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1. A rapid whole-blood adenosine triphosphate secretion test can be used to exclude platelet-dense granule deficiency

Author

Beckers, Erik, Coppens, Michiel, Eikenboom, Jeroen, Hooimeijer, Louise, Jansen, Gerard, Schutgens, Roger, Urbanus, Rolf, Zivkovic, Minka, van den Akker, Emile, Al Arashi, Wala, Arisz, Ryanne, Baas, Lieke, Bierings, Ruben, van den Biggelaar, Maartje, Boender, Johan, van der Bom, Anske, Bos, Mettine, Brands, Martijn, Bredenoord, Annelien, Bukkems, Laura, Burdorf, Lex, Del Castillo Alferez, Jessica, Cloesmeijer, Michael, Cnossen, Marjon, Driessens, Mariëtte, Fijnvandraat, Karin, Fischer, Kathelijn, Goedhart, Geertje, Goedhart, Tine, Gouw, Samantha, van der Graaf, Rieke, de Haas, Masja, Haverman, Lotte, Hazelzet, Jan, van Hoorn, Shannon, Huisman, Elise, Jansen, Nathalie, Janssen, Alexander, de Jong, Sean, Koopman, Sjoerd, Kruip, Marieke, Laan, Sebastiaan, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, Mathôt, Ron, van der Meer, Felix, Meijer, Karina, Meijer, Sander, Meijer, Stephan, van Moort, Iris, Mussert, Caroline, Ploos van Amstel, Hans Kristian, Polinder, Suzanne, Prameyllawati, Diaz, Reitsma, Simone, Roest, Eliza, Romano, Lorenzo, Schols, Saskia, Uyl, Carin, Voorberg, Jan, Zhang, Huan, Schutgens, Roger E.G., van der Vegte, Vossa, Lukasse, Janoek A., Roest, Mark, Huskens, Dana, de Moor, Annick S., Kremer Hovinga, Idske C.L., and Urbanus, Rolf T.

Published
2025
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2. Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Author

Beckers, Erik, Coppens, Michiel, Eikenboom, Jeroen, Hooimeijer, Louise, Jansen, Gerard, Schutgens, Roger, Urbanus, Rolf, Zivkovic, Minka, Akker, Emile van den, Al Arashi, Wala, Arisz, Ryanne, Baas, Lieke, Bierings, Ruben, van den Biggelaar, Maartje, Boender, Johan, van der Bom, Anske, Bos, Mettine, Brands, Martijn, Bredenoord, Annelien, Bukkems, Laura, Burdorf, Lex, Del Castillo Alferez, Jessica, Cloesmeijer, Michael, Cnossen, Marjon, Driessens, Mariëtte, Fijnvandraat, Karin, Fischer, Kathelijn, Goedhart, Geertje, Goedhart, Tine, Gouw, Samantha, van der Graaf, Rieke, de Haas, Masja, Haverman, Lotte, Hazelzet, Jan, van Hoorn, Shannon, Huisman, Elise, Jansen, Nathalie, Janssen, Alexander, de Jong, Sean, Koopman, Sjoerd, Kruip, Marieke, Laan, Sebastiaan, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, Mathôt, Ron, van der Meer, Felix, Meijer, Karina, Meijer, Sander, Meijer, Stephan, van Moort, Iris, Mussert, Caroline, Ploos van Amstel, Hans Kristian, Polinder, Suzanne, Prameyllawati, Diaz, Reitsma, Simone, Roest, Eliza, Romano, Lorenzo, Schols, Saskia, Uyl, Carin, Voorberg, Jan, Zhang, Huan, Pols - van Veen, Elisabeth, van der Vegte, Vossa, Sebastian, Silvie A.E., de Moor, Annick S., Korporaal, Suzanne J.A., Schutgens, Roger E.G., and Urbanus, Rolf T.

