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4. Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa

Author

Rautenberg, Tamlyn A., Ng, Shu Kay, George, Gavin, Moosa , Mahomed-Yunus S., McCluskey, Suzanne M., Gilbert, Rebecca F., Pillay, Selvan, Aturinda, Isaac, Ard, Kevin L., Muyindike , Winnie R., Musinguzi, Nicholas, Masette, Godfrey, Pillay, Melendhran, Moodley, Pravi, Brijkumar, Jaysingh, Gandhi, Rajesh T., Johnson, Brent, Sunpath, Henry, Bwana, Mwebesa B., Marconi, Vincent C., and Siedner, Mark J.

Published
2023
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6. Readiness of US federally qualified health centers to provide HIV pre-exposure prophylaxis

Author

Ard, Kevin L, Uzoeghelu, Ugochukwu, Bruno, Jack, Lambert, Cei, Mayer, Kenneth H, Davis, John A, and Keuroghlian, Alex S

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Behavioral and Social Science, Prevention, Infectious Diseases, Clinical Research, HIV/AIDS, Infection, Good Health and Well Being, health center, HIV, LGBTQ, PrEP, prevention, Clinical sciences, Medical microbiology
Abstract

We report the results of a survey on HIV pre-exposure prophylaxis (PrEP) perceptions, capacity, and barriers at federally qualified health centers (FQHCs) in high-HIV burden jurisdictions in the United States. Health care workers at FQHCs identified multiple barriers to, and strategies for, improving PrEP implementation.

Published
2021

7. Understanding the Impact of Mpox on Sexual Health Clinical Services: A National Knowledge, Attitudes, and Practices Survey—United States, 2022

Author

Schubert, Sara L., Miele, Kathryn, Quilter, Laura A.S., Agnew-Brune, Christine, Coor, Alexandra, Kachur, Rachel, Lewis, Felicia, Ard, Kevin L., Wendel, Karen, Anderson, Teri, Nagendra, Gowri, Tromble, Erin, Gilliams, Elizabeth, Hamill, Matthew M., Johnson, Kelly, Johnston, Christine, Kelley, Destiny, Liang, Philana, McNeil, Candice, Meyers, Kathrine, Neu, Natalie, Ooms, Tamara, Reno, Hilary, Van Wagoner, Nicholas Jay, and Zucker, Jason

Published
2024
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10. Separating the rash from the chaff: novel clinical decision support deployed during the mpox outbreak

Author

Lazarus, Jacob E., primary, Green, Chloe V., additional, Jerry, Michelle S., additional, Germaine, Lindsay, additional, McEvoy, Dustin S., additional, Dugdale, Caitlin M., additional, Hysell, Kristen M., additional, Craig, Rebecca L., additional, Paras, Molly L., additional, Heller, Howard M., additional, Ard, Kevin L., additional, Albin, John S., additional, Lee, Hang, additional, and Shenoy, Erica S., additional

Published
2024
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12. Health Outcomes of Obtaining Housing Among Older Homeless Adults.

Author

Brown, Rebecca T, Miao, Yinghui, Mitchell, Susan L, Bharel, Monica, Patel, Mitkumar, Ard, Kevin L, Grande, Laura J, Blazey-Martin, Deborah, Floru, Daniella, and Steinman, Michael A

Subjects
Public Health, Health Sciences, Homelessness, Aging, Social Determinants of Health, Health Services, Clinical Research, Behavioral and Social Science, Mental Health, Aged, Boston, Depression, Emergency Service, Hospital, Female, Health Status, Ill-Housed Persons, Hospitalization, Housing, Humans, Male, Middle Aged, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

ObjectivesWe determined the impact of obtaining housing on geriatric conditions and acute care utilization among older homeless adults.MethodsWe conducted a 12-month prospective cohort study of 250 older homeless adults recruited from shelters in Boston, Massachusetts, between January and June 2010. We determined housing status at follow-up, determined number of emergency department visits and hospitalizations over 12 months, and examined 4 measures of geriatric conditions at baseline and 12 months. Using multivariable regression models, we evaluated the association between obtaining housing and our outcomes of interest.ResultsAt 12-month follow-up, 41% of participants had obtained housing. Compared with participants who remained homeless, those with housing had fewer depressive symptoms. Other measures of health status did not differ by housing status. Participants who obtained housing had a lower rate of acute care use, with an adjusted annualized rate of acute care visits of 2.5 per year among participants who obtained housing and 5.3 per year among participants who remained homeless.ConclusionsOlder homeless adults who obtained housing experienced improved depressive symptoms and reduced acute care utilization compared with those who remained homeless.

