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This study conducted an overview of systematic reviews (SRs) and included randomized controlled trials (RCTs) to evaluate the predictability of tooth movements and clinical effectiveness of clear aligner therapy (CAT) compared to fixed appliances (FAs). The PRISMA guidelines were followed, and seven electronic databases were systematically searched for publications up to March 15, 2022. The quality of the included SRs and RCTs was assessed using the AMSTAR-2 and RoB-2 tools, respectively. Initially, 18 SRs and 2 RCTs were identified, and after quality assessments, 11 SRs and 1 RCT were retained for data synthesis. The comparison between software-predicted and actual tooth movements indicated that CAT's accuracy in predicting rotational movements, especially for canines, was not reliable. Horizontal movements, particularly in the upper incisors, were more predictable, while vertical movements were less predictable. The overall American Board of Orthodontics (ABO) objective grading system (OGS) scores did not show a significant difference between the CAT and FAs groups, with a high heterogeneity of 90 % (P

Introduction: Human pose estimation, a computer vision technique that identifies body parts and constructs human body representations from images and videos, has recently demonstrated high performance through deep learning. However, its potential application in clinical photography remains underexplored. This study aimed to establish photographic parameters for patients with adolescent idiopathic scoliosis (AIS) using pose estimation and to determine correlations between these photographic parameters and corresponding radiographic measures. Methods: We conducted a study involving 42 patients with AIS who had undergone spinal correction surgery and conservative treatment. Preoperative photographs were captured using an iPhone 13 Pro mounted on a tripod positioned at the head of an X-ray tube. From the outputs of pose estimation, we derived five photographic parameters and subsequently conducted a statistical analysis to assess their correlations with relevant conventional radiographic parameters. Results: In the sagittal plane, we identified significant correlations between photographic and radiographic parameters measuring trunk tilt angles. In the coronal plane, significant correlations were found between photographic parameters measuring shoulder height and trunk tilt and corresponding radiographic measurements. Conclusions: The results suggest that pose estimation, achievable with common mobile devices, offers potential for AIS screening, early detection, and continuous posture monitoring, effectively mitigating the need for X-ray radiation exposure. Level of Evidence: 3.

Research has demonstrated the important role of co-teacher communication and planning, but relatively little is understood about co-teacher interactions during the act of teaching itself and how these interactions relate to educators' positionings and ongoing identity development. This paper presents a case study of interaction between two co-facilitators of a team of Japanese youth during a week-long, synchronous, online workshop on human-centred design. One co-facilitator had several years of experience, and the other was a first-timer. Using positioning theory and discourse analysis, we show that the co-facilitators developed a relatively stable pattern of instructional authority delegation, or the social order that guides who has rights and responsibilities over which forms of instructional decision-making. We describe the delegation between the co-teachers in this study as involving 'instructional content authority' and 'instructional language authority', established through interactions of positioning early in the workshop. Then, we examine an interview activity later in the workshop that seemed to disrupt the established pattern. This work extends research on co-teacher communication and teacher learning to understand co-teacher interactions during live teaching, with potential implications for co-teacher preparation and the learning of less experienced co-teachers.

Background: Oral health issues have received significant attention from most global health agencies, which have integrated these issues into their noncommunicable disease, sustainable development, and universal health coverage objectives. Methods: This paper provides an update on the progress made in the last 2 decades and aims to highlight some of the challenges faced by the oral health care system in Kuwait. Results: Despite the nation's rising expenditure on oral health care, the prevalence of oral diseases remains high in Kuwait. The lack of reliable data on periodontitis and edentulism limits the ability of researchers to comment on the trends of these conditions. This emphasises the critical need for a nationwide household-level oral health survey in both pediatric and adult populations that would provide valuable information on the oral health status of these populations. Conclusion: In the future, Kuwait must invest more in oral disease prevention programs, especially among children and the high-risk communities of the population.

