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Your search keyword '"Arista, Maria Cristina"' showing total 18 results
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18 results on '"Arista, Maria Cristina"'

16. research paper Production of interferon-γ by lymphocytes from paroxysmal nocturnal haemoglobinuria patients: relationship with clinical status.

Author

Coluzzi, Serelina, Biffoni, Mauro, Pasqualetti, Daniela, Perrone, Maria Paola, Vaglio, Stefania, Rahimi, Hassan, Arista, Maria Cristina, Laurenti, Luca, Cerretti, Raffaella, and Girelli, Gabriella

Subjects
IMMUNE system, PAROXYSMAL hemoglobinuria, INTERFERONS, INTERLEUKIN-2, HEMOGLOBINURIA, MYELODYSPLASTIC syndromes
Abstract

Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by the expansion of phosphatidylinositol glycan class A (PIG-A) defective haematopoietic cells, probably due to the immune-mediated alterations of the bone marrow environment selecting PIG-A− stem cells. The present study investigated the presence of alterations of the immune system in a population of 11 PNH patients. The production of interferon- γ (IFN- γ) and interleukin-2 (IL-2), evaluated by intracellular cytokine analysis, and the frequencies of class I and II human leucocyte antigen (HLA) alleles were studied in comparison with healthy human subjects. Similar percentages of lymphocytes produced cytokines in PNH patients and controls after costimulation-independent activation; however, a negative correlation was found between the percentage of IFN- γ producing cells and white cell or platelets counts. PNH patients showed an higher percentage, compared with controls, of IFN- γ producing cells after costimulation-dependent activation. The frequency of HLA-A31 was higher in patients than in controls (27·2% vs. 4%), similarly to that of HLA-B7 (27·2% vs. 6%). With regard to class II alleles, 18% of PNH patients expressed DQB1*04 compared with none of 50 control cases. This study supports the hypothesis that immune alteration are present in PNH and that the immunogenetic background could influence the development of the disease. [ABSTRACT FROM AUTHOR]

Published
2004
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17. Incidence and prognostic significance of autoantibodies against erythrocytes and platelets in chronic lymphocytic leukemia (CLL)

Author

De Rossi, G, Granati, L, Girelli, Gabriella, Gandolfo, G, Arista, Maria Cristina, Martelli, Maurizio, Conti, L, Marini, R, La Tagliata, R, and Leone, R.

Subjects
Blood Platelets, Male, Middle Aged, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Thrombocytopenia, Coombs Test, Immunoglobulin G, Blood Group Antigens, Humans, Female, Anemia, Hemolytic, Autoimmune, Aged, Autoantibodies
Abstract

Antiglobulin Test (AT), and Dixon Tests (DT) have been studied in 100 patients with CLL. Thirty-five patients were Rai stage 0 and I, 19 patients stage 2, 13 patients stage 3 and 33 patients stage 4. Twelve patients showed a Red Blood Cells Autoantibodies (RBCAb) positivity; a positivity (direct, indirect, or both) of DT was present in 74% of patients. The presence of autoantibodies against erythrocytes and platelets did not influence survival curves, but anemia and thrombocytopenia are risk factors for survival, independently of the presence of an autoimmune disorder. Nine patients RBCAb positive and DT positive showed the worst survival curve, five out of these were anemic and one thrombocytopenic and anemic.

Published
1988

18. Production of interferon-gamma by lymphocytes from paroxysmal nocturnal haemoglobinuria patients: relationship with clinical status.

Author

Coluzzi S, Biffoni M, Pasqualetti D, Perrone MP, Vaglio S, Rahimi H, Arista MC, Laurenti L, Cerretti R, and Girelli G

Subjects
Adult, Aged, Female, Flow Cytometry, Glycosylphosphatidylinositols metabolism, Histocompatibility Antigens, Humans, Immunophenotyping, Interleukin-2 biosynthesis, Male, Middle Aged, Hemoglobinuria, Paroxysmal immunology, Interferon-gamma biosynthesis, Lymphocytes metabolism
Abstract

Paroxysmal nocturnal haemoglobinuria (PNH) is characterized by the expansion of phosphatidylinositol glycan class A (PIG-A) defective haematopoietic cells, probably due to the immune-mediated alterations of the bone marrow environment selecting PIG-A- stem cells. The present study investigated the presence of alterations of the immune system in a population of 11 PNH patients. The production of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), evaluated by intracellular cytokine analysis, and the frequencies of class I and II human leucocyte antigen (HLA) alleles were studied in comparison with healthy human subjects. Similar percentages of lymphocytes produced cytokines in PNH patients and controls after costimulation-independent activation; however, a negative correlation was found between the percentage of IFN-gamma producing cells and white cell or platelets counts. PNH patients showed an higher percentage, compared with controls, of IFN-gamma producing cells after costimulation-dependent activation. The frequency of HLA-A31 was higher in patients than in controls (27.2% vs. 4%), similarly to that of HLA-B7 (27.2% vs. 6%). With regard to class II alleles, 18% of PNH patients expressed DQB1*04 compared with none of 50 control cases. This study supports the hypothesis that immune alteration are present in PNH and that the immunogenetic background could influence the development of the disease.

Published
2004
Full Text
View/download PDF

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