Published
2015

15. Swiping right on PrEP: a qualitative study of MSM preferences for PrEP public health messaging on dating apps.

Author

Adan, Matthew A., Psaros, Christina, Chamberlin, Grace, Zionts, Dani, Iyer, Surabhi, Platt, Laura, Lopes, Mairead Day, Medeiros, Susana, O'Connor, Catherine, Bassett, Ingrid V., and Ard, Kevin L.

Subjects
HIV prevention, MOBILE apps, HEALTH literacy, SATISFACTION, QUALITATIVE research, FOCUS groups, RESEARCH funding, INTERVIEWING, MOBILE hospitals, CONTENT analysis, HEALTH, DATING (Social customs), INFORMATION resources, MEN who have sex with men, PRE-exposure prophylaxis, ADVERTISING, SPANISH language, PUBLIC health, TEXT messages, HEALTH promotion, SEXUAL health, ACCESS to information
Abstract

Men who have sex with men (MSM) are disproportionately affected by HIV. Given that over 70% of MSM meet sexual partners via dating apps, such apps may be an effective platform for promoting HIV pre-exposure prophylaxis (PrEP) use. We aimed to describe preferences among MSM for PrEP advertisements displayed on dating apps. We conducted individual in-depth interviews with 16 MSM recruited from a mobile sexual health unit in Boston, Massachusetts. Two focus groups were also held: one with mobile unit staff (N = 3) and one with mobile unit users (N = 3). Content analysis was used to identify themes related to advertisement content and integration with app use. Mean participant age was 28 (SD 6.8); 37% identified as White and 63% as Latinx. 21% of interviews were conducted in Spanish. Preferences were organized around four themes: (1) relevant and relatable advertisements, (2) expansion of target audiences to promote access, (3) concise and captivating advertisements, and (4) PrEP advertisements and services as options, not obligations. MSM are supportive of receiving information about PrEP on dating apps, but feel that existing advertisements require modification to better engage viewers. Dating apps may be an underutilized tool for increasing PrEP awareness and knowledge among MSM. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Case 19-2024: A 46-Year-Old Man with Arthritis and Rash.

Author

Jorge, April M., Ard, Kevin L., and Turbett, Sarah E.

Subjects
*SYPHILIS, *DERMATOMYOSITIS, *HEPATITIS C, *ARTHRITIS, *SEXUALLY transmitted diseases, *MEDICAL societies
Abstract

The article presents a case study of the 46-year-old man with arthritis, rash, and systemic symptoms. It describes his initial symptoms of lightheadedness, which prompted an emergency department visit, followed by joint swelling and rash development over a period of weeks. It discusses the differential diagnosis process, considering autoimmune conditions like systemic lupus erythematosus (SLE), sarcoidosis, and infectious causes such as parvovirus B19.

Published
2024
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24. Seemingly Unrelated Regression Analysis of the Cost and Health-Related Quality of Life Outcomes of the REVAMP Randomized Clinical Trial

Author

Rautenberg, Tamlyn A., primary, Ng, Shu Kay, additional, George, Gavin, additional, Moosa, Mahomed-Yunus S., additional, McCluskey, Suzanne M., additional, Gilbert, Rebecca F., additional, Pillay, Selvan, additional, Aturinda, Isaac, additional, Ard, Kevin L., additional, Muyindike, Winnie, additional, Musinguzi, Nicholas, additional, Masette, Godfrey, additional, Pillay, Melendhran, additional, Moodley, Pravi, additional, Brijkumar, Jaysingh, additional, Gandhi, Rajesh T., additional, Johnson, Brent, additional, Sunpath, Henry, additional, Bwana, Mwebesa B., additional, Marconi, Vincent C., additional, and Siedner, Mark J., additional

Published
2023
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27. PrEP Echo: A National Interdisciplinary Telementoring Program for HIV Prevention Through Practice Transformation.

Author

Ard, Kevin L., Bruno, Jack, Uzoeghelu, Ugochuckwu, Lambert, Cei, Khan, Taimur, Davis, John A., Mayer, Kenneth H., and Keuroghlian, Alex S.

Subjects
*HIV prevention, *AIDS education, *PRE-exposure prophylaxis, *HUMAN services programs, *PATIENTS' attitudes, *HEALTH care teams, *LGBTQ+ people, *DESCRIPTIVE statistics, *TELEMEDICINE, *LONGITUDINAL method, *VIDEO recording
Abstract