High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of existing LHC experiments. The proposed Forward Physics Facility (FPF), to be located several hundred meters from the ATLAS interaction point and shielded by concrete and rock, will host a suite of experiments to probe standard model (SM) processes and search for physics beyond the standard model (BSM). In this report, we review the status of the civil engineering plans and the experiments to explore the diverse physics signals that can be uniquely probed in the forward region. FPF experiments will be sensitive to a broad range of BSM physics through searches for new particle scattering or decay signatures and deviations from SM expectations in high statistics analyses with TeV neutrinos in this low-background environment. High statistics neutrino detection will also provide valuable data for fundamental topics in perturbative and non-perturbative QCD and in weak interactions. Experiments at the FPF will enable synergies between forward particle production at the LHC and astroparticle physics to be exploited. We report here on these physics topics, on infrastructure, detector, and simulation studies, and on future directions to realize the FPF's physics potential.

Developing electrochemical energy storage and conversion systems, such as capacitors, batteries, and fuel cells is crucial to address rapidly growing global energy demands and environmental concerns for a sustainable society. Significant efforts have been devoted to the structural design and engineering of various electrode materials to improve economic applicability and electrochemical performance. The yolk-shell structures represent a special kind of core-shell morphologies, which show great application potential in energy storage, controlled delivery, adsorption, nanoreactors, sensing, and catalysis. Their controllable void spaces may facilitate the exposure of more ative sites for redox reactions and enhance selective adsorption. Based on different nanoarchitectonic designs and fabrication techniques, the yolk-shell structures with controllable structural nanofeatures and the homo- or hetero-compositions provide multiple synergistic effects to promote reactions on the electrode/electrolyte interfaces. This review is focused on the key structural features of yolk-shell architectures, highlighting the recent advancements in their fabrication with adjustable space and mono- or multi-metallic composites. The effects of tailorable structure and functionality of yolk-shell nanostructures on various electrochemical processes are also summarized.

The spread of COVID-19 has drastically increased the number of people wearing masks in public areas and the opportunities to evaluate others’ faces based on limited information. This study investigates the cognitive bias in judging the attractiveness of faces partially hidden by sanitary masks. Experiment 1 revealed that men rated women's faces as more attractive when wearing masks, specifically in the context of rating women as romantic partners; however, this mask bias was absent when men rated women as friends. On the other hand, women did not show the mask bias irrespective of the assumed social relationship. Experiment 2 demonstrated that the mask bias among elderly men was less affected by the assumed social relationship (or the possibility of reproduction), compared to young men, though they showed the bias itself. These results suggest that the cognitive strategies related to reproduction underlie the attractiveness judgment of the partial faces.

From the inception of artificial intelligence (AI) in optical coherence tomography (OCT) for glaucoma diagnosis, the emphasis has always been on models focusing on visual data. The visual signals are extrapolated from the optic disc and retinal nerve fibre layer (RNFL) region and are processed visually. This manuscript introduces a novel bimodal AI model that combines visual data from OCT with numerical metrics such as RNFL thickness, vCDR, rim area, and cup volume. Furthermore, our unique model utilises an algorithm that goes one step further than existing models in the literature by providing multi-classification (normal vs mild/moderate vs severe) as opposed to binary classification.

The purpose of this activity is to provide insight and increase teacher knowledge at MI Al-Ittihad about making Algameta media, how to make QR-Code online, and the implementation of teaching aids with digital literacy. The service team uses the Participatory Action Research method in providing participatory training which makes educators as objects to be able to use digital media in the form of QR-Code. The service team participatively provides training at MI Al-Ittihad and involves educators to encourage changes in the teaching and learning process towards a creative, innovative and fun direction. Based on the results of the pretest and posttest that have been carried out, it can be seen that the service is running successfully. The results achieved from this activity are in the form of increased teacher creativity in innovating learning on teaching aids implemented with digital media, increasing teacher ability to make Algameta assisted by QR-Code digital media and increasing teacher digital literacy. This is evidenced by the Paired Sample Test which is known that the Sig. (2-tailed) of 0.021

