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2. P765: UPDATED ENROLLMENT AND RESULTS FROM THE PHASE 1 SUBSTUDY OF IVOSIDENIB IN PATIENTS WITH IDH1-MUTANT RELAPSED/REFRACTORY MYELODYSPLASTIC SYNDROME (R/R MDS)

Author

DiNardo, C. D., primary, Foran, J. M., additional, Watts, J. M., additional, Stein, E. M., additional, de Botton, S., additional, Fathi, A. T., additional, Prince, G. T., additional, Stone, R. M., additional, Patel, P. A., additional, Roboz, G. J., additional, Arellano, M. L., additional, Erba, H. P., additional, Pigneux, A., additional, Baratam, P., additional, Stuart, R. K., additional, Thomas, X., additional, Lemieux, I. R., additional, Bai, X., additional, Kapsalis, S. M., additional, Garcia-Manero, G., additional, and Sallman, D. A., additional

Published
2022
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3. P356: SUBGROUP ANALYSES OF KTE-X19, AN ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPY, IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (R/R B-ALL) IN ZUMA-3

Author

Shah, B. D., primary, Cassaday, R. D., additional, Park, J. H., additional, Houot, R., additional, Oluwole, O. O., additional, Logan, A. C., additional, Boissel, N., additional, Leguay, T., additional, Bishop, M. R., additional, Topp, M. S., additional, Tzachanis, D., additional, O’Dwyer, K. M., additional, Arellano, M. L., additional, Lin, Y., additional, Baer, M. R., additional, Schiller, G. J., additional, Subklewe, M., additional, Abedi, M., additional, Minnema, M. C., additional, Wierda, W. G., additional, DeAngelo, D. J., additional, Stiff, P., additional, Jeyakumar, D., additional, Dong, J., additional, Adhikary, S., additional, Zhou, L., additional, Schuberth, P. C., additional, Kharabi Masouleh, B., additional, and Ghobadi, A., additional

Published
2022
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4. Open Abdomen and Fluid Instillation in the Septic Abdomen: Results from the IROA Study

Author

Coccolini F., Gubbiotti F., Ceresoli M., Tartaglia D., Fugazzola P., Ansaloni L., Sartelli M., Kluger Y., Kirkpatrick A., Amico F., Catena F., Chiarugi M., Montori G., Salvetti F., Negoi I., Zese M., Occhionorelli S., Shlyapnikov S., Sugrue M., Demetrashvili Z., Dondossola D., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Rausei S., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Porta M., Li Y., Karateke F., Manatakis D., Mariani F., Lora F., Sahderov I., Atanasov B., Zegarra S., Fattori L., Ivatury R., Xiao J., Ben-Ishay O., Lippi A., Improta M., Zharikov A., Dubuisson V., Coccolini, F, Gubbiotti, F, Ceresoli, M, Tartaglia, D, Fugazzola, P, Ansaloni, L, Sartelli, M, Kluger, Y, Kirkpatrick, A, Amico, F, Catena, F, Chiarugi, M, Montori, G, Salvetti, F, Negoi, I, Zese, M, Occhionorelli, S, Shlyapnikov, S, Sugrue, M, Demetrashvili, Z, Dondossola, D, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Rausei, S, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Porta, M, Li, Y, Karateke, F, Manatakis, D, Mariani, F, Lora, F, Sahderov, I, Atanasov, B, Zegarra, S, Fattori, L, Ivatury, R, Xiao, J, Ben-Ishay, O, Lippi, A, Improta, M, Zharikov, A, and Dubuisson, V

Subjects
Adult, Male, medicine.medical_specialty, Original Scientific Report, Fistula, medicine.medical_treatment, open abdomen, Peritonitis, 030230 surgery, NO, 03 medical and health sciences, 0302 clinical medicine, Sepsis, peritoneal resuscitation, Negative-pressure wound therapy, Abdomen, medicine, Humans, Surgical Wound Infection, Prospective Studies, fascial closure, peritoneal resuscitation, management, therapy, fascial closure, Digestive System Surgical Procedures, Aged, therapy, business.industry, Peritoneal fluid, Abdominal Cavity, Abdominal Wound Closure Techniques, Middle Aged, medicine.disease, Surgery, Cardiac surgery, Treatment Outcome, medicine.anatomical_structure, Cardiothoracic surgery, 030220 oncology & carcinogenesis, fluid instillation, Fluid Therapy, Female, business, Negative-Pressure Wound Therapy, management, Abdominal surgery
Abstract

Background Open abdomen (OA) is a surgical option that can be used in patients with severe peritonitis. Few evidences exist to recommend the use of intraperitoneal fluid instillation associated with OA in managing septic abdomen. Materials and methods A prospective analysis of adult patients enrolled in the International Register of Open Abdomen (trial registration: NCT02382770) was performed. Results A total of 387 patients were enrolled in two groups: 84 with peritoneal fluid instillation (FI) and 303 without (NFI). The groups were homogeneous for baseline characteristics. Overall complications were 92.9% in FI and 86.3% in NFI (p = 0.106). Complications during OA were 72.6% in FI and 59.9% in NFI (p = 0.034). Complications after definitive closure were 70.8% in FI and 61.1% in NFI (p = 0.133). Entero-atmospheric fistula was 13.1% in FI and 12% in NFI (p = 0.828). Fascial closure was 78.6% in FI and 63.7% in NFI (p = 0.02). Analysis of FI in negative pressure wound therapy (NPWT) showed: Overall morbidity in NPWT was 94% and in non-NPWT 91.2% (p = 0.622) and morbidity during OA was 68% and 79.4% (p = 0.25), respectively. Definitive fascial closure in NPWT was 87.8% and 96.8% in non-NPWT (p = 0.173). Overall mortality was 40% in NPWT and 29.4% in non-NPWT (p = 0.32) and morality during OA period was 18% and 8.8% (p = 0.238), respectively. Conclusion We found intraperitoneal fluid instillation during open abdomen in peritonitic patients to increase the complication rate during the open abdomen period, with no impact on mortality, entero-atmospheric fistula rate and opening time. Fascial closure rate is increased by instillation. Fluid instillation is feasible even when associated with nonnegative pressure temporary abdominal closure techniques.

Published
2020
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6. Open Abdomen and Fluid Instillation in the Septic Abdomen: Results from the IROA Study

Author

Coccolini, F, Gubbiotti, F, Ceresoli, M, Tartaglia, D, Fugazzola, P, Ansaloni, L, Sartelli, M, Kluger, Y, Kirkpatrick, A, Amico, F, Catena, F, Chiarugi, M, Montori, G, Salvetti, F, Negoi, I, Zese, M, Occhionorelli, S, Shlyapnikov, S, Sugrue, M, Demetrashvili, Z, Dondossola, D, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Rausei, S, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Porta, M, Li, Y, Karateke, F, Manatakis, D, Mariani, F, Lora, F, Sahderov, I, Atanasov, B, Zegarra, S, Fattori, L, Ivatury, R, Xiao, J, Ben-Ishay, O, Lippi, A, Improta, M, Zharikov, A, Dubuisson, V, Coccolini F., Gubbiotti F., Ceresoli M., Tartaglia D., Fugazzola P., Ansaloni L., Sartelli M., Kluger Y., Kirkpatrick A., Amico F., Catena F., Chiarugi M., Montori G., Salvetti F., Negoi I., Zese M., Occhionorelli S., Shlyapnikov S., Sugrue M., Demetrashvili Z., Dondossola D., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Rausei S., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Porta M., Li Y., Karateke F., Manatakis D., Mariani F., Lora F., Sahderov I., Atanasov B., Zegarra S., Fattori L., Ivatury R., Xiao J., Ben-Ishay O., Lippi A., Improta M., Zharikov A., Dubuisson V., Coccolini, F, Gubbiotti, F, Ceresoli, M, Tartaglia, D, Fugazzola, P, Ansaloni, L, Sartelli, M, Kluger, Y, Kirkpatrick, A, Amico, F, Catena, F, Chiarugi, M, Montori, G, Salvetti, F, Negoi, I, Zese, M, Occhionorelli, S, Shlyapnikov, S, Sugrue, M, Demetrashvili, Z, Dondossola, D, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Rausei, S, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Porta, M, Li, Y, Karateke, F, Manatakis, D, Mariani, F, Lora, F, Sahderov, I, Atanasov, B, Zegarra, S, Fattori, L, Ivatury, R, Xiao, J, Ben-Ishay, O, Lippi, A, Improta, M, Zharikov, A, Dubuisson, V, Coccolini F., Gubbiotti F., Ceresoli M., Tartaglia D., Fugazzola P., Ansaloni L., Sartelli M., Kluger Y., Kirkpatrick A., Amico F., Catena F., Chiarugi M., Montori G., Salvetti F., Negoi I., Zese M., Occhionorelli S., Shlyapnikov S., Sugrue M., Demetrashvili Z., Dondossola D., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Rausei S., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Porta M., Li Y., Karateke F., Manatakis D., Mariani F., Lora F., Sahderov I., Atanasov B., Zegarra S., Fattori L., Ivatury R., Xiao J., Ben-Ishay O., Lippi A., Improta M., Zharikov A., and Dubuisson V.

