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In this work, a novel 4-aminophenylarsonic acid functionalized polyoxovanadates (POVs) hybrid material, namely, (Me2NH2)4 ·[(L)8(H12V16O32)] (H2L = 4-NH2C6H4AsO3H2) POVs 1 was solvothermally synthesized and fully characterized. The results revealed POVs 1 consists of four similar tetranuclear vanadium clusters bridged by eight organic 4-aminophenylarsonic acid ligands. Remarkably, functionalized hybrid POVs 1 was further investigated as a heterogeneous stable catalyst in oxidation of sulfide derivatives, and exhibited high catalytic activities (yields up to 96.7%). Additionally, the functionalized hybrid polyoxovanadates catalyst can be reused without losing activities after three runs cycle.

The crystal structures of the 1:1 proton-transfer compounds of (4-aminophenyl)arsonic acid (p-arsanilic acid) with the strong organic acids, 2,4,6-trinitrophenol (picric acid), 3,5-dinitrosalicylic acid, (3-carboxy-4-hydroxy)benzenesulfonic acid (5-sulfosalicylic acid) and toluene-4-sulfonic acid have been determined at 200 K and their hydrogen–bonding patterns examined. The compounds are, respectively, anhydrous 4-arsonoanilinium 2,4,6-trinitrophenolate (1), the hydrate 4-arsonoanilinium 2-carboxy-4,6-dinitrophenolate monohydrate (2), the hydrate 4-arsonoanilinium (3-carboxy-4-hydroxy)benzenesulfonate monohydrate (3) and the partial solvate 4-arsonoanilinium toluene-4-sulfonate 0.8 hydrate (4). The asymmetric unit of 2, a phenolate, comprises two independent but conformationally similar cation-anion pairs and two water molecules of solvation, and in all compounds, extensive inter-species hydrogen–bonding interactions involving arsono O–H···O and anilinium N–H···O hydrogen–bonds generate three-dimensional supramolecular structures. In the cases of 1 and 2, the acceptors include phenolate and nitro O-atom acceptors, with 3 and 4, additionally, sulfonate O-atom acceptors, and with the hydrates 2–4, the water molecules of solvation. A feature of the hydrogen–bonding in 3 is the presence of primary chains extending along (010) through centrosymmetric cyclic R 2 2(8) motifs together with conjoined cyclic R 3 4(12) motifs, which include the water molecule of solvation. The primary hydrogen–bonding in the substructure of 4 involves homomolecular cation–cation arsono O–H···O interactions forming columns down the crystallographic four-fold axis of the unit cell.

In the present study the use of 3-Nitro in the dosage 3mg/kg diet was found to impart a stimulatory effect on growth and early maturation among the treated males and females. The treatment of 3 mg 3-Nitro per kg of diet resulted in a higher percentage of males (70%) as compared to that of 5 mg treatment group (65%) and control group (50%). The treatment of 3 mg 3-Nitro per kg of diet was proved to be the best.

In order to use iron oxide nanoparticles (Fe3O4) in various applications, a surface modification that provides colloidal stability and additional functionality to the nanoparticles is necessary. For the modification of the nanoparticle surface with ligand molecules, the ligand molecule should contain an anchor group that has a strong affinity for the surface. However, currently used anchor groups have shown some problems such as low affinity and stability as well as reactivity with the surface. In this study, arsonic acid (RAsO(OH)2) was investigated as a novel anchor group. It was possible to introduce azide groups on the surface of iron oxide nanoparticles using 4-azidophenylarsonic acid, and the desired functional molecules could be chemically attached to the surface via copper-catalyzed azide-alkyne cycloaddition (click chemistry). By quantifying and comparing the amount of attached anchors on the surface, it was found that arsonic acid displays better affinity than other currently used anchors (catechol, carboxylic acid). Furthermore, we examined the binding reversibility, long-term anchoring stability, and anchoring stability at various pH values. It was revealed that arsonic acid is a stable anchor in various conditions.

The title pseudo-arsonolipid with palmitoyl side chain has been prepared in ∼70% yield from its parent DL-2,3-dihydroxybutane-1,4-bis(arsonic acid) after reduction of the As(V) to As(III) by thioph...

Possible routes for the preparation of 2,3,4-trihydroxybutylarsonic acid, a key compound for the synthesis of novel arsonolipids, were experimentally evaluated. The best substrate was found to be 3,4-epoxybutane-1,2-diol. Its reaction with alkaline sodium arsenite, “Na 3 AsO 3 ,” gave the arsonic acid in ∼ 50% yield, as two pairs of diastereoisomers, each pair being a racemic mixture.

2-Hydroxypropane-1,3-bis(arsonic acid) after six successive reactions gives the arsinolipid 2-acyloxy-As, As'-bis[2,3-di(acyloxy)propyl]propane-1,3-diylbis(arsinic acid) in 20-40% overall yields. This arsinolipid is a non-isosteric analogue of the fully acylated cardiolipin. The R- and S-glycidol, used to create the backbone of the lipid, give the optically active RR and SS, respectively, arsinolipids, while the rac-glycidol produces a mixture of diastereomers (a racemic pair, RR and SS, and two meso forms with an RS configuration). Some properties of these arsinolipids are described, from which the most interesting are the facile hydrolysis of the middle acyl group and their tendency to absorb environmental water.

