Search

Your search keyword '"Aruga, H."' showing total 96 results
Start Over Author "Aruga, H."
96 results on '"Aruga, H."'

5. Shock-compression of Eu2O3 doped polluctice phosphors

Author

Hamada, K., Kishimura, Hiroaki, Tominaga, Y., Morizumi, A., Aruga, H., and Matsumoto, Hitoshi

Subjects
Pollucite, Shock-compression, Photoluminescence, X-ray diffraction
Abstract

平成26年度衝撃波シンポジウム (2015年3月9日-11日. 群馬県伊香保温泉 ホテル天坊）渋川市, 群馬県, Symposium on Shock Waves in Japan, FY2014 (March 9-11, 2015. Hotel Tenbo), Shibukawa, Gunma, Japan, 資料番号: SA6000038032, レポート番号: 1C2-1（若）

Published
2015

6. Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells

Author

Maejima, T., Inoue, T., Kanki, Y., Kohro, T., Li, G., Ohta, Y., Kimura, Hiroshi, Kobayashi, M., Taguchi, A., Tsutsumi, S., Iwanari, H., Yamamoto, S., Aruga, H., Dong, S., Stevens, J. F., Poh, H. M., Yamamoto, K., Kawamura, T., Mimura, I., Suehiro, J., Sugiyama, A., Kaneki, K., Shibata, H., Yoshinaka, Y., Doi, T., Asanuma, A., Tanabe, S., Tanaka, T., Minami, T., Hamakubo, T., Sakai, J., Nozaki, N., Aburatani, H., Nangaku, M., Ruan, X., Tanabe, H., Ruan, Y., Ihara, S., Endo, A., Kodama, T., and Wada, Y.

Subjects
Microarrays, Thrombomodulin, lcsh:Medicine, Gene Expression, Nitric Oxide Synthase Type III/biosynthesis/genetics, Vascular Medicine, Epithelium, Chromosome conformation capture, Molecular Cell Biology, Medicine and Health Sciences, lcsh:Science, Regulation of gene expression, Multidisciplinary, Chromatin Assembly and Disassembly/*drug effects, Chromosome Biology, MEF2 Transcription Factors, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology, Quinolines/*pharmacology, Genomics, Animal Models, MEF2 Transcription Factors/genetics/metabolism, Chromatin, Bioassays and Physiological Analysis, Thrombomodulin ＜NLM MeSH Terms＞, Gene Knockdown Techniques, Quinolines, Anatomy, Cellular Types, Transcriptome Analysis, Research Article, Mef2, Chromosome Structure and Function, Drug Research and Development, Nitric Oxide Synthase Type III, Thrombomodulin/biosynthesis/genetics, Cardiology, Kruppel-Like Transcription Factors, Mouse Models, Kruppel-Like Transcription Factors/*biosynthesis/genetics, Biology, Research and Analysis Methods, Response Elements, Chromosomes, Kruppel-Like Factor 4, Model Organisms, Genetics, Human Umbilical Vein Endothelial Cells, Humans, Enhancer, Transcription factor, ChIA-PET, Pharmacology, lcsh:R, Biology and Life Sciences, Endothelial Cells, Computational Biology, Epithelial Cells, Cell Biology, Genome Analysis, Atherosclerosis, Chromatin Assembly and Disassembly, Molecular biology, Biological Tissue, Gene Expression Regulation, Cardiovascular Anatomy, Gene Expression Regulation/*drug effects/genetics, Human Umbilical Vein Endothelial Cells/cytology/*metabolism, lcsh:Q, Chromatin/genetics/*metabolism, Clinical Medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Genome Expression Analysis, Chromatin immunoprecipitation
Abstract

