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1. Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis

Author

Sirvent, Sofia, Vallejo, Andres F., Corden, Emma, Teo, Ying, Davies, James, Clayton, Kalum, Seaby, Eleanor G., Lai, Chester, Ennis, Sarah, Alyami, Rfeef, Douilhet, Gemma, Dean, Lareb S. N., Loxham, Matthew, Horswill, Sarah, Healy, Eugene, Roberts, Graham, Hall, Nigel J., Friedmann, Peter S., Singh, Harinder, Bennett, Clare L., Ardern-Jones, Michael R, and Polak, Marta E.

Published
2023
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2. Comparison of real-world treatment outcomes of systemic immunomodulating therapy in atopic dermatitis patients with dark and light skin types

Author

Bosma, Angela L., Ouwerkerk, Wouter, Heidema, Madeline J., Prieto-Merino, David, Ardern-Jones, Michael R., Beattie, Paula, Brown, Sara J., Ingram, John R., Irvine, Alan D., Ogg, Graham, Patel, Prakash, Reynolds, Nick J., Hearn, R.M. Ross, Wan, Mandy, Warren, Richard B., Woolf, Richard T., Hyseni, Ariënna M., Gerbens, Louise A.A., Spuls, Phyllis I., Flohr, Carsten, and Middelkamp-Hup, Maritza A.

Published
2023
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3. In Vitro Drug Allergy Testing

Author

Teo, Ying Xin, Ardern-Jones, Michael R., Berth-Jones, John, Series Editor, Goh, Chee Leok, Series Editor, Maibach, Howard I., Series Editor, Lee, Haur Yueh, editor, and Creamer, Daniel, editor

Published
2022
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7. Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity.

Author

Appios, Anna, Davies, James, Sirvent, Sofia, Henderson, Stephen, Trzebanski, Sébastien, Schroth, Johannes, Law, Morven L., Carvalho, Inês Boal, Pinto, Marlene Magalhaes, Carvalho, Cyril, Kan, Howard Yuan-Hao, Lovlekar, Shreya, Major, Christina, Vallejo, Andres, Hall, Nigel J., Ardern-Jones, Michael, Liu, Zhaoyuan, Ginhoux, Florent, Henson, Sian M., and Gentek, Rebecca

Subjects
LANGERHANS cells, HAIR follicles, DENDRITIC cells, SKIN innervation, PHAGOCYTES
Abstract

Langerhans cells (LCs) are distinct among phagocytes, functioning both as embryo-derived, tissue-resident macrophages in skin innervation and repair and as migrating professional antigen-presenting cells, a function classically assigned to dendritic cells (DCs). Here, we demonstrate that both intrinsic and extrinsic factors imprint this dual identity. Using ablation of embryo-derived LCs in the murine adult skin and tracking differentiation of incoming monocyte-derived replacements, we found intrinsic intraepidermal heterogeneity. We observed that ontogenically distinct monocytes give rise to LCs. Within the epidermis, Jagged-dependent activation of Notch signaling, likely within the hair follicle niche, provided an initial site of LC commitment before metabolic adaptation and survival of monocyte-derived LCs. In the human skin, embryo-derived LCs in newborns retained transcriptional evidence of their macrophage origin, but this was superseded by DC-like immune modules after postnatal expansion. Thus, adaptation to adult skin niches replicates conditioning of LC at birth, permitting repair of the embryo-derived LC network. Editor's summary: Langerhans cells (LCs) are specialized skin-resident antigen-presenting cells that not only share developmental origins with tissue-resident macrophages but also acquire the dendritic cell–like ability to migrate to draining lymph nodes. How this dual LC identity is imprinted and maintained is not completely understood. Using a mouse model of adult LC repopulation, Appios et al. found that both the developmental origin of repopulating monocytes and epidermal niche signaling imprint LC identity. A subset of infiltrating monocytes underwent stepwise differentiation involving loss of Zeb2-regulated macrophage identity, Jagged/Notch-dependent imprinting of LC fate, and survival signals in the epidermis. Similar developmental programs were detected among human embryo–derived LCs in postnatal skin. Together, these findings identify intrinsic and extrinsic factors guiding LC specification in the skin. —Claire Olingy [ABSTRACT FROM AUTHOR]

