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21. [L-glutamic acid--a modulator of the physiological status of myeloid series blood cells].

Author

Astapova MV, Lipkin VM, Arkhipova MV, Andreeva SG, Dranitsyna SM, Merkulova MI, Nurieva RI, Navolotskaia EV, and Kostanian IA

Subjects
Bone Marrow Cells metabolism, Cell Differentiation drug effects, HL-60 Cells, Humans, Interleukin-1 genetics, Interleukin-6 genetics, K562 Cells, RNA, Messenger genetics, RNA, Messenger metabolism, Tumor Necrosis Factor-alpha genetics, Bone Marrow Cells drug effects, Glutamic Acid pharmacology
Abstract

The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-1 beta, IL-6, and TNF alpha were studied. It was shown that TNF alpha actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.

Published
1999

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