Published
2024
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3. Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of endothelial colony forming cells

Author

Brands, Martijn, Koopman, Sjoerd, Bukkems, Laura, Cloesmeijer, Michael, Janssen, Alexander, Fijnvandraat, Karin, Gouw, Samantha, Mathôt, Ron, Haverman, Lotte, van den Akker, Emile, van den Biggelaar, Maartje, de Haas, Masja, Meijer, Sander, Voorberg, Jan, Del Castillo Alferez, Jessica, Zhang, Huan, Boender, Johan, Meijer, Stephan, Meijer, Karina, de Jong, Sean, Goedhart, Geertje, van der Bom, Anske, Bos, Mettine, Eikenboom, Jeroen, van der Meer, Felix, Laan, Sebastiaan, Schols, Saskia, Bierings, Ruben, Burdorf, Lex, Cnossen, Marjon, Hazelzet, Jan, Huisman, Elise, Kruip, Marieke, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, van Moort, Iris, Polinder, Suzanne, Reitsma, Simone, Roest, Eliza, Arisz, Ryanne, Romano, Lorenzo, Al Arashi, Wala, van Hoorn, Shannon, Goedhart, Tine, Mussert, Caroline, Prameyllawati, Diaz, Uyl, Carin, Jansen, Nathalie, Fischer, Kathelijn, Ploos van Amstel, Hans Kristian, Urbanus, Rolf, Zivkovic, Minka, Bredenoord, Annelien, van der Graaf, Rieke, Baas, Lieke, Schutgens, Roger, Driessens, Mariëtte, Laan, Sebastiaan N.J., de Boer, Suzan, Dirven, Richard J., Kuipers, Thomas B., and Mei, Hailiang

Published
2024
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4. SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

Author

Cnossen, Marjon H., van Moort, Iris, Reitsma, Simone H., de Maat, Moniek P.M., Schutgens, Roger E.G., Urbanus, Rolf T., Lingsma, Hester F., Mathot, Ron A.A., Gouw, Samantha C., Meijer, Karina, Bredenoord, Annelien L., van der Graaf, Rieke, Fijnvandraat, Karin, Meijer, Alexander B., van den Akker, Emile, Bierings, Ruben, Eikenboom, Jeroen C.J., van den Biggelaar, Maartje, de Haas, Masja, Voorberg, Jan, Leebeek, Frank W.G., Arisz, Ryanne A., Zivkovic, Minka, van Hoorn, E. Shannon, Bukkems, Laura H., Goedhart, Tine M.C.H.J., Romano, Lorenzo G.R., Al Arashi, Wala, Cloesmeijer, Michael E., Janssen, Alexander, Brands, Martijn R., Baas, Lieke, del Castillo Alferez, Jessica, Zhang, Huan, Laan, Sebastiaan N.J., Boender, Johan, van der Bom, Johanna G., Bos, Mettine H.A., Burdorf, Lex, Coppens, Michiel, Driessens, Mariette, Fischer, Kathelijne F., Haverman, Lotte, Hazelzet, Jan A., Huisman, Elise J., Jansen, Natalie, de Jong, Sean, Kruip, Marieke, van Leeuwen, Nikki, van der Meer, Felix, Meijer, Stephan, van Amstel, Hans Kristian Ploos, Polinder, Suzanne, Schols, Saskia E.M., Wijfjes, Guus, Kluft, Kees, van Heerde, Waander L., Goedhart, Geertje, Uyl, Carin, Timp, Jasmijn, Stekelenburg, Anke, Moenen, Floor, Ypma, Paula, Nieuwenhuizen, Laurens, and Plat, Arnoud

Published
2022
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6. Blood coagulation and beyond:Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Author