Published
2024
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9. Atopic Eczema

Author

Ardern‐Jones, Michael R., primary, Flohr, Carsten, additional, and Reynolds, Nick J., additional

Published
2024
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11. SJS/TEN 2019: From science to translation

Author

Chang, Wan-Chun, Abe, Riichiro, Anderson, Paul, Anderson, Wanpen, Ardern-Jones, Michael R., Beachkofsky, Thomas M., Bellón, Teresa, Biala, Agnieszka K., Bouchard, Charles, Cavalleri, Gianpiero L., Chapman, Nicole, Chodosh, James, Choi, Hyon K., Cibotti, Ricardo R., Divito, Sherrie J., Dewar, Karen, Dehaeck, Ulrike, Etminan, Mahyar, Forbes, Diane, Fuchs, Esther, Goldman, Jennifer L., Holmes, James H., IV, Hope, Elyse A., Hung, Shuen-Iu, Hsieh, Chia-Ling, Iovieno, Alfonso, Jagdeo, Julienne, Kim, Mee Kum, Koelle, David M., Lacouture, Mario E., Le Pallec, Sophie, Lehloenya, Rannakoe J., Lim, Robyn, Lowe, Angie, McCawley, Jean, McCawley, Julie, Micheletti, Robert G., Mockenhaupt, Maja, Niemeyer, Katie, Norcross, Michael A., Oboh, Douglas, Olteanu, Cristina, Pasieka, Helena B., Peter, Jonathan, Pirmohamed, Munir, Rieder, Michael, Saeed, Hajirah N., Shear, Neil H., Shieh, Christine, Straus, Sabine, Sukasem, Chonlaphat, Sung, Cynthia, Trubiano, Jason A., Tsou, Sheng-Ying, Ueta, Mayumi, Volpi, Simona, Wan, Chen, Wang, Hongsheng, Wang, Zhao-Qing, Weintraub, Jessica, Whale, Cindy, Wheatley, Lisa M., Whyte-Croasdaile, Sonia, Williams, Kristina B., Wright, Galen, Yeung, Sonia N., Zhou, Li, Chung, Wen-Hung, Phillips, Elizabeth J., and Carleton, Bruce C.

Published
2020
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13. 517 - Lebrikizumab demonstrates significant efficacy versus placebo across racial and ethnic subgroups in patients with moderate-to-severe atopic dermatitis

Author

Alexis, Andrew, primary, Ardern-Jones, Michael, additional, Chovatiya, Raj, additional, Flohr, Carsten, additional, Irvine, Alan, additional, AlMurrawi, Muna, additional, Atwater, Amber Reck, additional, Ding, Yuxin, additional, Qiao, Meihua, additional, Pierce, Evangeline, additional, Pau-Charles, Ignasi, additional, and Heath, Candrice, additional

Published
2024
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16. Glycolysis: An early marker for vancomycin‐specific T‐cell activation

Author

Gardner, Joshua, primary, Hammond, Sean, additional, Jensen, Rebecca, additional, Gibson, Andrew, additional, Krantz, Matthew S., additional, Ardern‐Jones, Michael, additional, Phillips, Elizabeth J., additional, Pirmohamed, Munir, additional, Chadwick, Amy E., additional, Betts, Catherine, additional, and Naisbitt, Dean J., additional

Published
2024
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18. Convergent evolution of monocyte differentiation in adult skin permits repair of the Langerhans cell network

Author

Appios, Anna, primary, Davies, James, additional, Sirvent, Sofia, additional, Henderson, Stephen, additional, Trzebanski, Sebastien, additional, Schroth, Johannes, additional, Law, Morven L, additional, Boal Carvalho, Ines, additional, Yuan-Hao Kan, Howard, additional, Major, Christina, additional, Vallejo, Andres, additional, Hall, Nigel J, additional, Ardern-Jones, Michael, additional, Henson, Sian M, additional, Emmerson, Elaine, additional, Jung, Steffen, additional, Polak, Marta E, additional, and Bennett, Clare L, additional