HIV pre-exposure prophylaxis (PrEP) is highly effective, but PrEP use has been suboptimal. We describe a telementoring program for clinics in high-HIV burden areas, focusing on systems-level practice transformation and care for populations disproportionately affected by HIV. We developed and delivered a telementoring program for U.S. health centers. We analyzed participants' baseline and post-session surveys to ascertain experiences providing PrEP and caring for people disproportionately affected by HIV, comparing responses between medical and behavioral health clinicians. Forty-eight people from 16 health centers participated. Medical clinicians were more likely than behavioral health clinicians to care for people taking PrEP, but the groups did not differ in self-rated capacity to counsel about PrEP or care for populations disproportionately affected by HIV. Virtual training on practice transformation for PrEP, involving medical and behavioral health clinicians, is feasible and acceptable. PrEP training and delivery efforts should include behavioral health clinicians. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Contributors

Author

Aagaard, Kjersti, primary, Abrahamian, Fredrick M., additional, Allos, Ban Mishu, additional, Andes, David R., additional, Aoki, Fred Y., additional, Apicella, Michael A., additional, Ard, Kevin L., additional, Arias, Cesar A., additional, Aronoff, David M., additional, Augenbraun, Michael H., additional, Averhoff, Francisco, additional, Azar, Dimitri T., additional, Baddour, Larry M., additional, Baden, Lindsey R., additional, Baker, Carol J., additional, Ballard, Ronald C., additional, Barber, Gerard R., additional, Barnes, Scott D., additional, Barouch, Dan H., additional, Barrett, Alan D., additional, Barshak, Miriam Baron, additional, Basavaraju, Sridhar V., additional, Batteiger, Byron E., additional, Baum, Stephen G., additional, Bayer, Arnold S., additional, Beckham, J. David, additional, Beekmann, Susan E., additional, Bell, Beth P., additional, Bennett, John E., additional, Bente, Dennis A., additional, Berbari, Elie F., additional, Berman, Jonathan, additional, Bertino, Joseph S., additional, Bhimraj, Adarsh, additional, Birdsall, Holly H., additional, Bisno, Alan L., additional, Blackburn, Brian G., additional, Blanton, Lucas S., additional, Blaser, Martin J., additional, Bleck, Thomas P., additional, Blijlevens, Nicole M.A., additional, Bobak, David A., additional, Bonnez, William, additional, Boothroyd, John C., additional, Borio, Luciana L., additional, Bosque, Patrick J., additional, Bower, John, additional, Bradsher, Robert W., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Brown, Patricia D., additional, Brown-Elliott, Barbara A., additional, Bruhn, Roberta L., additional, Bryant, Amy E., additional, Burd, Eileen M., additional, Burns, Jane C., additional, Bush, Larry M., additional, Calderwood, Stephen B., additional, Cano, Luz Elena, additional, Carpenter, Charles C.J., additional, Caserta, Mary T., additional, Castagnola, Elio, additional, Chaisson, Richard E., additional, Chambers, Henry F., additional, Chapman, Stephen J., additional, Chappell, James D., additional, Chen, Lea Ann, additional, Chen, Sharon C-A, additional, Chow, Anthony W., additional, Clark, Rebecca A., additional, Cohen, Jeffrey I., additional, Cohen, Myron S., additional, Cohen-Poradosu, Ronit, additional, Cohn, Susan E., additional, Connors, Mark, additional, Corey, Lawrence, additional, Cottrell, Mackenzie L., additional, Cover, Timothy L., additional, Cox, Heather L., additional, Craig, William A., additional, Crossley, Kent B., additional, Crumpacker, Clyde S., additional, Curran, James W., additional, Currie, Bart J., additional, D'Agata, Erika, additional, Damon, Inger K., additional, Darouiche, Rabih O., additional, DeBiasi, Roberta L., additional, Deepe, George S., additional, del Rio, Carlos, additional, Delemos, Andrew S., additional, DeLeo, Frank R., additional, DeMuri, Gregory P., additional, Densen, Peter, additional, Dermody, Terence S., additional, Dewar, Robin, additional, Diaz, James H., additional, Dieffenbach, Carl W., additional, Dienstag, Jules L., additional, Doi, Yohei, additional, Dolin, Raphael, additional, Donnelly, J. Peter, additional, Donnenberg, Michael S., additional, Donowitz, Gerald R., additional, Dormitzer, Philip R., additional, Drake, James M., additional, Dumler, J. Stephen, additional, Dummer, J. Stephen, additional, DuPont, Herbert L., additional, Durack, David T., additional, Durand, Marlene L., additional, Edelstein, Paul H., additional, Edmond, Michael B., additional, Edwards, John E., additional, Edwards, Morven S., additional, Eliopoulos, George M., additional, Ellison, Richard T., additional, Endy, Timothy P., additional, Engleberg, N. Cary, additional, Erdem, Hakan, additional, Ernst, Joel D., additional, Ernst, Peter B., additional, Fairhurst, Rick M., additional, Fairley, Jessica K., additional, Falkow, Stanley, additional, Falsey, Ann R., additional, Fauci, Anthony S., additional, Fekete, Thomas, additional, Fey, Paul