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18. Sacral Aneurysmal Bone Cyst

Author

Woodward, Chase C., Cahill, Patrick, Arkader, Alex, Neal, Kevin M., Section editor, Iobst, Christopher A., editor, and Frick, Steven L., editor

Published
2020
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20. Keratin-Positive Giant Cell Tumor of Bone and Soft Tissue With HMGA2::NCOR2 Fusion in Children Under 10 With Response to Imatinib Therapy: A Case Series.

Author

Rungsiprakarn, Phassawan, Ryan, Anne L., Wong, Daniel D., Luo, Minjie, Kazahaya, Ken, Arkader, Alexandre, Lau, Loretta M.S., Ajuyah, Pamela, Rudzinski, Erin, Kreiger, Portia A., Roebuck, Derek J., Surrey, Lea F., and Foo, Tiffany S.Y.

Subjects
SOFT tissue tumors, GENE expression, MACROPHAGE colony-stimulating factor, NATURAL history, MULTINUCLEATED giant cells, GIANT cell tumors
Abstract

The article discusses keratin-positive giant cell tumors of bone and soft tissue in children under 10 with HMGA2::NCOR2 fusion, focusing on three cases. The tumors are classified based on molecular alterations, with HMGA2::NCOR2 fusions distinguishing them from other giant cell-rich tumors. The youngest patient, a neonate with metastatic disease, showed a remarkable response to imatinib therapy. The study expands the understanding of these tumors and their response to targeted therapy, highlighting the importance of molecular characterization in diagnosis and treatment. [Extracted from the article]

Published
2024
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23. De Novo SOX6 Variants Cause a Neurodevelopmental Syndrome Associated with ADHD, Craniosynostosis, and Osteochondromas

Author

Ambrose, J.C., Bleda, M., Boardman-Pretty, F., Boissiere, J.M., Boustred, C.R., Caulfield, M.J., Chan, G.C., Craig, C.E.H., Daugherty, L.C., de Burca, A., Devereau, A., Elgar, G., Foulger, R.E., Fowler, T., Furió-Tarí, P., Hackett, J.M., Halai, D., Holman, J.E., Hubbard, T.J.P., Kasperaviciute, D., Kayikci, M., Lahnstein, L., Lawson, K., Leigh, S.E.A., Leong, I.U.S., Lopez, F.J., Maleady-Crowe, F., Mason, J., McDonagh, E.M., Moutsianas, L., Mueller, M., Need, A.C., Odhams, C.A., Patch, C., Perez-Gil, D., Polychronopoulos, D., Pullinger, J., Rahim, T., Rendon, A., Rogers, T., Ryten, M., Savage, K., Scott, R.H., Siddiq, A., Sieghart, A., Smedley, D., Smith, K.R., Sosinsky, A., Spooner, W., Stevens, H.E., Stuckey, A., Thomas, E.R.A., Thompson, S.R., Tregidgo, C., Tucci, A., Walsh, E., Watters, S.A., Welland, M.J., Williams, E., Witkowska, K., Wood, S.M., Zarowiecki, M., Tolchin, Dara, Yeager, Jessica P., Prasad, Priya, Dorrani, Naghmeh, Russi, Alvaro Serrano, Martinez-Agosto, Julian A., Haseeb, Abdul, Angelozzi, Marco, Santen, G.W.E., Ruivenkamp, Claudia, Mercimek-Andrews, Saadet, Depienne, Christel, Kuechler, Alma, Mikat, Barbara, Ludecke, Hermann-Josef, Bilan, Frederic, Le Guyader, Gwenael, Gilbert-Dussardier, Brigitte, Keren, Boris, Heide, Solveig, Haye, Damien, Van Esch, Hilde, Keldermans, Liesbeth, Ortiz, Damara, Lancaster, Emily, Krantz, Ian D., Krock, Bryan L., Pechter, Kieran B., Arkader, Alexandre, Medne, Livija, DeChene, Elizabeth T., Calpena, Eduardo, Melistaccio, Giada, Wilkie, Andrew O.M., Suri, Mohnish, Foulds, Nicola, Begtrup, Amber, Henderson, Lindsay B., Forster, Cara, Reed, Patrick, McDonald, Marie T., McConkie-Rosell, Allyn, Thevenon, Julien, Le Tanno, Pauline, Coutton, Charles, Tsai, Anne C.H., Stewart, Sarah, Maver, Ales, Gorazd, Rudolf, Pichon, Olivier, Nizon, Mathilde, Cogné, Benjamin, Isidor, Bertrand, Martin-Coignard, Dominique, Stoeva, Radka, Lefebvre, Véronique, and Le Caignec, Cédric