Akbulut, Asim Cengiz, Arisz, Ryanne A., Baaten, Constance C.F.M.J., Baidildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Berg, Jur ten, van den Broek, Wout W.A., Boer, H. C.de, Bonifay, Amandine, Bröker, Vanessa, Buka, Richard J., Cate, Hugo ten, Cate-Hoek, Arina J.ten, Cointe, S., Luca, C. De, Simone, Ilaria De, Diaz, Rocio Vacik, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric C.M., Habibi, Anxhela, Henskens, Yvonne M.C., Iding, Aaron F.J., Khan, Abdullah, Koenderink, Gijsje H., Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel E., Lorusso, Roberto, Luo, Qi, Maas, Coen, Mccarty, Owen J.T., van der Meijden, Paola E.J., Meijers, Joost C.M., Mohapatra, Adarsh K., Nevo, Neta, Robles, Alejandro Pallares, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schönichen, Claudia, Schutgens, Roger, Simioni, Paolo, Spada, Stefano, Spronk, Henri M.H., Tazhibayeva, Karlygash, Thachil, Jecko, Vallier, L., Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P., Wenzel, Philip, Willems, Ruth A.L., Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, Zonneveld, Anton Jan van, Akbulut, Asim Cengiz, Arisz, Ryanne A., Baaten, Constance C.F.M.J., Baidildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Berg, Jur ten, van den Broek, Wout W.A., Boer, H. C.de, Bonifay, Amandine, Bröker, Vanessa, Buka, Richard J., Cate, Hugo ten, Cate-Hoek, Arina J.ten, Cointe, S., Luca, C. De, Simone, Ilaria De, Diaz, Rocio Vacik, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric C.M., Habibi, Anxhela, Henskens, Yvonne M.C., Iding, Aaron F.J., Khan, Abdullah, Koenderink, Gijsje H., Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel E., Lorusso, Roberto, Luo, Qi, Maas, Coen, Mccarty, Owen J.T., van der Meijden, Paola E.J., Meijers, Joost C.M., Mohapatra, Adarsh K., Nevo, Neta, Robles, Alejandro Pallares, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schönichen, Claudia, Schutgens, Roger, Simioni, Paolo, Spada, Stefano, Spronk, Henri M.H., Tazhibayeva, Karlygash, Thachil, Jecko, Vallier, L., Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P., Wenzel, Philip, Willems, Ruth A.L., Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, and Zonneveld, Anton Jan van

Abstract

The 4th Maastricht Consensus Conference on Thrombosis (MCCT), included the following themes: Theme 1: The coagulome as a critical driver of cardiovascular disease Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbiome status. Virus infections associated-coagulopathies perturb the hemostatic balance resulting in thrombosis and/or bleeding. Theme 3: How to limit bleeding risks: insights from translational studies This theme included state of the art methodology for exploring the contribution of genetic determinants of a bleeding diathesis; determination of polymorphisms in genes that control the rate of metabolism by the liver of P2Y12 inhibitors, to improve safety of antithrombotic therapy. Novel reversal agents for direct oral anticoagulants are discussed. Theme 4: Hemostasis in extracorporeal systems: how to utilize ex vivo models? Perfusion flow chamber and nanotechnology developments are developed for studying bleeding and thrombosis tendencies. Vascularised organoids are utilized for disease modeling and drug development studies. Strategies for tackling extracorporeal membrane oxygenation (ECMO) associated coagulopathy are discussed. Theme 5: Clinical dilemmas in thrombosis and antithrombotic management Plenary presentations addressed controversial areas, ie thrombophilia testing, thrombosis risk assessment in hemophilia, novel antiplatelet strategies and clinically tested factor XI(a) inhibitors,both possibly with reduced bleeding risk. Finally, Covid-19 associated coagulopathy is revisited.

