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Background/research question: Loneliness is a common condition impacting productivity and wellbeing. Nature-based social prescribing (NBSP) may promote nature contact, activate and strengthen social structures, and improve longer term mental and physical health. In six studies (three observational [for full text, please go to the a.m. URL]

Introduction: Social prescribing (SP) refers people with a wide range of social, emotional, or practical needs to community-based, non-clinical services (e.g., volunteering, arts activities, gardening, peer support) in coordination with local agencies and care professionals [ref:1]. Nature-based [for full text, please go to the a.m. URL]

Background: Real world evidence (RWE) pose additional methodological challenges for evaluating causality, including confounding, missing/misclassified data, no clear treatment assignment, dynamic treatment regimens, and switching. We aimed to assess the type and impact of biases potentially occurring[for full text, please go to the a.m. URL], 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

Patient-reported outcomes (PROs) are relevant and valuable endpoints in the care of patients with myelodysplastic syndromes (MDS). However, a consensus-based selection of PROs for MDS, derived by both patients and hematologists, is lacking. We aimed to develop a core set of PROs for patients with MDS as part of the prospective European LeukemiaNet MDS (EUMDS) Registry. Following international guidelines, candidate PROs were identified from a comprehensive literature search in MDS studies. Overall, 40 PROs were selected and evaluated in a two-round Delphi survey by 40 patients with MDS and 38 hematologists in the first, and 38 and 32 in the second round, respectively. Based on an agreement scale and predefined inclusion criteria, both patients and hematologists selected "general quality of life" as a core PRO. Hematologists also selected "transfusion-dependency burden" and "ability to work/activities of daily living" as core PROs. The second Delphi round increased PRO rating agreements. Statistically significant rating differences between patients and hematologists were observed for 28 PROs (Mann-Whitney U test; p-value

Background and objectives: Myelodysplastic syndromes (MDS) comprise a diverse group of myeloid clonal hemopathies more prevalent in older patients. The decision on the treatment strategy, influenced by the advanced age at diagnosis and the common comorbidities, is additionally being undermined by the[for full text, please go to the a.m. URL], Brücken bauen – von der Evidenz zum Patientenwohl; 19. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Evaluation of clinical effectiveness of medical devices differs in some aspects from the evaluation of pharmaceuticals. One of the main challenges identified is lack of robust evidence and a will to make use of experimental and observational studies (OSs) in quantitative evidence synthesis accounting for internal and external biases. Using a case study of total hip replacement to compare the risk of revision of cemented and uncemented implant fixation modalities, we pooled treatment effect estimates from OS and RCTs, and simplified existing methods for bias‐adjusted evidence synthesis to enhance practical application.\ud \ud We performed an elicitation exercise using methodological and clinical experts to determine the strength of beliefs about the magnitude of internal and external bias affecting estimates of treatment effect. We incorporated the bias‐adjusted treatment effects into a generalized evidence synthesis, calculating both frequentist and Bayesian statistical models. We estimated relative risks as summary effect estimates with 95% confidence/credibility intervals to capture uncertainty.\ud \ud When we compared alternative approaches to synthesizing evidence, we found that the pooled effect size strongly depended on the inclusion of observational data as well as on the use bias‐adjusted estimates. We demonstrated the feasibility of using observational studies in meta‐analyses to complement RCTs and incorporate evidence from a wider spectrum of clinically relevant studies and healthcare settings. To ensure internal validity, OS data require sufficient correction for confounding and selection bias, either through study design and primary analysis, or by applying post‐hoc bias adjustments to the results.

OBJECTIVES Patients with inflammatory bowel disease (IBD) have a high resource consumption, with considerable costs for the healthcare system. In a system with sparse resources, treatment is influenced not only by clinical judgement but also by resource consumption. We aimed to determine the resource consumption of IBD patients and to identify its significant predictors. MATERIALS AND METHODS Data from the prospective Swiss Inflammatory Bowel Disease Cohort Study were analysed for the resource consumption endpoints hospitalization and outpatient consultations at enrolment [1187 patients; 41.1% ulcerative colitis (UC), 58.9% Crohn's disease (CD)] and at 1-year follow-up (794 patients). Predictors of interest were chosen through an expert panel and a review of the relevant literature. Logistic regressions were used for binary endpoints, and negative binomial regressions and zero-inflated Poisson regressions were used for count data. RESULTS For CD, fistula, use of biologics and disease activity were significant predictors for hospitalization days (all P-values

Objectives: Decision analytic modeling allows evidence for short and long term benefits, harms and risks to be synthesized and therefore, can be used to support reimbursement decisions. Validation is an important step in the modeling process to quantify and reduce uncertainty and hereby building confidence[for full text, please go to the a.m. URL], Entscheiden trotz Unsicherheit; 14. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin

Objective: Whether resistance training (RT) alters visceral fat and several proinflammatory cytokines produced in adipose tissue has not been convinced established. The objective of this review was (1) to perform a meta-analysis of randomized controlled trials (RCT) regarding the effect of RT on a) [for full text, please go to the a.m. URL], 7th EFSMA – European Congress of Sports Medicine, 3rd Central European Congress of Physical Medicine and Rehabilitation