Abstract

Background: Open abdomen (OA) is a surgical option that can be used in patients with severe peritonitis. Few evidences exist to recommend the use of intraperitoneal fluid instillation associated with OA in managing septic abdomen. Materials and methods: A prospective analysis of adult patients enrolled in the International Register of Open Abdomen (trial registration: NCT02382770) was performed. Results: A total of 387 patients were enrolled in two groups: 84 with peritoneal fluid instillation (FI) and 303 without (NFI). The groups were homogeneous for baseline characteristics. Overall complications were 92.9% in FI and 86.3% in NFI (p = 0.106). Complications during OA were 72.6% in FI and 59.9% in NFI (p = 0.034). Complications after definitive closure were 70.8% in FI and 61.1% in NFI (p = 0.133). Entero-atmospheric fistula was 13.1% in FI and 12% in NFI (p = 0.828). Fascial closure was 78.6% in FI and 63.7% in NFI (p = 0.02). Analysis of FI in negative pressure wound therapy (NPWT) showed: Overall morbidity in NPWT was 94% and in non-NPWT 91.2% (p = 0.622) and morbidity during OA was 68% and 79.4% (p = 0.25), respectively. Definitive fascial closure in NPWT was 87.8% and 96.8% in non-NPWT (p = 0.173). Overall mortality was 40% in NPWT and 29.4% in non-NPWT (p = 0.32) and morality during OA period was 18% and 8.8% (p = 0.238), respectively. Conclusion: We found intraperitoneal fluid instillation during open abdomen in peritonitic patients to increase the complication rate during the open abdomen period, with no impact on mortality, entero-atmospheric fistula rate and opening time. Fascial closure rate is increased by instillation. Fluid instillation is feasible even when associated with nonnegative pressure temporary abdominal closure techniques.

Published
2020

7. Open abdomen management for severe peritonitis in elderly. Results from the prospective International Register of Open Abdomen (IROA): Cohort study

Author

Rausei, S, Pappalardo, V, Ceresoli, M, Catena, F, Sartelli, M, Chiarugi, M, Kluger, Y, Kirkpatrick, A, Ansaloni, L, Coccolini, F, Montori, G, Salvetti, F, Fugazzola, P, Negoi, I, Zese, M, Occhionorelli, S, Shlyapnikov, S, Demetrashvili, Z, Dondossola, D, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Porta, M, Li, Y, Karateke, F, Manatakis, D, Mariani, F, Lora, F, Sahderov, I, Atanasov, B, Zegarra, S, Fattori, L, Ivatury, R, Xiao, J, Lippi, A, Improta, M, Gubbiotti, F, Zharikov, A, Dubuisson, V, Sugrue, M, Rausei S., Pappalardo V., Ceresoli M., Catena F., Sartelli M., Chiarugi M., Kluger Y., Kirkpatrick A., Ansaloni L., Coccolini F., Montori G., Salvetti F., Fugazzola P., Negoi I., Zese M., Occhionorelli S., Shlyapnikov S., Demetrashvili Z., Dondossola D., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Porta M., Li Y., Karateke F., Manatakis D., Mariani F., Lora F., Sahderov I., Atanasov B., Zegarra S., Fattori L., Ivatury R., Xiao J., Lippi A., Improta M., Gubbiotti F., Zharikov A., Dubuisson V., Sugrue M., Rausei, S, Pappalardo, V, Ceresoli, M, Catena, F, Sartelli, M, Chiarugi, M, Kluger, Y, Kirkpatrick, A, Ansaloni, L, Coccolini, F, Montori, G, Salvetti, F, Fugazzola, P, Negoi, I, Zese, M, Occhionorelli, S, Shlyapnikov, S, Demetrashvili, Z, Dondossola, D, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Porta, M, Li, Y, Karateke, F, Manatakis, D, Mariani, F, Lora, F, Sahderov, I, Atanasov, B, Zegarra, S, Fattori, L, Ivatury, R, Xiao, J, Lippi, A, Improta, M, Gubbiotti, F, Zharikov, A, Dubuisson, V, Sugrue, M, Rausei S., Pappalardo V., Ceresoli M., Catena F., Sartelli M., Chiarugi M., Kluger Y., Kirkpatrick A., Ansaloni L., Coccolini F., Montori G., Salvetti F., Fugazzola P., Negoi I., Zese M., Occhionorelli S., Shlyapnikov S., Demetrashvili Z., Dondossola D., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Porta M., Li Y., Karateke F., Manatakis D., Mariani F., Lora F., Sahderov I., Atanasov B., Zegarra S., Fattori L., Ivatury R., Xiao J., Lippi A., Improta M., Gubbiotti F., Zharikov A., Dubuisson V., and Sugrue M.

Abstract

Background: Analyzing the data of the International Register of Open Abdomen (IROA), the feasibility of open abdomen treatment has been demonstrated at every age. This new analysis on the IROA database investigates the risk factors for mortality in elderly patients treated with open abdomen for intra-abdominal infection. Methods: Data were derived from the IROA, a prospective observational international cohort study that enrolled patients treated with open abdomen worldwide. A univariate analysis of potential risk factors was performed. Inclusion criteria were patients older than 65 years and treated with open abdomen for intra-abdominal infection. End point was overall mortality, calculated within 30 days after open abdomen management, after 1-month and 1-year follow-up. Results: A total of 116 patients was analyzed with mean age of 76 ± 7 years. Definitive closure was achieved in 93 patients (93/116, 80.2%) for a mean open abdomen duration of 5.0 ± 5.0 days. Complicated patients were 101 (101/116, 87.1%) for a total of 201 complications. Overall, 62 out of 116 patients (53.4%) died: 23 patients (23/62, 37.1%) during open abdomen management, 29 patients (46.8%) within 30 days after abdominal closure, 9 patients (14.5%) after 1-month follow-up, and 1 patient (1.6%) after 1-year follow-up. Age did not affect mortality (75 ± 6 years in alive patients versus 77 ± 7 years in dead patients, p = 0.773). Definitive abdominal closure was the most important factor to prevent mortality. Conclusions: This study confirmed that age alone cannot be considered a determinant for death, even in elderly patients managed with open abdomen for severe intra-abdominal infection.

Published
2020

11. Intra-operative gallbladder scoring predicts conversion of laparoscopic to open cholecystectomy : a WSES prospective collaborative study

Author

Sugrue M., Coccolini F., Bucholc M., Johnston A., Manatakis D., Ioannidis O., Bonilauri S., Gachabayov M., Isik A., Ghnnam W., Shelat V., Aremu M., Mohan R., Montori G., Waledziak M., Pisarska M., Kong V., Strzalka M., Fugazzola P., Nita G. E., Nardi M., Major P., Negoi I., Allegri A., Konstantoudakis G., Di Carlo I., Massalou D., D'Amico G., Solaini L., Ceresoli M., Bini R., Zielinski M., Tomasoni M., Litvin A., De Simone B., Lostoridis E., Hernandez F., Panyor G., Machain G. M. V., Pentara I., Baiocchi L., Ng K. C., Ansaloni L., Sartelli M., Arellano M. L., Savala N., Couse N., McBride S., Michael Sugrue, Federico Coccolini, Magda Bucholc, Alison Johnston, Contributors from WSES, Leonardo Solaini, Sugrue, M, Coccolini, F, Bucholc, M, Johnston, A, Manatakis, D, Ioannidis, O, Bonilauri, S, Gachabayov, M, Isik, A, Ghnnam, W, Shelat, V, Aremu, M, Mohan, R, Montori, G, Waledziak, M, Pisarska, M, Kong, V, Strzalka, M, Fugazzola, P, Nita, G, Nardi, M, Major, P, Negoi, I, Allegri, A, Konstantoudakis, G, Di Carlo, I, Massalou, D, D'Amico, G, Solaini, L, Ceresoli, M, Bini, R, Zielinski, M, Tomasoni, M, Litvin, A, De Simone, B, Lostoridis, E, Hernandez, F, Panyor, G, Machain, G, Pentara, I, Baiocchi, L, Ng, K, Ansaloni, L, Sartelli, M, Arellano, M, Savala, N, Couse, N, and Mcbride, S

Subjects
Male, Fistula, medicine.medical_treatment, Cholangiography, Cholecystitis, Conversion to open cholecystectomy, Index surgery, Operative severity scoring system, Surgical outcomes, Surgery, Emergency Medicine, 80 and over, Cholecystiti, Prospective Studies, Prospective cohort study, Aged, 80 and over, medicine.diagnostic_test, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Gallbladder, Middle Aged, Conversion to Open Surgery, medicine.anatomical_structure, Cholecystectomy, Laparoscopic, Research Design, Female, Research Article, Human, Adult, medicine.medical_specialty, Adolescent, Aged, Cholecystectomy, Humans, Open cholecystectomy, lcsh:Surgery, Laparoscopic, medicine, Laparoscopic cholecystectomy, Surgical outcome, business.industry, General surgery, lcsh:RD1-811, lcsh:RC86-88.9, medicine.disease, Prospective Studie, business
Abstract

