, owing to the lower rates of adverse events and need for re-interventions in EUS-GBD.Strong recommendation, high quality of evidence. 6: ESGE recommends EUS-guided gastroenterostomy (EUS-GE), in an expert setting, for malignant gastric outlet obstruction, as an alternative to enteral stenting or surgery.Strong recommendation, low quality evidence. 7: ESGE recommends that EUS-GE may be considered in the management of afferent loop syndrome, especially in the setting of malignancy or in poor surgical candidates. Strong recommendation, low quality evidence. 8: ESGE suggests that endoscopic ultrasound-directed transgastric ERCP (EDGE) can be offered, in expert centers, to patients with a Roux-en-Y gastric bypass following multidisciplinary decision-making, with the ai

Published
2021

32. Chronic use of statins and acetylsalicylic acid and incidence of post-endoscopic retrograde cholangiopancreatography acute pancreatitis : A multicenter, prospective, cohort study

Author

Cárdenas-Jaén, Karina, Archibugi, Livia, Poropat, Goran, Korpela, Taija, Maisonneuve, Patrick, Aparicio, Jose R., Udd, Marianne, Stimac, Davor, Arcidiacono, Paolo G., De Pretis, Niccolò, Valente, Roberto, Di Giulio, Emilio, Casellas, Juan A., Kylänpää, Leena, Hauser, Goran, Mariani, Alberto, Gabbrielli, Armando, Löhr, Matthias, Vanella, Giuseppe, Rainio, Mia, Brozzi, Lorenzo, Arnelo, Urban, Fagerström, Niklas, Capurso, Gabriele, de-Madaria, Enrique, Cárdenas-Jaén, Karina, Archibugi, Livia, Poropat, Goran, Korpela, Taija, Maisonneuve, Patrick, Aparicio, Jose R., Udd, Marianne, Stimac, Davor, Arcidiacono, Paolo G., De Pretis, Niccolò, Valente, Roberto, Di Giulio, Emilio, Casellas, Juan A., Kylänpää, Leena, Hauser, Goran, Mariani, Alberto, Gabbrielli, Armando, Löhr, Matthias, Vanella, Giuseppe, Rainio, Mia, Brozzi, Lorenzo, Arnelo, Urban, Fagerström, Niklas, Capurso, Gabriele, and de-Madaria, Enrique

Abstract

OBJECTIVES: Post-endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis (PEP) is a frequent complication of this endoscopic procedure. Chronic statin intake has been linked to lower incidence and severity of acute pancreatitis (AP). Periprocedural rectal administration of non-steroidal anti-inflammatory drugs is protective against PEP, but the role of chronic acetylsalicylic acid (ASA) treatment is unclear. We aimed to investigate whether statins and chronic ASA intake are associated with lower risk of PEP. METHODS: An international, multicenter, prospective cohort study. Consecutive patients undergoing ERCP in seven European centers were included. Patients were followed-up to detect those with PEP. Multivariate analysis by means of binary logistic regression was performed, and adjusted odds ratios (aORs) were calculated. RESULTS: A total of 1150 patients were included, and 70 (6.1%) patients developed PEP. Among statins users, 8.1% developed PEP vs. 5.4% among non-users (P = 0.09). Multivariate analysis showed no association between statin use and PEP incidence (aOR 1.68 (95% CI 0.94-2.99, P = 0.08)). Statin use had no effect on severity of PEP, being mild in 92.0% of statin users vs. 82.2% in non-statin users (P = 0.31). Chronic ASA use was not associated with PEP either (aOR 1.02 (95% CI 0.49-2.13), P = 0.96). Abuse of alcohol and previous endoscopic biliary sphincterotomy were protective factors against PEP, while >1 pancreatic guidewire passage, normal bilirubin values, and duration of the procedure >20 minutes, were risk factors. CONCLUSIONS: The use of statins or ASA is not associated with a lower risk or a milder course of PEP.

