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20 results on '"Arita, Michitsune"'

1. Supplementary Figures 1-2 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

Author

Haugen, Astrid C., primary, Goel, Ajay, primary, Yamada, Kanae, primary, Marra, Giancarlo, primary, Nguyen, Thuy-Phuong, primary, Nagasaka, Takeshi, primary, Kanazawa, Shinsaku, primary, Koike, Junichi, primary, Kikuchi, Yoshinori, primary, Zhong, Xiaoling, primary, Arita, Michitsune, primary, Shibuya, Kazutoshi, primary, Oshimura, Mitsuo, primary, Hemmi, Hiromichi, primary, Boland, C. Richard, primary, and Koi, Minoru, primary

Published
2023
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2. Supplementary Table 1 from Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

Author

Haugen, Astrid C., primary, Goel, Ajay, primary, Yamada, Kanae, primary, Marra, Giancarlo, primary, Nguyen, Thuy-Phuong, primary, Nagasaka, Takeshi, primary, Kanazawa, Shinsaku, primary, Koike, Junichi, primary, Kikuchi, Yoshinori, primary, Zhong, Xiaoling, primary, Arita, Michitsune, primary, Shibuya, Kazutoshi, primary, Oshimura, Mitsuo, primary, Hemmi, Hiromichi, primary, Boland, C. Richard, primary, and Koi, Minoru, primary

Published
2023
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13. Genetic Instability Caused by Loss of MutS Homologue 3 in Human Colorectal Cancer

Author

Haugen, Astrid C., primary, Goel, Ajay, additional, Yamada, Kanae, additional, Marra, Giancarlo, additional, Nguyen, Thuy-Phuong, additional, Nagasaka, Takeshi, additional, Kanazawa, Shinsaku, additional, Koike, Junichi, additional, Kikuchi, Yoshinori, additional, Zhong, Xiaoling, additional, Arita, Michitsune, additional, Shibuya, Kazutoshi, additional, Oshimura, Mitsuo, additional, Hemmi, Hiromichi, additional, Boland, C. Richard, additional, and Koi, Minoru, additional

Published
2008
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20. Effects of new peritoneal dialysis solutions, pyridoxamine and AT1 receptor blocker, on TGF-beta1 and VEGF expression in rat peritoneal mesothelial cells.

Author

Mizuiri S, Ohashi Y, Hemmi H, Arita M, Yamada K, Aoki T, Miyagi M, Sakai K, and Aikawa A

Subjects
Animals, Cells, Cultured, Male, Peritoneum cytology, Rats, Rats, Sprague-Dawley, Angiotensin II Type 1 Receptor Blockers pharmacology, Epithelial Cells drug effects, Epithelial Cells metabolism, Hemodialysis Solutions, Peritoneal Dialysis, Peritoneum drug effects, Peritoneum metabolism, Pyridoxamine pharmacology, Transforming Growth Factor beta1 biosynthesis, Transforming Growth Factor beta1 drug effects, Vascular Endothelial Growth Factor A biosynthesis, Vascular Endothelial Growth Factor A drug effects
Abstract

Background: Transforming growth factor beta1 (TGF-beta1) and vascular endothelial growth factor (VEGF) are involved in peritoneal deterioration in continuous ambulatory peritoneal dialysis. The present study was designed to determine whether new peritoneal dialysis solutions (PDS), pyridoxamine (advanced glycation end products (AGE) inhibitor) or AT1 receptor blocker (ARB), affect the expression of VEGF and TGF-beta1 in rat peritoneal mesothelial cells (RPMC)., Methods: RPMC were stimulated by phosphate-buffered saline (PBS) as control, Dianeal 1.5% (D 1.5%), Dianeal 2.5% (D 2.5%), Dianeal 4.25% (D 4.25%), Dianeal N 1.5% (N 1.5%), Dianeal N 2.5% (N 2.5%) or Extraneal (Ex). In co-incubation experiments, RPMC were stimulated with N 2.5% including pyridoxamine or olmesartan (ARB). VEGF and TGF-beta1 protein and mRNA expression in RPMC were analyzed by ELISA and RT-PCR., Results: Glucose-containing PDS, even N 2.5% diluted twofold with M199 (which contains 1.25% glucose), increased VEGF and TGF-beta1 expression in RPMC (p < 0.05). Ex did not inhibit VEGF expression and did not inhibit TGF- beta1 expression after 24 h in RPMC. Pyridoxamine and ARB significantly reduced N 2.5%-induced VEGF and TGF-beta1 protein and mRNA expression in RPMC (p < 0.01)., Conclusions: Neither new pH-neutral, lactate-buffered, low-GDP, two-chamber bag PDS, nor 7.5% icodextrin PDS alone satisfactorily inhibited VEGF and TGF-beta1 overproduction in RPMC, but ARB or pyridoxamine effectively inhibited glucose-containing PDS (N 2.5%)-induced overproduction., (Copyright 2009 S. Karger AG, Basel.)

Published
2009
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