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1. Humoral immunity to SARS-CoV-2 in kidney transplant recipients and dialysis patients: IgA and IgG patterns unraveled after SARS-CoV-2 infection and vaccination

Author

De Bouver, Caroline, Bouziotis, Jason, Wijtvliet, Veerle P. W. M., Ariën, Kevin K., Mariën, Joachim, Heyndrickx, Leo, Couttenye, Marie M., de Fijter, Hans J. W., Mestrez, Fabienne, Treille, Serge, Mat, Olivier, Collart, Frederic, Allard, Sabine D., Vingerhoets, Lies, Moons, Pieter, Abramowicz, Daniel, De Winter, Benedicte Y., Pipeleers, Lissa, Wissing, Karl Martin, and Ledeganck, Kristien J.

Published
2024
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2. COVID-19 seroprevalence cohort survey among health care workers and their household members in Kinshasa, DR Congo, 2020–2022

Author

Madinga, Joule, Mbala-Kingebeni, Placide, Nkuba-Ndaye, Antoine, Baketana-Kinzonzi, Leonel, Matungulu-Biyala, Elysé, Mutombo-Lupola, Patrick, Seghers, Caroline-Aurore, Smekens, Tom, Ariën, Kevin K., Van Damme, Wim, Kalk, Andreas, Peeters, Martine, Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, and Vanlerberghe, Veerle

Published
2024
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5. Fatal meningoencephalitis associated with Ebola virus persistence in two survivors of Ebola virus disease in the Democratic Republic of the Congo: a case report study

Author

De Weggheleire, Anja, Soke, Gnakub N, Pallawo, Raymond, Ibrahima, Gouressy, Epaso Gelege, Victor, Kombe-Ngwama, John, Kahambwe-Ekoko, Grace, Mossoko Gbe, Mathias, Adikey Limne, Pierre-Céleste, Yuma-Kibondo, Etienne, Kinganda-Lusamaki, Eddy, Amuri Aziza, Adrienne, Tutu Tshia N'kasar, Yannick, Mumbere Kalemekwa, Elias, Kitsa-Mutsumbirwa, Divine, Mulopo-Mukanya, Noella, Mbelu-Matulu, Fyfy, Kavira-Muhindo, Marie-Anne, Kwizera Sendegeya, Jacques, Kavunga-Membo, Hugo, Mukadi-Bamuleka, Daniel, Edidi-Atani, François, Morales-Betoulle, Maria E, Legand, Anaïs, Nkuba-Ndaye, Antoine, Bulabula-Penge, Junior, Mbala-Kingebeni, Placide, Crozier, Ian, Mambu-Mbika, Fabrice, Whitmer, Shannon, Tshiani Mbaya, Olivier, Hensley, Lisa E, Kitenge-Omasumbu, Richard, Davey, Richard, Mulangu, Sabue, Fonjungo, Peter N, Wiley, Michael R, Klena, John D, Peeters, Martine, Delaporte, Eric, van Griensven, Johan, Ariën, Kevin K, Pratt, Catherine, Montgomery, Joel M, Formenty, Pierre, Muyembe-Tamfum, Jean-Jacques, and Ahuka-Mundeke, Steve

Published
2024
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6. Potential determinants of the decline in mpox cases in Belgium: A behavioral, epidemiological and seroprevalence study

Author

De Vos, Elise, Van Gestel, Liesbeth, Brosius, Isabel, Kenyon, Chris, Vuylsteke, Bea, De Baetselier, Irith, Mariën, Joachim, Bangwen, Eugene, Couvreur, Simon, Lecompte, Amaryl, Van Beckhoven, Dominique, Hoorelbeke, Bart, Verstrepen, Babs E., Zaeck, Luca M., de Vries, Rory D., Geurts van Kessel, Corine H., Hens, Niel, Ariën, Kevin K., Vercauteren, Koen, Van Esbroek, Marjan, Van Dijck, Christophe, and Liesenborghs, Laurens

Published
2024
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8. Hybrid Immunity Overcomes Defective Immune Response to COVID-19 Vaccination in Kidney Transplant Recipients

Author

Gemander, Nicolas, Kemlin, Delphine, Depickère, Stéphanie, Kelkar, Natasha S., Pannus, Pieter, Sharma, Shilpee, Waegemans, Alexandra, Olislagers, Véronique, Georges, Daphnée, Dhondt, Emilie, Braga, Margarida, Heyndrickx, Leo, Michiels, Johan, Thiriard, Anaïs, Lemy, Anne, Vandevenne, Marylène, Goossens, Maria E., Matagne, André, Desombere, Isabelle, Ariën, Kevin K., Ackerman, Margaret E., Le Moine, Alain, and Marchant, Arnaud

Published
2024
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12. Chikungunya fever

Author

Bartholomeeusen, Koen, Daniel, Matthieu, LaBeaud, Desiree A., Gasque, Philippe, Peeling, Rosanna W., Stephenson, Kathryn E., Ng, Lisa F. P., and Ariën, Kevin K.

