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3. An evidence review project for food with function claims ~Challenges of the Japan society for vascular failure for the promotion of adequate evidences for food with function claims

Author

Matsumoto, Chisa, Tomiyama, Hirofumi, Takahashi, Osamu, Maruhashi, Tatsuya, Matsuzawa, Yasushi, Masaki, Nobuyuki, Muraki, Isao, Yano, Yuichiro, Sugimoto, Tadafumi, Kabutoya, Tomoyuki, Sawami, Kosuke, Tanaka, Atsushi, Arima, Hisatomi, Sata, Masataka, and Node, Koichi

Published
2024
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5. Prologue: Special Spotlight Issue on Japan

Author

Yano, Yuichiro, Nishiyama, Akira, Ishimitsu, Toshihiko, Kashihara, Naoki, Rakugi, Hiromi, Tamura, Kouichi, Itoh, Hiroshi, Tsuchihashi, Takuya, Sakima, Atsushi, Arima, Hisatomi, Matayoshi, Tetsutaro, Imai, Yutaka, Miura, Katsuyuki, Hisamatsu, Takashi, Asayama, Kei, Ohkubo, Takayoshi, Node, Kouihci, and Kario, Kazuomi

Published
2024
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6. Influence of Time to Achieve Target Systolic Blood Pressure on Outcome After Intracerebral Hemorrhage: The Blood Pressure in Acute Stroke Collaboration

Author

Wang, Xia, Yang, Jie, Moullaali, Tom J., Sandset, Else Charlotte, Woodhouse, Lisa J., Law, Zhe Kang, Arima, Hisatomi, Butcher, Kenneth S., Delcourt, Candice, Edwards, Leon, Gupta, Salil, Jiang, Wen, Koch, Sebastian, Potter, John, Qureshi, Adnan I., Robinson, Thompson G., Al-Shahi Salman, Rustam, Saver, Jeffrey L., Sprigg, Nikola, Wardlaw, Joanna, Anderson, Craig S., Sakamoto, Yuki, Bath, Philip M., and Chalmers, John

Published
2024
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7. Update on the INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): progress and baseline features in 2053 participants

Author

Chen, Chen, Lin, Yapeng, Liu, Feifeng, Chen, Xiaoying, Billot, Laurent, Li, Qiang, Guo, Yiija, Liu, Hueiming, Si, Lei, Ouyang, Menglu, Zhang, Chunfang, Arima, Hisatomi, Bath, Philip M., Ford, Gary A., Robinson, Thompson, Sandset, Else Charlotte, Saver, Jeffrey L., Sprigg, Nikola, van der Worp, H. Bart, Liu, Gang, Song, Lili, Yang, Jie, Li, Gang, and Anderson, Craig S.

Published
2023
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9. Serum triglyceride levels and incidence of hypertension in a general Japanese population: ISSA-CKD study

Author

Ishida, Shintaro, Kondo, Seiji, Funakoshi, Shunsuke, Abe, Makiko, Satoh, Atsushi, Kawazoe, Miki, Maeda, Toshiki, Yoshimura, Chikara, Nishida, Yoshihiro, Tada, Kazuhiro, Takahashi, Koji, Ito, Kenji, Yasuno, Tetsuhiko, Kawanami, Daiji, Miura, Shin-ichiro, Kodama, Shohta, Saku, Keijiro, Mukobara, Shigeaki, Masutani, Kosuke, and Arima, Hisatomi

Published
2023
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11. Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data

Author

Moullaali, Tom J, Wang, Xia, Sandset, Else Charlotte, Woodhouse, Lisa J, Law, Zhe Kang, Arima, Hisatomi, Butcher, Kenneth S, Chalmers, John, Delcourt, Candice, Edwards, Leon, Gupta, Salil, Jiang, Wen, Koch, Sebastian, Potter, John, Qureshi, Adnan I, Robinson, Thompson G, Al-Shahi Salman, Rustam, Saver, Jeffrey L, Sprigg, Nikola, Wardlaw, Joanna M, Anderson, Craig S, and Bath, Philip M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Good Health and Well Being, Adult, Aged, Antihypertensive Agents, Blood Pressure, Cerebral Hemorrhage, Female, Humans, Hypertension, Male, Middle Aged, Randomized Controlled Trials as Topic, Treatment Outcome, stroke, meta-analysis, Blood Pressure in Acute Stroke (BASC) Investigators, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences, Neurosciences
Abstract