Published
2021
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33. Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk

Author

Lu, Ye, Corradi, Chiara, Gentiluomo, Manuel, López de Maturana, Evangelina, Theodoropoulos, George E., Roth, Susanne, Maiello, Evaristo, Morelli, Luca, Archibugi, Livia, Izbicki, Jakob R., Sarlós, Patricia, Kiudelis, Vytautas, Oliverius, Martin, Aoki, Mateus Nóbrega, Vashist, Yogesh, van Eijck, Casper H.J., Gazouli, Maria, Talar-Wojnarowska, Renata, Mambrini, Andrea, Pezzilli, Raffaele, Bueno-de-Mesquita, Bas, Hegyi, Péter, Souček, Pavel, Neoptolemos, John P., Di Franco, Gregorio, Sperti, Cosimo, Kauffmann, Emanuele F., Hlaváč, Viktor, Uzunoğlu, Faik G., Ermini, Stefano, Małecka-Panas, Ewa, Lucchesi, Maurizio, Vanella, Giuseppe, Dijk, Frederike, Mohelníková-Duchoňová, Beatrice, Bambi, Franco, Petrone, Maria Chiara, Jamroziak, Krzysztof, Guo, Feng, Kolarova, Katerina, Capretti, Giovanni, Milanetto, Anna Caterina, Ginocchi, Laura, Loveček, Martin, Puzzono, Marta, van Laarhoven, Hanneke W.M., Carrara, Silvia, Ivanauskas, Audrius, Papiris, Konstantinos, Basso, Daniela, Arcidiacono, Paolo G., Izbéki, Ferenc, Chammas, Roger, Vodicka, Pavel, Hackert, Thilo, Pasquali, Claudio, Piredda, Maria L., Costello-Goldring, Eithne, Cavestro, Giulia Martina, Szentesi, Andrea, Tavano, Francesca, Włodarczyk, Barbara, Brenner, Hermann, Kreivenaite, Edita, Gao, Xin, Bunduc, Stefania, Vermeulen, Roel C.H., Schneider, Martin A., Latiano, Anna, Gioffreda, Domenica, Testoni, Sabrina G.G., Kupcinskas, Juozas, Lawlor, Rita T., Capurso, Gabriele, Malats, Núria, Campa, Daniele, Canzian, Federico, Lu, Ye, Corradi, Chiara, Gentiluomo, Manuel, López de Maturana, Evangelina, Theodoropoulos, George E., Roth, Susanne, Maiello, Evaristo, Morelli, Luca, Archibugi, Livia, Izbicki, Jakob R., Sarlós, Patricia, Kiudelis, Vytautas, Oliverius, Martin, Aoki, Mateus Nóbrega, Vashist, Yogesh, van Eijck, Casper H.J., Gazouli, Maria, Talar-Wojnarowska, Renata, Mambrini, Andrea, Pezzilli, Raffaele, Bueno-de-Mesquita, Bas, Hegyi, Péter, Souček, Pavel, Neoptolemos, John P., Di Franco, Gregorio, Sperti, Cosimo, Kauffmann, Emanuele F., Hlaváč, Viktor, Uzunoğlu, Faik G., Ermini, Stefano, Małecka-Panas, Ewa, Lucchesi, Maurizio, Vanella, Giuseppe, Dijk, Frederike, Mohelníková-Duchoňová, Beatrice, Bambi, Franco, Petrone, Maria Chiara, Jamroziak, Krzysztof, Guo, Feng, Kolarova, Katerina, Capretti, Giovanni, Milanetto, Anna Caterina, Ginocchi, Laura, Loveček, Martin, Puzzono, Marta, van Laarhoven, Hanneke W.M., Carrara, Silvia, Ivanauskas, Audrius, Papiris, Konstantinos, Basso, Daniela, Arcidiacono, Paolo G., Izbéki, Ferenc, Chammas, Roger, Vodicka, Pavel, Hackert, Thilo, Pasquali, Claudio, Piredda, Maria L., Costello-Goldring, Eithne, Cavestro, Giulia Martina, Szentesi, Andrea, Tavano, Francesca, Włodarczyk, Barbara, Brenner, Hermann, Kreivenaite, Edita, Gao, Xin, Bunduc, Stefania, Vermeulen, Roel C.H., Schneider, Martin A., Latiano, Anna, Gioffreda, Domenica, Testoni, Sabrina G.G., Kupcinskas, Juozas, Lawlor, Rita T., Capurso, Gabriele, Malats, Núria, Campa, Daniele, and Canzian, Federico