Published
2023
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14. Head-to-head comparison of diagnostic accuracy of four Ebola virus disease rapid diagnostic tests versus GeneXpert® in eastern Democratic Republic of the Congo outbreaks: a prospective observational study

Author

Kavunga-Membo, Hgo, Ishara-Nshombo, Elie, Roge, Stijn, Mulopo-Mukanya, Noella, Tsiwedi-Tsilabia, Espérance, Muhindo-Milonde, Emile, Kavira-Muhindo, Marie-Anne, Morales-Betoulle, Maria E., Nkuba-Ndaye, Antoine, Mukadi-Bamuleka, Daniel, Bulabula-Penge, Junior, Jacobs, Bart K.M., De Weggheleire, Anja, Edidi-Atani, François, Mambu-Mbika, Fabrice, Legand, Anaïs, Klena, John D., Fonjungo, Peter N., Mbala-Kingebeni, Placide, Makiala-Mandanda, Sheila, Kajihara, Masahiro, Takada, Ayato, Montgomery, Joel M., Formenty, Pierre, Muyembe-Tamfum, Jean-Jacques, Ariën, Kevin K., van Griensven, Johan, and Ahuka-Mundeke, Steve

Published
2023
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15. Humoral and cellular immune correlates of protection against COVID-19 in kidney transplant recipients

Author

Kemlin, Delphine, Gemander, Nicolas, Depickère, Stéphanie, Olislagers, Véronique, Georges, Daphnée, Waegemans, Alexandra, Pannus, Pieter, Lemy, Anne, Goossens, Maria E., Desombere, Isabelle, Michiels, Johan, Vandevenne, Marylène, Heyndrickx, Leo, Ariën, Kevin K., Matagne, André, Ackerman, Margaret E., Le Moine, Alain, and Marchant, Arnaud

Published
2023
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16. Retrospective detection of asymptomatic monkeypox virus infections among male sexual health clinic attendees in Belgium

Author

De Baetselier, Irith, Van Dijck, Christophe, Kenyon, Chris, Coppens, Jasmine, Michiels, Johan, de Block, Tessa, Smet, Hilde, Coppens, Sandra, Vanroye, Fien, Bugert, Joachim Jakob, Girl, Philipp, Zange, Sabine, Liesenborghs, Laurens, Brosius, Isabel, van Griensven, Johan, Selhorst, Philippe, Florence, Eric, Van den Bossche, Dorien, Ariën, Kevin K., Rezende, Antonio Mauro, Vercauteren, Koen, and Van Esbroeck, Marjan

Published
2022
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17. Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak

Author

Van Dijck, Christophe, Hens, Matilde, Van Esbroeck, Marjan, Brosius, Isabel, Liesenborghs, Laurens, Van Gestel, Liesbeth, Rutgers, Jojanneke, Kenyon, Chris, De Baetselier, Irith, Coppens, Jasmine, Van den Bossche, Dorien, Florence, Eric, Vercauteren, Koen, van Griensven, Johan, Bottieau, Emmanuel, Soentjens, Patrick, Berens-Riha, Nicole, van Henten, Saskia, Bracke, Stefanie, Vanbaelen, Thibaut, Vandenhoven, Leen, Van Frankenhuijsen, Maartje, Vandenbruaene, Marc, Huyst, Veerle, Wouters, Kristien, Apers, Ludwig, Kint, Ilse, Caluwaerts, Séverine, Vanroye, Fien, Verschueren, Jacob, and Ariën, Kevin

Published
2023
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18. Field performance of three Ebola rapid diagnostic tests used during the 2018–20 outbreak in the eastern Democratic Republic of the Congo: a retrospective, multicentre observational study

Author

Mukadi-Bamuleka, Daniel, Bulabula-Penge, Junior, De Weggheleire, Anja, Jacobs, Bart K M, Edidi-Atani, François, Mambu-Mbika, Fabrice, Mbala-Kingebeni, Placide, Makiala-Mandanda, Sheila, Faye, Martin, Diagne, Cheick T, Diagne, Moussa M, Faye, Oumar, Kajihara, Masahiro, Faye, Ousmane, Takada, Ayato, Sall, Amadou A, Muyembe-Tamfum, Jean-Jacques, van Griensven, Johan, Ariën, Kevin K, and Ahuka-Mundeke, Steve

Published
2022
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19. Five accelerated schedules for the tick-borne encephalitis vaccine FSME-Immun® in last-minute travellers: an open-label, single-centre, randomized controlled pilot trial.

