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8 results on '"Arjona, Jennifer"'

1. Biosensor vital sign detects multiple sclerosis progression

Author

Krysko, Kristen M, Akhbardeh, Alireza, Arjona, Jennifer, Nourbakhsh, Bardia, Waubant, Emmanuelle, Gourraud, Pierre Antoine, and Graves, Jennifer S

Subjects
Clinical and Health Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Brain Disorders, Autoimmune Disease, Multiple Sclerosis, Clinical Research, Neurodegenerative, Neurological, Adult, Algorithms, Cohort Studies, Disability Evaluation, Female, Humans, Longitudinal Studies, Male, Middle Aged, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Signal Processing, Computer-Assisted, Vital Signs, Wearable Electronic Devices, Clinical Sciences, Clinical and health psychology
Abstract

ObjectiveTo determine whether a small, wearable multisensor device can discriminate between progressive versus relapsing multiple sclerosis (MS) and capture limb progression over a short interval, using finger and foot tap data.MethodsPatients with MS were followed prospectively during routine clinic visits approximately every 6 months. At each visit, participants performed finger and foot taps wearing the MYO-band, which includes accelerometer, gyroscope, and surface electromyogram sensors. Metrics of within-patient limb progression were created by combining the change in signal waveform features over time. The resulting upper (UE) and lower (LE) extremity metrics' discrimination of progressive versus relapsing MS were evaluated with calculation of AUROC. Comparisons with Expanded Disability Status Scale (EDSS) scores were made with Pearson correlation.ResultsParticipants included 53 relapsing and 15 progressive MS (72% female, baseline mean age 48 years, median disease duration 11 years, median EDSS 2.5, median 10 months follow-up). The final summary metrics differentiated relapsing from secondary progressive MS with AUROC UE 0.93 and LE 0.96. The metrics were associated with baseline EDSS (UE P = 0.0003, LE P = 0.0007). While most had no change in EDSS during the short follow-up, several had evidence of progression by the multisensor metrics.InterpretationWithin a short follow-up interval, this novel multisensor algorithm distinguished progressive from relapsing MS and captured changes in limb function. Inexpensive, noninvasive and easy to use, this novel outcome is readily adaptable to clinical practice and trials as a MS vital sign. This approach also holds promise to monitor limb dysfunction in other neurological diseases.

Published
2021

2. Novel MS vital sign: multi‐sensor captures upper and lower limb dysfunction

Author

Akhbardeh, Alireza, Arjona, Jennifer K, Krysko, Kristen M, Nourbakhsh, Bardia, Gourraud, Pierre Antoine, and Graves, Jennifer S

Subjects
Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Accelerometry, Adult, Cross-Sectional Studies, Diagnostic Techniques, Neurological, Electromyography, Female, Fingers, Foot, Humans, Male, Middle Aged, Motor Activity, Multiple Sclerosis, Severity of Illness Index, Signal Processing, Computer-Assisted, Treatment Outcome, Vital Signs, Wearable Electronic Devices, Clinical Sciences, Neurosciences
Abstract

ObjectiveTo create a novel neurological vital sign and reliably capture MS-related limb disability in less than 5 min.MethodsConsecutive patients meeting the 2010 MS diagnostic criteria and healthy controls were offered enrollment. Participants completed finger and foot taps wearing the MYO-band© (accelerometer, gyroscope, and surface electromyogram sensors). Signal processing was performed to extract spatiotemporal features from raw sensor data. Intraclass correlation coefficients (ICC) assessed intertest reproducibility. Spearman correlation and multivariable regression methods compared extracted features to physician- and patient-reported disability outcomes. Partial least squares regression identified the most informative extracted textural features.ResultsBaseline data for 117 participants with MS (EDSS 1.0-7.0) and 30 healthy controls were analyzed. ICCs for final selected features ranged from 0.80 to 0.87. Time-based features distinguished cases from controls (P = 0.002). The most informative combination of extracted features from all three sensors strongly correlated with physician EDSS (finger taps rs  = 0.77, P

Published
2020

3. Susceptibility-based Imaging Aids Accurate Distinction of Pediatric-onset MS from Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (S42.001)

Author

Virupakshaiah, Akash, primary, Sacco, Simone, additional, Papinutto, Nico, additional, Schoeps, Vinicius, additional, Akula, Amit, additional, Zhao, Haojun, additional, Arjona, Jennifer, additional, Stern, William, additional, Chong, Janet, additional, Hart, Janace, additional, Zamvil, Scott, additional, Sati, Pascal, additional, Henry, Roland, additional, and Waubant, Emmanuelle, additional

Published
2024
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4. The Pediatric Optic Neuritis Prospective Outcomes Study