Published
2023
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19. Shared Genetic Risk Variants in Both Male and Female Frontal Fibrosing Alopecia

Author

Rayinda, Tuntas, primary, McSweeney, Sheila M., additional, Fenton, David, additional, Stefanato, Catherine M., additional, Harries, Matthew, additional, Palamaras, Ioulios, additional, Tidman, Alice, additional, Holmes, Susan, additional, Koutalopoulou, Anastasia, additional, Ardern-Jones, Michael, additional, Williams, Greg, additional, Papanikou, Sofia, additional, Chasapi, Vasiliki, additional, Vañó-Galvan, Sergio, additional, Saceda-Corralo, David, additional, Melián-Olivera, Ana, additional, Azcarraga-Llobet, Carlos, additional, Lobato-Berezo, Alejandro, additional, Bustamante, Mariona, additional, Sunyer, Jordi, additional, Starace, Michela Valeria Rita, additional, Piraccini, Bianca Maria, additional, Wiss, Isabel Pupo, additional, Senna, Maryanne Makredes, additional, Singh, Rashmi, additional, Hilmann, Kathrin, additional, Kanti-Schmidt, Varvara, additional, Blume-Peytavi, Ulrike, additional, Simpson, Michael, additional, McGrath, John A., additional, Dand, Nick, additional, and Tziotzios, Christos, additional

Published
2023
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20. SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation

Author

White, Katie D., Abe, Riichiro, Ardern-Jones, Michael, Beachkofsky, Thomas, Bouchard, Charles, Carleton, Bruce, Chodosh, James, Cibotti, Ricardo, Davis, Robert, Denny, Joshua C., Dodiuk-Gad, Roni P., Ergen, Elizabeth N., Goldman, Jennifer L., Holmes, James H., IV, Hung, Shuen-Iu, Lacouture, Mario E., Lehloenya, Rannakoe J., Mallal, Simon, Manolio, Teri A., Micheletti, Robert G., Mitchell, Caroline M., Mockenhaupt, Maja, Ostrov, David A., Pavlos, Rebecca, Pirmohamed, Munir, Pope, Elena, Redwood, Alec, Rosenbach, Misha, Rosenblum, Michael D., Roujeau, Jean-Claude, Saavedra, Arturo P., Saeed, Hajirah N., Struewing, Jeffery P., Sueki, Hirohiko, Sukasem, Chonlaphat, Sung, Cynthia, Trubiano, Jason A., Weintraub, Jessica, Wheatley, Lisa M., Williams, Kristina B., Worley, Brandon, Chung, Wen-Hung, Shear, Neil H., and Phillips, Elizabeth J.

Published
2018
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22. Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis

Author

Waters, Margo, primary, Dobry, Allison, additional, Le, Stephanie T., additional, Shinkai, Kanade, additional, Beachkofsky, Thomas M., additional, Davis, Mark D. P., additional, Dominguez, Arturo R., additional, Kroshinsky, Daniela, additional, Markova, Alina, additional, Micheletti, Robert G., additional, Mostaghimi, Arash, additional, Pasieka, Helena B., additional, Rosenbach, Misha, additional, Seminario-Vidal, Lucia, additional, Trinidad, John, additional, Albrecht, Joerg, additional, Altman, Emily M., additional, Arakaki, Ryan, additional, Ardern-Jones, Michael, additional, Bridges, Alina G., additional, Cardones, Adela R., additional, Chadha, Angad A., additional, Chen, Jennifer K., additional, Chen, Steven T., additional, Cheng, Kyle, additional, Daveluy, Steven, additional, DeNiro, Katherine L., additional, Harp, Joanna, additional, Keller, Jesse J., additional, King, Brett, additional, Korman, Abraham M., additional, Lowenstein, Eve J., additional, Luxenberg, Erin, additional, Mancuso, Jennifer Brescoll, additional, Mauskar, Melissa M., additional, Milam, Philip, additional, Motaparthi, Kiran, additional, Nelson, Caroline A., additional, Nguyen, Cuong V., additional, Nutan, Fnu, additional, Ortega-Loayza, Alex G., additional, Patel, Tejesh, additional, Rahnama-Moghadam, Sahand, additional, Rekhtman, Sergey, additional, Rojek, Nathan W., additional, Sarihan, Mansi, additional, Shaigany, Sheila, additional, Sharma, Timmie R., additional, Shearer, Sabrina M., additional, Shields, Bridget E., additional, Strowd, Lindsay C., additional, Tartar, Danielle M., additional, Thomas, Cristina, additional, Wanat, Karolyn A., additional, Walls, Andrew C., additional, Zaba, Lisa C., additional, Ziemer, Carolyn M., additional, Maverakis, Emanual, additional, and Kaffenberger, Benjamin H., additional

