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Nofluxo de carga, a obtenção do estado da operação de redes elétricas de potência, tem como base matemática métodos numéricos comoNewton-Raphsoncom as variações dos métodos desacoplado e desacoplado rápido. Dentre as principais ferramentas as quaisutilizam estes métodos numéricos, sãoprogramas de modelagem computacional. Mesmo que tais programas sejam ótimas ferramentas de análise, as demandas atuais precisam de programas velozes ede simplesmodelagem para os sistemas de transmissão/ distribuição e operação deredeselétricasde potência. A utilização do software ATPDrawdeve-se pela simplificação e praticidade com a construção de suas simulações baseadas nos métodos já consagrados no estudo de fluxo de carga, sendouma excelente ferramenta para tais estudos. O presente trabalho aborda amodelagem de um sistema de transmissão de duas barras, com barras PQ e PVedo sistema de distribuição IEEE de quatro barras.As simulações dos sistemas de duas barrase do sistema IEEE 4 barra permitiram observar as tensões elétricas nas barras do sistemaeos fluxos de potência nas linhas de transmissão e distribuição, comprovando aeficácia do ATPDraw na análise da rede elétrica em regime permanente.

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PDF file, 146KB, Selected EDDMs of singlet transitions and empty frontier orbitals for 3.

PDF file, 138KB, Representative Annexin-V flow cytometry results.

PDF file, 105KB, 14N{1H} NMR spectra of unlabelled and 15N-NH3 labelled 3.

PDF file, 121KB, 14N {1H} NMR spectra monitoring the irradiation of 3 in buffered solution.

PDF file, 150KB, Effect of complex 3 on nuclear morphology of A2780 & A2780CIS cells.

Photoactivatable PtIV diazido complexes have unusual photobiologic properties. We show here that trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)] complex 3 is a potent photoactivated cytotoxin toward human cancer cells in culture, with an average IC50 value in 13 cell lines of 55 ± 28 μmol/L after 30 minutes (0.12 mW/cm2) photoactivation with UVA, although visible light was also effective. Photoactivated complex 3 was noncross-resistant to cisplatin in 3 of 4 resistant cell lines. Cell swelling but very little blebbing was seen for HL60 cells treated with irradiated complex 3. Unlike cisplatin and etoposide, both of which cause apoptosis in HL60 cells, no apoptosis was observed for UVA-activated complex 3 by the Annexin V/propidium iodide flow cytotometry assay. Changes in the levels of the autophagic proteins LC3B-II and p62 in HL60 cells treated with UVA-activated complex 3 indicate autophagy is active during cell death. In a clonogenic assay with the SISO human cervix cancer cell line, 3 inhibited colony formation when activated by UVA irradiation. Antitumor activity of complex 3 in mice bearing xenografted OE19 esophageal carcinoma tumors was photoaugmented by visible light. Insights into the novel reaction pathways of complex 3 have been obtained from 14N{1H} nuclear magnetic resonance studies, which show that photoactivation pathways can involve release of free azide in buffered solution. Density functional theory (DFT) and time-dependent DFT calculations revealed the dissociative character of singlet and triplet excited states of complex 3, which gives rise to reactive, possibly cytotoxic azidyl radicals. Mol Cancer Ther; 11(9); 1894–904. ©2012 AACR.

PDF file, 73KB, Calculated and experimental absorption spectra of 3.

The emergence of IoT opened new opportunities for development in various fields. With all the information that it gathers, it became an interesting target for multiple attackers. Thus, this study will enforce security solutions to IoT-based devices specifically in the perception layer by incorporating a Temperature Comparison Test, Keyed Hash Algorithm and evaluating it using SPRT especially in the defense against malicious activities detected in the nodes of a network namely for Mobile and Immobile attacks. For immobile attacks, using the keyed hash algorithm and the SPRT, the hash key of the passcodes was compared to determine the safety of the nodes. Hence, from the functionality test that was conducted, and evaluating the data gathered using SPRT and Bernoulli’s equation, the reliability of the protocol to detect Immobile attacks is concluded to have a 100% detection rate. For mobile node attacks, the study assumes the environment to be under normal, warm, and cold room temperatures. where both mobile and without mobile attack is simulated, the result shows that there is only an overall 3% difference from the temperature measure by the sensor to the ambient temperature. Hence, combining these protocols that are applied in the study eliminates the single points of failure in the nodes that are either applicable only to a distributed scheme or mobility support, the study also compared the tested protocol to the other existing protocols.