Author

Berens-Riha, Nicole, Andries, Petra, Aerssens, Annelies, Ledure, Quentin, Beken, Yolien Van Der, Heyndrickx, Leo, Genbrugge, Els, Tsoumanis, Achilleas, Herrewege, Yven Van, Ariën, Kevin K, Innis, Martine Van, Vanbrabant, Peter, Soentjens, Patrick, and Team, FASTBEPROTECT Research

Subjects
TICK-borne encephalitis, ANTIBODY titer, YELLOW fever, VIRAL antibodies, NEUTRALIZATION tests
Abstract

Background The purpose of this exploratory study was to evaluate different accelerated tick-borne encephalitis (TBE) vaccine schedules for last-minute travellers. Methods In a single-centre, open-label pilot study, 77 TBE-naïve Belgian soldiers were randomized to one of the following five schedules with FSME-Immun®: group 1 ('classical accelerated' schedule) received one intramuscular (IM) dose at Day 0 and Day 14, group 2 two IM doses at Day 0, group 3 two intradermal (ID) doses at Day 0, group 4 two ID doses at Day 0 and Day 7 and group 5 two ID doses at Day 0 and Day 14. The last dose(s) of the primary vaccination scheme were given after 1 year: IM (1 dose) or ID (2 doses). TBE virus neutralizing antibodies were measured in a plaque reduction neutralization test (PRNT90 and 50) at Days 0, 14, 21, 28, Months 3, 6, 12 and 12+21 days. Seropositivity was defined as neutralizing antibody titres ≥10. Results The median age was 19–19.5 years in each group. Median time to seropositivity up to Day 28 was shortest for PRNT90 in ID-group 4 and for PRNT50 in all ID groups. Seroconversion until Day 28 peaked highest for PRNT90 in ID-group 4 (79%) and for PRNT50 in ID-groups 4 and 5 (both 100%). Seropositivity after the last vaccination after 12 months was high in all groups. Previous yellow fever vaccination was reported in 16% and associated with lower geometric mean titres of TBE-specific antibodies at all-time points. The vaccine was generally well tolerated. However, mild to moderate local reactions occurred in 73–100% of ID compared with 0–38% of IM vaccinations, and persistent discolouration was observed in nine ID vaccinated individuals. Conclusion The accelerated two-visit ID schedules might offer a better immunological alternative to the recommended classical accelerated IM schedule, but an aluminium-free vaccine would be preferable. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Importance of anti-SARS-CoV-2 assay antigenic composition as revealed by the results of the Belgian external quality assessment (EQA) scheme

Author

Moerman, Alena, Vernelen, Kris, China, Bernard, Capron, Arnaud, Bossche, Dorien Van Den, Mariën, Joachim, Ariën, Kevin K., Van Acker, Jos, Delforge, Marie-Luce, Reynders, Marijke, Boel, An, Depypere, Melissa, Van Gasse, Natasja, Vijgen, Sara, Brauner, Jonathan, Dujardin, Barbara, and Padalko, Elizaveta

Published
2022
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25. Potential determinants of the decline in mpox cases in Belgium:A behavioral, epidemiological and seroprevalence study

Author

De Vos, Elise, Van Gestel, Liesbeth, Brosius, Isabel, Kenyon, Chris, Vuylsteke, Bea, De Baetselier, Irith, Mariën, Joachim, Bangwen, Eugene, Couvreur, Simon, Lecompte, Amaryl, Van Beckhoven, Dominique, Hoorelbeke, Bart, Verstrepen, Babs E., Zaeck, Luca M., de Vries, Rory D., Geurts van Kessel, Corine H., Hens, Niel, Ariën, Kevin K., Vercauteren, Koen, Van Esbroek, Marjan, Van Dijck, Christophe, Liesenborghs, Laurens, De Vos, Elise, Van Gestel, Liesbeth, Brosius, Isabel, Kenyon, Chris, Vuylsteke, Bea, De Baetselier, Irith, Mariën, Joachim, Bangwen, Eugene, Couvreur, Simon, Lecompte, Amaryl, Van Beckhoven, Dominique, Hoorelbeke, Bart, Verstrepen, Babs E., Zaeck, Luca M., de Vries, Rory D., Geurts van Kessel, Corine H., Hens, Niel, Ariën, Kevin K., Vercauteren, Koen, Van Esbroek, Marjan, Van Dijck, Christophe, and Liesenborghs, Laurens