ObjectiveTo summarise evidence of the effects of blood pressure (BP)-lowering interventions after acute spontaneous intracerebral haemorrhage (ICH).MethodsA prespecified systematic review of the Cochrane Central Register of Controlled Trials, EMBASE and MEDLINE databases from inception to 23 June 2020 to identify randomised controlled trials that compared active BP-lowering agents versus placebo or intensive versus guideline BP-lowering targets for adults 6 mL) and proportional (>33%) haematoma growth at 24 hours. Meta-analysis used a one-stage approach, adjusted using generalised linear mixed models with prespecified covariables and trial as a random effect.ResultsOf 7094 studies identified, 50 trials involving 11 494 patients were eligible and 16 (32.0%) shared patient-level data from 6221 (54.1%) patients (mean age 64.2 [SD 12.9], 2266 [36.4%] females) with a median time from symptom onset to randomisation of 3.8 hours (IQR 2.6-5.3). Active/intensive BP-lowering interventions had no effect on the primary outcome compared with placebo/guideline treatment (adjusted OR for unfavourable shift in modified Rankin scale scores: 0.97, 95% CI 0.88 to 1.06; p=0.50), but there was significant heterogeneity by strategy (pinteraction=0.031) and agent (pinteraction6 ml, adjusted OR 0.75, 95%CI 0.60 to 0.92; p=0.0077) and relative (≥33%, adjusted OR 0.82, 95%CI 0.68 to 0.99; p=0.034) haematoma growth.InterpretationOverall, a broad range of interventions to lower BP within 7 days of ICH onset had no overall benefit on functional recovery, despite reducing bleeding. The treatment effect appeared to vary according to strategy and agent.Prospero registration numberCRD42019141136.

Published
2022

16. Relationship between abdominal circumference and the incidence of hyperuricemia in the general Japanese population

Author

Kawano, Kazumi, Ueno, Tamami, Maeda, Toshiki, Nohara, Chihiro, Maki, Kaori, Iwanaga, Kazuyo, Morinaga, Akiko, Funakoshi, Shunsuke, Abe, Makiko, Satoh, Atsushi, Kawazoe, Miki, Yoshimura, Chikara, Takahashi, Koji, Tada, Kazuhiro, Ito, Kenji, Yasuno, Tetsuhiko, Mukobara, Shigeaki, Kawanami, Daiji, Masutani, Kosuke, and Arima, Hisatomi

Published
2024
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17. Skipping Breakfast and Progression of Chronic Kidney Disease in the General Japanese Population: the Iki City Epidemiological Study of Atherosclerosis and Chronic Kidney Disease (ISSA-CKD)

Author

Takahashi, Koji, primary, Inoue, Yori, additional, Tada, Kazuhiro, additional, Hiyamuta, Hiroto, additional, Ito, Kenji, additional, Yasuno, Tetsuhiko, additional, Sakaguchi, Takashi, additional, Katsuki, Shiori, additional, Shinohara, Yukiko, additional, Nohara, Chihiro, additional, Okutsu, Shota, additional, Abe, Makiko, additional, Satoh, Atsushi, additional, Kawazoe, Miki, additional, Maeda, Toshiki, additional, Yoshimura, Chikara, additional, Mukoubara, Shigeaki, additional, Arima, Hisatomi, additional, and Masutani, Kosuke, additional

Published
2024
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18. Alcohol consumption and the incidence of hyperuricemia in Japanese men and women: the ISSA-CKD study

Author

Ueno, Tamami, primary, Kawano, Kazumi, additional, Nohara, Chihiro, additional, Maki, Kaori, additional, Iwanaga, Kazuyo, additional, Morinaga, Akiko, additional, Funakoshi, Shunsuke, additional, Abe, Makiko, additional, Satoh, Atsushi, additional, Kawazoe, Miki, additional, Maeda, Toshiki, additional, Yoshimura, Chikara, additional, Takahashi, Koji, additional, Tada, Kazuhiro, additional, Ito, Kenji, additional, Yasuno, Tetsuhiko, additional, Mukobara, Shigeaki, additional, Kawanami, Daiji, additional, Masutani, Kosuke, additional, and Arima, Hisatomi, additional

Published
2024
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20. Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.