Published
2023

7. Blood coagulation and beyond: Position paper from the Fourth Maastricht Consensus Conference on Thrombosis

Author

CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Poli Van Creveldkliniek Medisch, Child Health, Infection & Immunity, Akbalut, Cengiz, Arisz, Ryanne, Baaten, Constance, Baildildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Ten Berg, Jurriën M, van den Broek, Wout, de Boer, Hetty C, Broker, Vanessa, Buka, Richard, Ten Cate, Hugo, Cate, Arina Ten, De Luca, Ciro, De Simone, Ilaria, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric, Habibi, Anxhela, Henskens, Yvonne M C, Iding, Aaron F J, Khan, Abdullah, Koenderink, Gijsje, Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel, Lorusso, Roberto, Luo, Qi, Maas, Coen, McCarty, Owen J T, van der Meijden, Paola, Meijers, Joost, Mohapatra, Adarsh, Nevo, Neta, Pallares Robles, Alejandro, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schonichen, Claudia, Schutgens, Roger E G, Simioni, Paolo, Spada, Stefano, Spronk, Henri M H, Tazhibayeva, Karlygash, Thachil, Jecko, Vacik-Diaz, Rocio, Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P, Wenzel, Philip, Willems, Ruth, Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, van Zonneveld, Anton-Jan, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, Poli Van Creveldkliniek Medisch, Child Health, Infection & Immunity, Akbalut, Cengiz, Arisz, Ryanne, Baaten, Constance, Baildildinova, Gaukhar, Barakzie, Aarazo, Bauersachs, Rupert, Ten Berg, Jurriën M, van den Broek, Wout, de Boer, Hetty C, Broker, Vanessa, Buka, Richard, Ten Cate, Hugo, Cate, Arina Ten, De Luca, Ciro, De Simone, Ilaria, Dignat-George, Françoise, Freson, Kathleen, Gazzaniga, Giulia, van Gorp, Eric, Habibi, Anxhela, Henskens, Yvonne M C, Iding, Aaron F J, Khan, Abdullah, Koenderink, Gijsje, Konkoth, Akhil, Lacroix, Romaric, Lahiri, Trisha, Lam, Wilbur, Lamerton, Rachel, Lorusso, Roberto, Luo, Qi, Maas, Coen, McCarty, Owen J T, van der Meijden, Paola, Meijers, Joost, Mohapatra, Adarsh, Nevo, Neta, Pallares Robles, Alejandro, Poncelet, Philippe, Reinhardt, Christoph, Ruf, Wolfram, Saraswat, Ronald, Schonichen, Claudia, Schutgens, Roger E G, Simioni, Paolo, Spada, Stefano, Spronk, Henri M H, Tazhibayeva, Karlygash, Thachil, Jecko, Vacik-Diaz, Rocio, Veninga, Alicia, Verhamme, Peter, Visser, Chantal, Watson, Steve P, Wenzel, Philip, Willems, Ruth, Willers, Anne, Zhang, Pengyu, Zifkos, Konstantinos, and van Zonneveld, Anton-Jan

Published
2023

8. Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis

Author

Akbulut, Asim Cengiz, additional, Arisz, Ryanne A., additional, Baaten, Constance C. F. M. J., additional, Baidildinova, Gaukhar, additional, Barakzie, Aarazo, additional, Bauersachs, Rupert, additional, ten Berg, Jur, additional, van den Broek, Wout W. A., additional, de Boer, H. C., additional, Bonifay, Amandine, additional, Bröker, Vanessa, additional, Buka, Richard J., additional, ten Cate, Hugo, additional, ten Cate-Hoek, Arina J., additional, Cointe, S., additional, De Luca, Ciro, additional, De Simone, Ilaria, additional, Diaz, Rocio Vacik, additional, Dignat-George, Françoise, additional, Freson, Kathleen, additional, Gazzaniga, Giulia, additional, van Gorp, Eric C. M., additional, Habibi, Anxhela, additional, Henskens, Yvonne M. C., additional, Iding, Aaron F. J., additional, Khan, Abdullah, additional, Koenderink, Gijsje H., additional, Konkoth, Akhil, additional, Lacroix, Romaric, additional, Lahiri, Trisha, additional, Lam, Wilbur, additional, Lamerton, Rachel E., additional, Lorusso, Roberto, additional, Luo, Qi, additional, Maas, Coen, additional, McCarty, Owen J. T., additional, van der Meijden, Paola E. J., additional, Meijers, Joost C. M., additional, Mohapatra, Adarsh K., additional, Nevo, Neta, additional, Robles, Alejandro Pallares, additional, Poncelet, Philippe, additional, Reinhardt, Christoph, additional, Ruf, Wolfram, additional, Saraswat, Ronald, additional, Schönichen, Claudia, additional, Schutgens, Roger, additional, Simioni, Paolo, additional, Spada, Stefano, additional, Spronk, Henri M. H., additional, Tazhibayeva, Karlygash, additional, Thachil, Jecko, additional, Vallier, L., additional, Veninga, Alicia, additional, Verhamme, Peter, additional, Visser, Chantal, additional, Watson, Steve P., additional, Wenzel, Philip, additional, Willems, Ruth A. L., additional, Willers, Anne, additional, Zhang, Pengyu, additional, Zifkos, Konstantinos, additional, and van Zonneveld, Anton Jan, additional

