Tuberculosis is still one of the diseases that cause health problems in the community. Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Indonesia is ranked third in the world with the highest burden in the world for TB cases, this can be influenced by several factors. This study aims to determine the factors that influence the level of knowledge and attitudes regarding the prevention and spread of TB in the ethnic Mandar of the Rangas village, Banggai District, Majene Regency, West Sulawesi. This study used an observational analytic design. 200 respondents were selected by purposive sampling. Data collected included gender, age, family income, education, knowledge about TB, and the attitude of respondents. Data was processed using SPSS for univariate analysis and path analysis to understand the relationship of variables. The results showed that there was a significant relationship between the knowledge and attitudes of respondents with a value of 2, 521.