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4. Microcalcification crystallography as a potential marker of DCIS recurrence

Author

Gosling, Sarah B, Arnold, Emily L, Davies, Samantha K, Cross, Hannah, Bouybayoune, Ihssane, Calabrese, Doriana, Nallala, Jayakrupakar, Pinder, Sarah E, Fu, Liping, Lips, Esther H, King, Lorraine, Marks, Jeffrey, Hall, Allison, Grimm, Lars J, Lynch, Thomas, Pinto, Donna, Stobart, Hilary, Hwang, E Shelley, Wesseling, Jelle, Geraki, Kalotina, Stone, Nicholas, Lyburn, Iain D, Greenwood, Charlene, Rogers, Keith D, Grand Challenge PRECISION Consortium, Gosling, Sarah B [0000-0002-7034-6547], Arnold, Emily L [0000-0001-5469-2071], Davies, Samantha K [0000-0002-1819-1904], Cross, Hannah [0000-0002-5339-4432], Bouybayoune, Ihssane [0000-0002-7185-1991], Calabrese, Doriana [0000-0002-3868-9830], Nallala, Jayakrupakar [0000-0002-9473-5782], and Apollo - University of Cambridge Repository

Subjects
Carcinoma, Intraductal, Noninfiltrating, Crystallography, Carcinoma, Ductal, Breast, Tumor Microenvironment, Humans, Calcinosis, Female, Breast Neoplasms, Neoplasm Recurrence, Local
Abstract

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.

Published
2023

7. Microcalcification crystallography as a potential marker of DCIS recurrence.

Author

Gosling, Sarah B., Arnold, Emily L., Davies, Samantha K., Cross, Hannah, Bouybayoune, Ihssane, Calabrese, Doriana, Nallala, Jayakrupakar, Pinder, Sarah E., Fu, Liping, Lips, Esther H., King, Lorraine, Marks, Jeffrey, Hall, Allison, Grimm, Lars J., Lynch, Thomas, Pinto, Donna, Stobart, Hilary, Hwang, E. Shelley, Wesseling, Jelle, and Geraki, Kalotina

Subjects
*CALCIFICATIONS of the breast, *CALCIUM ions, *CANCER invasiveness, *CANCER relapse, *PROGNOSIS, *CRYSTALLOGRAPHY
Abstract

Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation. [ABSTRACT FROM AUTHOR]

Published
2023
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