OBJECTIVES: This study was undertaken to assess reliable biological indicators for monitoring the occupational exposure to inorganic arsenic (iAs), taking into account the possible confounding role of arsenicals present in food and of the element present in drinking water. METHODS: 51 Glass workers exposed to As trioxide were monitored by measuring dust in the breathing zone, with personal air samplers. Urine samples at the end of work shift were analysed for biological monitoring. A control group of 39 subjects not exposed to As, and eight volunteers who drank water containing about 45 micrograms/l iAs for a week were also considered. Plasma mass spectrometry (ICP-MS) was used for the analysis of total As in air and urine samples, whereas the urinary As species (trivalent, As3; pentavalent, As5; monomethyl arsonic acid, MMA; dimethyl arsinic acid, DMA; arsenobetaine, AsB) were measured by liquid chromatography coupled with plasma mass spectrometry (HPLC-MS) RESULTS: Environmental concentrations of As in air varied widely (mean 84 micrograms/m3, SD 61, median 40) and also the sum of urinary iAs MMA and DMA, varied among the groups of exposed subjects (mean 106 micrograms/l, SD 84, median 65). AsB was the most excreted species (34% of total As) followed by DMA (28%), MMA (26%), and As3 + As5 (12%). In the volunteers who drank As in the water the excretion of MMA and DMA increased (from a median of 0.5 to 5 micrograms/day for MMA and from 4 to 13 micrograms/day for DMA). The best correlations between As in air and its urinary species were found for total iAs and As3 + As5. CONCLUSIONS: To avoid the effect of As from sources other than occupation on urinary species of the element, in particular on DMA, it is proposed that urinary As3 + As5 may an indicator for monitoring the exposure to iAs. For concentrations of 10 micrograms/m3 the current environmental limit for iAs, the limit for urinary As3 + As5 was calculated to be around 5 micrograms/l, even if the wide variation of values needs critical evaluation and application of data. The choice of this indicator might be relevant also from a toxicological point of view. Trivalent arsenic is in fact the most active species and its measure in urine could be the best indicator of some critical effects of the element, such as cancer.

The geometrical paramaters for the title compound, C9H10AsNO4 or [As(C9H8NO)O(OH)2], are normal. The dihedral angle between the benzene ring and the acrylamide group is 12.2 (2)°. A network of hydrogen bonds leads to a chain structure.

A series of 12 organic arsonic acid compounds has been synthesized and evaluated against human B-lineage (NALM-6) and T-lineage (MOLT-3) acute lymphoblastic leukemia (ALL) cell lines. The lead compounds 2-trichloromethyl-4-[4'-(4"-phenylazo)phenylarsonic acid]aminoquinazoline (compound 19, PHI-P518; IC(50)=1.1+/-0.5 microM against NALM-6 and 2.0+/-0.8 microM against MOLT-3) and 2-methylthio-4-(2'-phenylarsonic acid)aminopyrimidine (compound 15, PHI-P381; IC(50)=1.5+/-0.3 microM against NALM-6 and 2.3+/-0.5 microM against MOLT-3) exhibited potent antileukemic activity at low micromolar concentrations.

We report the synthesis and characterization of the arsonic acid-presenting superparamagnetic iron oxide (SPIO). We used arsonoacetic acid as the ligand for SPIOs in aqueous media. The surface modification of the SPIOs was accomplished via the ligand exchange from undecanoic acid to the carboxyl moiety of arsonoacetic acid. Consequently, the well-dispersed arsonic acid-presenting SPIOs in water were obtained. We found that the dispersion state of the arsonic acid-presenting SPIOs can be sharply regulated by pH changes in the biological significant region. The well dispersion state of the arsonic acid-presenting SPIOs can be maintained at the neutral pH region. In contrast, the arsonic acid-presenting SPIOs can sensitively form the aggregation below pH 6.1. Moreover, these dispersion states can be controlled reversibly by the pH alteration in the narrow region.

Treatment of (μ-H) 3 Os 3 (CO) 9 (μ 3 -CH) sequentially with trifluoromethanesulfonic acid followed by a phosphoric or arsonic acid provides compounds of the formula (μ-H) 2 Os 3 (CO) 9 (μ 3 η 3 -O 3 ER) [E  P, R  Ph( 3 ), Me( 4 ); E  As, R  Ph( 5 )] Assignments of important infrared bands for the coordinated oxyanions have been made. The complex (μ-H) 2 Os 3 (CO) 9 (μ,η 3 3 O 3 PPh) ( 3 ) has been studied by variable temperature 13 C NMR spectroscopy. The reaction of Os 3 (CO) 10 (S) 2 (S = C 8 H 14 ,CH 3 CN) with Ph 2 PO 2 H in THF at 55–60°C produces (μ-H)Os 5 (CO) 10 (μ,η 2 O 2 PPh 2 ) ( ca. 60%), the structure of which has been determined by X-ray crystallography.

The synthesis and properties of a key intermediate for arsonolipids, rac-1,2-dihydroxypropyl-3-arsonic acid and its salts, are described. The mechanism of the Meyer reaction with β-hydroxy alkyl halides is discussed.

The reaction of DL-1,3-butadiene diepoxide and of DL-1,4-dibromo-2,3-butanediol with aqueous alkaline sodium arsenite, "Na(3)AsO(3)", gave mixtures of the title arsonic acids which can be separated by anion exchange resin. Characterization of by-products leads to a better understanding of these reactions. These compounds are valuable intermediates for the preparation of novel arsonic acids and bis(arsonic acids).

The structure of the title salt adduct, (C(4)H(9))(4)N(+)·C(6)H(5)AsO(3)H(-)·C(6)H(5)AsO(3)H(2), features chains along the a axis comprising alternating hydrogen phenyl-arsonate anions and phenyl-arsonic acid mol-ecules linked by O-H⋯O hydrogen bonds.