Titanium dioxide is a widely-investigated semiconductor photocatalyst due to its wide availability and low cost. Although it has been successfully used in the photocatalytic treatment of various organics in wastewater, it remains a challenge to modify its structure to achieve enhanced catalytic properties at a wider light spectrum. Doping with transition metals was seen to narrow its optical band gap yet synthesis routes have been largely limited to the use of high-end equipment. Herein we demonstrate the use of a simpler one-pot approach to synthesize nanoporous arrays of silver-doped titanium dioxide nanotubes (Ag-TiNTs) by double anodization of titanium sheets. The synthesized Ag-TiNTs have an average inner diameter of 58.68 nm and a wall thickness of 16.46 nm. ATR-FTIR spectroscopy revealed its characteristic peaks attributed to O-Ti-O bonds. Silver doping increased the lattice volume and crystallite size of anatase with a corresponding decrease in the degree of crystallinity due to the introduction of impurity Ag atoms in its tetragonal structure. Silver was homogeneously distributed across the nanotube surface at an average loading of 1.41 at. %. The synthesized Ag-TiNTs were shown to have a superior photoelectrocatalytic activity in degrading C.I. Basic Blue 9 under UV illumination with a pseudo-first-order kinetic rate of 1.0253 x 10-2 min-1. Most importantly, the Ag-TiNTs are photoelectrocatalytically-active even at a low Ag loading.

(1) Background: Sepsis is a leading cause of death and a global public health problem. Accordingly, deciphering the underlying molecular mechanisms of this disease and the determinants of its morbidity and mortality is pivotal. This study examined the effect of the rs951818 SNP of the negative costimulatory lymphocyte-activation gene 3 (LAG-3) on sepsis mortality and disease severity. (2) Methods: 707 consecutive patients with sepsis were prospectively enrolled into the present study from three surgical ICUs at University Medical Center Goettingen. Both 28- and 90-day mortality were analyzed as the primary outcome, while parameters of disease severity served as secondary endpoints. (3) Results: In the Kaplan–Meier analysis LAG-3 rs951818 AA-homozygote patients showed a significantly lower 28-day mortality (17.3%) compared to carriers of the C-allele (23.7%, p = 0.0476). In addition, these patients more often received invasive mechanical ventilation (96%) during the course of disease than C-allele carriers (92%, p = 0.0466). (4) Conclusions: Genetic profiling of LAG-3 genetic variants alone or in combination with other genetic biomarkers may represent a promising approach for risk stratification of patients with sepsis. Patient-individual therapeutic targeting of immune checkpoints, such as LAG-3, may be a future component of sepsis therapy. Further detailed investigations in clinically relevant sepsis models are necessary.

Background Cardiac paragangliomas are rare tumors that develop from neural crest cells. They account for about 2% of all paragangliomas and there is only limited evidence of malignant transformation. Case presentation We present a young woman with atypical symptoms, which are related to the mass effect of the 40 × 49mm cardiac tumor on top of the left atrium. The patient underwent an extensive resection of the tumor including the root of the pulmonary trunk, the ascending aorta, and the left main artery. Conclusions The present case is of great importance showing the need for multidisciplinary approach in the management of cardiac tumors that infiltrate multiple anatomic structures.

Highly-organized one-dimensional arrays of copper-doped titanium dioxide nanotubes (Cu-TiNTs) were synthesized in a one-pot approach by double anodization of titanium sheets. Field-emission scanning electron microscopy showed that Cu-TiNTs have an average inner diameter of 52.13 nm, a wall thickness of 14.28 nm, and a tube length of 0.6401 μm. Fourier-transform infrared spectroscopy confirmed the presence of characteristic O-Ti-O bond of TiO2. X-ray fluorescence spectroscopy confirmed copper-doping with an average dopant loading of 0.0248%. Even at this low dopant loading, Cu-TiNTs were shown to be photo-active in degrading Acid Orange 52 (AO 52) under UV light illumination. The kinetic profiles of AO 52 photoelectrochemical degradation were best described by the pseudo-first-order kinetic model (R2 ≥ 0.991) with kinetic constants 9.42 x 10-3 min-1 for Cu-TiNTs as compared to 6.04 x 10-3 min-1 for pristine TiNTs. Overall, doping pristine TiNTs with Cu was shown to enhance its photoelectrocatalytic properties in degrading textile dyes such as AO 52.

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between ~10,500 and ~400 years ago. We date the most recent common ancestor of all HBV lineages to between ~20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for ~4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.