Author

Peters, Ruth, Yasar, Sevil, Anderson, Craig S, Andrews, Shea, Antikainen, Riitta, Arima, Hisatomi, Beckett, Nigel, Beer, Joanne C, Bertens, Anne Suzanne, Booth, Andrew, van Boxtel, Martin, Brayne, Carol, Brodaty, Henry, Carlson, Michelle C, Chalmers, John, Corrada, Maria, DeKosky, Steven, Derby, Carol, Dixon, Roger A, Forette, Françoise, Ganguli, Mary, van Gool, Willem A, Guaita, Antonio, Hever, Ann M, Hogan, David B, Jagger, Carol, Katz, Mindy, Kawas, Claudia, Kehoe, Patrick G, Keinanen-Kiukaanniemi, Sirkka, Kenny, Rose Ann, Köhler, Sebastian, Kunutsor, Setor K, Laukkanen, Jari, Maxwell, Colleen, McFall, G Peggy, van Middelaar, Tessa, Moll van Charante, Eric P, Ng, Tze-Pin, Peters, Jean, Rawtaer, Iris, Richard, Edo, Rockwood, Kenneth, Rydén, Lina, Sachdev, Perminder S, Skoog, Ingmar, Skoog, Johan, Staessen, Jan A, Stephan, Blossom CM, Sebert, Sylvain, Thijs, Lutgarde, Trompet, Stella, Tully, Phillip J, Tzourio, Christophe, Vaccaro, Roberta, Vaaramo, Eeva, Walsh, Erin, Warwick, Jane, and Anstey, Kaarin J

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Neurodegenerative, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Trials and Supportive Activities, Aging, Brain Disorders, Clinical Research, Cardiovascular, Dementia, Alzheimer's Disease, Prevention, Neurological, Aged, Aged, 80 and over, Antihypertensive Agents, Cognitive Dysfunction, Female, Humans, Hypertension, Male, Middle Aged, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveHigh blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data.MethodsTo identify suitable studies, MEDLINE, Embase, and PsycINFO and preexisting study consortia were searched from inception to December 2017. Authors of prospective longitudinal human studies or trials of antihypertensives were contacted for data sharing and collaboration. Outcome measures were incident dementia or incident cognitive decline (classified using the reliable change index method). Data were separated into mid and late-life (>65 years) and each antihypertensive class was compared to no treatment and to treatment with other antihypertensives. Meta-analysis was used to synthesize data.ResultsOver 50,000 participants from 27 studies were included. Among those aged >65 years, with the exception of diuretics, we found no relationship by class with incident cognitive decline or dementia. Diuretic use was suggestive of benefit in some analyses but results were not consistent across follow-up time, comparator group, and outcome. Limited data precluded meaningful analyses in those ≤65 years of age.ConclusionOur findings, drawn from the current evidence base, support clinical freedom in the selection of antihypertensive regimens to achieve blood pressure goals.Clinical trials registrationThe review was registered with the international prospective register of systematic reviews (PROSPERO), registration number CRD42016045454.

Published
2020

22. Safety and Potential Effect of Intrauterine Infusion of Autologous Adipose Tissue-Derived Regenerative Cells in Patients With Implantation Failure: A Pilot Study

Author

Yotsumoto, Fusanori, primary, Yoshikawa, Kenichi, additional, Hirakawa, Toyofumi, additional, Urushiyama, Daichi, additional, Kiyoshima, Chihiro, additional, Arima, Hisatomi, additional, Kodama, Shohta, additional, Nishikawa, Hiroaki, additional, Yasunaga, Shin’ichiro, additional, and Miyamoto, Shingo, additional

Published
2024
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23. Risk of recurrent stroke and dementia following acute stroke by changes in kidney function: results from the Perindopril Protection Against Recurrent Stroke Study

Author

Maeda, Toshiki, primary, Woodward, Mark, additional, Jun, Min, additional, Sakamoto, Yuki, additional, Chen, Xiaoying, additional, Matsushita, Kunihiro, additional, Mancia, Guiseppe, additional, Arima, Hisatomi, additional, Anderson, Craig S., additional, Chalmers, John, additional, and Harris, Katie, additional

Published
2024
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26. Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium

Author

Inker, Lesley A, Grams, Morgan E, Levey, Andrew S, Coresh, Josef, Cirillo, Massimo, Collins, John F, Gansevoort, Ron T, Gutierrez, Orlando M, Hamano, Takayuki, Heine, Gunnar H, Ishikawa, Shizukiyo, Jee, Sun Ha, Kronenberg, Florian, Landray, Martin J, Miura, Katsuyuki, Nadkarni, Girish N, Peralta, Carmen A, Rothenbacher, Dietrich, Schaeffner, Elke, Sedaghat, Sanaz, Shlipak, Michael G, Zhang, Luxia, van Zuilen, Arjan D, Hallan, Stein I, Kovesdy, Csaba P, Woodward, Mark, Levin, Adeera, Astor, Brad, Appel, Larry, Greene, Tom, Chen, Teresa, Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Yatsuya, Hiroshi, Tamakoshi, Koji, Li, Yuanying, Hirakawa, Yoshihisa, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Polkinghorne, Kevan, Chadban, Steven, Atkins, Robert, Djurdjev, Ognjenka, Liu, Lisheng, Zhao, Minghui, Wang, Fang, Wang, Jinwei, Ebert, Natalie, Martus, Peter, Tang, Mila, Heine, Gunnar, Emrich, Insa, Seiler, Sarah, Zawada, Adam, Nally, Joseph, Navaneethan, Sankar, Schold, Jesse, Shlipak, Michael, Sarnak, Mark, Katz, Ronit, Hiramoto, Jade, Iso, Hiroyasu, Yamagishi, Kazumasa, Umesawa, Mitsumasa, Muraki, Isao, Fukagawa, Masafumi, Maruyama, Shoichi, Hasegawa, Takeshi, Fujii, Naohiko, Wheeler, David, Emberson, John, Townend, John, Landray, Martin, Brenner, Hermann, Schöttker, Ben, Saum, Kai-Uwe, Fox, Caroline, Hwang, Shih-Jen, Köttgen, Anna, Schneider, Markus P, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, and Chang, Alex R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Women's Health, Renal and urogenital, Good Health and Well Being, Aged, Albuminuria, Blood Chemical Analysis, Creatinine, Cross-Sectional Studies, Disease Progression, Female, Global Health, Glomerular Filtration Rate, Humans, Hypertension, Renal, Internationality, Kidney Function Tests, Male, Middle Aged, Predictive Value of Tests, Renal Insufficiency, Chronic, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Urinalysis, CKD Prognosis Consortium, CKD stage, Chronic kidney disease, albuminuria, anemia, diabetes, glomerular filtration rate, hematocrit, hemoglobin, hyperparathyroidism, hypertension, individual-level meta-analysis, kidney function, laboratory abnormality, laboratory tests, meta-analysis, serum bicarbonate, serum calcium, serum intact parathyroid hormone, serum phosphorus, serum potassium, staging system, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale & objectiveChronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.Study designCross-sectional individual participant-level analyses in a global consortium.Setting & study populations17 CKD and 38 general population and high-risk cohorts.Selection criteria for studiesCohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension.Data extractionData were obtained and analyzed between July 2015 and January 2018.Analytical approachWe modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses.ResultsThe CKD cohorts (n=254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n=1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59mL/min/1.73m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30mg/g).LimitationsVariations in study era, health care delivery system, typical diet, and laboratory assays.ConclusionsLower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

Published
2019

27. Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium

Author

Chang, Alex R, Grams, Morgan E, Ballew, Shoshana H, Bilo, Henk, Correa, Adolfo, Evans, Marie, Gutierrez, Orlando M, Hosseinpanah, Farhad, Iseki, Kunitoshi, Kenealy, Timothy, Klein, Barbara, Kronenberg, Florian, Lee, Brian J, Li, Yuanying, Miura, Katsuyuki, Navaneethan, Sankar D, Roderick, Paul J, Valdivielso, Jose M, Visseren, Frank LJ, Zhang, Luxia, Gansevoort, Ron T, Hallan, Stein I, Levey, Andrew S, Matsushita, Kunihiro, Shalev, Varda, Woodward, Mark, Astor, Brad, Appel, Larry, Greene, Tom, Chen, Teresa, Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Yatsuya, Hiroshi, Tamakoshi, Koji, Hirakawa, Yoshihisa, Coresh, Josef, Sang, Yingying, Polkinghorne, Kevan, Chadban, Steven, Atkins, Robert, Levin, Adeera, Djurdjev, Ognjenka, Klein, Ron, Lee, Kristine, Liu, Lisheng, Zhao, Minghui, Wang, Fang, Wang, Jinwei, Tang, Mila, Heine, Gunnar, Emrich, Insa, Zawada, Adam, Bauer, Lucie, Nally, Joseph, Schold, Jesse, Shlipak, Michael, Sarnak, Mark, Katz, Ronit, Hiramoto, Jade, Iso, Hiroyasu, Yamagishi, Kazumasa, Umesawa, Mitsumasa, Muraki, Isao, Fukagawa, Masafumi, Maruyama, Shoichi, Hamano, Takayuki, Hasegawa, Takeshi, Fujii, Naohiko, Jafar, Tazeen, Hatcher, Juanita, Poulter, Neil, Chaturvedi, Nish, Wheeler, David, Emberson, John, Townend, John, Landray, Martin, Brenner, Hermann, Schöttker, Ben, Saum, Kai-Uwe, Rothenbacher, Dietrich, Fox, Caroline, Hwang, Shih-Jen, Köttgen, Anna, Schneider, Markus P, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, Ito, Sadayoshi, Miyazaki, Mariko, Nakayama, Masaaki, Yamada, Cirillo, Massimo, Romundstad, Solfrid, Øvrehus, Marius, Langlo, Knut Asbjørn, Irie, Fujiko, Sairenchi, Toshimi, Rebholz, Casey M, and Young, Bessie