Published
2023
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23. Genomic programming of IRF4-expressing human Langerhans cells

Author

Sirvent, Sofia, Vallejo, Andres F., Davies, James, Clayton, Kalum, Wu, Zhiguo, Woo, Jeongmin, Riddell, Jeremy, Chaudhri, Virendra K., Stumpf, Patrick, Nazlamova, Liliya Angelova, Wheway, Gabrielle, Rose-Zerilli, Matthew, West, Jonathan, Pujato, Mario, Chen, Xiaoting, Woelk, Christopher H., MacArthur, Ben, Ardern-Jones, Michael, Friedmann, Peter S., Weirauch, Matthew T., Singh, Harinder, and Polak, Marta E.

Published
2020
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24. Management of Adult Patients With Drug Reaction With Eosinophilia and Systemic Symptoms: A Delphi-Based International Consensus.

Author

Brüggen, Marie-Charlotte, Walsh, Sarah, Ameri, M. Milad, Anasiewicz, Natalie, Maverakis, Emanual, French, Lars E., Ingen-Housz-Oro, Saskia, Abe, Richiiro, Ardern-Jones, Michael, Assier, Haudrey, Barbaud, Annick, Bensaid, Benoit, Bernal, William, Bernier, Claire, Brassard, Alain, Březinová, Eva, Cabañas, Rosario, Cardones, Adela, Chu, Chia-Yu, and Chua, Ser-Ling

Published
2024
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27. Efficacy and safety of abrocitinib monotherapy in adolescents and adults: a post hoc analysis of the phase 3 JAK1 atopic dermatitis efficacy and safety (JADE) REGIMEN clinical trial

Author

Flohr, Carsten, primary, Cork, Michael J., additional, Ardern-Jones, Michael R., additional, Eichenfield, Lawrence F., additional, Barbarot, Sébastien, additional, Feeney, Claire, additional, Rojo, Ricardo, additional, Lazariciu, Irina, additional, and Nesnas, John, additional

Published
2023
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29. Mapping exercise and status update of eight established registries within the TREatment of ATopic eczema Registry Taskforce

Author

Bosma, Angela L., Musters, Annelie H., Bloem, Manja, Gerbens, Louise A.A., Middelkamp-Hup, Maritza A., Haufe, Eva, Schmitt, Jochen, Barbarot, Sebastien, Seneschal, Julien, Staumont-Sallé, Delphine, Johansson, Emma K., Bradley, Maria, von Kobyletzki, Laura B., Vittrup, Ida, Frier Ruge, Iben, Thyssen, Jacob P., Vestergaard, Christian, de Vega, Marina, García-Doval, Ignacio, Chiricozzi, Andrea, Stingeni, Luca, Calzavara-Pinton, Piergiacomo, Ardern-Jones, Michael R., Reynolds, Nick J., Flohr, Carsten, Spuls, Phyllis I., Bosma, Angela L., Musters, Annelie H., Bloem, Manja, Gerbens, Louise A.A., Middelkamp-Hup, Maritza A., Haufe, Eva, Schmitt, Jochen, Barbarot, Sebastien, Seneschal, Julien, Staumont-Sallé, Delphine, Johansson, Emma K., Bradley, Maria, von Kobyletzki, Laura B., Vittrup, Ida, Frier Ruge, Iben, Thyssen, Jacob P., Vestergaard, Christian, de Vega, Marina, García-Doval, Ignacio, Chiricozzi, Andrea, Stingeni, Luca, Calzavara-Pinton, Piergiacomo, Ardern-Jones, Michael R., Reynolds, Nick J., Flohr, Carsten, and Spuls, Phyllis I.