Hiroyuki Ohbayashi, Mitsue Ariga, Kunihiro Ohta, Sahori Kudo, Osamu Furuta, Akinori Yamamoto Medical Corporation, Syureikai, Tohno Chuo Clinic, Mizunami City, Gifu, JapanCorrespondence: Hiroyuki Ohbayashi, Medical Corporation, Syureikai, Tohno Chuo Clinic, 1-14-1, Matsugase Cho, Mizunami City, Gifu, 509-6134, Japan, Tel +81-572-67-1118, Fax +81-572-67-2277, Email ohbayasi@nn.iij4u.or.jp; aims_reserve@yahoo.co.jpPurpose: To present the preliminarily findings regarding the effects of a herbal medicine, Ninjin’yoeito, on comorbid frailty and sarcopenia in patients with chronic obstructive pulmonary disease (COPD).Patients and Methods: Patients with COPD (GOLD II or higher) and fatigue were randomly assigned to Group A (n = 28; no medication for 12 weeks, followed by 12-week administration) or B (n= 25; 24-week continuous administration). Visual analog scale (VAS) symptoms of fatigue, the COPD assessment test (CAT), and the modified Medical Research Council (mMRC) Dyspnea Scale were examined. Physical indices such asknee extension leg strength and walking speed, skeletal muscle mass index (SMI), and respiratory function test were also measured.Results: VAS fatigue scales in Group B significantly improved after 4, 8, and 12 weeks compared to those in Group A (each p< 0.001, respectively). Right and left knee extension leg strength in Group B significantly improved after 12 weeks compared to that in Group A (p=0.042 and p=0.037, respectively). The 1-s walking speed for continued to increase significantly over 24 weeks in Group B (p=0.016, p< 0.001, p< 0.001, p=0.004, p< 0.001, and p< 0.001 after 4, 8, 12, 16, 20, and 24 weeks, respectively); it also significantly increased after the administration of Ninjin’yoeito in Group A. In Group B, the SMI significantly increased at 12 weeks in patients with sarcopenia (p=0.025). The CAT scores in Group B significantly improved after 12 weeks compared to those in Group A (p=0.006). The mMRC scores in Group B also significantly improved after 8 and 12 weeks compared to those in Group A (p= 0.045 and p < 0.001, respectively). The changes in %FEV1.0 in Group B were significantly improved at 12 and 24 weeks (p=0.039 and p=0.036, respectively).Conclusion: Overall, Ninjin’yoeito significantly improved patients’ quality of life, physical activity, muscle mass, and possibly lung function, suggesting that Ninjin’yoeito may improve frailty and sarcopenia in patients with COPD.Keywords: clinical study, frailty, Ninjin’yoeito, sarcopenia, therapeutic effect

The crossbreed originated from male native chicken x female commercial layers, currently in Indonesia called a Super Native Chicken (Ayam Kampung Super). This study aimed to evaluate the ability of a selected local KUB (Ayam Kampung Unggul Balitbangtan) rooster to cross female ISA Brown chickens to produce Indonesian super native chickens. In comparison, the ISA hen was crossed with an unselected local chicken of bangkok descent (Ayam Kampung Turunan Bangkok, KTB) rooster, and the same hen strain was crossed with a Rhode Island Red (RIR) rooster. The treatment was crossbreeding (CB): CB1= KUB x ISA, CB2= KTB x ISA, and CB3= RIR x ISA. The results of the study showed that there were no significant (P>0.05) effects on fertility, hatchability, embryonic mortality, or chick abnormalities, but KUB x ISA resulted in significantly greater (P

Batuhampar merupakan salah satu Nagari yang ada di Kecamatan Akabiluru, Kabupaten 50 Kota, Provinsi Sumatera Barat. Hasil pertanian yang cukup banyak di Kenagarian Batuhampar adalah singkong dan padi. Selama ini limbah singkong dan padi langsung dibuang atau dibakar. Pembakaran limbah dapat menyebabkan polusi udara, sementara pembuangan limbah secara sembarangan dapat mencemari air tanah dan menciptakan masalah sanitasi. Selain itu, limbah ini juga dapat menjadi sumber penyakit dan merugikan kesehatan masyarakat setempat. Oleh karena itu kegiatan pemanfaatan limbah sekam padi dan kulit singkong menjadi biobriket merupakan solusi untuk mengurangi limbah tersebut. Tujuan kegiatan ini adalah pemanfaatan limbah sekam padi dan kulit singkong menjadi biobriket Di Kelompok Tani Nagari Batuhampar Kabupaten 50 Kota. Kegiatan ini dilakukan dengan beberapa metode, seperti survey lapangan, pembuatan biobriket, dan sosialisai pemanfaatan limbah sekam padi dan kulit singkong kepada para kelompok tani. Kegiatan ini telah terlaksana dari tanggal 24 Juli – 10 Agustus 2023. Hasil evaluasi akhir sosialisasi menunjukkan bahwa selama kegiatan ini berlangsung, kemauan dan semangat para peserta untuk mengikuti dan menyimak cukup tinggi. Hal ini teramati dari para peserta yang melontarkan pertanyaan dan tanggapan selama kegiatan berlangsung. Diharapkan agar kegiatan ini dapat dilanjutkan untuk kelompok tani dengan komoditi hasil pertanian yang berbeda agar limbah-limbah yang dihasilkan dapat dimanfaatkan dengan baik dan dapat meningkatkan perekonomian para petani.