Subjects
Epidemiology, Health Sciences, Obesity, Kidney Disease, Cardiovascular, Aging, Prevention, Nutrition, Clinical Research, Good Health and Well Being, Adiposity, Adult, Aged, Aged, 80 and over, Body Height, Body Mass Index, Cohort Studies, Female, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic, Male, Middle Aged, Mortality, Risk Factors, Waist Circumference, CKD Prognosis Consortium, Clinical Sciences, Public Health and Health Services, General & Internal Medicine, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

ObjectiveTo evaluate the associations between adiposity measures (body mass index, waist circumference, and waist-to-height ratio) with decline in glomerular filtration rate (GFR) and with all cause mortality.DesignIndividual participant data meta-analysis.SettingCohorts from 40 countries with data collected between 1970 and 2017.ParticipantsAdults in 39 general population cohorts (n=5 459 014), of which 21 (n=594 496) had data on waist circumference; six cohorts with high cardiovascular risk (n=84 417); and 18 cohorts with chronic kidney disease (n=91 607).Main outcome measuresGFR decline (estimated GFR decline ≥40%, initiation of kidney replacement therapy or estimated GFR

Published
2019

28. Comparative evaluation of standard maintenance-dose clopidogrel versus low-dose prasugrel in patients with stable coronary artery disease after percutaneous coronary intervention

Author

Akimaru, Kaoru, Iwabuchi, Masashi, Ishida, Akio, Uehara, Hiroki, Higa, Namio, Kakazu, Masanori, Wake, Minoru, Maeda, Taketoshi, Maeda, Toshiki, Arima, Hisatomi, Ohya, Yusuke, Tokashiki, Shinta, Wakugawa, Hayashi, Miyagi, Ayane, Shiohira, Shinya, Zaima, Satoshi, Shiohira, Tomohiro, Toma, Yuichirou, and Ikemiyagi, Hidekazu

Published
2022
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29. Metabolic changes induced by dapagliflozin, an SGLT2 inhibitor, in Japanese patients with type 2 diabetes treated by oral anti-diabetic agents: A randomized, clinical trial

Author

Horibe, Kayo, Morino, Katsutaro, Miyazawa, Itsuko, Tanaka-Mizuno, Sachiko, Kondo, Keiko, Sato, Daisuke, Ohashi, Natsuko, Ida, Shogo, Yanagimachi, Tsuyoshi, Yoshimura, Masahiro, Itoh, Ryuta, Murata, Kiyoshi, Miura, Katsuyuki, Arima, Hisatomi, Fujita, Yukihiro, Ugi, Satoshi, and Maegawa, Hiroshi

Published
2022
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32. Eating before bed and new-onset hypertension in a Japanese population: the Iki city epidemiological study of atherosclerosis and chronic kidney disease

Author

Funakoshi, Shunsuke, Satoh, Atsushi, Maeda, Toshiki, Kawazoe, Miki, Ishida, Shintaro, Yoshimura, Chikara, Tada, Kazuhiro, Takahashi, Koji, Ito, Kenji, Yasuno, Tetsuhiko, Nakashima, Hitoshi, Mukoubara, Shigeaki, Fujii, Hideyuki, Okutsu, Shota, Kawanami, Daiji, Nabeshima, Shigeki, Kondo, Seiji, Fujita, Masaki, Masutani, Kosuke, and Arima, Hisatomi

Published
2021
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34. Comparison of Body Mass Index and Waist Circumference in the Prediction of Diabetes: A Retrospective Longitudinal Study

Author

Abe, Makiko, Fujii, Hideyuki, Funakoshi, Shunsuke, Satoh, Atsushi, Kawazoe, Miki, Maeda, Toshiki, Tada, Kazuhiro, Yokota, Soichiro, Yamanokuchi, Toshitaka, Yoshimura, Chikara, Mimata, Ryosuke, Takahashi, Koji, Ito, Kenji, Yasuno, Tetsuhiko, Kuga, Takeshi, Mukoubara, Shigeki, Akiyoshi, Kozaburo, Kawanami, Daiji, Masutani, Kosuke, and Arima, Hisatomi

Published
2021
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35. Serum potassium and adverse outcomes across the range of kidney function: a CKD Prognosis Consortium meta-analysis.