Introduction: Laparoscopic cholecystectomy, the gold-standard approach for cholecystectomy, has surprisingly variable outcomes and conversion rates. Only recently has operative grading been reported to define disease severity and few have been validated. This multicentre, multinational study assessed an operative scoring system to assess its ability to predict the need for conversion from laparoscopic to open cholecystectomy. Methods: A prospective, web-based, ethically approved study was established by WSES with a 10-point gallbladder operative scoring system; enrolling patients undergoing elective or emergency laparoscopic cholecystectomy between January 2016 and December 2017. Gallbladder surgery was considered easy if the G10 score < 2, moderate (2 ≦ 4), difficult (5 ≦ 7) and extreme (8 ≦ 10). Demographics about the patients, surgeons and operative procedures, use of cholangiography and conversion rates were recorded. Results: Five hundred four patients, mean age 53.5 (range 18-89), were enrolled by 55 surgeons in 16 countries. Surgery was performed by consultants in 70% and was elective in (56%) with a mean operative time of 78.7 min (range 15-400). The mean G10 score was 3.21, with 22% deemed to have difficult or extreme surgical gallbladders, and 71/504 patients were converted. The G10 score was 2.98 in those completed laparoscopically and 4.65 in the 71/504 (14%) converted. (p < 0.0001; AUC 0.772 (CI 0.719-0.825). The optimal cut-off point of 0.067 (score of 3) was identified in G10 vs conversion to open cholecystectomy. Conversion occurred in 33% of patients with G10 scores of ≥ 5. The four variables statistically predictive of conversion were GB appearance - completely buried GB, impacted stone, bile or pus outside GB and fistula. Conclusion: The G10 operative scores provide simple grading of operative cholecystectomy and are predictive of the need to convert to open cholecystectomy. Broader adaptation and validation may provide a benchmark to understand and improve care and afford more standardisation in global comparisons of care for cholecystectomy.

Published
2019

12. Intra-operative gallbladder scoring predicts conversion of laparoscopic to open cholecystectomy: A WSES prospective collaborative study

Author

Sugrue, M, Coccolini, F, Bucholc, M, Johnston, A, Manatakis, D, Ioannidis, O, Bonilauri, S, Gachabayov, M, Isik, A, Ghnnam, W, Shelat, V, Aremu, M, Mohan, R, Montori, G, Waledziak, M, Pisarska, M, Kong, V, Strzalka, M, Fugazzola, P, Nita, G, Nardi, M, Major, P, Negoi, I, Allegri, A, Konstantoudakis, G, Di Carlo, I, Massalou, D, D'Amico, G, Solaini, L, Ceresoli, M, Bini, R, Zielinski, M, Tomasoni, M, Litvin, A, De Simone, B, Lostoridis, E, Hernandez, F, Panyor, G, Machain, G, Pentara, I, Baiocchi, L, Ng, K, Ansaloni, L, Sartelli, M, Arellano, M, Savala, N, Couse, N, Mcbride, S, Sugrue M., Coccolini F., Bucholc M., Johnston A., Manatakis D., Ioannidis O., Bonilauri S., Gachabayov M., Isik A., Ghnnam W., Shelat V., Aremu M., Mohan R., Montori G., Waledziak M., Pisarska M., Kong V., Strzalka M., Fugazzola P., Nita G. E., Nardi M., Major P., Negoi I., Allegri A., Konstantoudakis G., Di Carlo I., Massalou D., D'Amico G., Solaini L., Ceresoli M., Bini R., Zielinski M., Tomasoni M., Litvin A., De Simone B., Lostoridis E., Hernandez F., Panyor G., Machain G. M. V., Pentara I., Baiocchi L., Ng K. C., Ansaloni L., Sartelli M., Arellano M. L., Savala N., Couse N., McBride S., Sugrue, M, Coccolini, F, Bucholc, M, Johnston, A, Manatakis, D, Ioannidis, O, Bonilauri, S, Gachabayov, M, Isik, A, Ghnnam, W, Shelat, V, Aremu, M, Mohan, R, Montori, G, Waledziak, M, Pisarska, M, Kong, V, Strzalka, M, Fugazzola, P, Nita, G, Nardi, M, Major, P, Negoi, I, Allegri, A, Konstantoudakis, G, Di Carlo, I, Massalou, D, D'Amico, G, Solaini, L, Ceresoli, M, Bini, R, Zielinski, M, Tomasoni, M, Litvin, A, De Simone, B, Lostoridis, E, Hernandez, F, Panyor, G, Machain, G, Pentara, I, Baiocchi, L, Ng, K, Ansaloni, L, Sartelli, M, Arellano, M, Savala, N, Couse, N, Mcbride, S, Sugrue M., Coccolini F., Bucholc M., Johnston A., Manatakis D., Ioannidis O., Bonilauri S., Gachabayov M., Isik A., Ghnnam W., Shelat V., Aremu M., Mohan R., Montori G., Waledziak M., Pisarska M., Kong V., Strzalka M., Fugazzola P., Nita G. E., Nardi M., Major P., Negoi I., Allegri A., Konstantoudakis G., Di Carlo I., Massalou D., D'Amico G., Solaini L., Ceresoli M., Bini R., Zielinski M., Tomasoni M., Litvin A., De Simone B., Lostoridis E., Hernandez F., Panyor G., Machain G. M. V., Pentara I., Baiocchi L., Ng K. C., Ansaloni L., Sartelli M., Arellano M. L., Savala N., Couse N., and McBride S.

Abstract

Introduction: Laparoscopic cholecystectomy, the gold-standard approach for cholecystectomy, has surprisingly variable outcomes and conversion rates. Only recently has operative grading been reported to define disease severity and few have been validated. This multicentre, multinational study assessed an operative scoring system to assess its ability to predict the need for conversion from laparoscopic to open cholecystectomy. Methods: A prospective, web-based, ethically approved study was established by WSES with a 10-point gallbladder operative scoring system; enrolling patients undergoing elective or emergency laparoscopic cholecystectomy between January 2016 and December 2017. Gallbladder surgery was considered easy if the G10 score < 2, moderate (2 ≦ 4), difficult (5 ≦ 7) and extreme (8 ≦ 10). Demographics about the patients, surgeons and operative procedures, use of cholangiography and conversion rates were recorded. Results: Five hundred four patients, mean age 53.5 (range 18-89), were enrolled by 55 surgeons in 16 countries. Surgery was performed by consultants in 70% and was elective in (56%) with a mean operative time of 78.7 min (range 15-400). The mean G10 score was 3.21, with 22% deemed to have difficult or extreme surgical gallbladders, and 71/504 patients were converted. The G10 score was 2.98 in those completed laparoscopically and 4.65 in the 71/504 (14%) converted. (p < 0.0001; AUC 0.772 (CI 0.719-0.825). The optimal cut-off point of 0.067 (score of 3) was identified in G10 vs conversion to open cholecystectomy. Conversion occurred in 33% of patients with G10 scores of ≥ 5. The four variables statistically predictive of conversion were GB appearance - completely buried GB, impacted stone, bile or pus outside GB and fistula. Conclusion: The G10 operative scores provide simple grading of operative cholecystectomy and are predictive of the need to convert to open cholecystectomy. Broader adaptation and validation may provide a benchmark to unders

Published
2019

13. Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: A WSES observational study