Discontinuation of palliative radiotherapy due to a patient’s declining general condition poses a clinical dilemma for palliative care physicians. This study aimed to investigate the survival duration of patients whose performance status (PS) deteriorated during palliative radiotherapy and inform decisions regarding early treatment discontinuation. We retrospectively analyzed data from patients referred from our institute’s palliative care department who underwent ≥10 fractions of palliative radiotherapy between March 2017 and December 2021. PS was assessed using the Eastern Cooperative Oncology Group (ECOG) scale. Survival duration was calculated from the final day of palliative radiotherapy to death using the Kaplan–Meier method. A total of 35 patients underwent palliative radiotherapy. Seven (20%) experienced deterioration in ECOG PS during treatment. Their median survival duration was significantly shorter at 22 days (95% confidence interval: 1–94 days) compared to 125 days (95% confidence interval: 82–150 days) for the 28 patients whose PS remained stable (p = 0.0007). Deterioration in ECOG PS during palliative radiotherapy signifies a markedly shorter survival duration. Careful assessment of a patient’s condition throughout treatment is crucial, and early discontinuation should be considered if their general health worsens rather than strictly adhering to the initial schedule.

Background: The COVID-19 pandemic has led to instructions and suggestions from governments and experts to maintain social (physical) distance between people to prevent aerosol transmission of the virus, which is now becoming the norm. Thus, we examined whether the pandemic extended the distance between personal belongings. Methods: We recruited 68 university students and instructed them to place their belongings on a long table following another participant (i.e., confederate). We measured the physical distance between the two belongings (i.e., the participant’s and the confederate’s). We collected data between June 10, 2022 and January 23, 2023. Pre-pandemic data was from Ariga (2016). Analysis was completed with one-tailed t-tests. Results: Compared with the pre-pandemic results, via one-tailed t-test, the distance between the two belongings during the pandemic was significantly longer. Our results supported the hypothesis that the psychological framework for processing people’s belongings has dramatically changed during this pandemic. Conclusion: This change may have been driven by social distancing practices or an increase in perceived vulnerability to disease. Our results provide new implications for future public spatial design, in other words, not only the distance between people, but also the distance between their belongings.

The impact of contaminants on Copepod sp. and its molecular response is least explored, despite their abundance and dominance among invertebrates in aquatic environments. In the present investigation, Dioithona rigida, a cyclopoid zooplankton, was treated with selenium nanoparticles (SeNPs) to highlight the associated biochemical changes, and the chronic exposure effects were recorded using transcriptomic analysis. It was found that, SeNPs were acutely toxic with a lethal dose 50% of 140.9 mg/L. The de novo assembled transcriptome of the copepod comprised of 81,814 transcripts, which underwent subsequent annotations to biological processes (23,378), cellular components (21,414), and molecular functions (31,015). Comparison of the expressed transcripts against the treated sample showed that a total of 186 transcript genes were differentially expressed among the D. rigida treatments (control and SeNPs). The significant downregulated genes are coding for DNA repair, DNA-templated DNA replication, DNA integration, oxidoreductase activity and transmembrane transport. Similarly, significant upregulations were observed in protein phosphatase binding and regulation of membrane repolarization. Understanding the impact of SeNPs on copepods is crucial not only for aquatic ecosystem health but also for human health, as these organisms play a key role in marine food webs, ultimately affecting the fish consumed by humans. By elucidating the molecular responses and potential toxicological effects of SeNPs, explored in this provides key insights on risk assessments and regulatory policies, ensuring the safety of seafood and protecting human health from the unintended consequences of nanoparticle pollution.