Author

Kovesdy, Csaba P, Matsushita, Kunihiro, Sang, Yingying, Brunskill, Nigel J, Carrero, Juan J, Chodick, Gabriel, Hasegawa, Takeshi, Heerspink, Hiddo L, Hirayama, Atsushi, Landman, Gijs WD, Levin, Adeera, Nitsch, Dorothea, Wheeler, David C, Coresh, Josef, Hallan, Stein I, Shalev, Varda, Grams, Morgan E, Astor, Brad, Appel, Larry, Greene, Tom, Chen, Teresa, Chalmers, John, Woodward, Mark, Arima, Hisatomi, Perkovic, Vlado, Djurdjev, Ognjenka, Zhang, Luxia, Liu, Lisheng, Zhao, Minghui, Wang, Fang, Wang, Jinwei, Tang, Mila, Iso, Hiroyasu, Yamagishi, Kazumasa, Umesawa, Mitsumasa, Muraki, Isao, Fukagawa, Masafumi, Maruyama, Shoichi, Hamano, Takayuki, Fujii, Naohiko, Wheeler, David, Emberson, John, Townend, John, Landray, Martin, Green, Jamie, Kirchner, H Lester, Chang, Alex R, Cirillo, Massimo, Jee, Sun Ha, Kimm, Heejin, Mok, Yejin, Wetzels, Jack FM, Blankestijn, Peter J, van Zuilen, Arjan D, Bots, M, Sarnak, Mark, Inker, Lesley, Roderick, Paul, Fletcher, Astrid, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen B, Nadukuru, Rajiv, Brunskill, Nigel, Major, Rupert, Shepherd, David, Medcalf, James, Gansevoort, Ron T, Bakker, Stephan JL, Heerspink, Hiddo J Lambers, Jassal, Simerjot K, Bergstrom, Jaclyn, Ix, Joachim H, Barrett-Connor, Elizabeth, Kovesdy, Csaba, Kalantar-Zadeh, Kamyar, de Zeeuw, Dick, Brenner, Barry, Gasparini, Alessandro, Elinder, Carl-Gustaf, Barany, Peter, Evans, Marie, Segelmark, Mårten, Stendahl, Maria, Schön, Staffan, Tangri, Navdeep, Sud, Maneesh, Naimark, David, Wen, Chi-Pang, and Tsao, Chwen-Keng

Subjects
Kidney Disease, Prevention, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Renal and urogenital, Cardiovascular, Good Health and Well Being, Adult, Aged, Albuminuria, Cardiovascular Diseases, Cause of Death, Comorbidity, Glomerular Filtration Rate, Humans, Hyperkalemia, Hypokalemia, Kidney Failure, Chronic, Middle Aged, Prognosis, Renal Insufficiency, Chronic, Risk Factors, Potassium, Estimated glomerular filtration rate, End-stage renal disease, Mortality, CKD Prognosis Consortium, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology
Abstract

AimsBoth hypo- and hyperkalaemia can have immediate deleterious physiological effects, and less is known about long-term risks. The objective was to determine the risks of all-cause mortality, cardiovascular mortality, and end-stage renal disease associated with potassium levels across the range of kidney function and evaluate for consistency across cohorts in a global consortium.Methods and resultsWe performed an individual-level data meta-analysis of 27 international cohorts [10 general population, 7 high cardiovascular risk, and 10 chronic kidney disease (CKD)] in the CKD Prognosis Consortium. We used Cox regression followed by random-effects meta-analysis to assess the relationship between baseline potassium and adverse outcomes, adjusted for demographic and clinical characteristics, overall and across strata of estimated glomerular filtration rate (eGFR) and albuminuria. We included 1 217 986 participants followed up for a mean of 6.9 years. The average age was 55 ± 16 years, average eGFR was 83 ± 23 mL/min/1.73 m2, and 17% had moderate- to-severe increased albuminuria levels. The mean baseline potassium was 4.2 ± 0.4 mmol/L. The risk of serum potassium of >5.5 mmol/L was related to lower eGFR and higher albuminuria. The risk relationship between potassium levels and adverse outcomes was U-shaped, with the lowest risk at serum potassium of 4-4.5 mmol/L. Compared with a reference of 4.2 mmol/L, the adjusted hazard ratio for all-cause mortality was 1.22 [95% confidence interval (CI) 1.15-1.29] at 5.5 mmol/L and 1.49 (95% CI 1.26-1.76) at 3.0 mmol/L. Risks were similar by eGFR, albuminuria, renin-angiotensin-aldosterone system inhibitor use, and across cohorts.ConclusionsOutpatient potassium levels both above and below the normal range are consistently associated with adverse outcomes, with similar risk relationships across eGFR and albuminuria.