Author

Pineles, Stacy L., primary, Henderson, Robert J., additional, Repka, Michael X., additional, Heidary, Gena, additional, Liu, Grant T., additional, Waldman, Amy T., additional, Borchert, Mark S., additional, Khanna, Sangeeta, additional, Graves, Jennifer S., additional, Collinge, Janine E., additional, Conley, Julie A., additional, Davis, Patricia L., additional, Kraker, Raymond T., additional, Cotter, Susan A., additional, Holmes, Jonathan M., additional, Chang, Melinda Y., additional, Contractor, Dilshad, additional, Zolfaghari, Emily J., additional, Vyas, Aarti, additional, Yuen, Tiffany, additional, Shah, Veeral S., additional, Paysse, Evelyn A., additional, Romany, Gihan, additional, Peragallo, Jason H., additional, Brower, Judy L., additional, Raghuram, Aparna, additional, Al Wattar, Bilal, additional, Chinn, Ryan, additional, Kothari, Srishti, additional, Siatkowski, R. Michael, additional, Lim, Maria E., additional, Brewer, Alisha N., additional, Doughty, Annette M., additional, Icks, Sonny W., additional, Almeida, Shannon, additional, de Alba Campomanes, Alejandra, additional, Banwait, Premilla, additional, Hajkazemshirazi, Leila, additional, Bastea-Forte, Yizhuo, additional, Arjona, Jennifer K., additional, Chen, Jeremy, additional, Cooper, Karen, additional, Ghadban, Rafif, additional, Chung, Sophia M., additional, Cruz, Oscar A., additional, Christenson, Traci A., additional, Breeding, Lisa L., additional, Govreau, Dawn M., additional, Wallis, Beth A., additional, Geddie, Brooke E., additional, Wolinski, Elisabeth T., additional, Rudaitis, Indre M., additional, Twite, Jacqueline, additional, Bloomquist, Carrie S., additional, Laboy, Sarah R., additional, Twite, Jackie M., additional, Pineles, Stacy L., additional, Doan, Michelle V., additional, Bernardo, Marianne J., additional, Brodsky, Michael C., additional, Chen, John J., additional, Wernimont, Suzanne M., additional, Czaplewski, Lindsay L., additional, Eastman, Stacy L., additional, Keehn, Moriah A., additional, Priebe, Debbie M., additional, Bremer, Don L., additional, Golden, Richard P., additional, Jordan, Catherine O., additional, McGregor, Mary Lou, additional, Reem, Rachel E., additional, Rogers, David L., additional, Schreckengost, Amanda N., additional, Maletic, Sara A., additional, Dairi, Mays A., additional, Enyedi, Laura B., additional, Jones, Sarah K., additional, Barman, Navajyoti R., additional, House, Robert J., additional, Nasrazadani, David A., additional, Gratton, Sean M., additional, Marsh, Justin D., additional, Dent, Rebecca J., additional, Bond, Lezlie L., additional, Soske, Lori L., additional, Sudhakar, Padmaja, additional, Willen, Christi M., additional, Taylor, Deborah, additional, Moliterno, Nathaniel Q., additional, Nsoesie, Michael, additional, Vally, Shaista, additional, Phillips, Paul H., additional, Lowery, Robert S., additional, Colon, Beth, additional, Stotts, Nancy L., additional, To, Kelly D., additional, McClelland, Collin M., additional, Areaux, Raymond G., additional, Holleschau, Ann M., additional, Merrill, Kim S., additional, Ospina, Luis H., additional, Superstein, Rosanne, additional, Thibeault, Maryse, additional, Gagnon, Helene, additional, Donahue, Sean P., additional, Ruark, Scott T., additional, Fraine, Lisa A., additional, Sprouse, Petrice A., additional, Biernacki, Ronald J., additional, Avery, Robert A., additional, Forbes, Brian J., additional, Jivraj, Imran, additional, Kohli, Anita A., additional, Richter, Meg M., additional, Baumritter, Agnieshka, additional, Mitchell, Ellen B., additional, Nischal, Ken K., additional, Runkel, Lauren M., additional, Blaha, Bianca, additional, Churchfield, Whitney, additional, Fulwylie, Christina, additional, Ko, Melissa W., additional, Mejico, Luis J., additional, Iqbal, Muhammad, additional, Attanasio, Catherine E., additional, Deb, Lena F., additional, Goodrich, Courtney B., additional, Hartwell, Alisha M., additional, Moore, Jennifer A., additional, Bohra, Lisa, additional, Apkarian, Alexandra O., additional, Gianfermi, Elena M., additional, Roarty, John D., additional, Rotberg, Leemor B., additional, Perzyk, Susan N., additional, Beck, Roy W., additional, Austin, Darrell S., additional, Boyle, Nicole M., additional, Chandler, Danielle L., additional, Connelly, Patricia L., additional, Conner, Courtney L., additional, Dean, Trevano W., additional, Donahue, Quayleen, additional, Fimbel, Brooke P., additional, Hercinovic, Amra, additional, Hoepner, James E., additional, Kaplon, Joseph D., additional, Li, Zhuokai, additional, Ortiz, Gillaine, additional, Robinson, Julianne L., additional, Stutz, Kathleen M., additional, Toro, David O., additional, Woodard, Victoria C., additional, Wu, Rui, additional, Balcer, Laura, additional, Kupersmith, Mark, additional, Lazar, Elizabeth L., additional, Waldman, Amy, additional, Wallace, David K., additional, Birch, Eileen E., additional, Chen, Angela M., additional, Christiansen, Stephen P., additional, Erzurum, S. Ayse, additional, Everett, Donald F., additional, Freedman, Sharon F., additional, Good, William V., additional, Lee, Katherine A., additional, London, Richard, additional, Manh, Vivian M., additional, Manny, Ruth E., additional, Morrison, David G., additional, Schweinler, Bonita R., additional, Silver, Jayne L., additional, Verderber, Lisa C., additional, Weise, Katherine K., additional, Green, Ari, additional, Diener-West, Marie, additional, Baker, John D., additional, Davis, Barry, additional, Phelps, Dale L., additional, Poff, Stephen W., additional, Saunders, Richard A., additional, and Tychsen, Lawrence, additional

Published
2022
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6. Instrumental, Clinical, and Patient Reported Sensorimotor Correlates of Spinal Cord Grey and Total Cord Areas (P5.2-042)

Author

Alexander, Amber M., primary, Arjona, Jennifer, additional, Papinutto, Nico, additional, Stern, William, additional, Bischof, Antje, additional, Block, Valerie J., additional, Gelfand, Jeffrey, additional, Goodin, Douglas, additional, Jia, Xiaoming, additional, Romeo, Andrew, additional, Graves, Jennifer, additional, Cree, Bruce A.C., additional, Hauser, Stephen, additional, and Henry, Roland G., additional

Published
2019
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