Published
2023
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9. Interaction of von Willebrand factor with blood cells in flow models:A systematic review

Author

Arisz, Ryanne A., De Vries, Judith J., Schols, Saskia E.M., Eikenboom, Jeroen C.J., De Maat, Moniek P.M., Arisz, Ryanne A., De Vries, Judith J., Schols, Saskia E.M., Eikenboom, Jeroen C.J., and De Maat, Moniek P.M.

Abstract

The presence of blood flow influences the interaction between von Willebrand factor (VWF) and blood cells, affecting characteristics of forming blood clots. The interactions between coagulation and inflammation have mainly been studied in thrombosis models, but it remains unclear whether these interactions might also play a role in reduced bleeding in patients with bleeding disorders. In this systematic review, we provide an overview of the literature investigating the interactions between VWF and blood cells in flow models. For article selection, a systematic search was performed in Embase, Medline-Ovid, Cochrane Library, Web of Science databases, and Google Scholar. After selection, 24 articles were included. These articles describe direct or platelet-dependent interactions between VWF and neutrophils, monocytes, erythrocytes, or lymphocytes under different flow conditions. Almost all the described interactions required the presence of activated platelets. Only erythrocytes, monocytes, and natural killer cells were capable of directly binding the VWF multimers. Overall, interactions between VWF and blood cells mainly occurred in the presence of platelets. Because of the large variation in study design and used flow rates, further research is necessary to compare the results between studies and draw firm conclusions on when and under what conditions these interactions can occur. After our findings, many questions remained unanswered. This review might provide a starting point for future research. Extended knowledge on the influence of blood flow on VWF and blood cell interactions can contribute to improved understanding of the variation in bleeding in patients with bleeding disorders.

Published
2022

11. A rapid whole-blood adenosine triphosphate secretion test can be used to exclude platelet-dense granule deficiency

Author

Zivkovic, Minka, Schutgens, Roger E.G., van der Vegte, Vossa, Lukasse, Janoek A., Roest, Mark, Huskens, Dana, de Moor, Annick S., Kremer Hovinga, Idske C.L., Urbanus, Rolf T., Beckers, Erik, Coppens, Michiel, Eikenboom, Jeroen, Hooimeijer, Louise, Jansen, Gerard, Schutgens, Roger, Urbanus, Rolf, Zivkovic, Minka, van den Akker, Emile, Al Arashi, Wala, Arisz, Ryanne, Baas, Lieke, Bierings, Ruben, van den Biggelaar, Maartje, Boender, Johan, van der Bom, Anske, Bos, Mettine, Brands, Martijn, Bredenoord, Annelien, Bukkems, Laura, Burdorf, Lex, Del Castillo Alferez, Jessica, Cloesmeijer, Michael, Cnossen, Marjon, Driessens, Mariëtte, Eikenboom, Jeroen, Fijnvandraat, Karin, Fischer, Kathelijn, Goedhart, Geertje, Goedhart, Tine, Gouw, Samantha, van der Graaf, Rieke, de Haas, Masja, Haverman, Lotte, Hazelzet, Jan, van Hoorn, Shannon, Huisman, Elise, Jansen, Nathalie, Janssen, Alexander, de Jong, Sean, Koopman, Sjoerd, Kruip, Marieke, Laan, Sebastiaan, Leebeek, Frank, van Leeuwen, Nikki, Lingsma, Hester, de Maat, Moniek, Mathôt, Ron, van der Meer, Felix, Meijer, Karina, Meijer, Sander, Meijer, Stephan, van Moort, Iris, Mussert, Caroline, Ploos van Amstel, Hans Kristian, Polinder, Suzanne, Prameyllawati, Diaz, Reitsma, Simone, Roest, Eliza, Romano, Lorenzo, Schols, Saskia, Schutgens, Roger, Urbanus, Rolf, Uyl, Carin, Voorberg, Jan, Zhang, Huan, and Zivkovic, Minka