D., additional, Fine, Steven M., additional, Fitzgerald, Daniel W., additional, Flores, Anthony R., additional, Forster, Derek, additional, Fowler, Vance G., additional, Freedman, David O., additional, Friedlander, Arthur M., additional, Galgiani, John N., additional, Gallin, John I., additional, Gallo, Robert C., additional, Gandhi, Tejal N., additional, Garrett, Wendy S., additional, Gaydos, Charlotte A., additional, Geisbert, Thomas W., additional, Gelfand, Jeffrey A., additional, Gelone, Steven P., additional, Gerding, Dale N., additional, Gershon, Anne A., additional, Gilsdorf, Janet R., additional, Goldstein, Ellie J.C., additional, Gordin, Fred M., additional, Graman, Paul S., additional, Grayson, M. Lindsay, additional, Greene, Jeffrey Bruce, additional, Griffin, Patricia M., additional, Griffith, David E., additional, Guerrant, Richard L., additional, Gul, H. Cem, additional, Haake, David A., additional, Haas, David W., additional, Haines, Charles, additional, Hall, Caroline Breese, additional, Hallak, Joelle, additional, Halperin, Scott A., additional, Hammerschlag, Margaret R., additional, Haque, Rashidul, additional, Harris, Jason B., additional, Hawkins, Claudia, additional, Hay, Roderick J., additional, Hedberg, Craig W., additional, Henderson, David K., additional, Henderson, Donald A., additional, High, Kevin P., additional, Hill, Adrian V.S., additional, Hill, David R., additional, Hinman, Alan R., additional, Hirsch, Martin S., additional, Hodowanec, Aimee, additional, Hohl, Tobias M., additional, Holland, Steven M., additional, Holzman, Robert S., additional, Hook, Edward W., additional, Hooper, David C., additional, Hooton, Thomas M., additional, Horowitz, Harold W., additional, Horsburgh, C. Robert, additional, Horton, James M., additional, Hospenthal, Duane R., additional, Hsueh, Kevin, additional, Hughes, James M., additional, Hynes, Noreen A., additional, Iovine, Nicole M., additional, Iredell, Jonathan R., additional, Ison, Michael G., additional, Janda, J. Michael, additional, Janoff, Edward N., additional, Johannsen, Eric C., additional, Kashuba, Angela D.M., additional, Kasper, Dennis L., additional, Kaye, Donald, additional, Kaye, Keith S., additional, Kaye, Kenneth M., additional, Kazura, James W., additional, Keystone, Jay S., additional, Khabbaz, Rima, additional, Khan, David A., additional, Khudyakov, Yury, additional, Kim, Rose, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klein, Jerome O., additional, Klompas, Michael, additional, Knoll, Bettina M., additional, Knowlton, Kirk U., additional, Koehler, Jane E., additional, Kohlhoff, Stephan A., additional, Könönen, Eija, additional, Kontoyiannis, Dimitrios P., additional, Koralnik, Igor J., additional, Korpe, Poonum S., additional, Koshy, Anita A., additional, Kovacs, Joseph A., additional, Kozarsky, Phyllis, additional, Krieger, John, additional, Kroger, Andrew T., additional, Kuehnert, Matthew J., additional, Kumar, Nalin M., additional, Kuruvilla, Merin Elizabeth, additional, LaRocque, Regina C., additional, Leggett, James E., additional, Legido-Quigley, Helena, additional, Levett, Paul N., additional, Levine, Donald P., additional, Levison, Matthew E., additional, Levitt, Alexandra, additional, Lewis, Russell E., additional, Liles, W. Conrad, additional, Lima, Aldo A.M., additional, Limaye, Ajit P., additional, Lipkin, W. Ian, additional, Litman, Nathan, additional, Lorber, Bennett, additional, Luna, Ruth Ann, additional, MacDougall, Conan, additional, Roy, Rob, additional, Mackowiak, Philip A., additional, Madoff, Lawrence C., additional, Magill, Alan J., additional, Maguire, James H., additional, Maldarelli, Frank, additional, Markoff, Lewis, additional, Marrazzo, Jeanne M., additional, Marrie, Thomas J., additional, Marth, Thomas, additional, Martin, David H., additional, Martin, Gregory J., additional, Marty, Francisco M., additional, Maslow, Melanie Jane, additional, Masur, Henry, additional, Mawle, Alison, additional, Mayer, Kenneth H., additional, McBride, John T., additional, McCarthy, James S., additional, McCormack, William M., additional, McGowan, Catherine C., additional, McIntosh, Kenneth, additional, Mead, Paul S., additional, Mikulska, Malgorzata, additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mitchell, David H., additional, Modlin, John F., additional, Mody, Rajal K., additional, Moellering, Robert C., additional, Moffa, Matthew, additional, Moir, Susan, additional, Montoya, José G., additional, Moore, Thomas A., additional, Moreillon, Philippe, additional, Morris, J. Glenn, additional, Morse, Caryn Gee, additional, Moseley, Robin, additional, Munford, Robert S., additional, Murphy, Edward L., additional, Murphy, Timothy F., additional, Murray, Barbara E., additional, Murray, Clinton K., additional, Murray, Patrick R., additional, Musher, Daniel M., additional, Nagel, Jerod L., additional, Nannini, Esteban C., additional, Narezkina, Anna, additional, Nash, Theodore E., additional, Nauseef, William M., additional, Nayak, Jennifer