Abstract

Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched in silico the genome for SNPs in miRNA seed sequences or 3 prime untranslated regions (3'UTRs) of miRNA target genes. Genome-wide association data of PC cases and controls from the Pancreatic Cancer Cohort (PanScan) Consortium and the Pancreatic Cancer Case–Control (PanC4) Consortium were re-analyzed for discovery, and genotyping data from two additional consortia (PanGenEU and PANDoRA) were used for replication, for a total of 14,062 cases and 11,261 controls. None of the SNPs reached genome-wide significance in the meta-analysis, but for three of them the associations were in the same direction in all the study populations and showed lower value of p in the meta-analyses than in the discovery phase. Specifically, rs7985480 was consistently associated with PC risk (OR = 1.12, 95% CI 1.07–1.17, p = 3.03 × 10−6 in the meta-analysis). This SNP is in linkage disequilibrium (LD) with rs2274048, which modulates binding of various miRNAs to the 3'UTR of UCHL3, a gene involved in PC progression. In conclusion, our results expand the knowledge of the genetic PC risk through miRNA-related SNPs and show the usefulness of functional prioritization to identify genetic polymorphisms associated with PC risk.

Published
2021

36. Chronic use of statins and acetylsalicylic acid and incidence of post‐endoscopic retrograde cholangiopancreatography acute pancreatitis: A multicenter, prospective, cohort study

Author

Cárdenas‐Jaén, Karina, primary, Archibugi, Livia, additional, Poropat, Goran, additional, Korpela, Taija, additional, Maisonneuve, Patrick, additional, Aparicio, Jose R., additional, Udd, Marianne, additional, Stimac, Davor, additional, Arcidiacono, Paolo G., additional, De Pretis, Niccolò, additional, Valente, Roberto, additional, Di Giulio, Emilio, additional, Casellas, Juan A., additional, Kylänpää, Leena, additional, Hauser, Goran, additional, Mariani, Alberto, additional, Gabbrielli, Armando, additional, Löhr, Matthias, additional, Vanella, Giuseppe, additional, Rainio, Mia, additional, Brozzi, Lorenzo, additional, Arnelo, Urban, additional, Fagerström, Niklas, additional, Capurso, Gabriele, additional, and de‐Madaria, Enrique, additional

Published
2020
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37. Sa1476 IMMUNOMODULATION INDUCED BY ENDOSCOPIC ULTRASOUND-GUIDED ABLATION WITH THE HYBRIDTHERM PROBE IN STAGE III PANCREATIC DUCTAL ADENOCARCINOMA: SINGLE-CENTER PRELIMINARY RESULTS FROM A PHASE II/III RANDOMIZED-CONTROLLED TRIAL

Author

Testoni, Sabrina G., primary, Della Torre, Emanuel, additional, Clemente, Francesca, additional, Sciorati, Clara, additional, Boselli, Daniela, additional, Petrone, Maria, additional, Capurso, Gabriele, additional, Rossi, Gemma, additional, Archibugi, Livia, additional, Mariani, Alberto, additional, Linzenbold, Walter, additional, Enderle, Markus D., additional, Reni, Michele, additional, Falconi, Massimo, additional, and Arcidiacono, Paolo G., additional

Published
2020
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39. Sa1458 DIAGNOSTIC ACCURACY OF ENDOSCOPIC ULTRASOUND-FINE NEEDLE ASPIRATION (EUS-FNA) IN THE EVALUATION OF PANCREATIC NEUROENDOCRINE NEOPLASMS (PNEN) GRADING