Abstract

Background: The TREatment of ATopic eczema (TREAT) Registry Taskforce is a collaborative international network of registries collecting data of atopic eczema (AE) patients receiving systemic and phototherapy with the common goal to provide long-term real-world data on the effectiveness, safety and cost-effectiveness of therapies. A core dataset, consisting of domains and domain items with corresponding measurement instruments, has been developed to harmonize data collection. Objectives: We aimed to give an overview of the status and characteristics of the eight established TREAT registries, and to perform a mapping exercise to examine the degree of overlap and pooling ability between the national registry datasets. This will allow us to determine which research questions can be answered in the future by pooling data. Methods: All eight registries were asked to share their dataset and information on the current status and characteristics. The overlap between the core dataset and each registry dataset was identified (according to the domains, domain items and measurement instruments of the TREAT core dataset). Results and conclusions: A total of 4702 participants have been recruited in the eight registries as of 1st of May 2022. Of the 69 core dataset domain items, data pooling was possible for 69 domain item outcomes in TREAT NL (the Netherlands), 61 items in A-STAR (UK and Ireland), 38 items in TREATgermany (Germany), 36 items in FIRST (France), 33 items in AtopyReg (Italy), 29 items in Biobadatop (Spain), 28 items in SCRATCH (Denmark) and 20 items in SwedAD (Sweden). Pooled analyses across all registries can be performed on multiple important domain items, covering the main aims of analysing data on the (cost-)effectiveness and safety of AE therapies. These results will facilitate future comparative or joint analyses.

Published
2023

31. Electromagnetic sensing techniques for monitoring atopic dermatitis - current practices and possible advancements: a review

Author

Todorov, Alexandar, Torah, Russel, Ardern-Jones, Michael R., and Beeby, Steve P.

Abstract

Atopic dermatitis (AD) is one of the most common skin disorders, affecting nearly one-fifth of children and adolescents worldwide, and currently, the only method of monitoring the condition is through an in-person visual examination by a clinician. This method of assessment poses an inherent risk of subjectivity and can be restrictive to patients who do not have access to or cannot visit hospitals. Advances in digital sensing technologies can serve as a foundation for the development of a new generation of e-health devices that provide accurate and empirical evaluation of the condition to patients worldwide. The goal of this review is to study the past, present, and future of AD monitoring. First, current medical practices such as biopsy, tape stripping and blood serum are discussed with their merits and demerits. Then, alternative digital methods of medical evaluation are highlighted with the focus on non-invasive monitoring using biomarkers of AD—TEWL, skin permittivity, elasticity, and pruritus. Finally, possible future technologies are showcased such as radio frequency reflectometry and optical spectroscopy along with a short discussion to provoke research into improving the current techniques and employing the new ones to develop an AD monitoring device, which could eventually facilitate medical diagnosis.

Published
2023

32. Design of a Flexible, Wearable Interdigitated Capacitive Sensor for Monitoring Biomarkers of Atopic Dermatitis

Author

Todorov, Alexandar R., Goyal, Krittika, Torah, Russel N., Wagih, Mahmoud, Ardern-Jones, Michael R., Day, Steven W., and Beeby, Stephen P.