L., additional, Neill, Marguerite A., additional, O'Donnell, Judith A., additional, Ohl, Christopher A., additional, Okhuysen, Pablo C., additional, Onderdonk, Andrew B., additional, Opal, Steven M., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Osterholm, Michael T., additional, Ostroff, Stephen M., additional, Oxman, Michael N., additional, Paessler, Slobodan, additional, Page, Andrea V., additional, Pai, Manjunath P., additional, Palmore, Tara N., additional, Palraj, Raj, additional, Pappas, Peter G., additional, Pasternack, Mark S., additional, Patterson, Thomas F., additional, Pavan-Langston, Deborah, additional, Pegues, David A., additional, Penn, Robert L., additional, Perfect, John R., additional, Perlman, Stanley, additional, Petersen, Brett W., additional, Peterson, Phillip K., additional, Petri, William A., additional, Petti, Cathy A., additional, Philips, Jennifer A., additional, Philley, Julie V., additional, Phillips, Michael, additional, Pickering, Larry K., additional, Piot, Peter, additional, Pogue, Jason M., additional, Pop-Vicas, Aurora, additional, Portal-Celhay, Cynthia, additional, Powers, John H., additional, Price, Richard N., additional, Que, Yok-Ai, additional, Radolf, Justin D., additional, Ram, Sanjay, additional, Raoult, Didier, additional, Ravdin, Jonathan I., additional, Ray, Stuart C., additional, Reboli, Annette C., additional, Reitz, Marvin S., additional, Relman, David A., additional, Renault, Cybèle A., additional, Restrepo, Angela, additional, Rex, John H., additional, Rhee, Elizabeth G., additional, Roberts, Norbert J., additional, Romero, José R., additional, Rothman, Alan L., additional, Roy, Craig R., additional, Ruoff, Kathryn L., additional, Rupp, Mark E., additional, Rupprecht, Charles E., additional, Russo, Thomas A., additional, Rutala, William A., additional, Ryan, Edward T., additional, Safdar, Amar, additional, Sajadi, Mohammad M., additional, Salazar, Juan C., additional, Sarria, Juan Carlos, additional, Savoia, Maria C., additional, Sax, Paul E., additional, Scheld, W. Michael, additional, Schiffer, Joshua T., additional, Schlossberg, David, additional, Schneider, Thomas, additional, Schuchat, Anne, additional, Schwebke, Jane R., additional, Sears, Cynthia L., additional, Segal, Leopoldo N., additional, Sendi, Parham, additional, Sepkowitz, Kent A., additional, Septimus, Edward J., additional, Seregin, Alexey, additional, Shulman, Stanford T., additional, Siberry, George K., additional, Siddiqi, Omar K., additional, Sifri, Costi D., additional, Simberkoff, Michael S., additional, Simonetti, Francesco R., additional, Singh, Kamaljit, additional, Singh, Nina, additional, Singh, Upinder, additional, Sinner, Scott W., additional, Sivapalasingam, Sumathi, additional, Slater, Leonard N., additional, Smulian, A. George, additional, Sobel, Jack D., additional, Sohail, M. Rizwan, additional, Soper, David E., additional, Sorrell, Tania C., additional, Steckelberg, James M., additional, Steere, Allen C., additional, Steigbigel, Neal H., additional, Steinberg, James P., additional, Stephens, David S., additional, Sterling, Timothy R., additional, Stevens, David A., additional, Stevens, Dennis L., additional, Strahilevitz, Jacob, additional, Stratton, Charles W., additional, Suffredini, Anthony F., additional, Suh, Kathryn N., additional, Sulkowski, Mark S., additional, Swartz, Morton N., additional, Talbot, Thomas R., additional, Tan, C. Sabrina, additional, Tan, Ming, additional, Thio, Chloe Lynne, additional, Thomas, David L., additional, Thomas, Lora D., additional, Thomas, Stephen J., additional, Thorner, Anna R., additional, María Tobón, Angela, additional, Tramont, Edmund C., additional, Treanor, John J., additional, Trubiano, Jason, additional, Tsibris, Athe M.N., additional, Tunkel, Allan R., additional, Turner, Ronald B., additional, Tyler, Kenneth L., additional, Uluer, Ahmet, additional, van de Beek, Diederik, additional, van der Velden, Walter J.F.M., additional, Vannier, Edouard G., additional, Van, Trevor C., additional, Versalovic, James, additional, Viscoli, Claudio, additional, Wald, Ellen R., additional, Waldor, Matthew K., additional, Walker, David H., additional, Wallace, Richard J., additional, Walsh, Edward E., additional, Walsh, Stephen R., additional, Walzer, Peter D., additional, Wanke, Christine A., additional, Warren, Cirle A., additional, Washburn, Ronald G., additional, Waters, Valerie, additional, Weber, David J., additional, Weiden, Michael D., additional, Weinberg, Geoffrey A., additional, Weisdorf, Daniel J., additional, Weiss, Louis M., additional, Welch, David F., additional, Wellems, Thomas E., additional, Wenzel, Richard P., additional, Wharton, Melinda, additional, White, A. Clinton, additional, Whitley, Richard J., additional, Wilson, Walter R., additional, Wortmann, Glenn W., additional, Wright, William F., additional, Young, Jo-Anne H., additional, Young, Vincent B., additional, Yun, Nadezhda, additional, Zimmerli, Werner, additional, Zinner, Stephen H., additional, and Zurlo, John J., additional

