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Your search keyword '"Arumugam, Surendar"' showing total 14 results
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14 results on '"Arumugam, Surendar"'

1. Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer

Author

Akıncılar, Semih Can, primary, Chua, Joelle Yi Heng, additional, Ng, Qin Feng, additional, Chan, Claire Hian Tzer, additional, Eslami-S, Zahra, additional, Chen, Kaijing, additional, Low, Joo-Leng, additional, Arumugam, Surendar, additional, Aswad, Luay, additional, Chua, Clarinda, additional, Tan, Iain Beehuat, additional, DasGupta, Ramanuj, additional, Fullwood, Melissa Jane, additional, and Tergaonkar, Vinay, additional

Published
2022
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3. Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”

Author

Silva, Amanda K.A., primary, Morille, Marie, additional, Piffoux, Max, additional, Arumugam, Surendar, additional, Mauduit, Phlippe, additional, Larghero, Jérôme, additional, Bianchi, Arnaud, additional, Aubertin, Kelly, additional, Blanc-Brude, Olivier, additional, Noël, Danièle, additional, Velot, Emilie, additional, Ravel, Célia, additional, Elie-Caille, Céline, additional, Sebbagh, Anna, additional, Boulanger, Chantal, additional, Wilhelm, Claire, additional, Rahmi, Gabriel, additional, Raymond-Letron, Isabelle, additional, Cherukula, Kondareddy, additional, Montier, Tristan, additional, Martinaud, Christophe, additional, Bach, Jean-Marie, additional, Favre-Bulle, Olivier, additional, Spadavecchia, Jolanda, additional, Jorgensen, Christian, additional, Menasché, Philippe, additional, Aussel, Clotilde, additional, Chopineau, Joël, additional, Mosser, Mathilde, additional, Ullah, Matti, additional, Sailliet, Nicolas, additional, Luciani, Nathalie, additional, Mathieu, Noëlle, additional, Rautou, Pierre-Emmanuel, additional, Brouard, Sophie, additional, Boireau, Wilfrid, additional, Jauliac, Sébastien, additional, Dedier, Marianne, additional, Trouvin, Jean-Hugues, additional, Gazeau, Florence, additional, Trouillas, Marina, additional, Peltzer, Juliette, additional, Monsel, Antoine, additional, and Banzet, Sébastien, additional

Published
2021
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6. Abstract 2285: HFB10-1E1, a novel OX-40 agonistic antibody with a unique pharmacological profile and biomarker strategy

Author

Raue, Andreas, primary, Lu, Yun-Yueh, additional, Li, Ouyang, additional, Lu, Minmin, additional, Pi, Joyce, additional, Wu, Jia, additional, Feng, Mingfang, additional, Zhang, Qian, additional, Arumugam, Surendar, additional, Jin, Ruina, additional, Wang, Yuan, additional, Fulton, Ross, additional, Delince, Matthieu, additional, Crivello, Juliana, additional, Duda, Zachary, additional, Staskus, Alexandra, additional, Ortega, Charina, additional, Mary, Pascaline, additional, Zhang, Hongkai, additional, Beltraminelli, Nicola, additional, Adrian, Francisco, additional, and Schweizer, Liang, additional

Published
2020
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9. ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization.

Author

Hiu Yan Lam, Arumugam, Surendar, Han Gyu Bae, Cheng Chun Wang, Sangyong Jung, John, Ashley Lauren St., Wanjin Hong, Weiping Han, and Tergaonkar, Vinay

Subjects
*MEMBRANE fusion, *UBIQUITINATION, *MAST cells, *IMMUNOGLOBULIN E, *SECRETORY granules
Abstract

The article offers a study that demonstrates ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization. It focuses on an impaired degranulation that caused by reduced transcription of Syntaxin 4 (STX4) and Syntaxin binding protein 2 (Stxpb2), resulting from a lack of ELKS1-mediated stabilization of lysine-specific demethylase 2B (Kdm2b).

Published
2020
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10. Correction: Role of novel histone modifications in cancer

Author

Shanmugam, Muthu K., primary, Arfuso, Frank, additional, Arumugam, Surendar, additional, Chinnathambi, Arunachalam, additional, Bian, Jinsong, additional, Warrier, Sudha, additional, Wang, Ling Zhi, additional, Kumar, Alan Prem, additional, Ahn, Kwang Seok, additional, Sethi, Gautam, additional, and Lakshmanan, Manikandan, additional

Published
2018
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11. Role of novel histone modifications in cancer

Author

Shanmugam, Muthu K., primary, Arfuso, Frank, additional, Arumugam, Surendar, additional, Chinnathambi, Arunachalam, additional, Jinsong, Bian, additional, Warrier, Sudha, additional, Wang, Ling Zhi, additional, Kumar, Alan Prem, additional, Ahn, Kwang Seok, additional, Sethi, Gautam, additional, and Lakshmanan, Manikandan, additional

Published
2017
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14. Topiramate and Type 2 diabetes: an old wine in a new bottle

Author

Khanna, Vivek, Arumugam, Surendar, Roy, Subhasis, Mittra, Shivani, and Bansal, Vinay S

Abstract

Topiramate, a marketed antiepileptic drug, has been used to treat seizures and allied neurological problems since 1999. Recently, a series of newer findings for the use of topiramate have cropped up, which include Type 2 diabetes and obesity. In a series of clinical studies, a subset of neurological patients with Type 2 diabetes mellitus (T2DM) serendipitously showed better glycaemic control when treated with topiramate. It has since been demonstrated that topiramate can act both as an insulin secretagogue and sensitiser in T2DM animal models. Pathogenesis of Type 2 diabetes involves both β-cell dysfunction and insulin resistance. Therefore, an agent that has dual action (insulin secretagougue and sensitisation) is preferred for T2DM. Topiramate seems to act through multiple mechanisms to ameliorate diabetic symptoms, some of them unknown. Hence, it becomes imperative to discuss its probable modes of action. Topiramate raises new hope as an antidiabetic agent or a potential new chemotype with a better safety profile for the treatment of T2DM.

Published
2008
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