Abstract

The emergence of wearable and remote sensing devices in e-health has revolutionized personalized healthcare monitoring, but the field of dermatology has yet to witness significant progress in this area. The diagnosis and monitoring of atopic dermatitis (AD), a common skin disease causing inflammation and rashes, depend on in-person assessment, leading to subjective evaluations and treatment procedures. This work presents a novel interdigitated capacitive sensor, specifically designed to detect biomarkers of AD and to empirically estimate the severity of the condition. The design was proven by finite-element analysis software to detect only biomarkers of AD—dehydration of the outermost skin layer. The IDC sensor has a compact and flexible footprint (sensing area of around 40 mm2); it is compatible with a wearable and noninvasive system, and can be used to remotely gather localized data about the condition. To calibrate its measurements, a novel hydration-gradient skin-mimicking phantom was developed, which simulates varying skin hydration conditions on the same substrate. The sensor is compared against a commercial skin hydration device, and its sensitivity is mapped against the arbitrary units (A.U.s) of the commercial device, resulting in a normalized capacitance sensitivity of 13.1 pF/cm2 per 1 A.U. This novel IDC sensor is the first sensor to accurately measure the permittivity of specific layers of the skin. Its bespoke design is the main enabler of the outermost layer’s permittivity to be isolated from the skin. This presents promising prospects for remote patient care, enabling accurate diagnosis, treatment monitoring, and personalized interventions for AD.

Published
2024
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34. The risk of venous thromboembolism in atopic dermatitis: a matched cohort analysis in UK primary care.

Author

Warren, Richard B, Basey, Victoria, Lynam, Anita, Curtis, Charlotte, and Ardern-Jones, Michael R

Subjects
PULMONARY embolism, THROMBOEMBOLISM, ATOPIC dermatitis, COHORT analysis, PROPORTIONAL hazards models, VENOUS thrombosis
Abstract

Background Atopic dermatitis (AD) is a common chronic inflammatory skin condition. While other chronic inflammatory conditions are associated with increased risk of venous thromboembolism (VTE), associations between AD and VTE have not been established. Objectives We examined whether AD is associated with an increased risk of VTE in a population-based study. Methods Electronic health records were extracted from UK general practices contributing to the Optimum Patient Care Research Database (1 January 2010 to 1 January 2020). All adults with AD were identified (n = 150 975) and age- and sex-matched with unaffected controls (n = 603 770). The risk of VTE, consisting of pulmonary embolism (PE) or deep-vein thrombosis (DVT), was compared in people with AD vs. controls using Cox proportional hazard models. PE and DVT were examined separately as secondary outcomes. Results We identified 150 975 adults with active AD and matched them with 603 770 unaffected controls. During the study, 2576 of those with active AD and 7563 of the matched controls developed VTE. Individuals with AD had a higher risk of VTE than controls [adjusted hazard ratio (aHR) 1.17, 95% confidence interval (CI) 1.12–1.22]. When assessing VTE components, AD was associated with a higher risk of DVT (aHR 1.30, 95% CI 1.23–1.37) but not PE (aHR 0.94, 95% CI 0.87–1.02). The VTE risk was greater in older people with AD (≥ 65 years: aHR 1.22, 95% CI 1.15–1.29; 45–65 years: aHR 1.15, 95% CI 1.05–1.26; < 45 years: aHR 1.07, 95% CI 0.97–1.19) and those with obesity [body mass index (BMI) ≥ 30: aHR 1.25, 95% CI 1.12–1.39; BMI < 30: aHR 1.08, 95% CI 1.01–1.15). Risk was broadly consistent across mild, moderate or severe AD. Conclusions AD is associated with a small increase in risk of VTE and DVT, with no increase in risk of PE. The magnitude of this risk increase is modest in younger people, and those without obesity. [ABSTRACT FROM AUTHOR]

Published
2023
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36. A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort

Author

Ardern-Jones, Michael R., primary, Phan, Hang T. T., additional, Borca, Florina, additional, Stammers, Matt, additional, Batchelor, James, additional, Reading, Isabel C., additional, Fletcher, Sophie V., additional, Smith, Trevor, additional, and Duncombe, Andrew S., additional

Published
2023
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38. Efficacy and safety of abrocitinib monotherapy in adolescents and adults: a post hoc analysis of the phase 3 JAK1 atopic dermatitis efficacy and safety (JADE) REGIMEN clinical trial

Author

Flohr, Carsten, Cork, Michael J., Ardern-Jones, Michael R., Eichenfield, Lawrence F., Barbarot, Sébastien, Feeney, Claire, Rojo, Ricardo, Lazariciu, Irina, and Nesnas, John