Abstract

Objectives: The 2022 mpox epidemic reached a peak in Belgium and the rest of Europe in July 2022, after which it unexpectedly subsided. This study investigates epidemiological, behavioral, and immunological factors behind the waning of the epidemic in Belgium. Methods: We investigated temporal evolutions in the characteristics and behavior of mpox patients using national surveillance data and data from a prospective registry of mpox patients in the Institute of Tropical Medicine (Antwerp). We studied behavioral changes in the population at risk using a survey among HIV-preexposure prophylaxis (PrEP) users. We determined the seroprevalence of anti-orthopoxvirus antibodies among HIV-PrEP users across four-time points in 2022. Results: Mpox patients diagnosed at the end of the epidemic had less sexual risk behavior compared to those diagnosed earlier: they engaged less in sex at mass events, had fewer sexual partners, and were less likely to belong to the sexual network's central group. Among HIV-PrEP users there were no notable changes in sexual behavior. Anti-orthopoxvirus seroprevalence did not notably increase before the start of national vaccination campaigns. Conclusion: The observed changes in group immunity and behavior in the population at greater risk of exposure to mpox seem unable to explain the waning of the mpox epidemic. A change in the profile of mpox patients might have contributed to the decline in cases.

Published
2024

26. Antibodies against medically relevant arthropod-borne viruses in the ubiquitous African rodent Mastomys natalensis.

Author

De Kesel, Wim, Vanden Broecke, Bram, Borremans, Benny, Fourchault, Léa, Willems, Elisabeth, Ceulemans, Ann, Sabuni, Christopher, Massawe, Apia, Makundi, Rhodes H., Leirs, Herwig, Peeters, Martine, Verheyen, Erik, Gryseels, Sophie, Mariën, Joachim, and Ariën, Kevin K.

Subjects
ARBOVIRUSES, YELLOW fever, CHIKUNGUNYA virus, DENGUE viruses, ZOONOSES, DENGUE hemorrhagic fever, ALPHAVIRUSES
Abstract

Over the past decades, the number of arthropod-borne virus (arbovirus) outbreaks has increased worldwide. Knowledge regarding the sylvatic cycle (i.e., non-human hosts/environment) of arboviruses is limited, particularly in Africa, and the main hosts for virus maintenance are unknown. Previous studies have shown the presence of antibodies against certain arboviruses (i.e., chikungunya-, dengue-, and zika virus) in African non-human primates and bats. We hypothesize that small mammals, specifically rodents, may function as amplifying hosts in anthropogenic environments. The detection of RNA of most arboviruses is complicated by the viruses' short viremic period within their hosts. An alternative to determine arbovirus hosts is by detecting antibodies, which can persist several months. Therefore, we developed a high-throughput multiplex immunoassay to detect antibodies against 15 medically relevant arboviruses. We used this assay to assess approximately 1,300 blood samples of the multimammate mouse, Mastomys natalensis from Tanzania. In 24% of the samples, we detected antibodies against at least one of the tested arboviruses, with high seroprevalences of antibodies reacting against dengue virus serotype one (7.6%) and two (8.4%), and chikungunya virus (6%). Seroprevalence was higher in females and increased with age, which could be explained by inherent immunity and behavioral differences between sexes, and the increased chance of exposure to an arbovirus with age. We evaluated whether antibodies against multiple arboviruses co-occur more often than randomly and found that this may be true for some members of the Flaviviridae and Togaviridae. In conclusion, the development of an assay against a wide diversity of medically relevant arboviruses enabled the analysis of a large sample collection of one of the most abundant African small mammals. Our findings highlight that Mastomys natalensis is involved in the transmission cycle of multiple arboviruses and provide a solid foundation to better understand the role of this ubiquitous rodent in arbovirus outbreaks. Author summary: One of the main causes of zoonotic related human morbidity and mortality is the transmission of arthropod-borne viruses such as dengue virus, Yellow Fever virus, and chikungunya virus. These viruses cannot only infect humans but also livestock, pets, and wildlife, though our understanding of their non-human hosts remains limited. Rodents are thought to be an important host for these viruses because they can be abundant, often live near humans, and some are already known to be viral hosts. However, research has focused mostly on non-human primates, neglecting other potential wild hosts. To address this gap, we have developed a high-throughput antibody test to screen rodent blood against 15 different arboviruses. Our findings reveal that Mastomys natalensis, a common African rodent species, carries antibodies that (cross-)react against these viruses. We hypothesize that immunologically naïve juveniles may drive transmission, particularly during population outbreaks. These outbreaks coincide with environmental conditions that are favorable for mosquitoes, thus increasing the risk of spillover to humans, livestock, and wildlife. Understanding the role of rodents in arbovirus transmission dynamics is crucial for mitigating zoonotic disease risks. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Predictors of neutralizing antibody response to BNT162b2 vaccination in allogeneic hematopoietic stem cell transplant recipients

Author

Canti, Lorenzo, Humblet-Baron, Stéphanie, Desombere, Isabelle, Neumann, Julika, Pannus, Pieter, Heyndrickx, Leo, Henry, Aurélie, Servais, Sophie, Willems, Evelyne, Ehx, Grégory, Goriely, Stanislas, Seidel, Laurence, Michiels, Johan, Willems, Betty, Liston, Adrian, Ariën, Kevin K., Beguin, Yves, Goossens, Maria E., Marchant, Arnaud, and Baron, Frédéric

