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Neuroticism, i.e., the disposition to experiencing feelings of emotional distress, including anxiety, depression, and anger, is often considered a relatively stable and fundamental personality characteristic (trait neuroticism). However, the level of neuroticism can also vary within individuals (state neuroticism), depending on external factors such as life events and work stress. The aim of the current study was to examine to what extent having a holiday can reduce state neuroticism. A survey was conducted among n = 213 young adults who were on holiday in Fiji (mean ± SD age of 24.5 ± 4.3, 46.9% women). In addition to demographics, they completed the neuroticism scale of the Eysenck Personality Questionnaire—revised Short Scale (EPQ-RSS). Compared to at home, a significant reduction (p < 0.001) in neuroticism was reported when they were on holiday (mean ± SD of 4.5 ± 3.0 versus 2.1 ± 2.3, respectively). The effect was seen in both men and women. Women had significantly higher neuroticism ratings than men, both at home (mean ± SD of 5.4 ± 2.9 versus 3.6 ± 2.9, respectively, p < 0.001) and on holiday (mean ± SD of 2.5 ± 2.4 versus 1.6 ± 2.0, respectively, p < 0.001). No significant differences were seen between individuals with a job at home or students. The correlation between neuroticism at home and the difference rating in neuroticism (‘at home’—‘in Fiji’ assessment) was highly significant (r = 0.68, p < 0.001). In conclusion, having a holiday was associated with significantly reduced levels of neuroticism. Those with the highest levels of neuroticism at home benefited the most from having a holiday.

The overall objective of the present systematic review is to explore the relationship between different dietary patterns and brain imaging outcomes in older adults published between 1900 and 2020. Aim: Systematically review published literature exploring the role of dietary patterns on neuroimaging outcomes in adults. Questions: - Which neuroimaging outcomes are used to examine this relationship? - What is the association between dietary pattern adherence and white matter integrity, brain volume, and biomarkers of Alzheimer’s disease in older individuals? /Which AD- biomarkers and brain areas are associated with the dietary patterns? - What is the association between dietary patterns and cognitive performance measures? - What are the strengths and weaknesses of the current published research? - What are future research directions?

The alcohol hangover is defined as the combination of negative mental and physical symptoms, which can be experienced after a single episode of alcohol consumption, starting when blood alcohol concentration (BAC) approaches zero. Here, we present the book "The alcohol hangover: causes, consequences, and treatment", written to celebrate the 10th anniversary of the Alcohol Hangover Research Group (AHRG), summarizing recent advances in the field of alcohol hangover research.

The aim of this study was to investigate whether baseline mood and/or mood while drinking have an impact on alcohol hangover severity. A survey was held among N = 331 young adults (mean age = 23.6 years, range = 18-35 years). Demographics, alcohol consumption, subjective intoxication, and hangover severity were assessed for the past three days. In addition, mood (baseline, while drinking, and during hangover) was also assessed. N = 143 participants reported to be hungover on the day of assessment, N = 122 participants reported to have been hungover the previous day ('yesterday'), and N = 87 participants reported to have been hungover two days before the assessment ('2 days ago'). The analyses revealed that baseline mood and mood while drinking had no relevant effect on the amount of consumed alcohol and did not significantly contribute to hangover severity. However, hangover severity was associated with significantly increased negative affect, particularly with higher levels of subjective stress on the day of the hangover.