Author

Tacelli, Matteo, primary, Petrone, Maria Chiara, additional, Capurso, Gabriele, additional, Rossi, Gemma, additional, Archibugi, Livia, additional, Testoni, Sabrina G., additional, Muffatti, Francesca, additional, Andreasi, Valentina, additional, Partelli, Stefano, additional, Doglioni, Claudio, additional, Falconi, Massimo, additional, and Arcidiacono, Paolo G., additional

Published
2020
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40. Sa1421 GLUCOSE LEVELS IN EUS-ASPIRATED CYST FLUID HAVE A HIGH ACCURACY FOR THE DIAGNOSIS OF MUCINOUS PANCREATIC CYSTIC LESIONS

Author

Rossi, Gemma, primary, Petrone, Maria, additional, Capurso, Gabriele, additional, Locatelli, Massimo, additional, Crippa, Stefano, additional, Doglioni, Claudio, additional, Mariani, Alberto, additional, Testoni, Sabrina G., additional, Archibugi, Livia, additional, Tacelli, Matteo, additional, and Arcidiacono, Paolo G., additional

Published
2020
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43. Chronic use of statins and acetylsalicylic acid and incidence of post-ERCP acute pancreatitis: a multicenter, prospective, cohort study

Author

Kardenas-Jaen, Karina, Archibugi, Livia, Poropat, Goran, Korpela, Taija, Maisonneuve, Aparicio, Jose R, Udd, Marianne, Štimac, Davor, Arcidiacono, Paolo G, De Pretis, Niccolo, Valente, Roberto, Di Giulio, Emilio, Casellas, Juan A, Kylanpaa, Leena, Hauser, Goran, Mariani, Alberto, Gabbrielli, Armando, Lohr, Matthias, Vanella, Giuseppe, Rainio, Mia, Brozzi, Lorenzo, Arnelo, Urban, Fagerstrom, Niklas, Capurso, Gabriele, and De-Madaria, Enrique

Subjects
endoscopic retrograde cholangiopancreatography, hydroxymethylglutaryl-CoA reductase inhibitors, pancreatitis, prevention, salicylates, education, cardiovascular system, circulatory and respiratory physiology
Abstract

Objectives: post-endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis (PEP) is a frequent complication of this endoscopic procedure. Chronic statin intake has been linked to lower incidence and severity of acute pancreatitis (AP). Periprocedural rectal administration of non-steroidal anti- inflammatory drugs is protective against PEP, but the role of chronic acetylsalicylic-acid (ASA) treatment is unclear. We aimed to investigate whether statins and chronic ASA intake are associated with lower risk of PEP. Methods: an international, multicenter, prospective cohort study. Consecutive patients undergoing ERCP in seven european centers were included. Patients were followed-up to detect those with PEP. Multivariate analysis by means of binary logistic regression was performed, and adjusted odds ratios (aORs) were calculated. Results: a total of 1, 150 patients were included, and 70 (6.1%) patients developed PEP. Among statins users, 8.1% developed PEP vs. 5.4% among non-users (p = 0.09). Multivariate analysis showed no association between statin use and PEP incidence (aOR 1.68 (95% CI 0.94- 2.99, p = 0.08). Statin use had no effect on severity of PEP, being mild in 92.0% of statin users vs. 82.2% in non-statin users (p = 0.31). Chronic ASA use was not associated with PEP either (aOR 1.02 (95% CI 0.49-2.13), p = 0.96). Abuse of alcohol and previous endoscopic biliary sphincterotomy were protective factors against PEP, while >1 pancreatic guidewire passage, normal bilirubin values, and duration of the procedure >20 minutes, were risk factors. Conclusions: the use of statins or ASA is not associated with a lower risk or a milder course of PEP.

Published
2020

45. Therapeutic endoscopic ultrasound: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Author

van der Merwe, Schalk W., van Wanrooij, Roy L. J., Bronswijk, Michiel, Everett, Simon, Lakhtakia, Sundeep, Rimbas, Mihai, Hucl, Tomas, Kunda, Rastislav, Badaoui, Abdenor, Law, Ryan, Arcidiacono, Paolo G., Larghi, Alberto, Giovannini, Marc, Khashab, Mouen A., Binmoeller, Kenneth F., Barthet, Marc, Perez-Miranda, Manuel, and van Hooft, Jeanin E.