Author

Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Sartelli M., Abu-Zidan F. M., Labricciosa F. M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A. W., Tolonen M., Trana C., Regimbeau J. -M., Hardcastle T., Koshy R. M., Abbas A., Aday U., Adesunkanmi A. R. K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A. B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A. C., Chiarugi M., Cillara N., Cuesta R. C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G. P., Gachabayov M., Gerard G., Ghnnam W., Maurel T. G., Gkiokas G., Gomes C. A., Guner A., Gupta S., Hecker A., Hirano E. S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J. I., Kong V., Korkolis D., Kruger V. F., Kshirsagar A., Simoes R. L., Lanaia A., Lasithiotakis K., Leao P., Arellano M. L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G. M., Major P., Manatakis D., Reitz M. M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F. G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G. -E., Occhionorelli S., Olaoye I., Ordonez C. A., Ozkan Z., Pal A., Palini G. M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G. A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R. A., Tochie J. N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M. Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A. I., Yalkin O., Yilmaz T. U., Unal A. E., Yuan K. -C., Zachariah S. K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G. L., Catena F., Sartelli, M, Abu-Zidan, F, Labricciosa, F, Kluger, Y, Coccolini, F, Ansaloni, L, Leppaniemi, A, Kirkpatrick, A, Tolonen, M, Trana, C, Regimbeau, J, Hardcastle, T, Koshy, R, Abbas, A, Aday, U, Adesunkanmi, A, Ajibade, A, Akhmeteli, L, Akln, E, Akkapulu, N, Alotaibi, A, Altintoprak, F, Anyfantakis, D, Atanasov, B, Augustin, G, Azevedo, C, Bala, M, Balalis, D, Baraket, O, Baral, S, Barkai, O, Beltran, M, Bini, R, Bouliaris, K, Caballero, A, Calu, V, Catani, M, Ceresoli, M, Charalampakis, V, Jusoh, A, Chiarugi, M, Cillara, N, Cuesta, R, Cobuccio, L, Cocorullo, G, Colak, E, Conti, L, Cui, Y, De Simone, B, Delibegovic, S, Demetrashvili, Z, Demetriades, D, Dimova, A, Dogjani, A, Enani, M, Farina, F, Ferrara, F, Foghetti, D, Fontana, T, Fraga, G, Gachabayov, M, Gerard, G, Ghnnam, W, Maurel, T, Gkiokas, G, Gomes, C, Guner, A, Gupta, S, Hecker, A, Hirano, E, Hodonou, A, Hutan, M, Ilaschuk, I, Ioannidis, O, Isik, A, Ivakhov, G, Jain, S, Jokubauskas, M, Karamarkovic, A, Kaushik, R, Kenig, J, Khokha, V, Khokha, D, Kim, J, Kong, V, Korkolis, D, Kruger, V, Kshirsagar, A, Simoes, R, Lanaia, A, Lasithiotakis, K, Leao, P, Arellano, M, Listle, H, Litvin, A, Lizarazu Perez, A, Lopez-Tomassetti Fernandez, E, Lostoridis, E, Luppi, D, Machain V, G, Major, P, Manatakis, D, Reitz, M, Marinis, A, Marrelli, D, Martinez-Perez, A, Marwah, S, Mcfarlane, M, Mesic, M, Mesina, C, Michalopoulos, N, Misiakos, E, Moreira, F, Mouaqit, O, Muhtaroglu, A, Naidoo, N, Negoi, I, Nikitina, Z, Nikolopoulos, I, Nita, G, Occhionorelli, S, Olaoye, I, Ordonez, C, Ozkan, Z, Pal, A, Palini, G, Papageorgiou, K, Papagoras, D, Pata, F, Pedziwiatr, M, Pereira, J, Pereira Junior, G, Perrone, G, Pintar, T, Pisarska, M, Plehutsa, O, Podda, M, Poillucci, G, Quiodettis, M, Rahim, T, Rios-Cruz, D, Rodrigues, G, Rozov, D, Sakakushev, B, Sall, I, Sazhin, A, Semiao, M, Sharda, T, Shelat, V, Sinibaldi, G, Skicko, D, Skrovina, M, Stamatiou, D, Stella, M, Strzalka, M, Sydorchuk, R, Teixeira Gonsaga, R, Tochie, J, Tomadze, G, Ugoletti, L, Ulrych, J, Umarik, T, Uzunoglu, M, Vasilescu, A, Vaz, O, Vereczkei, A, Vlad, N, Waledziak, M, Yahya, A, Yalkin, O, Yilmaz, T, Unal, A, Yuan, K, Zachariah, S, Zilinskas, J, Zizzo, M, Pattonieri, V, Baiocchi, G, Catena, F, Sartelli M., Abu-Zidan F. M., Labricciosa F. M., Kluger Y., Coccolini F., Ansaloni L., Leppaniemi A., Kirkpatrick A. W., Tolonen M., Trana C., Regimbeau J. -M., Hardcastle T., Koshy R. M., Abbas A., Aday U., Adesunkanmi A. R. K., Ajibade A., Akhmeteli L., Akln E., Akkapulu N., Alotaibi A., Altintoprak F., Anyfantakis D., Atanasov B., Augustin G., Azevedo C., Bala M., Balalis D., Baraket O., Baral S., Barkai O., Beltran M., Bini R., Bouliaris K., Caballero A. B., Calu V., Catani M., Ceresoli M., Charalampakis V., Jusoh A. C., Chiarugi M., Cillara N., Cuesta R. C., Cobuccio L., Cocorullo G., Colak E., Conti L., Cui Y., De Simone B., Delibegovic S., Demetrashvili Z., Demetriades D., Dimova A., Dogjani A., Enani M., Farina F., Ferrara F., Foghetti D., Fontana T., Fraga G. P., Gachabayov M., Gerard G., Ghnnam W., Maurel T. G., Gkiokas G., Gomes C. A., Guner A., Gupta S., Hecker A., Hirano E. S., Hodonou A., Hutan M., Ilaschuk I., Ioannidis O., Isik A., Ivakhov G., Jain S., Jokubauskas M., Karamarkovic A., Kaushik R., Kenig J., Khokha V., Khokha D., Kim J. I., Kong V., Korkolis D., Kruger V. F., Kshirsagar A., Simoes R. L., Lanaia A., Lasithiotakis K., Leao P., Arellano M. L., Listle H., Litvin A., Lizarazu Perez A., Lopez-Tomassetti Fernandez E., Lostoridis E., Luppi D., Machain V G. M., Major P., Manatakis D., Reitz M. M., Marinis A., Marrelli D., Martinez-Perez A., Marwah S., McFarlane M., Mesic M., Mesina C., Michalopoulos N., Misiakos E., Moreira F. G., Mouaqit O., Muhtaroglu A., Naidoo N., Negoi I., Nikitina Z., Nikolopoulos I., Nita G. -E., Occhionorelli S., Olaoye I., Ordonez C. A., Ozkan Z., Pal A., Palini G. M., Papageorgiou K., Papagoras D., Pata F., Pedziwiatr M., Pereira J., Pereira Junior G. A., Perrone G., Pintar T., Pisarska M., Plehutsa O., Podda M., Poillucci G., Quiodettis M., Rahim T., Rios-Cruz D., Rodrigues G., Rozov D., Sakakushev B., Sall I., Sazhin A., Semiao M., Sharda T., Shelat V., Sinibaldi G., Skicko D., Skrovina M., Stamatiou D., Stella M., Strzalka M., Sydorchuk R., Teixeira Gonsaga R. A., Tochie J. N., Tomadze G., Ugoletti L., Ulrych J., Umarik T., Uzunoglu M. Y., Vasilescu A., Vaz O., Vereczkei A., Vlad N., Waledziak M., Yahya A. I., Yalkin O., Yilmaz T. U., Unal A. E., Yuan K. -C., Zachariah S. K., Zilinskas J., Zizzo M., Pattonieri V., Baiocchi G. L., and Catena F.

Abstract

Background: Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Methods: This worldwide multicentre observational study included 153 surgical departments across 56 countries over a 4-month study period between February 1, 2018, and May 31, 2018. Results: A total of 3137 patients were included, with 1815 (57.9%) men and 1322 (42.1%) women, with a median age of 47 years (interquartile range [IQR] 28-66). The overall in-hospital mortality rate was 8.9%, with a median length of stay of 6 days (IQR 4-10). Using multivariable logistic regression, independent variables associated with in-hospital mortality were identified: age > 80 years, malignancy, severe cardiovascular disease, severe chronic kidney disease, respiratory rate ≥ 22 breaths/min, systolic blood pressure < 100 mmHg, AVPU responsiveness scale (voice and unresponsive), blood oxygen saturation level (SpO2) < 90% in air, platelet count < 50,000 cells/mm3, and lactate > 4 mmol/l. These variables were used to create the PIPAS Severity Score, a bedside early warning score for patients with acute peritonitis. The overall mortality was 2.9% for patients who had scores of 0-1, 22.7% for those who had scores of 2-3, 46.8% for those who had scores of 4-5, and 86.7% for those who have scores of 7-8. Conclusions: The simple PIPAS Severity Score can be used on a global level and can help clinicians to identify patients at high risk for treatment failure and mortality.

Published
2019

16. Erratum to: IROA: International Register of Open Abdomen, preliminary results. [World J Emerg Surg. 12, (2017), (10)] DOI: 10.1186/s13017-017-0123-8

Author

Coccolini, F., Montori, G., Ceresoli, M., Catena, F., Ivatury, R., Sugrue, M., Sartelli, M., Fugazzola, P., Corbella, D., Salvetti, F., Negoi, I., Zese, M., Occhionorelli, S., Maccatrozzo, S., Shlyapnikov, S., Galatioto, C., Chiarugi, M., Demetrashvili, Z., Dondossola, D., Yovtchev, Y., Ioannidis, O., Novelli, G., Nacoti, M., Khor, D., Inaba, K., Demetriades, D., Kaussen, T., Jusoh, A. C., Ghannam, W., Sakakushev, B., Guetta, O., Dogjani, A., Costa, S., Singh, S., Damaskos, D., Isik, A., Yuan, K. -C., Trotta, F., Rausei, S., Martinez-Perez, A., Bellanova, G., Fonseca, V. C., Hernandez, F., Marinis, A., Fernandes, W., Quiodettis, M., Bala, M., Vereczkei, A., Curado, R. L., Fraga, G. P., Pereira, B. M., Gachabayov, M., Chagerben, G. P., Arellano, M. L., Ozyazici, S., Costa, G., Tezcaner, T., and Ansaloni, L.