Subjects
Dermatology
Abstract

Background: differences in atopic dermatitis (AD) disease course and manifestation with age may extend to treatment response.Objectives: so evaluate response maintenance with continuous-/reduced-dose abrocitinib or withdrawal and response to treatment reintroduction after flare in adolescent and adult participants in JADE REGIMEN (NCT03627767).Methods: adolescents (12-17 years) and adults with moderate-to-severe AD responding to abrocitinib 200-mg induction were randomly assigned to 40-week maintenance with abrocitinib (200 mg/100 mg) or placebo. Patients who experienced flare during maintenance received rescue treatment.Results: of 246 adolescents and 981 adults, 145/246 (58.9%) and 655/981 (66.8%), respectively, responded to induction. Similar proportions of adolescents and adults experienced flare during maintenance with abrocitinib 200 mg (14.9%/16.9%), 100 mg (42.9%/38.9%), and placebo (75.5%/78.0%). From the abrocitinib 200-mg, 100-mg, and placebo arms, respectively, Eczema Area and Severity Index response was recaptured by 28.6%, 25.0%, and 52.9% of adolescents and 34.3%, 33.7%, and 58.0% of adults; Investigator's Global Assessment response, by 42.9%, 50.0%, and 73.5% of adolescents and 34.3%, 50.6%, and 74.1% of adults. Abrocitinib had a similar safety profile regardless of age; nausea incidence was higher in adolescents.Limitations: adolescents represented 20% of the trial population.Conclusions: abrocitinib was effective in preventing flare in adolescents and adults.Clinicaltrials.gov listing: NCT03627767.

Published
2023
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40. Skin programming of inflammatory responses to Staphylococcus aureus is compartmentalized according to epidermal keratinocyte differentiation status

Author

Clayton, Kalum, primary, Holbrook, Daniel J, additional, Vallejo, Andres, additional, Porter, Gemma, additional, Sirvent, Sofia, additional, Davies, James , additional, Pople, Jenny, additional, Lim, Fei Ling, additional, Christodoulides, Myron, additional, Polak, Marta E, additional, and Ardern-Jones, Michael R, additional

Published
2022
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41. BSACIguideline for the set‐up of penicillin allergy de‐labelling services by non‐allergists working in a hospital setting

Author

Savic, Louise, primary, Ardern‐Jones, Michael, additional, Avery, Anthony, additional, Cook, Tim, additional, Denman, Sarah, additional, Farooque, Sophie, additional, Garcez, Tomaz, additional, Gold, Rochelle, additional, Jay, Nicola, additional, Krishna, Mamidipudi Thirumala, additional, Leech, Sue, additional, McKibben, Shauna, additional, Nasser, Shuaib, additional, Premchand, Nikhil, additional, Sandoe, Jonathan, additional, Sneddon, Jacqueline, additional, and Warner, Amena, additional

Published
2022
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43. Mapping exercise and status update of eight established registries within the TREatment of ATopic eczema Registry Taskforce

Author

Bosma, Angela L., primary, Musters, Annelie H., additional, Bloem, Manja, additional, Gerbens, Louise A. A., additional, Middelkamp‐Hup, Maritza A., additional, Haufe, Eva, additional, Schmitt, Jochen, additional, Barbarot, Sebastien, additional, Seneschal, Julien, additional, Staumont‐Sallé, Delphine, additional, Johansson, Emma K., additional, Bradley, Maria, additional, von Kobyletzki, Laura B., additional, Vittrup, Ida, additional, Frier Ruge, Iben, additional, Thyssen, Jacob P., additional, Vestergaard, Christian, additional, de Vega, Marina, additional, García‐Doval, Ignacio, additional, Chiricozzi, Andrea, additional, Stingeni, Luca, additional, Calzavara‐Pinton, Piergiacomo, additional, Ardern‐Jones, Michael R., additional, Reynolds, Nick J., additional, Flohr, Carsten, additional, and Spuls, Phyllis I., additional

Published
2022
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46. Defining Gaps in Dermatitis Care