Published
2018

37. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data

Author

Matsushita, Kunihiro, Ballew, Shoshana H, Coresh, Josef, Arima, Hisatomi, Ärnlöv, Johan, Cirillo, Massimo, Ebert, Natalie, Hiramoto, Jade S, Kimm, Heejin, Shlipak, Michael G, Visseren, Frank LJ, Gansevoort, Ron T, Kovesdy, Csaba P, Shalev, Varda, Woodward, Mark, Kronenberg, Florian, Chalmers, John, Perkovic, Vlado, Grams, Morgan E, Sang, Yingying, Schaeffner, Elke, Martus, Peter, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Heine, Gunnar, Seiler, Sarah, Zawada, Adam, Emrich, Insa, Sarnak, Mark, Katz, Ronit, Brenner, Hermann, Schöttker, Ben, Rothenbacher, Dietrich, Saum, Kai-Uwe, Köttgen, Anna, Schneider, Markus, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, Chang, Alex R, Black, Corri, Marks, Angharad, Prescott, Gordon, Clark, Laura, Fluck, Nick, Jee, Sun Ha, Mok, Yejin, Chodick, Gabriel, Wetzels, Jack FM, Blankestijn, Peter J, van Zuilen, Arjan D, Bots, M, Peralta, Carmen, Hiromoto, Jade, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen B, Nadukuru, Rajiv, Kenealy, Timothy, Elley, C Raina, Collins, John F, Drury, Paul L, Bakker, Stephan JL, Heerspink, Hiddo J Lambers, Jassal, Simerjot K, Bergstrom, Jaclyn, Ix, Joachim H, Barrett-Connor, Elizabeth, Kalantar-Zadeh, Kamyar, Carrero, Juan J, Gasparini, Alessandro, Qureshi, Abdul Rashid, Barany, Peter, Algra, Ale, van der Graaf, Yolanda, Evans, Marie, Segelmark, Mårten, Stendahl, Maria, Schön, Staffan, Tangri, Navdeep, Sud, Maneesh, Naimark, David, Lannfelt, Lars, Larsson, Anders, Hallan, Stein, Levey, Andrew S, Chen, Jingsha, and Kwak, Lucia

Subjects
Clinical Research, Kidney Disease, Prevention, Renal and urogenital, Good Health and Well Being, Adult, Aged, Albuminuria, Creatinine, Databases, Factual, Female, Glomerular Filtration Rate, Humans, Incidence, Male, Middle Aged, Peripheral Arterial Disease, Renal Insufficiency, Chronic, Risk Factors, Chronic Kidney Disease Prognosis Consortium, Medical Biochemistry and Metabolomics, Clinical Sciences, Public Health and Health Services
Abstract

BackgroundSome evidence suggests that chronic kidney disease is a risk factor for lower-extremity peripheral artery disease. We aimed to quantify the independent and joint associations of two measures of chronic kidney disease (estimated glomerular filtration rate [eGFR] and albuminuria) with the incidence of peripheral artery disease.MethodsIn this collaborative meta-analysis of international cohorts included in the Chronic Kidney Disease Prognosis Consortium (baseline measurements obtained between 1972 and 2014) with baseline measurements of eGFR and albuminuria, at least 1000 participants (this criterion not applied to cohorts exclusively enrolling patients with chronic kidney disease), and at least 50 peripheral artery disease events, we analysed adult participants without peripheral artery disease at baseline at the individual patient level with Cox proportional hazards models to quantify associations of creatinine-based eGFR, urine albumin-to-creatinine ratio (ACR), and dipstick proteinuria with the incidence of peripheral artery disease (including hospitalisation with a diagnosis of peripheral artery disease, intermittent claudication, leg revascularisation, and leg amputation). We assessed discrimination improvement through c-statistics.FindingsWe analysed 817 084 individuals without a history of peripheral artery disease at baseline from 21 cohorts. 18 261 cases of peripheral artery disease were recorded during follow-up across cohorts (median follow-up was 7·4 years [IQR 5·7-8·9], range 2·0-15·8 years across cohorts). Both chronic kidney disease measures were independently associated with the incidence of peripheral artery disease. Compared with an eGFR of 95 mL/min per 1·73 m2, adjusted hazard ratios (HRs) for incident study-specific peripheral artery disease was 1·22 (95% CI 1·14-1·30) at an eGFR of 45 mL/min per 1·73 m2 and 2·06 (1·70-2·48) at an eGFR of 15 mL/min per 1·73 m2. Compared with an ACR of 5 mg/g, the adjusted HR for incident study-specific peripheral artery disease was 1·50 (1·41-1·59) at an ACR of 30 mg/g and 2·28 (2·12-2·44) at an ACR of 300 mg/g. The adjusted HR at an ACR of 300 mg/g versus 5 mg/g was 3·68 (95% CI 3·00-4·52) for leg amputation. eGFR and albuminuria contributed multiplicatively (eg, adjusted HR 5·76 [4·90-6·77] for incident peripheral artery disease and 10·61 [5·70-19·77] for amputation in eGFR