Abstract

Delta storage pool disease (δ-SPD) is a rare platelet function disorder (PFD) characterized by a deficiency of dense granules or defective granule secretion, leading to bleeding diathesis. Diagnostics of δ-SPD are difficult and lack standardization, leading to underestimation of its prevalence. Current diagnostic methods are based on granule content assays or lumi-aggregometry, which have limited availability. Therefore, there is an unmet need for a rapid, accessible test for δ-SPD.

Published
2025
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12. Impact of COVID‐19 pandemic on the quality of test output in haemostasis laboratories.

Author

Arisz, Ryanne A., Meijer, Piet, Péquériaux, Nathalie C.V., van de Leur, Sjef J., Lukens, Michaël V., de Maat, Moniek P. M., and Hollestelle, Martine J.

Subjects
*PATHOLOGICAL laboratories, *HEMOSTASIS, *SURVEYS, *COMPARATIVE studies, *QUALITY assurance, *QUALITY control, *QUESTIONNAIRES, *DESCRIPTIVE statistics, *COVID-19 pandemic, *FIBRIN fibrinogen degradation products
Abstract

Introduction: The high incidence of thrombotic events in patients with COVID‐19 affects health care worldwide and results in an increased workload in haemostasis laboratories due to more frequent testing of D‐dimer, haemostatic parameters and anti‐Xa tests. However, the impact of this increase in assay requests on the quality of performance in haemostasis laboratories remains unclear. In this study, the impact of the COVID‐19 pandemic on the quality of performance and management of haemostasis laboratories was evaluated. Methods: The impact on the quality of performance was studied using external quality assessment data from 2019 to 2020 derived from ECAT surveys. A questionnaire was sent to Dutch haemostasis laboratories to identify challenges and management strategies. Furthermore, the number of assays performed in 2019 and 2020 was supplied by four Dutch hospitals, located in regions with different disease incidence. Results: No differences in response rate nor the quality of the measurements were observed between the EQA surveys in 2019 and 2020. The questionnaire results showed a large increase of >25% in the number of test requests for anti‐Xa, D‐dimer and fibrinogen assays in 2020 compared to 2019. Extreme peaks in test requests were also observed in the four evaluated hospitals. Additionally, 84% of the respondents indicated that they had experienced increased work pressure, and increased sick leave was observed in 71% of the participating laboratories. Conclusions: The enormous increase in test requests, especially for D‐dimer assays and anti‐Xa activity, did not affect the quality of performance within haemostatic laboratories during the COVID‐19 pandemic. [ABSTRACT FROM AUTHOR]

Published
2022
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13. SYMPHONYconsortium: Orchestrating personalized treatment for patients with bleeding disorders