ABSTRACTThe ever-growing use of nature-derived materials creates exciting opportunities for novel development in various therapeutic biomedical applications. Living cells, serving as the foundation of nanoarchitectonics, exhibit remarkable capabilities that enable the development of bioinspired and biomimetic systems, which will be explored in this review. To understand the foundation of this development, we first revisited the anatomy of cells to explore the characteristics of the building blocks of life that is relevant. Interestingly, animal cells have amazing capabilities due to the inherent functionalities in each specialized cell type. Notably, the versatility of cell membranes allows red blood cells and neutrophils’ membranes to cloak inorganic nanoparticles that would naturally be eliminated by the immune system. This underscores how cell membranes facilitate interactions with the surroundings through recognition, targeting, signalling, exchange, and cargo attachment. The functionality of cell membrane-coated nanoparticles can be tailored and improved by strategically engineering the membrane, selecting from a variety of cell membranes with known distinct inherent properties. On the other hand, plant cells exhibit remarkable capabilities for synthesizing various nanoparticles. They play a role in the synthesis of metal, carbon-based, and polymer nanoparticles, used for applications such as antimicrobials or antioxidants. One of the versatile components in plant cells is found in the photosynthetic system, particularly the thylakoid, and the pigment chlorophyll. While there are challenges in consistently synthesizing these remarkable nanoparticles derived from nature, this exploration begins to unveil the endless possibilities in nanoarchitectonics research.

ABSTRACTA series of porous organic polymers based on a singlet oxygen generating oxoporphyinogen (‘OxP’) has been successfully prepared from a pseudotetrahedral OxP-tetraamine precursor (OxP(4-NH2Bn)4) by its reaction with tetracarboxylic acid dianhydrides under suitable conditions. Of the compounds studied, those containing naphthalene (OxP-N) and perylene (OxP-P) spacers, respectively, have large surface areas (~530 m2 g−1). On the other hand, the derivative with a simple benzene spacer (OxP-B) exhibits the best 1O2 generating capability. Although the starting OxP-tetraamine precursor is a poor 1O2 generator, its incorporation into OxP POPs leads to a significant enhancement of 1O2 productivity, which is largely due to the transformation of NH2 groups to electron-withdrawing diimides. Overall 1O2 production efficacy of OxP-POPs under irradiation by visible light is significantly improved over the common reference material PCN-222. All the materials OxP-B, OxP-N and OxP-P promote oxidation of thioanisole involving conversion of ambient triplet state oxygen to singlet oxygen under visible light irradiation and its reaction with the sulfide. Although the reaction rate of the oxidation promoted by OxP POPs is generally lower than for conventional materials (such as PCN-222) or previously studied OxP derivatives, undesired overoxidation of the substrate to methyl phenyl sulfone is suppressed. For organic sulfides, selectivity of oxidation is especially important for detoxification of mustard gas (bis(2-chloroethyl)sulfide) or similarly toxic compounds since controlled oxidation leads to the low toxicity bis(2-chloroethyl)sulfoxide while overoxidation leads to intoxification (since bis(2-chloroethyl)sulfone presents greater toxicity to humans than the sulfide substrate). Therefore, OxP POPs capable of promoting selective oxidation of sulfides to sulfoxides have excellent potential to be used as mild and selective detoxification agents.

ABSTRACTThe interaction between diverse nanoarchitectured fullerenes and cells is crucial for biomedical applications. Here, we detailed the preparation of hydrophilic self-assembled fullerenes by the liquid-liquid interfacial precipitation (LLIP) method and hydrophilic coating of the materials as a possible vascularization strategy. The interactions of vascular endothelial cells (ECs) with hydrophilic fullerene nanotubes (FNT-P) and hydrophilic fullerene nanowhiskers (FNW-P) were investigated. The average length and diameter of FNT-P were 16 ± 2 μm and 3.4 ± 0.4 μm (i.e. aspect ratios of 4.6), respectively. The average length and diameter of FNW-P were 65 ± 8 μm and 1.2 ± 0.2 μm (i.e. aspect ratios of 53.9), respectively. For two-dimensional (2D) culture after 7 days, the ECs remained viable and proliferated up to ~ 420% and ~ 400% with FNT-P and FNW-P of 50 μg/mL, respectively. Furthermore, an optimized chitosan-based self-healing hydrogel with a modulus of ~400 Pa was developed and used to incorporate self-assembled fullerenes as in vitro three-dimensional (3D) platforms to investigate the impact of FNT-P and FNW-P on ECs within a 3D environment. The addition of FNW-P or FNT-P (50 μg/mL) in the hydrogel system led to proliferation rates of ECs up to ~323% and ~280%, respectively, after 7 days of culture. The ECs in FNW-P hydrogel displayed an elongated shape with aligned morphology, while those in FNT-P hydrogel exhibited a rounded and clustered distribution. Vascular-related gene expressions of ECs were significantly upregulated through interactions with these fullerenes. Thus, the combined use of different nanoarchitectured self-assembled fullerenes and self-healing hydrogels may offer environmental cues influencing EC development in a 3D biomimetic microenvironment, holding promise for advancing vascularization strategy in tissue engineering.