Published
2015
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31. Who’s slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first‐line HIV treatment in Uganda and South Africa

Author

Reynolds, Zahra, primary, McCluskey, Suzanne M., additional, Moosa, Mahomed Yunus S., additional, Gilbert, Rebecca F., additional, Pillay, Selvan, additional, Aturinda, Isaac, additional, Ard, Kevin L., additional, Muyindike, Winnie, additional, Musinguzi, Nicholas, additional, Masette, Godfrey, additional, Moodley, Pravi, additional, Brijkumar, Jaysingh, additional, Rautenberg, Tamlyn, additional, George, Gavin, additional, Johnson, Brent A., additional, Gandhi, Rajesh T., additional, Sunpath, Henry, additional, Marconi, Vincent C., additional, Bwana, Mwebesa Bosco, additional, and Siedner, Mark J., additional

Published
2021
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38. Who's slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first‐line HIV treatment in Uganda and South Africa.

Author

Reynolds, Zahra, McCluskey, Suzanne M., Moosa, Mahomed Yunus S., Gilbert, Rebecca F., Pillay, Selvan, Aturinda, Isaac, Ard, Kevin L., Muyindike, Winnie, Musinguzi, Nicholas, Masette, Godfrey, Moodley, Pravi, Brijkumar, Jaysingh, Rautenberg, Tamlyn, George, Gavin, Johnson, Brent A., Gandhi, Rajesh T., Sunpath, Henry, Marconi, Vincent C., Bwana, Mwebesa Bosco, and Siedner, Mark J.

Subjects
HIV infections, ANTI-HIV agents, CONFIDENCE intervals, ANTIRETROVIRAL agents, DRUG resistance, TREATMENT failure, COMPARATIVE studies, DESCRIPTIVE statistics, CD4 lymphocyte count, DRUG resistance in microorganisms, STATISTICAL models, LONGITUDINAL method
Abstract

Objectives: HIV virological failure remains a major threat to programme success in sub‐Saharan Africa. While HIV drug resistance (HIVDR) and inadequate adherence are the main drivers of virological failure, the individual, clinical and health system characteristics that lead to poor outcomes are not well understood. The objective of this paper is to identify those characteristics among people failing first‐line antiretroviral therapy (ART). Methods: We enrolled a cohort of adults in HIV care experiencing virological failure on first‐line ART at five sites and used standard statistical methods to characterize them with a focus on three domains: individual/demographic, clinical, and health system, and compared each by country of enrolment. Results: Of 840 participants, 51% were women, the median duration on ART was 3.2 years [interquartile range (IQR) 1.1, 6.4 years] and the median CD4 cell count prior to failure was 281 cells/µL (IQR 121, 457 cells/µL). More than half of participants [53%; 95% confidence interval (CI) 49–56%] stated that they had > 90% adherence and 75% (95% CI 72–77%) took their ART on time all or most of the time. Conversely, the vast majority (90%; 95% CI 86–92%) with a completed genotypic drug resistance test had any HIV drug resistance. This population had high health system use, reporting a median of 3 (IQR 2.6) health care visits and a median of 1 (IQR 1.1) hospitalization in the preceding 6 months. Conclusions: Patients failing first‐line ART in sub‐Saharan Africa generally report high rates of adherence to ART, have extremely high rates of HIV drug resistance and utilize significant health care resources. Health systems interventions to promptly detect and manage treatment failure will be a prerequisite to establishing control of the HIV epidemic. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Peritoneal tuberculosis in a pregnant woman from Haiti, United States

Author

Ard, Kevin L., Chan, Brian T., Milner, Jr., Danny A., Farmer, Paul E., and Koenig, Serena P.