Subjects
Surgery, Emergency Medicine, NO
Published
2017

18. IROA: International Register of Open Abdomen, preliminary results

Author

Coccolini, F, Montori, G, Ceresoli, M, Catena, F, Ivatury, R, Sugrue, M, Sartelli, M, Fugazzola, P, Corbella, D, Salvetti, F, Negoi, I, Zese, M, Occhionorelli, S, Maccatrozzo, S, Shlyapnikov, S, Galatioto, C, Chiarugi, M, Demetrashvili, Z, Dondossola, D, Yovtchev, Y, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Rausei, S, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Ansaloni, L, Coccolini F., Montori G., Ceresoli M., Catena F., Ivatury R., Sugrue M., Sartelli M., Fugazzola P., Corbella D., Salvetti F., Negoi I., Zese M., Occhionorelli S., Maccatrozzo S., Shlyapnikov S., Galatioto C., Chiarugi M., Demetrashvili Z., Dondossola D., Yovtchev Y., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Rausei S., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R. L., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., Ansaloni L., Coccolini, F, Montori, G, Ceresoli, M, Catena, F, Ivatury, R, Sugrue, M, Sartelli, M, Fugazzola, P, Corbella, D, Salvetti, F, Negoi, I, Zese, M, Occhionorelli, S, Maccatrozzo, S, Shlyapnikov, S, Galatioto, C, Chiarugi, M, Demetrashvili, Z, Dondossola, D, Yovtchev, Y, Ioannidis, O, Novelli, G, Nacoti, M, Khor, D, Inaba, K, Demetriades, D, Kaussen, T, Jusoh, A, Ghannam, W, Sakakushev, B, Guetta, O, Dogjani, A, Costa, S, Singh, S, Damaskos, D, Isik, A, Yuan, K, Trotta, F, Rausei, S, Martinez-Perez, A, Bellanova, G, Fonseca, V, Hernandez, F, Marinis, A, Fernandes, W, Quiodettis, M, Bala, M, Vereczkei, A, Curado, R, Fraga, G, Pereira, B, Gachabayov, M, Chagerben, G, Arellano, M, Ozyazici, S, Costa, G, Tezcaner, T, Ansaloni, L, Coccolini F., Montori G., Ceresoli M., Catena F., Ivatury R., Sugrue M., Sartelli M., Fugazzola P., Corbella D., Salvetti F., Negoi I., Zese M., Occhionorelli S., Maccatrozzo S., Shlyapnikov S., Galatioto C., Chiarugi M., Demetrashvili Z., Dondossola D., Yovtchev Y., Ioannidis O., Novelli G., Nacoti M., Khor D., Inaba K., Demetriades D., Kaussen T., Jusoh A. C., Ghannam W., Sakakushev B., Guetta O., Dogjani A., Costa S., Singh S., Damaskos D., Isik A., Yuan K. -C., Trotta F., Rausei S., Martinez-Perez A., Bellanova G., Fonseca V. C., Hernandez F., Marinis A., Fernandes W., Quiodettis M., Bala M., Vereczkei A., Curado R. L., Fraga G. P., Pereira B. M., Gachabayov M., Chagerben G. P., Arellano M. L., Ozyazici S., Costa G., Tezcaner T., and Ansaloni L.

Abstract

Background: No definitive data about open abdomen (OA) epidemiology and outcomes exist. The World Society of Emergency Surgery (WSES) and the Panamerican Trauma Society (PTS) promoted the International Register of Open Abdomen (IROA). Methods: A prospective observational cohort study including patients with an OA treatment. Data were recorded on a web platform (Clinical Registers®) through a dedicated website: www.clinicalregisters.org. Results: Four hundred two patients enrolled. Adult patients: 369 patients; Mean age: 57.39±18.37; 56% male; Mean BMI: 36±5.6. OA indication: Peritonitis (48.7%), Trauma (20.5%), Vascular Emergencies/Hemorrhage (9.4%), Ischemia (9.1%), Pancreatitis (4.2%),Post-operative abdominal-compartment-syndrome (3.9%), Others (4.2%). The most adopted Temporary-abdominal-closure systems were the commercial negative pressure ones (44.2%). During OA 38% of patients had complications; among them 10.5% had fistula. Definitive closure: 82.8%; Mortality during treatment: 17.2%. Mean duration of OA: 5.39(±4.83) days; Mean number of dressing changes: 0.88(±0.88). After-closure complications: (49.5%) and Mortality: (9%). No significant associations among TACT, indications, mortality, complications and fistula. A linear correlationexists between days of OA and complications (Pearson linear correlation = 0.326 p<0.0001) and with the fistula development (Pearson = 0.146 p= 0.016). Pediatric patients: 33 patients. Mean age: 5.91±(3.68) years; 60% male. Mortality: 3.4%; Complications: 44.8%; Fistula: 3.4%. Mean duration of OA: 3.22(±3.09) days. Conclusion: Temporary abdominal closure is reliable and safe. The different techniques account for different results according to the different indications. In peritonitis commercial negative pressure temporary closure seems to improve results. In trauma skin-closure and Bogotà-bag seem to improve results. Trial registration: ClinicalTrials.gov NCT02382770

Published
2017

19. Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin

Author

Elf, S, primary, Lin, R, additional, Xia, S, additional, Pan, Y, additional, Shan, C, additional, Wu, S, additional, Lonial, S, additional, Gaddh, M, additional, Arellano, M L, additional, Khoury, H J, additional, Khuri, F R, additional, Lee, B H, additional, Boggon, T J, additional, Fan, J, additional, and Chen, J, additional

Published
2016
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20. Endometriosis, endometrium, implantation and fallopian tube

Author

Tan, C. W., primary, Lee, Y. H., additional, Choolani, M., additional, Tan, H. H., additional, Griffith, L., additional, Chan, J., additional, Chuang, P. C., additional, Wu, M. H., additional, Lin, Y. J., additional, Tsai, S. J., additional, Rahmati, M., additional, Petitbarat, M., additional, Dubanchet, S., additional, Bensussan, A., additional, Chaouat, G., additional, Ledee, N., additional, Bissonnette, L., additional, Haouzi, D., additional, Monzo, C., additional, Traver, S., additional, Bringer, S., additional, Faidherbe, J., additional, Perrochia, H., additional, Ait-Ahmed, O., additional, Dechaud, H., additional, Hamamah, S., additional, Ibrahim, M. G., additional, de Arellano, M. L. B., additional, Sachtleben, M., additional, Chiantera, V., additional, Frangini, S., additional, Younes, S., additional, Schneider, A., additional, Plendl, J., additional, Mechsner, S., additional, Ono, M., additional, Hamai, H., additional, Chikawa, A., additional, Teramura, S., additional, Takata, R., additional, Sugimoto, T., additional, Iwahashi, K., additional, Ohhama, N., additional, Nakahira, R., additional, Shigeta, M., additional, Park, I. H., additional, Lee, K. H., additional, Sun, H. G., additional, Kim, S. G., additional, Lee, J. H., additional, Kim, Y. Y., additional, Kim, H. J., additional, Jeon, G. H., additional, Kim, C. M., additional, Bocca, S., additional, Wang, H., additional, Anderson, S., additional, Yu, L., additional, Horcajadas, J., additional, Oehninger, S., additional, Bastu, E., additional, Mutlu, M. F., additional, Celik, C., additional, Yasa, C., additional, Dural, O., additional, Buyru, F., additional, Quintana, F., additional, Cobo, A., additional, Remohi, J., additional, Ferrando, M., additional, Matorras, R., additional, Bermejo, A., additional, Iglesias, C., additional, Cerrillo, M., additional, Ruiz, M., additional, Blesa, D., additional, Simon, C., additional, Garcia-Velasco, J. A., additional, Chamie, L., additional, Ribeiro, D. M. F., additional, Riboldi, M., additional, Pereira, R., additional, Rosa, M. B., additional, Gomes, C., additional, de Mello, P. H., additional, Fettback, P., additional, Domingues, T., additional, Cambiaghi, A., additional, Soares, A. C. P., additional, Kimati, C., additional, Motta, E. L. A., additional, Serafini, P., additional, Hapangama, D. K., additional, Valentijn, A. J., additional, Al-Lamee, H., additional, Palial, K., additional, Drury, J. A., additional, von Zglinicki, T., additional, Saretzki, G., additional, Gargett, C. E., additional, Liao, C. Y., additional, Sung, Y. J., additional, Li, H. Y., additional, Morotti, M., additional, Remorgida, V., additional, Venturini, P. L., additional, Ferrero, S., additional, Nabeta, M., additional, Iki, A., additional, Hashimoto, H., additional, Koizumi, M., additional, Matsubara, Y., additional, Hamada, K., additional, Fujioka, T., additional, Matsubara, K., additional, Kusanagi, Y., additional, Nawa, A., additional, Zanatta, A., additional, da Rocha, A. M., additional, Guerra, J. L., additional, Cogliati, B., additional, Bianchi, P. d. M., additional, Prieto, B., additional, Exposito, A., additional, Mendoza, R., additional, Rabanal, A., additional, Bedaiwy, M., additional, Yi, L., additional, Dahoud, W., additional, Liu, J., additional, Hurd, W., additional, Falcone, T., additional, Biscotti, C., additional, Mesiano, S., additional, Sugiyama, R., additional, Nakagawa, K., additional, Nishi, Y., additional, Kuribayashi, Y., additional, Akira, S., additional, Germeyer, A., additional, Rosner, S., additional, Jauckus, J., additional, Strowitzki, T., additional, von Wolff, M., additional, Khan, K. N., additional, Kitajima, M., additional, Fujishita, A., additional, Nakashima, M., additional, Masuzaki, H., additional, Kajihara, T., additional, Ishihara, O., additional, Brosens, J., additional, Vezmar, K., additional, Savournin, V., additional, Balet, R., additional, Loh, S. F., additional, Tannenbaum, S. R., additional, Chan, J. K. Y., additional, Scarella, A., additional, Chamy, V., additional, Devoto, L., additional, Abrao, M., additional, Sovino, H., additional, Krasnopolskaya, K., additional, Popov, A., additional, Kabanova, D., additional, Beketova, A., additional, Ivakhnenko, V., additional, Shohayeb, A., additional, Wahba, A., additional, Abousetta, A., additional, al-inany, H., additional, El Daly, A., additional, Zayed, M., additional, Kvaskoff, M., additional, Han, J., additional, Missmer, S. A., additional, Navarro, P., additional, Meola, J., additional, Ribas, C. P., additional, Paz, C. P., additional, Ferriani, R. A., additional, Donabela, F. C., additional, Tafi, E., additional, Maggiore, U. L. R., additional, Scala, C., additional, Hackl, J., additional, Strehl, J., additional, Wachter, D., additional, Dittrich, R., additional, Cupisti, S., additional, Hildebrandt, T., additional, Lotz, L., additional, Attig, M., additional, Hoffmann, I., additional, Renner, S., additional, Hartmann, A., additional, Beckmann, M. W., additional, Urquiza, F., additional, Ferrer, C., additional, Incera, E., additional, Azpiroz, A., additional, Junovich, G., additional, Pappalardo, C., additional, Guerrero, G., additional, Pasqualini, S., additional, Gutierrez, G., additional, Corti, L., additional, Sanchez, A. M., additional, Bordignon, P. P., additional, Santambrogio, P., additional, Levi, S., additional, Persico, P., additional, Vigano, P., additional, Papaleo, E., additional, Ferrari, S., additional, Candiani, M., additional, van der Houwen, L. E. E., additional, Schreurs, A. M. F., additional, Lambalk, C. B., additional, Schats, R., additional, Hompes, P. G. A., additional, Mijatovic, V., additional, Xu, S. Y., additional, Li, J., additional, Chen, X. Y., additional, Chen, S. Q., additional, Guo, L. Y., additional, Mathew, D., additional, Nunes, Q., additional, Lane, B., additional, Fernig, D., additional, Hapangama, D., additional, Lind, T., additional, Hammarstrom, M., additional, Golmann, D., additional, Rodriguez-Wallberg, K., additional, Hestiantoro, A., additional, Cakra, A., additional, Aulia, A., additional, Al-Inany, H., additional, Houston, B., additional, Farquhar, C., additional, Tagliaferri, V., additional, Gagliano, D., additional, Immediata, V., additional, Tartaglia, C., additional, Zumpano, A., additional, Campagna, G., additional, Lanzone, A., additional, Guido, M., additional, Matsuzaki, S., additional, Darcha, C., additional, Botchorishvili, R., additional, Pouly, J. L., additional, Mage, G., additional, Canis, M., additional, Shivhare, S. B., additional, Bulmer, J. N., additional, Innes, B. A., additional, Lash, G. E., additional, de Graaff, A. A., additional, Zandstra, H., additional, Smits, L. J., additional, Van Beek, J. J., additional, Dunselman, G. A. J., additional, Bozdag, G., additional, Calis, P. T., additional, Demiralp, D. O., additional, Ayhan, B., additional, Igci, N., additional, Yarali, H., additional, Acar, N., additional, Er, H., additional, Ozmen, A., additional, Ustunel, I., additional, Korgun, E. T., additional, Kuroda, K., additional, Kuroda, M., additional, Arakawa, A., additional, Kitade, M., additional, Brosens, A. I., additional, Brosens, J. J., additional, Takeda, S., additional, and Yao, T., additional