Published
2021
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30. Revisiting a COVID-19 seroprevalence cohort survey among health care workers and their household members in Kinshasa, DR Congo, 2020-2022

Author

Madinga, Joule, primary, Mbala, Placide, additional, Nkuba, Antoine-Jeremy, additional, Baketana, Leonel, additional, Matungulu, Elysé, additional, Vanlerberghe, Veerle, additional, Lupola, Patrick Mutombo, additional, Seghers, Caroline-Aurore, additional, Smekens, Tom, additional, Ariën, Kevin K., additional, Damme, Wim Van, additional, Kalk, Andreas, additional, Peeters, Martine, additional, Muyembe, Jean-Jacques, additional, and Ahuka, Steve, additional

Published
2023
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31. Hybrid immunity overcomes defective immune response to COVID-19 vaccination in kidney transplant recipients

Author

Gemander, Nicolas, primary, Kemlin, Delphine, additional, Depickère, Stéphanie, additional, Kelkar, Natasha S., additional, Pannus, Pieter, additional, Sharma, Shilpee, additional, Waegemans, Alexandra, additional, Olislagers, Véronique, additional, Georges, Daphnée, additional, Dhondt, Emilie, additional, Braga, Margarida, additional, Heyndrickx, Leo, additional, Michiels, Johan, additional, Thiriard, Anaïs, additional, Lemy, Anne, additional, Vandevenne, Marylène, additional, Goossens, Maria E., additional, Matagne, André, additional, Desombere, Isabelle, additional, Ariën, Kevin K., additional, Ackerman, Margaret E., additional, Le Moine, Alain, additional, and Marchant, Arnaud, additional

Published
2023
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35. Arbovirus researchers unite: expanding genomic surveillance for an urgent global need

Author

Wallau, Gabriel Luz, primary, Abanda, Ngu Njei, additional, Abbud, Adriano, additional, Abdella, Saro, additional, Abera, Adugna, additional, Ahuka-Mundeke, Steve, additional, Falconi-Agapito, Francesca, additional, Alagarasu, Kalichamy, additional, Ariën, Kevin K, additional, Ayres, Constancia Flávia Junqueira, additional, Barzon, Luisa, additional, Bonney, Joseph Humphrey Kofi, additional, Boumbaly, Sanaba, additional, Buchy, Philippe, additional, Cao-Lormeau, Van-Mai, additional, Chem, Yu Kie, additional, Cardenas, Paul A, additional, Castillo, Andres E, additional, Delfraro, Adriana, additional, Devine, Gregor, additional, Duong, Veasna, additional, Dupont-Rouzeyrol, Myrielle, additional, Fadeev, Artem V, additional, Fajardo, Alvaro, additional, Diaz, Luis Adrián, additional, Gómez, Lara Ferrero, additional, Gudo, Eduardo Samo, additional, Gutierrez-Bugallo, Gladys, additional, Hapuarachchi, Hapuarachchige Chanditha, additional, Heraud, Jean-Michel, additional, Hibberd, Martin L, additional, Inlamea, Osvaldo Frederico, additional, Jasmin, Nik, additional, Kydyshov, Kalysbek, additional, Kelly, Maria Ezekiely, additional, Khan, Salim, additional, Komissarov, Andrey B, additional, Leaungwutiwong, Pornsawan, additional, Leguia, Mariana, additional, Lustig, Yaniv, additional, Maciel-de-Freitas, Rafael, additional, Malavige, Gathsaurie Neelika, additional, Martinez, Alexander A, additional, Mendoza, Maria L, additional, Mo, Luong T, additional, Moreno, Brechla, additional, Mwasi, Lydia, additional, Naveca, Felipe Gomes, additional, NG, Lee Ching, additional, Njouom, Richard, additional, Nogueira, Mauricio Lacerda, additional, Ntoumi, Francine, additional, Nzoyikorera, Nehemie, additional, Parra, Barbara A, additional, Pichardo, Mauricio Vázquez, additional, Privaldos, Kristine Joy Ragual, additional, Rivero, Ricardo, additional, Rojas, Alejandra María, additional, Salvato, Richard Steiner, additional, Sasmono, R Tedjo, additional, Schmidt-Chanasit, Jonas, additional, Simon-Loriere, Etienne, additional, Sy, Ava Kristy Dy, additional, Talledo-Albujar, Michael, additional, Tizhe, Daniel Thakuma, additional, Toloshovich, Usenbaev Nurbolot, additional, Tran, Vi Thuy, additional, Troupin, Cécile, additional, Kayiwa, John Timothy, additional, van den Hurk, Andrew, additional, Vasilakis, Nikolaos, additional, Weldemariam, Atsbeha Gebreegziabxier, additional, Yacoub, Sophie, additional, Zaini, Zainun, additional, and Wallau, Gabriel Luz, additional