Subjects
Diagnosis, Research, Risk factors, Health aspects, Tuberculosis -- Risk factors -- Diagnosis -- Research, Pregnant women -- Health aspects
Abstract

To the Editor: A 29-year-old woman at 23 weeks' gestation during her first pregnancy came to our hospital's obstetrics clinic after 6 days of vaginal bleeding and abdominal pain. She [...]

Published
2013

42. P220: Understanding the Impact of Mpox on Sexual Health Clinical Services: A National Knowledge, Attitudes, and Practices Survey -- United States, 2022.

Author

Schubert, Sara L., Agnew-Brune, Christine, Anderson, Teri, Ard, Kevin L., Coor, Allie, Gilliams, Elizabeth, Hamill, Matthew M., Johnson, Kelly A., Johnston, Christine, Kachur, Rachel, Kathryn, Miele, Kelley, Destiny, Lewis, Felicia, Liang, Philana, McNeil, Candice J., Meyers, Kathrine, Nagendra, Gowri, Neu, Natalie, Ooms, Tamara, and Quilter, Laura A. S.

Published
2024

43. Mycobacterium talmoniae , a Potential Pulmonary Pathogen Isolated from Multiple Patients with Bronchiectasis in the United States, Including the First Case of Clinical Disease in a Patient with Cystic Fibrosis

Author

Vasireddy, Ravikiran, primary, Vasireddy, Sruthi, additional, Brown-Elliott, Barbara A., additional, Greninger, Alexander L., additional, Davidson, Rebecca M., additional, Ard, Kevin L., additional, Turenne, Christine Y., additional, and Wallace, Richard J., additional

Published
2019
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48. Colaboradores