Published
2020
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31. Interstitial mycosis fungoides

Author

Miguel Augusto M. Pereira, Mayara Toledo, Breno Arkader, and Luciana Pantaleão

Subjects
lymphoma, lymphoproliferative disorders, mycosis fungoides, granuloma annulare, Pathology, RB1-214
Abstract

ABSTRACT Interstitial mycosis fungoides (IMF) is a rare variant of mycosis fungoides, a cutaneous T-cell non-Hodgkin’s lymphoma. It is characterized by an interstitial dermal infiltrate of lymphocytes and histiocytes between collagen bundles. We report the case of a 54-year-old patient with pruritic hypochromic macules on the arms and forearms diagnosed with IMF. Special attention was given to the anatomopathological features that differentiate this entity from its differential diagnoses, such as inflammatory morphea, interstitial annular granuloma, and other variants of the mycosis fungoides itself. We also present a review of the literature on the classification of the IMF.

Published
2021
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38. Do Not Miss the Tumor: A Novel Presentation of Osteosarcoma

Author

Michael DePalma, Sachin Gupta, Jie Nguyen, Divya Talwar, Alexandre Arkader, and Lawrence Wells

Subjects
Pediatrics, RJ1-570
Abstract

Antalgic gait is a common clinical presentation among pediatric patients and can have many different etiologies, with rare life-threatening etiologies including primary bone malignancies. Osteosarcoma is the most common primary malignancy of bone in pediatric and adolescent patients. The incidence rate of osteosarcoma has been reported as high as 5 to 7 per million among patients 19 years old or younger with males slightly more affected than females and African-Americans more than other racial groups. This report describes the case of a five-year-old African-American female who presented with an antalgic gait secondary to osteosarcoma in the left distal femur and follows her through treatment. In this case, the age is atypical as the peak incidence for osteosarcoma is around 16 years of age and is postulated to coincide with growth spurts. Osteosarcoma can have a range of presentations making it difficult to diagnose, which can cause delays in treatment and potential poor patient outcomes. Due to this, such a diagnosis must be included in the differential for patients presenting with antalgic gait. Because primary-care physicians and pediatricians may be the first medical providers to encounter patients with osteosarcoma, it is imperative that such clinicians are familiar with the signs and symptoms associated with osteosarcomas in order to reduce the risk of metastasis and disease progression and prevent treatment delays. Additionally, we believe these clinicians should have a low threshold to refer patients to orthopedists or oncologic specialists in the cases of persistent pain or inconsistencies with history, physical exam, and diagnostic studies. Finally, direct communication and discussion between radiologists and referring clinicians helps decrease delays in diagnosing of osteosarcoma and other life-threatening conditions.

Published
2021
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40. 43. LONG-TERM OUTCOMES FOLLOWING FREE VASCULARIZED FIBULA PHYSEAL TRANSFER FOR PROXIMAL HUMERUS ONCOLOGIC RECONSTRUCTION IN CHILDREN: AN INTERNATIONAL MULTI-INSTITUTIONAL STUDY

Author

Said Azoury, MD, Ronnie Shammas, MD, Sammy Othman, MD, Amanda Sergesketter, MD, Brian Brigman, MD, Jie Nguyen, MD, Alexandre Arkader, MD, Kristy Weber, MD, Detlev Erdmann, MD PhD MHSc, Scott Levin, MD, Marco Innocenti, MD, and Stephen Kovach, MD

Subjects
Surgery, RD1-811
Published
2022
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41. Síndrome de Burnout entre cirurgiões

Author

Carvalho, Carlos José Barbosa de, primary, Oliveira, Lucas Cezar de, additional, Tavares, Natália Neves, additional, Carvalho, Luiza Lopes, additional, Abreu, Bernardo Costa Berriel, additional, Jiquiriçá, Larissa de Menezes, additional, Arkader, Breno Teixeira Faria, additional, Duarte, Carlos Henrique Jardim, additional, Wanderley, Ligia Souza, additional, and Cazagrande, Géssica Silva, additional

Published
2023
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