Published
2023
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36. A randomized, multicentre, open-label phase II proof-of-concept trial investigating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients hospitalized with COVID-19: the Donated Antibodies Working against nCoV (DAWn-Plasma) trial

Author

Devos, Timothy, Geukens, Tatjana, Schauwvlieghe, Alexander, Ariën, Kevin K., Barbezange, Cyril, Cleeren, Myriam, Compernolle, Veerle, Dauby, Nicolas, Desmecht, Daniël, Grimaldi, David, Lambrecht, Bart N., Luyten, Anne, Maes, Piet, Moutschen, Michel, Romano, Marta, Seyler, Lucie, Nevessignsky, Michel Toungouz, Vandenberghe, Katleen, van Griensven, Johan, Verbeke, Geert, Vlieghe, Erika, Yombi, Jean Cyr, Liesenborghs, Laurens, Verhamme, Peter, and Meyfroidt, Geert

Published
2020
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37. Correction to: A randomized, multicentre, open-label phase II proof-of-concept trial investigating the clinical efficacy and safety of the addition of convalescent plasma to the standard of care in patients hospitalized with COVID-19: the Donated Antibodies Working against nCoV (DAWn-Plasma) trial

Author

Devos, Timothy, Geukens, Tatjana, Schauwvlieghe, Alexander, Ariën, Kevin K., Barbezange, Cyril, Cleeren, Myriam, Compernolle, Veerle, Dauby, Nicolas, Desmecht, Daniël, Grimaldi, David, Lambrecht, Bart N., Luyten, Anne, Maes, Piet, Moutschen, Michel, Romano, Marta, Seyler, Lucie, Nevessignsky, Michel Toungouz, Vandenberghe, Katleen, van Griensven, Johan, Verbeke, Geert, Vlieghe, Erika, Yombi, Jean Cyr, Liesenborghs, Laurens, Verhamme, Peter, and Meyfroidt, Geert

Published
2020
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39. Head-to-head comparison of diagnostic accuracy of four Ebola virus disease rapid diagnostic tests versus GeneXpert® in eastern Democratic Republic of the Congo outbreaks: a prospective observational study

Author

Mukadi-Bamuleka, Daniel, primary, Bulabula-Penge, Junior, additional, Jacobs, Bart K.M., additional, De Weggheleire, Anja, additional, Edidi-Atani, François, additional, Mambu-Mbika, Fabrice, additional, Legand, Anaïs, additional, Klena, John D., additional, Fonjungo, Peter N., additional, Mbala-Kingebeni, Placide, additional, Makiala-Mandanda, Sheila, additional, Kajihara, Masahiro, additional, Takada, Ayato, additional, Montgomery, Joel M., additional, Formenty, Pierre, additional, Muyembe-Tamfum, Jean-Jacques, additional, Ariën, Kevin K., additional, van Griensven, Johan, additional, Ahuka-Mundeke, Steve, additional, Kavunga-Membo, Hgo, additional, Ishara-Nshombo, Elie, additional, Roge, Stijn, additional, Mulopo-Mukanya, Noella, additional, Tsiwedi-Tsilabia, Espérance, additional, Muhindo-Milonde, Emile, additional, Kavira-Muhindo, Marie-Anne, additional, Morales-Betoulle, Maria E., additional, and Nkuba-Ndaye, Antoine, additional

Published
2023
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40. Validation of a Reporter Cell Line for Flavivirus Inhibition Assays

Author

Rezende, Tatiana M. T., primary, Macera, Gabriella, additional, Heyndrickx, Leo, additional, Michiels, Johan, additional, Coppens, Sandra, additional, Thibaut, Hendrik Jan, additional, Dallmeier, Kai, additional, Van Esbroeck, Marjan, additional, Neyts, Johan, additional, Ariën, Kevin K., additional, and Bartholomeeusen, Koen, additional

Published
2023
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41. Data from Humoral and Cellular Immune Responses against SARS-CoV-2 after Third Dose BNT162b2 following Double-Dose Vaccination with BNT162b2 versus ChAdOx1 in Patients with Cancer

Author

Debie, Yana, primary, Van Audenaerde, Jonas R.M., primary, Vandamme, Timon, primary, Croes, Lieselot, primary, Teuwen, Laure-Anne, primary, Verbruggen, Lise, primary, Vanhoutte, Greetje, primary, Marcq, Elly, primary, Verheggen, Lisa, primary, Le Blon, Debbie, primary, Peeters, Bart, primary, Goossens, Maria E., primary, Pannus, Pieter, primary, Ariën, Kevin K., primary, Anguille, Sébastien, primary, Janssens, Annelies, primary, Prenen, Hans, primary, Smits, Evelien L.J., primary, Vulsteke, Christof, primary, Lion, Eva, primary, Peeters, Marc, primary, and van Dam, Peter A., primary