Published
2013
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22. ENDOMETRIOSIS, ENDOMETRIUM, IMPLANTATION AND FALLOPIAN TUBE

Author

Nesbitt-Hawes, E., primary, Campbell, N., additional, Won, H., additional, Maley, P., additional, Henry, A., additional, Abbott, J., additional, Potdar, N., additional, Mason-Birks, S., additional, Elson, C. J., additional, Gelbaya, T. A., additional, Nardo, L. G., additional, Stavroulis, A., additional, Nnoaham, K., additional, Hummelshoj, L., additional, Zondervan, K., additional, Saridogan, E., additional, GSWH Consortium, W. E. R. F., additional, Chamie, L. P., additional, Soares, A. C. P., additional, Kimati, C. T., additional, Gomes, C., additional, Fettback, P., additional, Riboldi, M., additional, Serafini, P., additional, Lalitkumar, S., additional, Menezes, J., additional, Evdokia, D., additional, Gemzell-Danielsson, K., additional, Lalitkumar, P. G. L., additional, Bailey, J., additional, Newman, T. A., additional, Johnston, A., additional, Zisimopoulou, K., additional, White, M., additional, Sadek, K., additional, Shreeve, N., additional, Macklon, N., additional, Cheong, Y., additional, Al-Akoum, M., additional, Akoum, A., additional, Giles, J., additional, Garrido, N., additional, Vidal, C., additional, Mondion, M., additional, Gallo, C., additional, Ramirez, J., additional, Pellicer, A., additional, Remohi, J., additional, Ghosh, S., additional, Chattopadhyay, R., additional, Jana, S., additional, Goswami, S. K., additional, Bose, G., additional, Chakravarty, M., additional, Chowdhuri, K., additional, Chakravarty, B. N., additional, Kendirci Ceviren, A., additional, Ozcelik Tanriverdi, N., additional, Urfan, A., additional, Donmez, L., additional, Isikoglu, M., additional, Romano, A., additional, Schreinemacher, M. H., additional, Backes, W. H., additional, Slenter, J. M., additional, Xanthoulea, S. A., additional, Delvoux, B., additional, van Winden, L., additional, Beets-Tan, R. G., additional, Evers, J. L. H., additional, Dunselman, G. A. J., additional, Jana, S. K., additional, Chaudhury, K., additional, Maruyama, T., additional, Yamasaki, A., additional, Miyazaki, K., additional, Arase, T., additional, Uchida, H., additional, Yoshimura, Y., additional, Kaser, D., additional, Ginsburg, E., additional, Missmer, S., additional, Correia, K., additional, Racowsky, C., additional, Streuli, I., additional, Chouzenoux, S., additional, de Ziegler, D., additional, Chereau, C., additional, Weill, B., additional, Chapron, C., additional, Batteux, F., additional, Arianmanesh, M., additional, Fowler, P. A., additional, Al-Gubory, K. H., additional, Urata, Y., additional, Osuga, Y., additional, Izumi, G., additional, Nagai, M., additional, Takamura, M., additional, Yamamoto, N., additional, Saito, A., additional, Hasegawa, A., additional, Takemura, Y., additional, Harada, M., additional, Hirata, T., additional, Hirota, Y., additional, Yoshino, O., additional, Koga, K., additional, Taketani, Y., additional, Mohebbi, A., additional, Janan, A., additional, Nasri, S., additional, Lakpour, M. R., additional, Ramazanali, F., additional, Moini, A., additional, Aflatoonian, R., additional, Germeyer, A., additional, Novak, O., additional, Renke, T., additional, Jung, M., additional, Jackus, J., additional, Toth, B., additional, Strowitzki, T., additional, Bhattacharya, J., additional, Mitra, A., additional, Kundu, S., additional, Pal, M., additional, Kundu, A., additional, Gumusel, A., additional, Basar, M., additional, Yaprak, E., additional, Aslan, E., additional, Arda, O., additional, Ilvan, S., additional, Kayisli, U., additional, Guzel, E., additional, Haouzi, D., additional, Monzo, C., additional, Lehmann, S., additional, Hirtz, C., additional, Tiers, L., additional, Hamamah, S., additional, Choi, D., additional, Choi, J., additional, Jo, M., additional, Lee, E., additional, Shen, X., additional, Wang, B. I. N., additional, Li, X., additional, Tamura, I., additional, Maekawa, R., additional, Asada, H., additional, Tamura, H., additional, Sugino, N., additional, Liu, H., additional, Jiang, Y., additional, Chen, J., additional, Zhu, L., additional, Wang, B., additional, Yan, G., additional, Sun, H., additional, Coughlan, C., additional, Sinagra, M., additional, Ledger, W., additional, Li, T. C., additional, Laird, S. M., additional, Dafopoulos, K., additional, Vrekoussis, T., additional, Chalvatzas, N., additional, Messini, C. I., additional, Kalantaridou, S., additional, Georgoulias, P., additional, Messinis, I. E., additional, Makrigiannakis, A., additional, Xue, Q., additional, Xu, Y., additional, Zuo, W. L., additional, Zhang, L., additional, Shang, J., additional, Zhu, S. N., additional, Bulun, S. E., additional, Tomassetti, C., additional, Geysenbergh, B., additional, Meuleman, C., additional, Fieuws, S., additional, D'Hooghe, T., additional, Suginami, K., additional, Sato, Y., additional, Horie, A., additional, Matsumoto, H., additional, Fujiwara, H., additional, Konishi, I., additional, Jung, Y., additional, Cho, S., additional, Choi, Y., additional, Lee, B., additional, Seo, S., additional, Urman, B., additional, Yakin, K., additional, Oktem, O., additional, Alper, E., additional, Taskiran, C., additional, Aksoy, S., additional, Takeuchi, K., additional, Kurematsu, T., additional, Yu-ki, Y., additional, Fukumoto, Y., additional, Homan, Y., additional, Sata, Y., additional, Kuroki, Y., additional, Takeuchi, M., additional, Awata, S., additional, Muneyyirci-Delale, O., additional, Charles, C., additional, Anopa, J., additional, Osei-Tutu, N., additional, Dalloul, M., additional, Weedon, J., additional, Muney, A., additional, Stratton, P., additional, Yilmaz, B., additional, Kilic, S., additional, Aksakal, O., additional, Kelekci, S., additional, Aksoy, Y., additional, Lordlar, N., additional, Sut, N., additional, Gungor, T., additional, Chan, J., additional, Tan, C. W., additional, Lee, Y. H., additional, Tan, H. H., additional, Choolani, M., additional, Griffith, L., additional, Oldeweme, J., additional, Barcena de Arellano, M. L., additional, Reichelt, U., additional, Schneider, A., additional, Mechsner, S., additional, Munch, S., additional, Vercellino, G. F., additional, Chiantera, V., additional, Santoro, L., additional, D'Onofrio, F., additional, Campo, S., additional, Ferraro, P. M., additional, Tondi, P., additional, Gasbarrini, A., additional, Santoliquido, A., additional, Jung, M. H., additional, Kim, H. Y., additional, Arnold, J., additional, Buttner, A., additional, Karaer, A., additional, Celik, O., additional, Bay Karabulut, A., additional, Celik, E., additional, Kiran, T. R., additional, Simsek, O. Y., additional, Yilmaz, E., additional, Turkcuoglu, I., additional, Tanrikut, E., additional, Alieva, K., additional, Kulakova, E., additional, Ipatova, M., additional, Smolnikova, V., additional, and Kalinina, E., additional

