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Objective: to detect lung morphological changes in acute intoxications with clozapine, ethanol, and their combination 3 and 24 hours after poisoning. Materials and methods. Experiments were carried out in outbred male rats weighing 270—300 g. Clozapine was given in a dose of 250 mg per kg animal body weight under chloralose anesthesia. Following 3 and 24 hours, the animals were withdrawn from the experiment by decapitation. Lung histological sections from 6 rats that had received oral clozapine 250 mg/kg, 6 rats that had oral ethanol 8.6 ml/kg, and 6 rats that had a combination of ethanol and clozapine orally in the above doses were examined 3 hours after intoxication. Those from 18 rats that had been orally given the similar agents in the above doses and withdrawn from the experiment were also investigated 24 hours after drug administration. The sections were compared with those from 6 rats that had not received the above agents. Nonparametric methods (χ2 test) were used for statistical processing. The investigators assessed the following morphological signs: circulatory disorders (plethora, hemorrhages), interstitial and alveolar edema, damage to the bronchial and alveolar epithelium and to the endothelium, and a cell reaction. The differences were considered significant at p

Objective: to reveal early lung morphological changes after acidin-pepsin aspiration (a combination of hydrochloric acid and proteolytic enzyme). Material and methods. An experiment was made on 30 non-inbred albino male rats whose trachea acidin-pepsin solution (pH 1.2) was administered into. The experiment lasted 1 to 24 hours. Lung histological specimens were stained with hematoxylin and eosin. Results. After an hour of surgery, all the animals developed interstitial edema, had the desquamated bronchial epithelium, segmented leukocytic infiltration of alveolar septa, hemorrhages, and sludges. Conclusion. Acidin-pepsin aspiration leads to the development of acute lung injury verified by morphological studies. Key words: aspiration, acute lung lesion.