Published
2023
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42. Figure S1 from Humoral and Cellular Immune Responses against SARS-CoV-2 after Third Dose BNT162b2 following Double-Dose Vaccination with BNT162b2 versus ChAdOx1 in Patients with Cancer

Author

Debie, Yana, primary, Van Audenaerde, Jonas R.M., primary, Vandamme, Timon, primary, Croes, Lieselot, primary, Teuwen, Laure-Anne, primary, Verbruggen, Lise, primary, Vanhoutte, Greetje, primary, Marcq, Elly, primary, Verheggen, Lisa, primary, Le Blon, Debbie, primary, Peeters, Bart, primary, Goossens, Maria E., primary, Pannus, Pieter, primary, Ariën, Kevin K., primary, Anguille, Sébastien, primary, Janssens, Annelies, primary, Prenen, Hans, primary, Smits, Evelien L.J., primary, Vulsteke, Christof, primary, Lion, Eva, primary, Peeters, Marc, primary, and van Dam, Peter A., primary

Published
2023
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43. Supplementary Tables S1-S2 from Humoral and Cellular Immune Responses against SARS-CoV-2 after Third Dose BNT162b2 following Double-Dose Vaccination with BNT162b2 versus ChAdOx1 in Patients with Cancer

Author

Debie, Yana, primary, Van Audenaerde, Jonas R.M., primary, Vandamme, Timon, primary, Croes, Lieselot, primary, Teuwen, Laure-Anne, primary, Verbruggen, Lise, primary, Vanhoutte, Greetje, primary, Marcq, Elly, primary, Verheggen, Lisa, primary, Le Blon, Debbie, primary, Peeters, Bart, primary, Goossens, Maria E., primary, Pannus, Pieter, primary, Ariën, Kevin K., primary, Anguille, Sébastien, primary, Janssens, Annelies, primary, Prenen, Hans, primary, Smits, Evelien L.J., primary, Vulsteke, Christof, primary, Lion, Eva, primary, Peeters, Marc, primary, and van Dam, Peter A., primary

Published
2023
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44. Third dose of COVID-19 mRNA vaccine closes the gap in immune response between naïve nursing home residents and healthy adults

Author

Pannus, Pieter, primary, Depickère, Stéphanie, additional, Kemlin, Delphine, additional, Georges, Daphnée, additional, Houben, Sarah, additional, Olislagers, Véronique, additional, Waegemans, Alexandra, additional, De Craeye, Stéphane, additional, Francotte, Antoine, additional, Chaumont, Félicie, additional, Van Oostveldt, Celien, additional, Heyndrickx, Leo, additional, Michiels, Johan, additional, Willems, Elisabeth, additional, Dhondt, Emilie, additional, Krauchuk, Marharyta, additional, Schmickler, Marie-Noëlle, additional, Verbrugghe, Mathieu, additional, Van Loon, Nele, additional, Dierick, Katelijne, additional, Matagne, André, additional, Desombere, Isabelle, additional, Ariën, Kevin K., additional, Marchant, Arnaud, additional, and Goossens, Maria E., additional

Published
2023
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45. SARS-CoV-2 vaccination elicits broad and potent antibody effector functions to variants of concern in vulnerable populations.

Author

Hederman, Andrew P, Natarajan, Harini, Heyndrickx, Leo, Ariën, Kevin K, Wiener, Joshua A, Wright, Peter F, Bloch, Evan M, Tobian, Aaron A R, Redd, Andrew D, Blankson, Joel N, Rottenstreich, Amihai, Zarbiv, Gila, Wolf, Dana, Goetghebuer, Tessa, Marchant, Arnaud, Ackerman, Margaret M.E., Hederman, Andrew P, Natarajan, Harini, Heyndrickx, Leo, Ariën, Kevin K, Wiener, Joshua A, Wright, Peter F, Bloch, Evan M, Tobian, Aaron A R, Redd, Andrew D, Blankson, Joel N, Rottenstreich, Amihai, Zarbiv, Gila, Wolf, Dana, Goetghebuer, Tessa, Marchant, Arnaud, and Ackerman, Margaret M.E.