Author

Nedorost, Susan, Atwater, Amber, Ardern-Jones, Michael, Elias, Peter, Mukherjee, Pranab, Honari, Golara, Ertel, Mary, Hammond, Maggie, Machler, Brian, Scheman, Andrew, Mulligan, Kammy, Montanez-Wiskovich, Marjorie, Jacob, Sharon, and Brod, Bruce

Published
2017
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47. When does atopic dermatitis warrant systemic therapy? Recommendations from an expert panel of the International Eczema Council

Author

Simpson, Eric L., Bruin-Weller, Marjolein, Flohr, Carsten, Ardern-Jones, Michael R., Barbarot, Sebastien, Deleuran, Mette, Bieber, Thomas, Vestergaard, Christian, Brown, Sara J., Cork, Michael J., Drucker, Aaron M., Eichenfield, Lawrence F., Foelster-Holst, Regina, Guttman-Yassky, Emma, Nosbaum, Audrey, Reynolds, Nick J., Silverberg, Jonathan I., Schmitt, Jochen, Seyger, Marieke M.B., Spuls, Phyllis I., Stalder, Jean-Francois, Su, John C., Takaoka, Roberto, Traidl-Hoffmann, Claudia, Thyssen, Jacob P., van der Schaft, Jorien, Wollenberg, Andreas, Irvine, Alan D., and Paller, Amy S.

Published
2017
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48. Skin programming of inflammatory responses to Staphylococcus aureus is compartmentalized according to epidermal keratinocyte differentiation status.

Author

Clayton, Kalum, Holbrook, Daniel J, Vallejo, Andres, Porter, Gemma, Sirvent, Sofia, Davies, James, Pople, Jenny, Lim, Fei Ling, Christodoulides, Myron, Polak, Marta E, and Ardern-Jones, Michael R

Subjects
KERATINOCYTE differentiation, STAPHYLOCOCCUS aureus, INFLAMMATION, ANTIMICROBIAL peptides, INFLAMMATORY mediators
Abstract

Background Acute cutaneous inflammation causes microbiome alterations as well as ultrastructural changes in epidermis stratification. However, the interactions between keratinocyte proliferation and differentiation status and the skin microbiome have not been fully explored. Objectives Hypothesizing that the skin microbiome contributes to regulation of keratinocyte differentiation and can modify antimicrobial responses, we examined the effect of exposure to commensal (Staphylococcus epidermidis , SE) or pathogenic (Staphylococcus aureus , SA) challenge on epidermal models. Methods Explant biopsies were taken to investigate species-specific antimicrobial effects of host factors. Further investigations were performed in reconstituted epidermal models by bulk transcriptomic analysis alongside secreted protein profiling. Single-cell RNA sequencing analysis was performed to explore the keratinocyte populations responsible for SA inflammation. A dataset of 6391 keratinocytes from control (2044 cells), SE challenge (2028 cells) and SA challenge (2319 cells) was generated from reconstituted epidermal models. Results Bacterial lawns of SA, not SE, were inhibited by human skin explant samples, and microarray analysis of three-dimensional epidermis models showed that host antimicrobial peptide expression was induced by SE but not SA. Protein analysis of bacterial cocultured models showed that SA exposure induced inflammatory mediator expression, indicating keratinocyte activation of other epidermal immune populations. Single-cell DropSeq analysis of unchallenged naive, SE-challenged and SA-challenged epidermis models was undertaken to distinguish cells from basal, spinous and granular layers, and to interrogate them in relation to model exposure. In contrast to SE, SA specifically induced a subpopulation of spinous cells that highly expressed transcripts related to epidermal inflammation and antimicrobial response. Furthermore, SA, but not SE, specifically induced a basal population that highly expressed interleukin-1 alarmins. Conclusions These findings suggest that SA-associated remodelling of the epidermis is compartmentalized to different keratinocyte populations. Elucidating the mechanisms regulating bacterial sensing-triggered inflammatory responses within tissues will enable further understanding of microbiome dysbiosis and inflammatory skin diseases, such as atopic eczema. [ABSTRACT FROM AUTHOR]

Published
2023
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