The recognition of the importance of nanostructures is mainly due to the development of nanotechnology. For further developments in materials sciences, a concept that integrates nanotechnology with material chemistry to fabricate functional materials has to be proposed. Nanoarchitectonics will carry out this task. In nanoarchitectonics, we architect functional material systems from nano-units (atoms, molecules, nanomaterials). The methodology is not specific to any particular material or application. It covers a wide range. Therefore, nanoarchitectonics can be thought of as the method for everything in materials science. As typical demonstrations for usages of nanoarchitectonics, this review paper presents our work on nanoarchitectonics for supercapacitors. We divide it into two categories with different approaches. The first is the development of carbon materials as supercapacitor electrode materials from biomass. The second category is preparing carbon materials using structures created by supramolecular assembly of fullerenes such as C60 and C70. By presenting examples using opposite starting materials, a complex natural material, and an ultimately simple molecule, we will demonstrate the versatility and breadth of possibilities of this approach.

ABSTRACT Background: Acute pancreatitis following surgical or endoscopic procedures on the pancreas can compromise the outcome and lead to severe complications and even death. The aim of this study was to determine whether prolonged fasting affects the severity of acute pancreatitis (AP). Methods: Male mice were divided into 4 groups: Group CF (n=5) control animals that fasted for 24 hours; Group CNF (n=5) control animals that did not fast; Group APF (n=7) that fasted for 24 hours and underwent induction of acute pancreatitis (AP) and Group APNF (n=7) that did not fast and underwent AP. Eight hours after AP blood was collected for evaluation of cytokines: IL-1β, IL-6, IL-10, TNF-α and MCP-1. Liver tissue was collected for determination of Malondialdehyde, pancreatic tissue for determination of enzyme content and lung tissue for determination of myeloperoxidase. Results: Significant increase in pancreatic amylase content was observed in group CF and increased serum levels of IL -6, Il-10 and MCP-1 were in group APF. Liver malondialdehyde was also increased in APF animals. APF group showed much more necrosis of the pancreatic acinar cells. Conclusion: In the present study, we observed an increase in the severity of acute pancreatitis with prolonged fasting in a severe acute pancreatitis model. These results suggest that in clinical practice, the preoperative fasting time should be shortened before pancreatic procedures.

The weak equivalence principle states that the motion of a body in a gravitational field is independent of its structure or composition. This postulate of general relativity has been tested to very high precision with ordinary matter, but no relevant experimental verification with antimatter has ever been carried out. The AEGIS experiment will measure the gravitational acceleration of antihydrogen to ultimately 1% precision. For this purpose, a pulsed horizontal antihydrogen beam with a velocity of several 100 m s−1 will be produced. Its vertical deflection due to gravity will be detected by a setup consisting of material gratings coupled with a position-sensitive detector, operating as a moiré deflectometer or an atom interferometer. The AEGIS experiment is installed at CERN’s Antiproton Decelerator, currently the only facility in the world which produces copious amounts of low-energy antiprotons. The construction of the setup has been going on since 2010 and is nearing completion. A proof-of-principle experiment with antiprotons has demonstrated that the deflection of antiparticles by a few μm due to an external force can be detected. Technological and scientific development pertaining to specific challenges of the experiment, such as antihydrogen formation by positronium charge exchange or the position-sensitive detection of antihydrogen annihilations, is ongoing.