Abstract

SARS-CoV-2 variants have continuously emerged in the face of effective vaccines. Reduced neutralization against variants raises questions as to whether other antibody functions are similarly compromised, or if they might compensate for lost neutralization activity. Here, the breadth and potency of antibody recognition and effector function is surveyed following either infection or vaccination. Considering pregnant women as a model cohort with higher risk of severe illness and death, we observe similar binding and functional breadth for healthy and immunologically vulnerable populations, but considerably greater functional antibody breadth and potency across variants associated with vaccination. In contrast, greater antibody functional activity targeting the endemic coronavirus OC43 is noted among convalescent individuals, illustrating a dichotomy in recognition between close and distant human coronavirus strains associated with exposure history. This analysis of antibody functions suggests the differential potential for antibody effector functions to contribute to protecting vaccinated and convalescent subjects as novel variants continue to evolve., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

46. Third dose of COVID-19 mRNA vaccine closes the gap in immune response between naïve nursing home residents and healthy adults.

Author

Pannus, Pieter, Depickère, Stéphanie, Kemlin, Delphine, Georges, Daphnée, Houben, Sarah, Olislagers, Véronique, Waegemans, Alexandra, De Craeye, Stéphane, Francotte, Antoine, Chaumont, Félicie, Van Oostveldt, Celien, Heyndrickx, Leo, Michiels, Johan, Willems, Elisabeth, Dhondt, Emilie, Krauchuk, Marharyta, Schmickler, Marie-Noëlle, Verbrugghe, Mathieu, Van Loon, Nele, Dierick, Katelijne, Matagne, André, Desombere, Isabelle, Ariën, Kevin K, Marchant, Arnaud, Goossens, Maria M.E., Pannus, Pieter, Depickère, Stéphanie, Kemlin, Delphine, Georges, Daphnée, Houben, Sarah, Olislagers, Véronique, Waegemans, Alexandra, De Craeye, Stéphane, Francotte, Antoine, Chaumont, Félicie, Van Oostveldt, Celien, Heyndrickx, Leo, Michiels, Johan, Willems, Elisabeth, Dhondt, Emilie, Krauchuk, Marharyta, Schmickler, Marie-Noëlle, Verbrugghe, Mathieu, Van Loon, Nele, Dierick, Katelijne, Matagne, André, Desombere, Isabelle, Ariën, Kevin K, Marchant, Arnaud, and Goossens, Maria M.E.

Abstract

Nursing home residents, a frail and old population group, respond poorly to primary mRNA COVID-19 vaccination. A third dose has been shown to boost protection against severe disease and death in this immunosenescent population, but limited data is available on the immune responses it induces., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

47. Essentials of filoviral load quantification

Author

Cnops, Lieselotte, van Griensven, Johan, Honko, Anna N, Bausch, Daniel G, Sprecher, Armand, Hill, Charles E, Colebunders, Robert, Johnson, Joshua C, Griffiths, Anthony, Palacios, Gustavo F, Kraft, Colleen S, Kobinger, Gary, Hewlett, Angela, Norwood, David A, Sabeti, Pardis, Jahrling, Peter B, Formenty, Pierre, Kuhn, Jens H, and Ariën, Kevin K

Published
2016
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49. Inactivation of SARS-CoV-2 and Other Enveloped and Non-Enveloped Viruses with Non-Thermal Plasma for Hospital Disinfection

Author

Sahun, Maxime, primary, Privat-Maldonado, Angela, additional, Lin, Abraham, additional, De Roeck, Naomi, additional, Van der Heyden, Lisa, additional, Hillen, Michaël, additional, Michiels, Johan, additional, Steenackers, Gunther, additional, Smits, Evelien, additional, Ariën, Kevin K., additional, Jorens, Philippe G., additional, Delputte, Peter, additional, and Bogaerts, Annemie, additional

Published
2023
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50. Characteristics of confirmed mpox cases among clinical suspects: A prospective single-centre study in Belgium during the 2022 outbreak

Author

Hens, Matilde, primary, Brosius, Isabel, additional, Berens-Riha, Nicole, additional, Coppens, Jasmine, additional, Van Gestel, Liesbeth, additional, Rutgers, Jojanneke, additional, Kenyon, Chris, additional, Soentjens, Patrick, additional, van Henten, Saskia, additional, Bracke, Stefanie, additional, Vanbaelen, Thibaut, additional, Vandenhoven, Leen, additional, Bottieau, Emmanuel, additional, Vercauteren, Koen, additional, Van Esbroeck, Marjan, additional, Liesenborghs, Laurens, additional, Van Dijck, Christophe, additional, Hens, Matilde, additional, De Baetselier, Irith, additional, Van den Bossche, Dorien, additional, Florence, Eric, additional, van Griensven, Johan, additional, Van Frankenhuijsen, Maartje, additional, Vandenbruaene, Marc, additional, Huyst, Veerle, additional, Wouters, Kristien, additional, Apers, Ludwig, additional, Kint, Ilse, additional, Caluwaerts, Séverine, additional, Vanroye, Fien, additional, Verschueren, Jacob, additional, and Ariën, Kevin, additional

Published
2023
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