Author

Aagaard, Kjersti, Abdallah, Marie, Abrahamian, Fredrick M., Agnihotri, Shruti, Ahmed, Sana S., Allos, Ban Mishu, Alqahtani, Saleh A., Anderson, Jeffrey L., Andes, David R., Andrews, Jason R., Aoki, Fred Y., Apicella, Michael A., Araos, Rafael, Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Aronson, Naomi E., Augenbraun, Michael H., Auwaerter, Paul G., Averhoff, Francisco, Azar, Dimitri T., Babu, Tara M., Bachmann, Laura Hinkle, Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Sarah-Blythe, Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Bartelt, Luther A., Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Beigi, Richard H., Bennett, John E., Berbari, Elie F., Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birch, Torrey Boland, Birdsall, Holly H., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Blazes, David L., Bleck, Thomas P., Blijlevens, Nicole M.A., Blyth, Dana M., Boggild, Andrea K., Bogoch, Isaac I., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Braden, Christopher R., Branche, Angela R., Britt, William J., Brook, Itzhak, Brouwer, Matthijs C., Brown, Kevin E., Brown, Patricia, Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Casadevall, Arturo, Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chapman, Stephen J., Chappell, Catherine A., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chiang, Augusto Dulanto, Chopra, Sanjiv, Chow, Anthony W., Clancy, Cornelius J., Clark, Richard B., Cohen, Jeffrey I., Cohen, Myron S., Cohen, Yehuda Z., Cohen-Poradosu, Ronit, Cohn, Susan E., Colton, Benjamin, Connors, Mark, Copeland, Nathanial K., Corey, Lawrence, Cosgrove, Sara E., Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Crass, Ryan L., Cunha, Cheston B., Curran, James W., Currie, Bart J., D’Agata, Erika, Daly, Jennifer S., Damon, Inger K., Darouiche, Rabih O., Dawid, Suzanne, Deepe, George S., Jr., Dekker, John P., del Rio, Carlos, DeLeo, Frank R., DeMuri, Gregory P., Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donowitz, Gerald R., Donskey, Curtis J., Dormitzer, Philip R., Dumler, J. Stephen, Dupnik, Kathryn, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Duval, Xavier, Edelstein, Paul H., Edwards, John E., Jr., Edwards, Morven S., Ellison, Richard T., III, Embry, Alan C., Endy, Timothy P., Engleberg, N. Cary, Englund, Janet A., Erdem, Hakan, Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Monica, Garrett, Wendy S., Gauthier, Gregory M., Gaydos, Charlotte A., Gea-Banacloche, Juan C., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Giri, Pushpanjali, Gold, Howard S., Goldstein, Ellie J.C., González-Marín, Ángel, Graman, Paul S., Grayson, M. Lindsay, Greenberg, David, Greene, Matthew H., Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, Hanefi C., Haake, David A., Haas, David W., Haidar, Ghady, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hartzell, Joshua D., Hasbun, Rodrigo, Hawkins, Claudia, Hay, Roderick J., Henderson, David K., High, Kevin P., Hill, Adrian V.S., Hinman, Alan R., Hirsch, Martin S., Hochman, Sarah, Hoen, Bruno, Hohl, Tobias M., Holland, Steven M., Holland, Thomas L., Holzman, Robert S., Hooper, David C., Hooton, Thomas M., Hoover, Susan E., Horowitz, Harold W., Horton, James M., Hospenthal, Duane R., Hotez, Peter J., Hynes, Noreen A., Iovine, Nicole M., Ison, Michael G., Jaggi, Preeti, Janda, J. Michael, Janoff, Edward N., Jernigan, Daniel, Johannsen, Eric C., Johnson, Jennie E., Juliano, Jonathan J., Kamboj, Mini, Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima F., Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Kirkpatrick, Beth D., Kiyono, Hiroshi, Klein, Bruce S., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., LaSalvia, Mary T., Leaf, Howard L., Leggett, James E., Lepak, Alexander J., Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lionakis, Michail S., Lipkin, W. Ian, Litman, Nathan, Luna, Ruth Ann, Lutgring, Joseph D., MacDougall, Conan, Maddocks, Susan, Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McCarthy, James S., McCormack, William, McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mejia, Rojelio, Mekala, Vijayashree, Messonnier, Nancy, Mikulska, Małgorzata, Miller, Robert F., Miller, Samuel I., Miller, William R., Moffa, Matthew, Moir, Susan, Montoya, José G., Moonah, Shannon N., Moore, Thomas A., Moreillon, Philippe, Morgan, Janet, Morris, J. Glenn, Jr., Munita, Jose M., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Musher, Daniel M., Mylonakis, Eleftherios, Nagel, Jerod L., Naggie, Susanna, Nannini, Esteban C., Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., Nelson, George E., Nelson, Joanna K., Nesbitt, Whitney J., Nguyen, M. Hong, O’Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Paris, Daniel H., Parks, Tom, Parsonnet, Julie, Parta, Mark, Pasternack, Mark S., Pastula, Daniel M., Patel, Robin, Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Pelton, Stephen I., Penn, Robert L., Perfect, John R., Perkins, Ryan, Perlman, Stanley, Petersen, Brett W., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Polsky, Bruce, Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Ramakrishnan, Lalita, Raoult, Didier, Ravdin, Jonathan I., Reboli, Annette C., Redel, Henry, Reitz, Marvin S., Jr., Relman, David A., Reno, Hilary E.L., Restrepo-Moreno, Ángela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romanovsky, Andrej A., Romero, José R., Rose, Stacey R., Rosenberg, Ronald, Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Sajadi, Mohammad M., Salazar, Juan C., Saleeb, Paul G., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco, Singh, Nina, Singh, Upinder, Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Sorrell, Tania C., Spellberg, Brad, Steckelberg, James M., Steere, Allen C., Steinberg, James P., Stephens, David S., Stephenson, Kathryn E., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Stoner, Bradley P., Strahilevitz, Jacob, IV, Charles W. Stratton, Strnad, Luke C., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talati, Naasha J., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Tande, Aaron J., Tesini, Brenda L., Thio, Chloe Lynne, Thomas, Stephen J., Thompson, George R., III, Thorner, Anna R., Tobón-Orozco, Ángela Ma., Tramont, Edmund C., Trautner, Barbara W., Treanor, John J., Trivedi, Hirsh D., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Tyler, Kenneth L., Uluer, Ahmet Z., Urban, Marguerite A., Ustun, Celalettin, Uyeki, Timothy M., van de Beek, Diederik, van der Poll, Tom, van der Velden, Walter J.F.M., Van Schooneveld, Trevor C., Vannier, Edouard, Vellozzi, Claudia, Versalovic, James, Vijayan, Vini, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Ward, Honorine D., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Watkins, Richard R., Watts, Matthew R., Weatherhead, Jill, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weiss, Louis M., Wellems, Thomas E., White, A. Clinton, Jr., Whitley, Richard J., Wiersinga, Willem Joost, Williams, Brett, Wilson, Walter R., Winslow, Dean L., Winthrop, Kevin L., Wong, Karen K., Wortmann, Glenn W., Wright, William F., Wyles, David L., Young, Jo-Anne H., Young, Vincent Bensan, Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.

Published
2021
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