Published
2012
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23. SESSION 74: ENDOMETRIOSIS/ENDOMETRIUM: MOLECULAR AND CELLULAR INSIGHTS 3

Author

Dutta, M., primary, Joshi, M., additional, Srivastava, S., additional, Chakravarty, B., additional, Chaudhury, K., additional, Juan, Z., additional, Cui, Y. G., additional, Hou, Z., additional, Mao, Y. D., additional, Liu, J. Y., additional, Dogan, O. E., additional, Soysal, D., additional, Posaci, C., additional, Saatli, H. B., additional, Kizildag, S., additional, Soysal, S., additional, Koyuncuoglu, M., additional, Chan, R. W. S., additional, Chan, Y. Y., additional, Lee, C. L., additional, Ng, E. H. Y., additional, Yeung, W. S. B., additional, Maruyama, T., additional, Yamasaki, A., additional, Miyazaki, K., additional, Arase, T., additional, Uchida, H., additional, Yoshimura, Y., additional, Novella-Maestre, E., additional, Herraiz, S., additional, Vila, J. M., additional, Pellicer, A., additional, Arellano Estrada, C., additional, Barcena de Arellano, M. L., additional, Vercellino, G. F., additional, Chiantera, V., additional, Schneider, A., additional, and Mechsner, S., additional

Published
2012
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30. First Record of Batrachochytrium dendrobatidis in Pleurodema somuncurense, a Critically Endangered Species from Argentina.

Author

ARELLANO, M. L., VELASCO, M. A., KACOLIRIS, F. P., BELASEN, ANAT M., and JAMES, TIMOTHY Y.

Subjects
*BATRACHOCHYTRIUM dendrobatidis, *ENDANGERED species, *BROOK trout, *HOT springs, *ENDEMIC species
Abstract

The article offers information on the assessment of chytridiomycosis in the critically endangered Valcheta Frog (Pleurodema somuncurense) from northern Patagonia, Argentina. Topics include the habitat and conservation status of the Valcheta Frog, the methods used for detecting the presence of the chytrid fungus Batrachochytrium dendrobatidis (Bd), and the findings from a population study conducted in February 2015.

Published
2017

31. First Report of Batrachochytrium dendrobatidis in Atelognathus reverberii, a Threatened Species in Argentina.

Author

ARELLANO, M. L., AKMENTINS, M. S., VELASCO, M. A., KASS, C., and KACOLIRIS, F. P.

Subjects
*BATRACHOCHYTRIUM dendrobatidis, *CHYTRIDIOMYCOSIS, *FROGS, *AMPHIBIANS, *ANIMAL species
Abstract

The article focuses on the first record of the presence of Batrachochytrium dendrobatidis in Atelognathus reverberii in Argentina as well as discusses the associated mortality supporting a disease threat for the rare species. An overview of the Laguna Raimunda Frog, Atelognathus reverberii, which is an endemic species of conservation concern, is presented.

Published
2015

33. [Chemical-nutritional evaluation of Sorghum saccharatum var. sugar drip. A supplementation study with lactoserum proteins].

Author

de Arellano ML, Cid JA, Gimenez IT, and Mucciarelli S

Subjects
Animals, Flour, Milk, Rats, Rats, Wistar, Edible Grain chemistry, Food, Fortified, Nutritive Value, Proteins
Abstract

The chemical-nutritional composition and some indexes of biological quality of sorghum (Sorghum saccharum, var. sugar drip) unwashed whole flour were studied. The culture and selection of sorghum were assayed in the "San Roque" Experimental Station of the Agriculture Department, Undersecretary of Agricultural Affairs, San Luis, Argentina. The obtained protein content was 7.5% (Nx6.25). The values for net protein utilization (NPU); true digestibility (tD); net protein ratio (NPR) and and relative net protein ratio (RNPR) were 12.4 +/- 0.6, 22.0 +/- 0.2, 0.8 +/- 0.1 and 24%, respectively. Deficient nitrogen utilization constitutes a limitation for the use of sorghum. However, considering its abundance and low cost, sorghum could become a profitable feeding resource if conveniently supplemented without increasing costs. Sorghum flour was supplemented with protein recovered from ricotta serum (50:50), discarded as industrial waste, in order to compensate for lysine and threonine deficiency in this cereal. Studies performed on this mixture gave RNPR values of 85.7%. This might permit us to infer that despite its low biological value, sorghum can be used as food resource, potentially for poultry, with adequate supplementation.

Published
1998

34. [Protein concentrate from Amaranthus mantegazzianus. Physical, chemical and biological characterization].

Author

de Luquez N, Fernández S, de Arellano ML, and de Mucciarelli SI

Subjects
Dietary Supplements, Nutritive Value, Flour, Magnoliopsida chemistry, Plant Proteins analysis, Seeds chemistry
Abstract

The aim of this study was the obtainment of a protein concentrate (PC) from A. mantegazzianus seed powder and the evaluation of its percentual chemical composition, functional properties and biological protein quality. For this purpose, the optimal PC conditions assessed were: pH values for maximal and minimal solubility 11.5 and 5 respectively; flour/solvent ratio 1:20, stirring time 1.30 h at room temperature. A product exhibiting a protein content value of 55.3 g/ 100 g was obtained. The functional properties were evaluated by means of the following indexes Nitrogen Solubility Index (NSI) 94.9% at pH 11.5; emulsification activity (EA) 47 +/- 4.8; water absorption capacity (WAC) 2.1 +/- 0.3 and oil absorption capacity (AOAC) 0.8 +/- 0.1. The water and oil absorption index (WOAI) expressed as WAI/OAI was 2.6. These results render the product useful for bread baking due its high solubility, water absorption capacity and the OAI value which shows hydrophilic characteristics. The PC biological quality were calculated determining the net protein utilization (NPU): 64 +/- 7.4, true digestibility (tD): 88 +/- 7.6, biological value (BV): 73, intake: (I) 74 +/- 8.9 and weight gain (delta P) 23 +/- 4.5. The results of this study show a good nitrogen utilization, which plus the functional characterization let us infer that the A. mantegazzianus PC constitutes a good resource for the enrichment of bread baking products, preparing of diets for special regimens and protein complement for deficient foods.

Published
1997

35. Chemical and nutritional assessment of heifer's omasum flour.

Author

Fernández S, Cid J, de Arellano ML, de Hauria GA, Luco J, and de Mucciarelli SL

Subjects
Animals, Cattle physiology, Flour, Nutritive Value, Omasum chemistry
Abstract

The chemical and nutricional properties of flour from total calf omasum are assessed with the purpose of considering the utilization of a waste product from the meat industry as animal food. The results of the chemical percent analysis showed a high protein content of 78.6 g/100 g, a total lipid amount of 3.70 g/100 g and a cholesterol concentration of 0.14 g/100 g. From the study of the total saturated fatty acid composition it is deduced that palmitic acid prevails with a value of 28.4%. Unsaturated fatty acids show a value of 75% for oleic acid, this being the highest concentration. The values found for lipid composition are similar a fat bovine. Biological techniques were used to evaluate nitrogen utilization: Net Protein Utilization (NPU), true Digestibility (tD) and Biological Value (BV); a proof with casein as reference was simultaneously performed. The NPU, tD and the BV values found were: 58 +/- 7.0; 87 +/- 8.5 and 67 respectively. These results demonstrate that the assayed meat by-product had the adecuate nutritive elements for its industrialization as porcine balanced food.