Statins exert atheroprotective effects through the induction of specific transcriptional factors in multiple organs. In endothelial cells, statin-dependent atheroprotective gene up-regulation is mediated by Kruppel-like factor (KLF) family transcription factors. To dissect the mechanism of gene regulation, we sought to determine molecular targets by performing microarray analyses of human umbilical vein endothelial cells (HUVECs) treated with pitavastatin, and KLF4 was determined to be the most highly induced gene. In addition, it was revealed that the atheroprotective genes induced with pitavastatin, such as nitric oxide synthase 3 (NOS3) and thrombomodulin (THBD), were suppressed by KLF4 knockdown. Myocyte enhancer factor-2 (MEF2) family activation is reported to be involved in pitavastatin-dependent KLF4 induction. We focused on MEF2C among the MEF2 family members and identified a novel functional MEF2C binding site 148 kb upstream of the KLF4 gene by chromatin immunoprecipitation along with deep sequencing (ChIP-seq) followed by luciferase assay. By applying whole genome and quantitative chromatin conformation analysis {chromatin interaction analysis with paired end tag sequencing (ChIA-PET), and real time chromosome conformation capture (3C) assay}, we observed that the MEF2C-bound enhancer and transcription start site (TSS) of KLF4 came into closer spatial proximity by pitavastatin treatment. 3D-Fluorescence in situ hybridization (FISH) imaging supported the conformational change in individual cells. Taken together, dynamic chromatin conformation change was shown to mediate pitavastatin-responsive gene induction in endothelial cells.

Published
2014

21. STATIC SCALING IN A SHORT-RANGE ISING SPIN-GLASS

Author

GUNNARSSON, K, SVEDLINDH, P, NORDBLAD, P, LUNDGREN, L, ARUGA, H, ITO, A, GUNNARSSON, K, SVEDLINDH, P, NORDBLAD, P, LUNDGREN, L, ARUGA, H, and ITO, A

Abstract

The nonlinear ac susceptibility chi’-nl of the short-range Ising spin glass Fe0.5Mn0.5TiO3 has been measured using a superconducting-quantum-interference-device magnetometer. The spin-glass temperature, T(g), and the critical exponent gamma were estimated from the temperature dependence of the quadratic field term of chi’nl, yielding T(g) = 20.70 and gamma = 4.0. Static-scaling analyses, using different scaling equations, gave similar results. Using gamma and results from previous dynamic-scaling analyses, a number of critical exponents have been obtained through different scaling relations, e.g., delta = 8.4 and nu = 1.7. The results support the existence of a finite-temperature phase transition in a three-dimensional Ising spin glass.

Published
1991
Full Text
View/download PDF

31. 1.3-μm uncooled DFB laser-diode module with a coupled differential feed for 10-Gb/s ethernet applications.

Author

Sakai, K., Aruga, H., Takagi, S.-I., Kawano, M., Negishi, M., Kondoh, Y., and Kaneko, S.-I.

Abstract

A coaxial 10-Gb/s 1.3-μm distributed feedback (DFB) laser-diode module with a coupled differential feed has been developed. The differential cascaded feed with the characteristic impedance of 100 Ω, which consists of a 140-Ω ground-signal-signal-ground (GSSG) leads, a small-sized 60-Ω feed-through, and a 140-Ω wire-bonding pad, provides less sensitivity to the lead length. Integrating with 25-Ω matching resistances and a 60-Ω differential microstrip line, whose length corresponds to one eighth of wavelength at 7 GHz, gives wide-band impedance matching between the feed and the laser diode portion with small power loss. Experiment shows good return loss of greater than 9 dB at 10 GHz, and small change of bit error rate (BER) up to the lead length of 4 mm. With a newly developed 250-μm cavity laser chip, we have demonstrated stable eye diagrams with the mask margins of 31 and 29% at case temperature of 0 and 85°C, respectively. [ABSTRACT FROM PUBLISHER]

Published
2004
Full Text
View/download PDF

36. Studies on spin-glass freezing and antiferromagnetic long-range order in an Ising spin-glass system FexMn1−xTiO3

Author

Ito, A., Morimoto, S., and Aruga, H.

Abstract

Abstract: A Mssbauer time window has been positively used for studying the behavior of spins in Fe x Mn1−x TiO3 withx=0.50, 0.60 and 0.65 which are of typical Ising spin-glass systems. Spin dynamics aboveT SG andT N (RSG) (definition is given in the text) are discussed. In the RSG samples, the existence of contributions of the transverse spin component to the hyperfine fields is pointed out.

Published
1990
Full Text
View/download PDF

41. Occurrence of an enzyme acting on xanthopterin-B in Bombyx mori.

Author

Aruga, H., Kawase, S., and Akino, M.

Abstract

Copyright of Experientia is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1954
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results