Subjects
ENDOSCOPIC ultrasonography, ULTRASONIC therapy, GASTRIC outlet obstruction, ENDOSCOPIC retrograde cholangiopancreatography, PANCREATIC duct, ENDOSCOPY
Abstract

1: ESGE recommends the use of endoscopic ultrasound-guided biliary drainage (EUS-BD) over percutaneous transhepatic biliary drainage (PTBD) after failed endoscopic retrograde cholangiopancreatography (ERCP) in malignant distal biliary obstruction when local expertise is available.Strong recommendation, moderate quality evidence. 2: ESGE suggests EUS-BD with hepaticogastrostomy only for malignant inoperable hilar biliary obstruction with a dilated left hepatic duct when inadequately drained by ERCP and/or PTBD in high volume expert centers.Weak recommendation, moderate quality evidence. 3: ESGE recommends that EUS-guided pancreatic duct (PD) drainage should only be considered in symptomatic patients with an obstructed PD when retrograde endoscopic intervention fails or is not possible.Strong recommendation, low quality evidence. 4: ESGE recommends rendezvous EUS techniques over transmural PD drainage in patients with favorable anatomy owing to its lower rate of adverse events.Strong recommendation, low quality evidence. 5: ESGE recommends that, in patients at high surgical risk, EUS-guided gallbladder drainage (GBD) should be favored over percutaneous gallbladder drainage where both techniques are available, owing to the lower rates of adverse events and need for re-interventions in EUS-GBD.Strong recommendation, high quality of evidence. 6: ESGE recommends EUS-guided gastroenterostomy (EUS-GE), in an expert setting, for malignant gastric outlet obstruction, as an alternative to enteral stenting or surgery.Strong recommendation, low quality evidence. 7: ESGE recommends that EUS-GE may be considered in the management of afferent loop syndrome, especially in the setting of malignancy or in poor surgical candidates. Strong recommendation, low quality evidence. 8: ESGE suggests that endoscopic ultrasound-directed transgastric ERCP (EDGE) can be offered, in expert centers, to patients with a Roux-en-Y gastric bypass following multidisciplinary decision-making, with the aim of overcoming the invasiveness of laparoscopy-assisted ERCP and the limitations of enteroscopy-assisted ERCP.Weak recommendation, low quality evidence. [ABSTRACT FROM AUTHOR]

Published
2022
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46. Tu1388 ENDOSCOPIC ULTRASOUND-GUIDED HYBRIDTHERM ABLATION (EUS-HTP) IN PATIENTS (PTS) WITH LOCALLY ADVANCED (LA) PANCREATIC DUCTAL ADENOCARCINOMA (PDAC): A CASE-CONTROL COMPARATIVE SURVIVAL ANALYSIS

Author

Testoni, Sabrina G., primary, Petrone, Maria, additional, Linzenbold, Walter, additional, Enderle, Markus D., additional, Capurso, Gabriele, additional, Rossi, Gemma, additional, Archibugi, Livia, additional, Traini, Mariaemilia, additional, Mariani, Alberto, additional, Reni, Michele, additional, Falconi, Massimo, additional, and Arcidiacono, Paolo G., additional

Published
2019
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50. Sa1371 – Eus and Ct Scan Diagnostic Yield in Establishing the T Stage in Surgically Resected Pancreatic Cancer Based on the Tnm 8Th Edition

Author

Archibugi, Livia, primary, Petrone, Maria, additional, Tamburrino, Domenico, additional, Crippa, Stefano, additional, Mariani, Alberto, additional, Nicoletti, Roberto, additional, Doglioni, Claudio, additional, Capurso, Gabriele, additional, Falconi, Massimo, additional, and Arcidiacono, Paolo G., additional

Published
2019
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