Published
1996

36. Archives of Medical Research: an historical and subject coverage overview.

Author

Lozoya X, Rivera-Arce E, Domínguez F, Arellano ML, and Muñoz O

Subjects
Animals, History, 20th Century, Mexico, Bibliometrics, Periodicals as Topic history
Abstract

A bibliometric study about the subject content of the articles published in the Mexican scientific journal Archives of Medical Research is reported. The journal, published by the Mexican Institute of Social Security (IMSS), is comprised of 100 regular issues and 12 special supplements giving a total amount of 1,424 reports on medical research performed in Mexico during the last 25 years. According to the type of studies published during this period, we found that there is a similar percent of biomedical and clinical reports in the journal (47 and 42%, respectively) and a low proportion of epidemiological and medical educational reports (8 and 3%, respectively). Six thematic areas of research have been permanently published in this journal: investigations on infectious and neurological diseases being the areas mainly represented (34% of the total, corresponding to 17% in each area), followed by studies in reproductive biology (10%) and endocrine (7%), oncological (5%) and cardiovascular (3%) diseases. The tendency of the subjects covered by the journal during this period shows an increment in reports on infectious and parasitic disorders together with an increase in publications related to medicinal plant pharmacology; reproductive biology and endocrine studies show also an increasing tendency. On the other hand, a moderate decrease in studies related to neurological, oncological and cardiovascular diseases is observed. The origin of contributions during the last five years has balanced the proportion of papers published from IMSS scientists, other Mexican biomedical researchers and foreign contributions, thus reflecting favorably the recent changes in the journal's policies. This journal represents a clear example of a scientific publication edited in a developing country, originating as a national publication that evolved progressively into an international biomedical journal.

Published
1995

37. [Chemical composition of 6 unconventional plants from Oaxaca State, Mexico, as potential resources for animal feed].

Author

Arellano ML, Carranco JM, Pérez-Gil RF, Hernández PE, Partida IH, and Ripoll SH

Subjects
Alkaloids analysis, Animals, Dietary Fiber analysis, Dietary Proteins analysis, Hemagglutinins analysis, Mexico, Minerals analysis, Plants, Toxic chemistry, Ruminants, Species Specificity, Trypsin Inhibitors analysis, Animal Feed, Plants, Edible chemistry
Abstract

Characteristics and distribution of six plants are described. The chemical composition and in vitro digestibility of leaf and stem of Polymnia maculata, Trigonospermum annuum, Buddleia parviflora Kunt, Canna indica L, Gnaphalium oxyphyllum y Saurauia scabrida Hensl., selected for farmers information, were analysed as a potential resources in animal feeding. The results in dry matter: Crude protein (%): Go and Ss 10.9, Bp 16.7, Pm 11.7 and Ta 11.3. Cell wall (%): Go 54.1, Ss 52.3, Ci 54.4, Bp 68.3, Pm 27.8 and Ta 30.9. Lignin (%): Go and Ss 16.6, Ci 15.5, Bp 10.4, Pm 10.6 and Ta 13.3. IN vitro dry matter digestibility (%): Go 55.1, Ss 37.6, Ci 55.4, Bp 46.5, Pm 82.4 and Ta 81.4. Calcium and phosphorus (mg/100g) respectively: Go 1095 and 379, Ss 1132 and 387, Ci 600 and 421, Bp 800 and 855, Pm 1146 and 421 and Ta 905 and 480. Tannic acid (mg/100g): Go 1450, Ss 1480, Bp 575, Ci 518, Pm 3329 and Ta 2760. Trypsin inhibitor (UIT/g): Go 22264, Ss 29720, Bp 755, Ci 4228, Pm 931 and Ta 4412. Hemagglutinins were detected in Pm and Ta. Alkaloids were detected as scarce in Bp, Ci and Pm, moderate in Ta. Saponins and Cyanogenic glucosides were not detected. It is concluded that Pm and Ta could be considered as a forage for ruminants; Go, Bp and Ci as a complement; recommended the voluntary intake, in vivo digestibility and weight increase trials.

Published
1993

38. [Mountain chinchilla (Lagostomus maximus maximus Blainv) meat. Biological value].

Author

de Arellano ML, Luco JM, Fernández S, Micalizzi Y, Fisetti M, Lucero JB, and Mucciarelli S

Subjects
Animals, Dietary Fats analysis, Dietary Proteins analysis, Fatty Acids analysis, Food Preferences, Humans, Minerals analysis, Rats, Rats, Wistar, Chinchilla, Meat analysis
Abstract

In order to establish the vizcacha meat quality as food, the percentual chemical composition, cholesterol content and values of some fatty acids were determined. Assays were performed using Wistar rats for estimation of Net Protein Utilization (UPN), True Digestibility (TD) and Biological Value (BV). The results obtained were: protein, 23.87 g/100 g; total lipids, 3.74g/100g and a low content of cholesterol of 50 mg/100g. From the analysis of the fatty acids composition it is noticed a remarkable high proportion of insatured C18 fatty acids. The nitrogen availability calculated from UPN studies gave a value of 60.50 +/- 9.7, a TD of 85.00 +/- 13.20 and a BV of 70.60. Considering on the whole the results here obtained and the optimal approval of this product by man, it is inferred that vizcacha meat constitutes a good base for the production of foods suitable to be manufactured as can products. An adequate promotion of this product will be needed for its introduction in new markets.

Published
1993

39. [Cassia aphylla flour. Study of its chemical composition and the biological quality of its proteins].

Author

de Mucciarelli SI, de Arellano ML, del Cid JA, and Giménez MS

Subjects
Animals, Female, Male, Nutritive Value, Rats, Animal Feed, Cassia analysis, Dietary Proteins analysis, Flour analysis, Plant Proteins analysis, Plants, Medicinal analysis
Abstract

The chemical and biological value of the flour from Cassia aphylla was determined. The chemical study showed that this flour contains a good amount of protein, calcium, phosphorus, iron, ascorbic acid, niacin and thiamine. It is also a good source of lysine and sulfur amino acids. Tests concerning nutritive value carried out were: net protein utilization (NPU), 54.7 +/- 2.45; digestibility, 71.00 +/- 0.30; biological value, 77.00, and protein efficiency ratio (PER) 1.74, corrected with respect to casein. Toxicological tests were performed with rats during a period of 30 days. The criteria used in these tests were: hematological data, organ weights, liver composition and histopathology of the liver and kidney. These tests revealed no signs of pathological damage under the experimental conditions used by us. Based on these results, it can be concluded that this product has a potential value as a feedstuff.

Published
1981

40. [Obtaining flour and protein concentrate from seeds of Melilotus albus. Study of the protein quality].

Author

de Mucciarelli SI, de Arellano ML, de Pedernera MM, Cid JA, and Guardia CE

Subjects
Animals, Diet, Female, Male, Nutritive Value, Organ Size, Plants, Edible, Rats, Rats, Inbred Strains, Dietary Proteins analysis, Flour analysis, Methionine analysis, Plant Proteins analysis, Seeds, Threonine analysis
Abstract

The present research was carried out to determine the nutritive quality of the flour and protein concentrate from Melilotus albus (white clover) seeds. The flour was studied first. The protein analysis showed methionine to be the first limiting amino acid with a chemical score of 25, with threonine as the second. The biological value obtained was 27. Supplementation studies were performed with different levels of methionine and it was found that the 0.3% level resulted in the best net performance. The biological value obtained under these conditions was 60. The protein efficiency ratio (PER) was also determined, with a value of 1.40 after being corrected with respect to casein. The protein was isolated after studying the pH optimum solubility and precipitation conditions until the flour coumarin compounds were eliminated. Further biological experiments were carried out with the supplemented isolated protein. Under these conditions, a PER value of 2.4 and a biological value of 69 were obtained. No toxicity was observed in rats of both sexes by administration of the protein concentrate during 60 days, at least in the parameters studied during this period.

Published
1984

41. [Effects of treatment with polyvinylpyrrolidone on nutritional quality of sorghum].

Author

de Mucciarelli SI, de Arellano ML, de Lúquez NG, Cid J, and Fernández S

Subjects
Animals, Dietary Proteins analysis, Phenols metabolism, Polymers metabolism, Polyphenols, Rats, Rats, Inbred Strains, Edible Grain, Flavonoids, Nitrogen metabolism, Nutritive Value, Phenols pharmacology, Polymers pharmacology, Povidone pharmacology
Abstract

The purpose of this paper was to show that a high polyphenolic compound content in the sorghum grain (Sorghum saccharatum, var sugar drip) has an unfavorable influence on the nitrogen absorption. In order to arrive at this conclusion, the tannin content in sorghum flour was reduced by means of a treatment with polyvinylpyrrolidone (PVP) as a complexing agent. Several biological experiments were performed with non-treated flour (S) and with PVP-treated flour (S + PVP). Treatment improved true digestibility (D), having obtained the following values: for S = 31 +/- 2.67, and for S + PVP = 55.8 +/- 3.48 (significance P less than 0.001). The tannin evaluation yielded the following results: S = 1.90 g/100 g, and S + PVP = 0.85 g/100 g reported as tannic acid. The digestibility increase induced a better nitrogenous utilization, the net protein utilization (NPU) values being from 19 +/- 1.58 to 37 +/- 3.36 for S, and S + PVP, respectively.

Published
1987

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