1. Randomized controlled trial of vitamin d supplementation on toll-like receptor-2 (tlr-2) and toll-like receptor-4 (tlr-4) in tuberculosis spondylitis patients.
- Author
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Arifin, Jainal, Massi, Muhammad Nasrum, Biakto, Karya Triko, Bukhari, Agussalim, Noor, Zairin, and Johan, Muhammad Phetrus
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ANALYSIS of variance , *ANKYLOSING spondylitis , *VITAMIN D , *DIETARY supplements , *RANDOMIZED controlled trials , *TUBERCULOSIS , *DESCRIPTIVE statistics , *ENZYME-linked immunosorbent assay , *STATISTICAL sampling , *DATA analysis software , *TOLL-like receptors , *BLOOD - Abstract
Background: Tuberculosis spondylitis accounts for approximately 50% of all cases of skeletal tuberculosis. Vitamin D plays a role in the immune system. Vitamin D helps in the activation of TLR-2 and TLR-4, which play a role in the process of tuberculosis infection. The objective of this study was to investigate the effect of oral supplementation with vitamin D on TLR-2 and TLR-4 levels in tuberculosis spondylitis patients. Methods: The true Experiment Design Pretest–Posttest with Control Group (Pretest–Posttest with Control Group) was used for this research. TLR-2 and TLR-4 were measured by ELISA. Repeated ANOVA, ANOVA tests, and Kolmogorov–Smirnov normality tests on the SPSS program were used to statistically analyze the results. Result: In the dose groups of 10,000 IU and 5000 IU, significant increases in the levels of vitamin D, TLR-2, and TLR-4 were observed at weeks 4 and 8 (p < 0.05). In the control group, there was no significant increase. Conclusions: Vitamin D supplements can significantly increase TLR-2 and TLR-4 levels. Supplementation with vitamin D 10,000 IU/day for 8 weeks can increase vitamin D levels > 50 ng/dl to optimally act as an immunomodulator. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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