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In this article we examine recent developments in the research area concerning the creation of end-to-end models for the complete optimization of measuring instruments. The models we consider rely on differentiable programming methods and on the specification of a software pipeline including all factors impacting performance -- from the data-generating processes to their reconstruction and the extraction of inference on the parameters of interest of a measuring instrument -- along with the careful specification of a utility function well aligned with the end goals of the experiment. Building on previous studies originated within the MODE Collaboration, we focus specifically on applications involving instruments for particle physics experimentation, as well as industrial and medical applications that share the detection of radiation as their data-generating mechanism., Comment: 70 pages, 17 figures. To be submitted to journal

Mergers and Acquisitions represent important forms of business deals, both because of the volumes involved in the transactions and because of the role of the innovation activity of companies. Nevertheless, Economic Complexity methods have not been applied to the study of this field. By considering the patent activity of about one thousand companies, we develop a method to predict future acquisitions by assuming that companies deal more frequently with technologically related ones. We address both the problem of predicting a pair of companies for a future deal and that of finding a target company given an acquirer. We compare different forecasting methodologies, including machine learning and network-based algorithms, showing that a simple angular distance with the addition of the industry sector information outperforms the other approaches. Finally, we present the Continuous Company Space, a two-dimensional representation of firms to visualize their technological proximity and possible deals. Companies and policymakers can use this approach to identify companies most likely to pursue deals or to explore possible innovation strategies.