Author

Cnossen, Marjon H., Moort, Iris, Reitsma, Simone H., Maat, Moniek P. M., Schutgens, Roger E. G., Urbanus, Rolf T., Lingsma, Hester F., Mathot, Ron A. A., Gouw, Samantha C., Meijer, Karina, Bredenoord, Annelien L., Graaf, Rieke, Fijnvandraat, Karin, Meijer, Alexander B., Akker, Emile, Bierings, Ruben, Eikenboom, Jeroen C. J., Biggelaar, Maartje, Haas, Masja, Voorberg, Jan, Leebeek, Frank W. G., Cnossen, Marjon H., Reitsma, Simone H., Haas, Masja, Biggelaar, Maartje, Leebeek, Frank W. G., Voorberg, Jan, Maat, Moniek P. M., Schutgens, Roger E. G., Urbanus, Rolf T., Lingsma, Hester F., Mathot, Ron A. A., Gouw, Samantha C., Meijer, Karina, Bredenoord, Annelien L., Graaf, Rieke, Fijnvandraat, Karin, Meijer, Alexander B., Akker, Emile, Bierings, Ruben, Eikenboom, Jeroen C. J., Moort, Iris, Arisz, Ryanne A., Zivkovic, Minka, Hoorn, E. Shannon, Bukkems, Laura H., Goedhart, Tine M. C. H. J., Romano, Lorenzo G. R., Al Arashi, Wala, Cloesmeijer, Michael E., Janssen, Alexander, Brands, Martijn R., Baas, Lieke, Castillo Alferez, Jessica, Zhang, Huan, Laan, Sebastiaan N. J., Boender, Johan, Bom, Johanna G., Bos, Mettine H. A., Burdorf, Lex, Coppens, Michiel, Driessens, Mariette, Fischer, Kathelijne F., Haverman, Lotte, Hazelzet, Jan A., Huisman, Elise J., Jansen, Natalie, Jong, Sean, Kruip, Marieke, Leeuwen, Nikki, Meer, Felix, Meijer, Stephan, Amstel, Hans Kristian Ploos, Polinder, Suzanne, Schols, Saskia E. M., Wijfjes, Guus, Kluft, Kees, Heerde, Waander L., Goedhart, Geertje, Uyl, Carin, Timp, Jasmijn, Stekelenburg, Anke, Moenen, Floor, Ypma, Paula, Nieuwenhuizen, Laurens, and Plat, Arnoud

Abstract

Treatment choices for individual patients with an inborn bleeding disorder are increasingly challenging due to increasing options and rising costs for society. We have initiated an integrated interdisciplinary national research program. The SYMPHONY consortium strives to orchestrate personalized treatment in patients with an inborn bleeding disorder, by unraveling the mechanisms behind interindividual variations of bleeding phenotype. The SYMPHONY consortium will investigate patients with an inborn bleeding disorder, both diagnosed and not yet diagnosed. Research questions are categorized under the themes: (1) diagnosis, (2) treatment, and (3) fundamental research, and consist of work packages addressing specific domains. Importantly, collaborations between patients and talented researchers from different areas of expertise promise to augment the impact of the SYMPHONY consortium, leading to unique interactions and intellectual property. SYMPHONY will perform research on all aspects of care, treatment individualization in patients with inborn bleeding disorders, as well as diagnostic innovations and results of molecular genetics and cellular model technology with regard to the hemostatic process. We believe that these research investments will lead to health‐care innovations with long‐term clinical and societal impact. This consortium has been made possible by a governmental, competitive grant from the Netherlands Organization for Scientific Research (NWO) within the framework of the NWA‐ORC Call grant agreement NWA.1160.18.038.

Published
2022
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14. The Interaction of Von Willebrand Factor with Blood Cells in Flow Models: A Systematic Review

Author

Arisz, Ryanne A., de Vries, Judith J., Schols, Saskia E.M., Eikenboom, Jeroen C.J., and de Maat, Moniek P.M.

Abstract

The presence of blood flow influences the interaction between von Willebrand factor (VWF) and blood cells, affecting characteristics of forming blood clots. The interactions between coagulation and inflammation have mainly been studied in thrombosis models, but it remains unclear whether these interactions might also play a role in reduced bleeding in patients with bleeding disorders. In this systematic review, we provide an overview of the literature that investigated the interactions between VWF and blood cells in flow models. For article selection, a systematic search was performed in Embase, Medline-Ovid, Cochrane Library, Web of Science databases, and Google Scholar. After selection, 24 articles were included. These articles described direct or platelet-dependent interactions between VWF and neutrophils, monocytes, erythrocytes, or lymphocytes under different flow conditions. Almost all described interactions required the presence of activated platelets. Only erythrocytes, monocytes, and natural killer cells were capable to directly bind the VWF multimers. Overall, interactions between VWF and blood cells mainly occur in the presence of platelets. Due to the large variation in study design and used flow rates, further research is necessary to compare the results between studies and draw firm conclusions when and under what conditions these interactions can occur. Based on our findings, still many questions remained unanswered. This review might provide a starting point for future research. Extended knowledge on the influence of blood flow on VWF - blood cell interactions can contribute to improved understanding of the variation in bleeding in patients with bleeding disorders.

Published
2022
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