The 2010 Alcohol Hangover Research Group consensus paper defined a cutoff blood alcohol concentration (BAC) of 0.11% as a toxicological threshold indicating that sufficient alcohol had been consumed to develop a hangover. The cutoff was based on previous research and applied mostly in studies comprising student samples. Previously, we showed that sensitivity to hangovers depends on (estimated) BAC during acute intoxication, with a greater percentage of drinkers reporting hangovers at higher BAC levels. However, a substantial number of participants also reported hangovers at comparatively lower BAC levels. This calls the suitability of the 0.11% threshold into question. Recent research has shown that subjective intoxication, i.e., the level of severity of reported drunkenness, and not BAC, is the most important determinant of hangover severity. Non-student samples often have a much lower alcohol intake compared to student samples, and overall BACs often remain below 0.11%. Despite these lower BACs, many non-student participants report having a hangover, especially when their subjective intoxication levels are high. This may be the case when alcohol consumption on the drinking occasion that results in a hangover significantly exceeds their "normal" drinking level, irrespective of whether they meet the 0.11% threshold in any of these conditions. Whereas consumers may have relative tolerance to the adverse effects at their "regular" drinking level, considerably higher alcohol intake-irrespective of the absolute amount-may consequentially result in a next-day hangover. Taken together, these findings suggest that the 0.11% threshold value as a criterion for having a hangover should be abandoned.

The self-assessment of perceived immune status is important, as this subjective observation leads individuals to decide whether or not to seek medical help or adapt their lifestyle. In addition, it can be used in clinical settings and research. The aim of this series of studies was to develop and validate a short questionnaire to assess perceived immune functioning. Five surveys were conducted among Dutch and International young healthy adults (18&ndash, 30 years old), and two others among older age groups with various health complaints. For the first study, an existing immune functioning scale was modified and elaborated resulting in 23 immune-health-related items, of which the occurrence was rated on a 5-point Likert scale. A student sample was surveyed, and the results were used to shorten the 23-item listing into a 7-item scale with a predictive validity of 85%. Items include &ldquo, sudden high fever&rdquo, &ldquo, diarrhea&rdquo, headache&rdquo, skin problems (e.g., acne and eczema)&rdquo, muscle and joint pain&rdquo, common cold&rdquo, and &ldquo, coughing&rdquo, The scale is named Immune Status Questionnaire (ISQ), and it aims to assess perceived immune status over the preceding year. The second study revealed that the ISQ score correlated significantly with a 1-item perceived immune functioning (r = 0.383, p &lt, 0.0001). In the third study, the final Likert scale descriptors were determined (&ldquo, never&rdquo, sometimes&rdquo, regularly&rdquo, often&rdquo, (almost) always)&rdquo, The fourth study showed that the test&ndash, retest reliability of the ISQ is acceptable (r = 0.80). The fifth study demonstrated the association of ISQ scores with various neuropsychological and health correlates in an international sample, including perceived health and immune fitness, as well as levels of stress, fatigue, depression and anxiety. Study 6 demonstrated significant associations between ISQ scores and experiencing irritable bowel syndrome (IBS) symptoms in a sample of insomnia patients. Study 7 compared the effect of a dietary intervention in participants reporting &ldquo, poor health&rdquo, versus &ldquo, normal health&rdquo, It is shown that ISQ scores can differentiate between those with poor and normal health, and that an effective intervention is associated with a significant improvement in ISQ scores. Data from Study 7 were further used to determine an ISQ cut-off value for reduced immune functioning, and a direct comparison with 1-item perceived immune functioning scores enabled constructing the final scoring format of the ISQ. In conclusion, the ISQ has appropriate face, content, and construct validity and is a reliable, stable and valid method to assess the past 12 month&rsquo, s perceived immune status.

Although hangover is a common consequence of heavy alcohol consumption, the area is heavily under-researched. Hangover frequency is a potential predictor of future alcohol use disorder that may be affected by hangover severity, yet the relationship between hangover frequency and severity has not been investigated. Using different methodologies and assessment instruments, two surveys, and one naturalistic study collected data on hangover frequency, hangover severity, and alcohol consumption. The relationship between hangover frequency and severity was investigated via correlational analysis, considering potentially moderating variables including alcohol intake, estimated blood alcohol concentration, demographics, and personality characteristics. In all the three studies, a positive and significant association between hangover frequency and severity was found, which remained significant after correcting for alcohol intake and other moderating factors. These findings suggest that hangover severity increases when hangovers are experienced more frequently and may be driven by sensitization or reverse tolerance to this aspect of alcohol consumption. Future research should further investigate the relationship between hangover frequency and severity and alcohol use disorder and its implications for prevention.