Published
2017

38. Intensive blood pressure lowering and renal function in ischemic stroke patients: secondary analysis of ENCHANTED trial

Author

Chen, Chen, primary, Ren, Xinwen, additional, Zhao, Yang, additional, Ouyang, Menglu, additional, Li Mbiostat, Qiang, additional, Wang, Xia, additional, Li, Yunke, additional, You, Shoujiang, additional, Wang, Yanan, additional, Robinson, Thompson G., additional, Lindley, Richard, additional, Arima, Hisatomi, additional, Chalmers, John, additional, Li, Gang, additional, Chen, Xiaoying, additional, Anderson, Craig S., additional, and Song, Lili, additional

Published
2024
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40. S38 Efficacy and Safety of Nonmedical Switching From Infliximab Originator to Infliximab Biosimilar CT-P13 in Patients With Inflammatory Bowel Disease, A Single-Center Prospective Study in Japan

Author

Takeda, Teruyuki, primary, Takahashi, Atsushi, additional, Mikumo, Hiroyuki, additional, Kinjo, Ken, additional, Yasukawa, Shigeyoshi, additional, Koga, Akihiro, additional, Takatsu, Noritaka, additional, Hisabe, Takashi, additional, Arima, Hisatomi, additional, Imakiire, Sou, additional, Yamauchi, Eri, additional, Yao, Kenshi, additional, and Hirai, Fumihito, additional

Published
2023
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44. Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Author

Horie, Minoru, Nakagawa, Yoshihisa, Yamamoto, Takashi, Nakano, Yasutaka, Ogawa, Emiko, Maegawa, Hiroshi, Morino, Katsutaro, Miyazawa, Itsuko, Watanabe, Yoshiyuki, Nozaki, Kazuhiko, Tooyama, Ikuo, Shiino, Akihiko, Andoh, Akira, Tsuru, Teruhiko, Ogita, Hisakazu, Miyamatsu, Naomi, Nakamura, Yasuyuki, Kadota, Aya, Kondo, Keiko, Torii, Sayuki, Kadowaki, Takashi, Kadowaki, Sayaka, Suzuki, Sentaro, Ito, Takahiro, Kunimura, Ayako, Segawa, Hiroyoshi, Fujiyoshi, Akira, Higashiyama, Aya, Okamura, Tomonori, Azuma, Koichiro, Sawamura, Tatsuya, Igase, Michiya, Tabara, Yasuharu, Sekikawa, Akira, Barinas-Mitchell, Emma J.M., Edmundowicz, Daniel, Ohkubo, Takayoshi, Hozawa, Atsushi, Murakami, Yoshitaka, Okuda, Nagako, Arima, Hisatomi, Satoh, Atsushi, Kita, Yoshikuni, Hisamatsu, Takashi, Yanagita, Masahiko, Abbott, Robert D., Ohno, Seiko, Takashima, Naoyuki, Miyagawa, Naoko, Zaid, Maryam, Saito, Yoshino, Syaifullah, Ali Haidar, Moniruzzaman, Mohammad, Waki, Takashi, Ueshima, Hirotsugu, and Miura, Katsuyuki

Published
2021
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49. INTEnsive ambulance-delivered blood pressure Reduction in hyper-ACute stroke Trial (INTERACT4): study protocol for a randomized controlled trial

Author

Song, Lili, Chen, Chen, Chen, Xiaoying, Guo, Yijia, Liu, Feifeng, Lin, Yapeng, Billot, Laurent, Li, Qiang, Liu, Hueiming, Si, Lei, Ouyang, Menglu, Arima, Hisatomi, Bath, Philip M., Ford, Gary A., Robinson, Thompson, Sandset, Else Charlotte, Saver, Jeffrey L., Sprigg, Nikola, van der Worp, H. Bart, Zhang, Chunfang, Yang, Jie, Li, Gang, and Anderson, Craig S.

Published
2021
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50. Association between pulse pressure and progression of chronic kidney disease

Author

Maeda, Toshiki, Yokota, Soichiro, Nishi, Takumi, Funakoshi, Shunsuke, Tsuji, Masayoshi, Satoh, Atsushi, Abe, Makiko, Kawazoe, Miki, Yoshimura, Chikara, Tada, Kazuhiro, Takahashi, Koji, Ito, Kenji, Yasuno, Tetsuhiko, Yamanokuchi, Toshitaka, Iwanaga, Kazuyo, Morinaga, Akiko, Maki, Kaori, Ueno, Tamami, Masutani, Kousuke, Mukoubara, Shigeaki, and Arima, Hisatomi

Published
2021
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